Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

122 institutional holders +0 vs Q3 2022
54,795,97554.8m shares reported held*
$1.0bnreported value*
11 new 44 added 37 reduced 13 sold out net sold ≈ $17.2m (-940.7k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $18.30. Options: 3 managers hold calls ($43.1k notional), 2 hold puts ($20.1k).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 122Q4 22: 122122Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022122
Q4 2022122

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ3 22 calls: $2.5mQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $43.1kQ4 22 puts: $20.1kQ4 22P/C 0.47
Numbers
QuarterCallsPutsP/C
Q3 2022$2.5m$00.00
Q4 2022$43.1k$20.1k0.47

Biggest buyers

Finepoint Capital LP New +822,745+822.7k
Paradigm Biocapital Advisors LP Added +370,849+370.8k
MILLENNIUM MANAGEMENT LLC Added +253,736+253.7k
STATE STREET CORP Added +196,119+196.1k
Ensign Peak Advisors, Inc Added +177,945+177.9k
WELLINGTON MANAGEMENT GROUP LLP Added +171,474+171.5k
BlackRock Inc. Added +165,467+165.5k
Walleye Capital LLC Added +155,545+155.5k
BNP PARIBAS ASSET MANAGEMENT Holding S.A. Added +155,271+155.3k
NOVO HOLDINGS A/S Added +105,430+105.4k

Biggest sellers

PERCEPTIVE ADVISORS LLC Reduced -1,281,756-1.3m
BVF INC/IL Reduced -942,334-942.3k
FMR LLC Reduced -798,485-798.5k
BAKER BROS. ADVISORS LP Sold out -735,716-735.7k
Nuveen Asset Management, LLC Reduced -158,898-158.9k
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) Sold out -90,460-90.5k
VICTORY CAPITAL MANAGEMENT INC Reduced -32,640-32.6k
TWO SIGMA ADVISERS, LP Reduced -29,100-29.1k
Jump Financial, LLC Sold out -28,500-28.5k
DIMENSIONAL FUND ADVISORS LP Reduced -27,222-27.2k

Biggest calls

CITADEL ADVISORS LLC Reduced $42.1k2.3k shares
SIMPLEX TRADING, LLC Reduced $1.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC New $20.1k1.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Driehaus Capital Management LLC 1.53% of their portfolio Chicago, IL 5,624,7445.6m $102.9m $102.9m 1.53% Reduced -7.2k -7,214
2 PERCEPTIVE ADVISORS LLC 2.13% of their portfolio NEW YORK, NY 4,039,2764.0m $73.9m $73.9m 2.13% Reduced -1.3m -1,281,756
3 BlackRock Inc. 0.00% of their portfolio New York, NY 3,917,4893.9m $71.7m $71.7m 0.00% Added +165.5k +165,467
4 BRAIDWELL LP 2.13% of their portfolio STAMFORD, CT 3,469,6743.5m $63.5m $63.5m 2.13% First filing
5 ORBIMED ADVISORS LLC 1.12% of their portfolio New York, NY 3,196,8763.2m $58.5m $58.5m 1.12% Unchanged
6 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 2,804,4852.8m $51.3m $51.3m 0.01% Added +171.5k +171,474
7 BVF INC/IL 2.11% of their portfolio San Francisco, CA 2,736,6132.7m $50.1m $50.1m 2.11% Reduced -942.3k -942,334
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,386,3872.4m $43.7m $43.7m 0.00% Added +29.7k +29,740
9 Bain Capital Life Sciences Investors, LLC 4.71% of their portfolio Boston, MA 2,305,5582.3m $42.2m $42.2m 4.71% Unchanged
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,004,7842.0m $36.7m $36.7m 0.00% Added +196.1k +196,119
11 FMR LLC 0.00% of their portfolio BOSTON, MA 1,883,1181.9m $34.5m $34.5m 0.00% Reduced -798.5k -798,485
12 Frazier Life Sciences Management, L.P. 1.61% of their portfolio PALO ALTO, CA 1,414,8231.4m $25.9m $25.9m 1.61% Unchanged
13 Point72 Asset Management, L.P. 0.09% of their portfolio STAMFORD, CT 1,361,0001.4m $24.9m $24.9m 0.09% Added +50.8k +50,800
14 EcoR1 Capital, LLC 0.74% of their portfolio San Francisco, CA 1,330,2631.3m $24.3m $24.3m 0.74% Unchanged
15 First Light Asset Management, LLC 2.26% of their portfolio Edina, MN 1,329,3131.3m $24.3m $24.3m 2.26% Reduced -17.3k -17,339
16 Deep Track Capital, LP 0.84% of their portfolio GREENWICH, CT 1,048,8291.0m $19.2m $19.2m 0.84% Reduced -4.2k -4,171
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 921,230921.2k $16.9m $16.9m 0.00% Added +38.1k +38,135
18 Paradigm Biocapital Advisors LP 1.91% of their portfolio NEW YORK, NY 890,105890.1k $16.3m $16.3m 1.91% Added +370.8k +370,849
19 5AM Venture Management, LLC 4.24% of their portfolio SAN FRANCISCO, CA 862,286862.3k $15.8m $15.8m 4.24% Unchanged
20 Finepoint Capital LP 4.87% of their portfolio BOSTON, MA 822,745822.7k $15.1m $15.1m 4.87% New
21 NOVO HOLDINGS A/S 0.84% of their portfolio HELLERUP, G7 737,057737.1k $13.5m $13.5m 0.84% Added +105.4k +105,430
22 Opaleye Management Inc. 4.66% of their portfolio BOSTON, MA 732,000732.0k $13.4m $13.4m 4.66% Added +60.7k +60,700
23 SPHERA FUNDS MANAGEMENT LTD. 3.86% of their portfolio TEL AVIV, L3 671,644671.6k $12.3m $12.3m 3.86% Added +45.1k +45,092
24 Saturn V Capital Management LP 9.41% of their portfolio AUSTIN, TX 623,819623.8k $11.3m $11.3m 9.41% First filing
25 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio Paris, I0 610,690610.7k $11.2m $11.2m 0.04% Added +155.3k +155,271
26 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 575,488575.5k $10.5m $10.5m 0.01% Added +253.7k +253,736
27 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 508,848508.8k $9.3m $9.3m 0.00% Reduced -27.2k -27,222
28 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 480,800480.8k $8.8m $8.8m 0.00% Added +2.4k +2,418
29 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 406,264406.3k $7.4m $7.4m 0.01% Added +26.6k +26,568
30 Walleye Capital LLC 0.16% of their portfolio NEW YORK, NY 405,559405.6k $7.4m $7.4m 0.16% Added +155.5k +155,545
31 MPM BIOIMPACT LLC 1.76% of their portfolio BOSTON, MA 371,639371.6k $6.8m $6.8m 1.76% Added +6.9k +6,929
32 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 351,759351.8k $6.4m $6.4m 0.00% Added +10.3k +10,277
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 343,055343.1k $6.3m $6.3m 0.00% Added +6.9k +6,865
34 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 270,269270.3k $4.9m $4.9m 0.01% Added +177.9k +177,945
35 SILVERARC CAPITAL MANAGEMENT, LLC 0.96% of their portfolio BOSTON, MA 152,747152.7k $2.8m $2.8m 0.96% Added +3.7k +3,720
36 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 152,588152.6k $2.8m $2.8m 0.00% Added +50.6k +50,556
37 FIRST MANHATTAN CO. LLC. 0.01% of their portfolio NEW YORK, NY 152,200152.2k $2.8m $2.8m 0.01% Unchanged
38 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 147,000147.0k $2.7m $2.7m 0.00% Unchanged
39 New Leaf Venture Partners, L.L.C. 1.87% of their portfolio New York, NY 141,000141.0k $2.6m $2.6m 1.87% Unchanged
40 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 137,693137.7k $2.5m $2.5m 0.00% Reduced -158.9k -158,898
41 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 133,316133.3k $2.4m $2.4m 0.00% Added +10.6k +10,648
42 Monarch Partners Asset Management LLC 0.70% of their portfolio BOSTON, MA 128,974129.0k $2.4m $2.4m 0.70% Reduced -1.9k -1,886
43 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 124,067124.1k $2.3m $2.3m 0.00% Added +64.6k +64,610
44 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 106,498106.5k $1.9m $1.9m 0.02% Added +31.0k +31,045
45 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 99,40099.4k $1.8m $1.8m 0.01% Reduced -29.1k -29,100
46 HighVista Strategies LLC 1.02% of their portfolio BOSTON, MA 93,89393.9k $1.7m $1.7m 1.02% Added +1.8k +1,846
47 Swiss National Bank 0.00% of their portfolio ZURICH, V8 90,80090.8k $1.7m $1.7m 0.00% Added +2.8k +2,800
48 Atom Investors LP 0.75% of their portfolio AUSTIN, TX 81,46681.5k $1.5m $1.5m 0.75% Added +32.5k +32,541
49 UBS Group AG 0.00% of their portfolio ZURICH, V8 80,69480.7k $1.5m $1.5m 0.00% Added +72.6k +72,555
50 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 78,98879.0k $1.4m $1.4m 0.00% Reduced -7 -7
51 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 76,92476.9k $1.4m $1.4m 0.00% Added +23.6k +23,568
52 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 68,84368.8k $1.3m $1.3m 0.00% First filing
53 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 66,42866.4k $1.2m $1.2m 0.00% Reduced -32.6k -32,640
54 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 63,10063.1k $1.2m $1.2m 0.00% New
55 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 53,67853.7k $982.3k $982.3k 0.00% Added +668 +668
56 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 51,93151.9k $951.0k $951.0k 0.00% Reduced -9.7k -9,704
57 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 51,20051.2k $937.0k $937.0k 0.00% Unchanged
58 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 48,87148.9k $894.3k $894.3k 0.00% Reduced -21.6k -21,615
59 Tekla Capital Management LLC 0.03% of their portfolio Boston, MA 45,86145.9k $839.3k $839.3k 0.03% New
60 MARTINGALE ASSET MANAGEMENT L P 0.02% of their portfolio BOSTON, MA 45,68045.7k $835.9k $835.9k 0.02% New
61 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 44,98945.0k $823.0k $823.0k 0.01% Unchanged
62 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 39,12039.1k $715.9k $715.9k 0.00% Reduced -28 -28
63 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 37,35637.4k $683.6k $683.6k 0.00% Reduced -2.9k -2,855
64 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 36,47736.5k $667.5k $667.5k 0.01% Added +7.2k +7,151
65 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 35,79435.8k $655.0k $655.0k 0.00% Reduced -2.3k -2,303
66 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 34,69434.7k $636.0k $636.0k 0.00% Added +2.0k +2,004
67 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 31,41731.4k $574.9k $574.9k 0.00% Reduced -5.7k -5,738
68 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 29,68229.7k $543.2k $543.2k 0.00% Reduced -1.4k -1,384
69 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 29,25729.3k $535.4k $535.4k 0.00% Added +7.7k +7,736
70 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 28,04728.0k $513.3k $513.3k 0.00% Added +792 +792
71 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 27,64427.6k $505.9k $505.9k 0.00% Reduced -17.8k -17,841
72 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 26,06626.1k $477.0k $477.0k 0.00% Unchanged
73 WESTWOOD HOLDINGS GROUP INC 0.00% of their portfolio DALLAS, TX 25,37125.4k $464.0k $464.0k 0.00% Added +4.3k +4,329
74 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 25,26925.3k $462.4k $462.4k 0.00% Added +1.8k +1,833
75 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 24,89324.9k $455.5k $455.5k 0.00% Reduced -91 -91
76 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 24,61224.6k $450.4k $450.4k 0.00% Added +1.4k +1,356
77 PUTNAM INVESTMENTS LLC 0.00% of their portfolio BOSTON, MA 23,33823.3k $427.1k $427.1k 0.00% Reduced -13 -13
78 BIT Capital GmbH 0.08% of their portfolio BERLIN, 2M 22,13722.1k $405.1k $405.1k 0.08% Reduced -8.0k -8,049
79 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 20,60620.6k $377.1k $377.1k 0.00% Unchanged
80 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 20,41520.4k $373.6k $373.6k 0.00% Added +22 +22
81 J.P. Morgan Private Wealth Advisors LLC 0.00% of their portfolio SAN FRANCISCO, CA 19,21619.2k $351.7k $351.7k 0.00% New
82 Ergoteles LLC 0.01% of their portfolio NEW YORK, NY 19,08419.1k $349.2k $349.2k 0.01% New
83 SANDERS MORRIS HARRIS LLC 0.13% of their portfolio Houston, TX 18,60018.6k $340.4k $340.4k 0.13% Unchanged
84 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 18,28118.3k $334.5k $334.5k 0.00% Reduced -366 -366
85 Walleye Trading LLC 0.01% of their portfolio NEW YORK, NY 17,82817.8k $326.3k $326.3k 0.01% Reduced -4.8k -4,845
86 ALGERT GLOBAL LLC 0.02% of their portfolio SAN FRANCISCO, CA 17,40617.4k $318.5k $318.5k 0.02% Unchanged
87 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 17,03817.0k $311.8k $311.8k 0.00% Unchanged
88 Legal & General Group Plc 0.00% of their portfolio London, X0 15,94615.9k $291.8k $291.8k 0.00% Added +685 +685
89 Connacht Asset Management LP 0.46% of their portfolio New York, NY 12,33712.3k $225.8k $225.8k 0.46% Reduced -2.8k -2,786
90 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 12,33412.3k $225.7k $225.7k 0.00% New
91 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 11,76411.8k $215.0k $215.0k 0.00% Reduced -84 -84
92 TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio AUSTIN, TX 11,35011.3k $208.0k $208.0k 0.00% Reduced -924 -924
93 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 11,30011.3k $206.0k $206.0k 0.00% Unchanged
94 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 11,22211.2k $205.4k $205.4k 0.00% Added +913 +913
95 ARIZONA STATE RETIREMENT SYSTEM 0.00% of their portfolio PHOENIX, AZ 10,61710.6k $194.3k $194.3k 0.00% Added +439 +439
96 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 10,23510.2k $187.3k $187.3k 0.00% Reduced -26.1k -26,062
97 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 9,7679.8k $179.0k $179.0k 0.00% Reduced -5.6k -5,559
98 VIRTUS ADVISERS, LLC 0.08% of their portfolio HARTFORD, CT 8,5988.6k $157.3k $157.3k 0.08% Added +2.4k +2,370
99 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 7,2417.2k $132.5k $132.5k 0.00% Reduced -164 -164
100 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 6,9687.0k $128.0k $128.0k 0.00% Unchanged