VOR BIOPHARMA INC
COM · CUSIP 929033108
59
institutional holders
+10 vs Q3 2022
60.2m
shares reported held*
$400.3mreported value*
14 new
26 added
6 reduced
5 sold out
net bought ≈ $190.0m (+28.6m shares)
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $6.65. Options: 4 managers hold calls ($216.6k notional), 3 hold puts ($41.6k).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 49 |
| Q4 2022 | 59 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
CallsPuts
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $31.0k | $20.0k | 0.65 |
| Q4 2022 | $216.6k | $41.6k | 0.19 |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | Added | +11.6m |
| FMR LLC | Added | +4.8m |
| Paradigm Biocapital Advisors LP | Added | +4.7m |
| Artal Group S.A. | Added | +2.3m |
| Laurion Capital Management LP | Added | +2.3m |
| JANUS HENDERSON GROUP PLC | New | +1.9m |
| VANGUARD GROUP INC | Added | +534.2k |
| Walleye Capital LLC | New | +163.4k |
| MILLENNIUM MANAGEMENT LLC | Added | +159.2k |
| AWM Investment Company, Inc. | New | +100.0k |
Biggest sellers
| Ally Bridge Group (NY) LLC | Sold out | -255.2k |
| BlackRock Inc. | Reduced | -200.3k |
| ORBIMED ADVISORS LLC | Sold out | -111.8k |
| Ergoteles LLC | Reduced | -42.5k |
| Tower Research Capital LLC (TRC) | Reduced | -20.8k |
| GOLDMAN SACHS GROUP INC | Sold out | -19.1k |
| Chicago Partners Investment Group LLC | Reduced | -3.6k |
| JPMORGAN CHASE & CO | Reduced | -1.1k |
| ROYAL BANK OF CANADA | Reduced | -734 |
| China Universal Asset Management Co., Ltd. | Sold out | -356 |
Biggest calls
| CITADEL ADVISORS LLC | New | $158.3k23.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $39.0k5.9k shares |
| GROUP ONE TRADING LLC | New | $19.3k2.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Reduced | $33.0k5.0k shares |
| CITADEL ADVISORS LLC | New | $8.6k1.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence -0.1 pts · filed 2025-06-27 | 31.8% |
Reprogrammed Interchange LLC
13D · may seek influence
-1.5 pts · filed 2025-10-16
Stated purposeItem 4 of Schedule 13D is hereby amended and supplemented as follows: From October 10, 2025 through October 14, 2025, Reprogrammed Interchange LLC sold the following shares of Vor Biopharma Inc. in open market transactions, resulting in a decrease in the number of shares of Common Stock beneficially owned by the Reporting Persons by more than one percent of the outstanding shares of Common Stock of the Issuer. 1. 40,983 shares on October 10, 2025, at a weighted average per share sale price of $30.9673. 2. 22,006 shares on October 13, 2025, at a weighted average per share sale price of $32.436. 3. 33,668 shares on October 14, 2025, at a weighted average per share sale price of $30.3192. Full filing |
18.6% |
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 3.07% of their portfolio | 22.7m $151.3m | Added +11.6m |
| FMR LLC 0.01% of their portfolio | 8.0m $53.0m | Added +4.8m |
| Paradigm Biocapital Advisors LP 5.03% of their portfolio | 6.4m $42.8m | Added +4.7m |
| 5AM Venture Management, LLC 11.37% of their portfolio | 6.4m $42.3m | Unchanged |
| Laurion Capital Management LP 0.59% of their portfolio | 3.2m $21.2m | Added +2.3m |
| Artal Group S.A. 1.10% of their portfolio | 2.9m $19.1m | Added +2.3m |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 1.9m $12.4m | New |
| BAKER BROS. ADVISORS LP 0.06% of their portfolio | 1.5m $9.7m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.2m $7.9m | Added +534.2k |
| Woodline Partners LP 0.10% of their portfolio | 1.1m $7.4m | Unchanged |
| JOHNSON & JOHNSON 2.08% of their portfolio | 1.1m $7.1m | Unchanged |
| Sarissa Capital Management LP 0.49% of their portfolio | 618.0k $4.1m | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 498.1k $3.3m | Added +159.2k |
| OUP Management Co., LLC 4.07% of their portfolio | 374.7k $2.5m | Unchanged |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 306.8k $2.0m | Added +4.4k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 299.5k $2.0m | Added +90.0k |
| BlackRock Inc. 0.00% of their portfolio | 237.3k $1.6m | Reduced -200.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 166.8k $1.1m | Added +31.2k |
| Walleye Capital LLC 0.02% of their portfolio | 163.4k $1.1m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 127.9k $851.0k | Reduced -1.1k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 100.2k $666.3k | Added +20.8k |
| AWM Investment Company, Inc. 0.10% of their portfolio | 100.0k $665.0k | New |
| Trustees of Columbia University in the City of New York 1.26% of their portfolio | 91.9k $611.0k | First filing |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 68.4k $454.9k | Added +58.0k |
| Bollard Group LLC 0.01% of their portfolio | 55.6k $369.0k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 54.4k $361.8k | Added +39.8k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 50.9k $338.5k | New |
| STATE STREET CORP 0.00% of their portfolio | 49.9k $331.9k | Added +8.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 47.9k $318.5k | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 46.0k $306.0k | Added +14.1k |
| LMR Partners LLP 0.01% of their portfolio | 43.2k $287.1k | Added +16.4k |
| CITIGROUP INC 0.00% of their portfolio | 41.5k $276.2k | Added +41.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 41.5k $276.0k | Added +8.5k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 36.8k $244.6k | Added +13.7k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 30.5k $202.7k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 28.4k $189.0k | Added +6.0k |
| Tower Research Capital LLC (TRC) 0.01% of their portfolio | 25.9k $172.0k | Reduced -20.8k |
| 683 Capital Management, LLC 0.02% of their portfolio | 25.4k $169.0k | New |
| Ergoteles LLC 0.01% of their portfolio | 22.9k $152.0k | Reduced -42.5k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 19.8k $131.9k | Added +5.0k |
| HRT FINANCIAL LP 0.00% of their portfolio | 17.9k $119.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 17.0k $112.7k | Added +9.3k |
| Man Group plc 0.00% of their portfolio | 17.0k $112.7k | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio | 14.3k $95.2k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 12.2k $81.4k | New |
| BOURGEON CAPITAL MANAGEMENT LLC 0.02% of their portfolio | 11.2k $74.5k | Added +500 |
| Chicago Partners Investment Group LLC 0.00% of their portfolio | 10.9k $62.8k | Reduced -3.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 10.9k $72.3k | Unchanged |
| GRIMES & Co WEALTH MANAGEMENT, LLC 0.00% of their portfolio | 10.9k $72.2k | New |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 7.0k $46.0k | Added +3.6k |
| UBS Group AG 0.00% of their portfolio | 4.1k $27.2k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 3.9k $26.2k | Added +2.2k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 3.9k $26.0k | Unchanged |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.6k $10.0k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 838 $6.0k | Reduced -734 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 250 $1.7k | Unchanged |
| Eagle Bay Advisors LLC 0.00% of their portfolio | 150 $998 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 116 $771 | Added +6 |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |