Vault-13

ASCENDIS PHARMA A/S

SPONSORED ADR · CUSIP 04351P101 · ISIN US04351P1012

187 institutional holders +4 vs Q3 2022
65,946,77465.9m shares reported held*
$8.1bnreported value*
26 new 68 added 68 reduced 23 sold out net sold ≈ $544.8m (-4.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $122.12. Options: 14 managers hold calls ($109.7m notional), 13 hold puts ($23.3m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 183Q4 22: 187187Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022183
Q4 2022187

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ3 22 calls: $224.7mQ3 22 puts: $20.5mQ3 22P/C 0.09Q4 22 calls: $109.7mQ4 22 puts: $23.3mQ4 22P/C 0.21
Numbers
QuarterCallsPutsP/C
Q3 2022$224.7m$20.5m0.09
Q4 2022$109.7m$23.3m0.21

Biggest buyers

T. Rowe Price Investment Management, Inc. Added +796,087+796.1k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +410,000+410.0k
Sofinnova Investments, Inc. Added +380,976+381.0k
Avoro Capital Advisors LLC Added +250,000+250.0k
Capital International Investors Added +248,546+248.5k
WESTFIELD CAPITAL MANAGEMENT CO LP Added +247,444+247.4k
FRANKLIN RESOURCES INC Added +223,430+223.4k
CITADEL ADVISORS LLC Added +202,346+202.3k
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New +172,751+172.8k
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ Added +159,246+159.2k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -4,029,561-4.0m
WELLINGTON MANAGEMENT GROUP LLP Reduced -618,621-618.6k
RA CAPITAL MANAGEMENT, L.P. Reduced -610,721-610.7k
EVENTIDE ASSET MANAGEMENT, LLC Reduced -416,291-416.3k
GOLDMAN SACHS GROUP INC Reduced -338,918-338.9k
Logos Global Management LP Sold out -250,000-250.0k
Spyglass Capital Management LLC Reduced -235,454-235.5k
Artisan Partners Limited Partnership Reduced -229,137-229.1k
BROWN ADVISORY INC Reduced -197,709-197.7k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -165,022-165.0k

Biggest calls

Deep Track Capital, LP Reduced $30.4m249.3k shares
JANE STREET GROUP, LLC Added $20.3m166.2k shares
Caption Management, LLC Reduced $19.4m159.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $18.8m154.2k shares
CITADEL ADVISORS LLC Reduced $10.8m88.6k shares
GROUP ONE TRADING LLC Reduced $3.0m24.5k shares
CITIGROUP INC New $3.0m24.2k shares
SIMPLEX TRADING, LLC Reduced $1.2m9.9k shares
Walleye Trading LLC Added $879.3k7.2k shares
GOLDMAN SACHS GROUP INC Reduced $806.1k6.6k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $5.2m42.4k shares
CITADEL ADVISORS LLC Added $3.9m31.9k shares
JANE STREET GROUP, LLC Added $3.7m30.6k shares
Caption Management, LLC Added $3.1m25.0k shares
CITIGROUP INC New $3.0m24.2k shares
SIMPLEX TRADING, LLC New $1.1m9.0k shares
Walleye Trading LLC Added $1.1m8.9k shares
SG3 Management, LLC Not comparable $916.0k7.5k shares
Walleye Capital LLC Added $671.7k5.5k shares
GROUP ONE TRADING LLC Reduced $342.0k2.8k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +0.6 pts · filed 2026-05-07 10.5% +0.6 pts 6.5m 2026-05-07
WESTFIELD CAPITAL MANAGEMENT CO LP 13G · institution -0.7 pts · filed 2026-02-11 8.5% -0.7 pts 5.2m 2026-02-11
FMR LLC 13G · institution filed 2025-05-12 8.0% 4.6m 2025-05-12
JANUS HENDERSON GROUP PLC 13G · institution -1.8 pts · filed 2026-05-15 6.0% -1.8 pts 3.7m 2026-05-15
Artisan Partners Limited Partnership 13G · institution filed 2026-02-03 5.2% 3.2m 2026-02-03

Fell to 5% or below in the last year: Capital International Investors (3.2%, 2026-05-14)

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 17.23% of their portfolio BOSTON, MA 6,957,1797.0m $849.7m $849.7m 17.23% Reduced -610.7k -610,721
2 Artisan Partners Limited Partnership 1.50% of their portfolio Milwaukee, WI 6,920,3566.9m $845.2m $845.2m 1.50% Reduced -229.1k -229,137
3 FMR LLC 0.06% of their portfolio BOSTON, MA 5,229,0705.2m $638.6m $638.6m 0.06% Reduced -49.8k -49,795
4 BAKER BROS. ADVISORS LP 3.63% of their portfolio NEW YORK, NY 4,954,8555.0m $605.1m $605.1m 3.63% Added +102.2k +102,200
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.07% of their portfolio BALTIMORE, MD 3,709,8413.7m $453.1m $453.1m 0.07% Reduced -165.0k -165,022
6 JANUS HENDERSON GROUP PLC 0.32% of their portfolio LONDON, X0 3,643,9553.6m $445.0m $445.0m 0.32% Reduced -4.0m -4,029,561
7 WESTFIELD CAPITAL MANAGEMENT CO LP 2.98% of their portfolio BOSTON, MA 3,158,1683.2m $385.7m $385.7m 2.98% Added +247.4k +247,444
8 Avoro Capital Advisors LLC 5.66% of their portfolio NEW YORK, NY 3,100,0003.1m $378.6m $378.6m 5.66% Added +250.0k +250,000
9 WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio Boston, MA 3,053,6053.1m $372.9m $372.9m 0.07% Reduced -618.6k -618,621
10 T. Rowe Price Investment Management, Inc. 0.27% of their portfolio BALTIMORE, MD 2,828,2672.8m $345.4m $345.4m 0.27% Added +796.1k +796,087
11 GOLDMAN SACHS GROUP INC 0.09% of their portfolio NEW YORK, NY 2,519,5122.5m $307.7m $307.7m 0.09% Reduced -338.9k -338,918
12 Capital International Investors 0.05% of their portfolio Los Angeles, CA 1,567,9971.6m $191.5m $191.5m 0.05% Added +248.5k +248,546
13 FRANKLIN RESOURCES INC 0.09% of their portfolio San Mateo, CA 1,377,5221.4m $168.2m $168.2m 0.09% Added +223.4k +223,430
14 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.06% of their portfolio Boston, MA 1,343,6021.3m $164.1m $164.1m 0.06% Added +159.2k +159,246
15 Sofinnova Investments, Inc. 6.54% of their portfolio Menlo Park, CA 880,800880.8k $107.6m $107.6m 6.54% Added +381.0k +380,976
16 TimesSquare Capital Management, LLC 1.37% of their portfolio NEW YORK, NY 791,245791.2k $96.6m $96.6m 1.37% Added +151.6k +151,570
17 EVENTIDE ASSET MANAGEMENT, LLC 1.88% of their portfolio Boston, MA 782,709782.7k $95.6m $95.6m 1.88% Reduced -416.3k -416,291
18 Spyglass Capital Management LLC 7.01% of their portfolio Greenbrae, CA 714,461714.5k $87.3m $87.3m 7.01% Reduced -235.5k -235,454
19 PUTNAM INVESTMENTS LLC 0.15% of their portfolio BOSTON, MA 706,409706.4k $86.3m $86.3m 0.15% Reduced -81.7k -81,656
20 Deep Track Capital, LP 3.73% of their portfolio GREENWICH, CT 700,000700.0k $85.5m $85.5m 3.73% Reduced -100.0k -100,000
21 Invesco Ltd. 0.02% of their portfolio ATLANTA, GA 660,786660.8k $80.7m $80.7m 0.02% Added +60.8k +60,763
22 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.19% of their portfolio Boston, MA 640,000640.0k $78.2m $78.2m 0.19% Added +410.0k +410,000
23 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 489,946489.9k $59.8m $59.8m 0.03% Reduced -149.9k -149,930
24 BROWN ADVISORY INC 0.10% of their portfolio BALTIMORE, MD 440,292440.3k $53.8m $53.8m 0.10% Reduced -197.7k -197,709
25 SEI INVESTMENTS CO 0.12% of their portfolio OAKS, PA 437,251437.3k $53.4m $53.4m 0.12% Reduced -36.3k -36,268
26 Rock Springs Capital Management LP 1.25% of their portfolio Baltimore, MD 425,500425.5k $52.0m $52.0m 1.25% Unchanged
27 BlackRock Inc. 0.00% of their portfolio New York, NY 394,770394.8k $48.2m $48.2m 0.00% Added +21.1k +21,146
28 Point72 Asset Management, L.P. 0.17% of their portfolio STAMFORD, CT 374,710374.7k $45.8m $45.8m 0.17% Reduced -9.5k -9,490
29 DEUTSCHE BANK AG\ 0.03% of their portfolio FRANKFURT AM MAIN, 2M 366,138366.1k $44.7m $44.7m 0.03% Unchanged
30 Paradigm Biocapital Advisors LP 5.06% of their portfolio NEW YORK, NY 352,808352.8k $43.1m $43.1m 5.06% Reduced -144.5k -144,539
31 AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio KANSAS CITY, MO 343,694343.7k $42.0m $42.0m 0.03% Added +1.1k +1,094
32 CITADEL ADVISORS LLC 0.04% of their portfolio MIAMI, FL 256,286256.3k $31.3m $31.3m 0.04% Added +202.3k +202,346
33 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 255,506255.5k $31.2m $31.2m 0.04% Reduced -22.6k -22,611
34 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 250,650250.7k $30.6m $30.6m 0.01% Reduced -10.8k -10,791
35 Allspring Global Investments Holdings, LLC 0.05% of their portfolio CHARLOTTE, NC 250,570250.6k $30.6m $30.6m 0.05% Reduced -5.4k -5,358
36 ARS Investment Partners, LLC 3.88% of their portfolio New York, NY 238,621238.6k $29.1m $29.1m 3.88% Added +11.2k +11,194
37 TD Asset Management Inc 0.03% of their portfolio Toronto, A6 196,300196.3k $24.0m $24.0m 0.03% Added +64.7k +64,700
38 Candriam S.C.A. 0.16% of their portfolio STRASSEN, N4 190,375190.4k $23.2m $23.2m 0.16% Reduced -16.0k -16,000
39 Driehaus Capital Management LLC 0.33% of their portfolio Chicago, IL 180,227180.2k $22.0m $22.0m 0.33% Added +56.9k +56,887
40 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.54% of their portfolio Boston, MA 172,751172.8k $21.1m $21.1m 1.54% New
41 Nicholas Investment Partners, LP 1.78% of their portfolio RANCHO SANTA FE, CA 165,937165.9k $20.3m $20.3m 1.78% Added +28.4k +28,383
42 COMERICA BANK 0.14% of their portfolio DALLAS, TX 153,719153.7k $18.4m $18.4m 0.14% Added +41.1k +41,112
43 Q Global Advisors, LLC 8.95% of their portfolio FORT WORTH, TX 151,409151.4k $18.5m $18.5m 8.95% Added +6.2k +6,200
44 RICE HALL JAMES & ASSOCIATES, LLC 1.02% of their portfolio San Diego, CA 145,739145.7k $17.8m $17.8m 1.02% Added +9.3k +9,294
45 Finepoint Capital LP 5.29% of their portfolio BOSTON, MA 134,036134.0k $16.4m $16.4m 5.29% Added +10.6k +10,636
46 DAFNA Capital Management LLC 4.48% of their portfolio LOS ANGELES, CA 130,212130.2k $15.9m $15.9m 4.48% Reduced -5.5k -5,500
47 Ghost Tree Capital, LLC 6.78% of their portfolio NEW YORK, NY 130,000130.0k $15.9m $15.9m 6.78% Added +35.0k +35,000
48 Thrivent Financial for Lutherans 0.04% of their portfolio Minneapolis, MN 125,198125.2k $15.3m $15.3m 0.04% Added +2.3k +2,270
49 Tekla Capital Management LLC 0.57% of their portfolio Boston, MA 123,791123.8k $15.1m $15.1m 0.57% Added +56.0k +55,997
50 J.P. Morgan Private Wealth Advisors LLC 0.03% of their portfolio SAN FRANCISCO, CA 117,323117.3k $14.3m $14.3m 0.03% Added +102.3k +102,323
51 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 116,704116.7k $14.3m $14.3m 0.02% Added +24.9k +24,894
52 MARSHALL WACE, LLP 0.03% of their portfolio LONDON, X0 103,426103.4k $12.6m $12.6m 0.03% Reduced -155.4k -155,449
53 Tri Locum Partners LP 5.36% of their portfolio NEW YORK, NY 99,21599.2k $12.1m $12.1m 5.36% New
54 Woodline Partners LP 0.16% of their portfolio San Francisco, CA 95,11395.1k $11.6m $11.6m 0.16% Reduced -116.3k -116,280
55 Boxer Capital, LLC 0.61% of their portfolio San Diego, CA 95,00095.0k $11.6m $11.6m 0.61% Added +25.0k +25,000
56 BAILLIE GIFFORD & CO 0.01% of their portfolio EDINBURGH, X0 91,68291.7k $11.2m $11.2m 0.01% Added +3.2k +3,185
57 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 86,04986.0k $10.5m $10.5m 0.00% Added +61.4k +61,429
58 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 82,94382.9k $10.1m $10.1m 0.00% Reduced -88.5k -88,514
59 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 76,74476.7k $9.4m $9.4m 0.00% Reduced -14.4k -14,375
60 Affinity Asset Advisors, LLC 3.97% of their portfolio NEW YORK, NY 70,99771.0k $8.7m $8.7m 3.97% Reduced -29.0k -29,003
61 Saturn V Capital Management LP 6.60% of their portfolio AUSTIN, TX 68,40468.4k $8.0m $8.0m 6.60% First filing
62 Schonfeld Strategic Advisors LLC 0.07% of their portfolio NEW YORK, NY 67,85867.9k $8.3m $8.3m 0.07% Added +52.4k +52,358
63 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 67,69367.7k $8.3m $8.3m 0.02% Added +44.6k +44,650
64 Matisse Capital 3.54% of their portfolio PORTLAND, OR 61,04061.0k $7.5m $7.5m 3.54% Added +35.6k +35,630
65 Alberta Investment Management Corp 0.07% of their portfolio EDMONTON, A0 60,48560.5k $7.4m $7.4m 0.07% Added +13.2k +13,205
66 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 60,22160.2k $7.4m $7.4m 0.01% Added +2.1k +2,094
67 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 58,96359.0k $7.2m $7.2m 0.01% Reduced -7.2k -7,239
68 Sessa Capital IM, L.P. 0.44% of their portfolio NEW YORK, NY 58,50058.5k $7.1m $7.1m 0.44% Unchanged
69 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 56,70756.7k $6.9m $6.9m 0.01% First filing
70 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 54,13654.1k $6.6m $6.6m 0.00% Reduced -331 -331
71 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 53,49753.5k $6.5m $6.5m 0.02% New
72 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 52,89352.9k $6.5m $6.5m 0.01% Reduced -18.4k -18,392
73 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 51,19251.2k $6.3m $6.3m 0.00% Added +6 +6
74 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 51,02851.0k $6.2m $6.2m 0.00% Added +387 +387
75 Cormorant Asset Management, LP 0.41% of their portfolio BOSTON, MA 50,00050.0k $6.1m $6.1m 0.41% Unchanged
76 FIL Ltd 0.01% of their portfolio HAMILTON, D0 45,06545.1k $5.5m $5.5m 0.01% New
77 Tamarack Advisers, LP 3.97% of their portfolio CARLSBAD, CA 45,00045.0k $5.5m $5.5m 3.97% Added +30.0k +30,000
78 Resolute Capital Asset Partners LLC 4.09% of their portfolio DENVER, CO 37,50037.5k $4.6m $4.6m 4.09% Added +7.5k +7,500
79 WESTPAC BANKING CORP 0.07% of their portfolio SYDNEY, C3 36,74236.7k $4.5m $4.5m 0.07% Reduced -44.9k -44,858
80 TANG CAPITAL MANAGEMENT LLC 0.64% of their portfolio SAN DIEGO, CA 36,09036.1k $4.4m $4.4m 0.64% Reduced -30.0k -30,000
81 BAMCO INC /NY/ 0.01% of their portfolio NEW YORK, NY 35,30635.3k $4.3m $4.3m 0.01% Added +27.8k +27,806
82 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 29,80829.8k $3.6m $3.6m 0.00% Added +9.2k +9,192
83 INTERNATIONAL BIOTECHNOLOGY TRUST PLC 1.11% of their portfolio London, X0 29,40029.4k $3.6m $3.6m 1.11% Unchanged
84 ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.00% of their portfolio BOSTON, MA 29,21829.2k $3.6m $3.6m 0.00% New
85 TUDOR INVESTMENT CORP ET AL 0.08% of their portfolio STAMFORD, CT 27,47627.5k $3.4m $3.4m 0.08% Reduced -4.5k -4,456
86 Henry James International Management Inc. 1.54% of their portfolio NEW YORK, NY 26,02326.0k $3.2m $3.2m 1.54% Unchanged
87 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 24,97525.0k $3.1m $3.1m 0.00% Added +9.8k +9,805
88 SILVERARC CAPITAL MANAGEMENT, LLC 0.97% of their portfolio BOSTON, MA 23,15123.2k $2.8m $2.8m 0.97% Added +18.2k +18,151
89 Evolutionary Tree Capital Management, LLC 2.62% of their portfolio ALEXANDRIA, VA 22,34722.3k $2.7m $2.7m 2.62% Reduced -6.8k -6,799
90 SG Americas Securities, LLC 0.04% of their portfolio NEW YORK, NY 20,93020.9k $2.6m $2.6m 0.04% Added +19.8k +19,838
91 MOORE CAPITAL MANAGEMENT, LP 0.07% of their portfolio NEW YORK, NY 20,00020.0k $2.4m $2.4m 0.07% New
92 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 20,00020.0k $2.4m $2.4m 0.01% Unchanged
93 Mirae Asset Global Investments Co., Ltd. 0.01% of their portfolio SEOUL, M5 19,73419.7k $2.4m $2.4m 0.01% Reduced -3.8k -3,755
94 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 18,77518.8k $2.3m $2.3m 0.00% Added +17.5k +17,496
95 Erste Asset Management GmbH 0.05% of their portfolio VIENNA, C4 18,50018.5k $2.2m $2.2m 0.05% Added +7.4k +7,400
96 Parkwood LLC 0.44% of their portfolio CLEVELAND, OH 17,55317.6k $2.1m $2.1m 0.44% Reduced -2.9k -2,876
97 CAPITAL FUND MANAGEMENT S.A. 0.04% of their portfolio PARIS, I0 16,35116.4k $2.0m $2.0m 0.04% Reduced -5.6k -5,628
98 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 15,32715.3k $1.9m $1.9m 0.01% Reduced -541 -541
99 FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 14,55614.6k $1.8m $1.8m 0.01% New
100 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 13,66013.7k $1.7m $1.7m 0.00% Reduced -499 -499