BICYCLE THERAPEUTICS PLC BCYC
SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088
Company in Cambridge, United Kingdom
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, United Kingdom
- Founded2009
- Websitebicycletherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($390.4k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $29.60. Options: 4 managers hold calls ($538.2k notional), 6 hold puts ($3.3m).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 80 |
| Q4 2022 | 87 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $18.0k | $18.0k | 1.00 |
| Q4 2022 | $538.2k | $3.3m | 6.12 |
Biggest buyers
| Polar Capital Holdings Plc | New | +750.0k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | New | +301.0k |
| Soleus Capital Management, L.P. | New | +258.4k |
| Paradigm Biocapital Advisors LP | Added | +74.6k |
| Schonfeld Strategic Advisors LLC | Added | +58.9k |
| GROUP ONE TRADING LLC | New | +38.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | +37.1k |
| ExodusPoint Capital Management, LP | Added | +26.2k |
| PURA VIDA INVESTMENTS, LLC | Added | +25.9k |
| MILLENNIUM MANAGEMENT LLC | Added | +25.7k |
Biggest sellers
| JANUS HENDERSON GROUP PLC | Reduced | -1.9m |
| Logos Global Management LP | Reduced | -565.0k |
| AXA S.A. | Reduced | -440.7k |
| Verition Fund Management LLC | Reduced | -316.2k |
| SAMLYN CAPITAL, LLC | Reduced | -306.2k |
| FMR LLC | Reduced | -287.2k |
| Point72 Asset Management, L.P. | Reduced | -247.4k |
| MORGAN STANLEY | Reduced | -138.3k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | Reduced | -135.6k |
| TWO SIGMA ADVISERS, LP | Reduced | -100.9k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $313.8k10.6k shares |
| CITADEL ADVISORS LLC | New | $186.5k6.3k shares |
| SIMPLEX TRADING, LLC | Added | $38.0k1.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| GROUP ONE TRADING LLC | New | $1.1m38.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $1.1m36.4k shares |
| CITADEL ADVISORS LLC | New | $657.1k22.2k shares |
| SIMPLEX TRADING, LLC | Added | $411.0k13.9k shares |
| Cutler Group LLC / CA | New | $7.0k800 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 | 7.3% |
| ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 | 6.7% |
| Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 | 6.6% |
Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 3 | $9.4m | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
None reported in Q4 2022.
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| Deep Track Capital, LP 3.64% of their portfolio | 2.8m $83.4m | Reduced -81.0k |
| Ridgeback Capital Investments L.P. 80.44% of their portfolio | 2.3m $67.0m | Not comparable |
| JANUS HENDERSON GROUP PLC 0.03% of their portfolio | 1.5m $44.5m | Reduced -1.9m |
| Logos Global Management LP 4.98% of their portfolio | 1.4m $42.5m | Reduced -565.0k |
| RTW INVESTMENTS, LP 0.76% of their portfolio | 1.3m $37.3m | Reduced -17.7k |
| Paradigm Biocapital Advisors LP 4.29% of their portfolio | 1.2m $36.5m | Added +74.6k |
| Candriam S.C.A. 0.23% of their portfolio | 1.2m $34.8m | Reduced -57.0k |
| Point72 Asset Management, L.P. 0.11% of their portfolio | 1.0m $29.8m | Reduced -247.4k |
| SAMLYN CAPITAL, LLC 0.57% of their portfolio | 987.9k $29.2m | Reduced -306.2k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 2.67% of their portfolio | 905.7k $26.8m | Reduced -135.6k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.50% of their portfolio | 853.8k $25.3m | Unchanged |
| BAKER BROS. ADVISORS LP 0.15% of their portfolio | 843.8k $25.0m | Unchanged |
| Polar Capital Holdings Plc 0.18% of their portfolio | 750.0k $22.2m | New |
| MORGAN STANLEY 0.00% of their portfolio | 721.6k $21.4m | Reduced -138.3k |
| First Light Asset Management, LLC 1.91% of their portfolio | 696.4k $20.6m | Reduced -8.3k |
| Sio Capital Management, LLC 10.78% of their portfolio | 683.4k $20.2m | Unchanged |
| Verition Fund Management LLC 0.22% of their portfolio | 380.8k $11.3m | Reduced -316.2k |
| AXA S.A. 0.04% of their portfolio | 380.6k $11.3m | Reduced -440.7k |
| FMR LLC 0.00% of their portfolio | 377.6k $11.2m | Reduced -287.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 338.7k $10.0m | Reduced -78.6k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio | 301.0k $8.9m | New |
| Soleus Capital Management, L.P. 1.10% of their portfolio | 258.4k $7.6m | New |
| PURA VIDA INVESTMENTS, LLC 1.19% of their portfolio | 239.0k $7.1m | Added +25.9k |
| BlackRock Inc. 0.00% of their portfolio | 189.8k $5.6m | Added +8.8k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 168.7k $5.0m | Added +25.7k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 161.8k $4.8m | Reduced -100.9k |
| Handelsbanken Fonder AB 0.02% of their portfolio | 131.8k $3.9m | Added +1.8k |
| DAFNA Capital Management LLC 1.02% of their portfolio | 122.2k $3.6m | Unchanged |
| ExodusPoint Capital Management, LP 0.05% of their portfolio | 104.9k $3.1m | Added +26.2k |
| HighVista Strategies LLC 1.62% of their portfolio | 92.4k $2.7m | Reduced -44.3k |
| Parkman Healthcare Partners LLC 0.72% of their portfolio | 91.3k $2.7m | Added +10.0k |
| Tekla Capital Management LLC 0.10% of their portfolio | 88.7k $2.6m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 83.2k $2.5m | Reduced -42.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 80.6k $2.4m | Reduced -24.7k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 79.7k $2.4m | Added +58.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 72.5k $2.1m | Added +9.1k |
| Bellevue Group AG 0.03% of their portfolio | 70.2k $2.1m | Reduced -27.9k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 66.0k $2.0m | Reduced -1.7k |
| GROUP ONE TRADING LLC 0.04% of their portfolio | 38.8k $1.1m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 37.1k $1.1m | New |
| L & S Advisors Inc 0.19% of their portfolio | 35.0k $1.0m | Reduced -7.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 33.0k $976.5k | Reduced -15.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 25.1k $743.0k | Unchanged |
| HARBOR CAPITAL ADVISORS, INC. 0.69% of their portfolio | 24.1k $714.8k | Reduced -21.5k |
| Vident Investment Advisory, LLC 0.03% of their portfolio | 24.0k $709.1k | New |
| TD Asset Management Inc 0.00% of their portfolio | 23.6k $698.1k | Added +8.0k |
| Eagle Health Investments LP 0.16% of their portfolio | 23.5k $695.6k | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 17.1k $507.0k | Reduced -4.3k |
| AtonRa Partners 0.64% of their portfolio | 17.1k $505.2k | Reduced -4.5k |
| Allianz Asset Management GmbH 0.00% of their portfolio | 15.2k $449.9k | Unchanged |
| WOODSTOCK CORP 0.06% of their portfolio | 14.8k $439.3k | Unchanged |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 14.3k $424.0k | Added +14.1k |
| Erste Asset Management GmbH 0.01% of their portfolio | 14.0k $413.8k | Unchanged |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 13.2k $375.0k | Unchanged |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 13.2k $390.4k | New |
| UBS Group AG 0.00% of their portfolio | 12.9k $383.1k | Reduced -15.5k |
| Legal & General Group Plc 0.00% of their portfolio | 10.5k $311.8k | Added +1.4k |
| FISHMAN JAY A LTD/MI 0.04% of their portfolio | 10.5k $310.8k | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 9.3k $274.4k | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 8.9k $262.3k | Added +39 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.4k $247.8k | Reduced -6.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 8.0k $237.9k | Reduced -27.8k |
| Jump Financial, LLC 0.01% of their portfolio | 7.4k $219.0k | New |
| Twelve Points Wealth Management LLC 0.15% of their portfolio | 7.2k $213.1k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.5k $163.2k | Reduced -3.6k |
| VIRTUS ADVISERS, LLC 0.07% of their portfolio | 4.4k $129.1k | Reduced -3.6k |
| HighMark Wealth Management LLC 0.09% of their portfolio | 4.2k $125.4k | Unchanged |
| NATIXIS 0.00% of their portfolio | 3.6k $106.9k | New |
| Cutler Group LLC / CA 0.01% of their portfolio | 2.0k $60.0k | Reduced -60 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.3k $38.0k | Reduced -100 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.2k $35.0k | Reduced -1.1k |
| CITIGROUP INC 0.00% of their portfolio | 511 $15.1k | Reduced -23 |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 395 $11.7k | Reduced -140 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 259 $7.7k | Added +20 |
| US BANCORP \DE\ 0.00% of their portfolio | 234 $6.9k | Unchanged |
| Atle Fund Management AB 0.01% of their portfolio | 226 $6.7k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 211 $7.0k | Added +3 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 162 $4.8k | New |
| Advisory Services Network, LLC 0.00% of their portfolio | 115 $3.4k | New |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 103 $3.0k | Added +45 |
| Crewe Advisors LLC 0.00% of their portfolio | 83 $2.5k | Unchanged |
| TCI Wealth Advisors, Inc. 0.00% of their portfolio | 73 $2.2k | New |
| Zullo Investment Group, Inc. 0.00% of their portfolio | 50 $1.5k | Unchanged |
| NFSG Corp 0.00% of their portfolio | 40 $1.2k | Unchanged |
| Blue Trust, Inc. 0.00% of their portfolio | 20 $0 | New |
| Parallel Advisors, LLC 0.00% of their portfolio | 5 $148 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |