Vault-13

BICYCLE THERAPEUTICS PLC BCYC

SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088

Company in Cambridge, United Kingdom

87 institutional holders +7 vs Q3 2022
23,497,80623.5m shares reported held*
$695.5mreported value*
16 new 16 added 35 reduced 8 sold out net sold ≈ $101.1m (-3.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($390.4k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $29.60. Options: 4 managers hold calls ($538.2k notional), 6 hold puts ($3.3m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 80Q4 22: 8787Q3 22Q4 22
Numbers
QuarterHolders
Q3 202280
Q4 202287

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3m$4mQ3 22 calls: $18.0kQ3 22 puts: $18.0kQ3 22P/C 1.00Q4 22 calls: $538.2kQ4 22 puts: $3.3mQ4 22P/C 6.12
Numbers
QuarterCallsPutsP/C
Q3 2022$18.0k$18.0k1.00
Q4 2022$538.2k$3.3m6.12

Biggest buyers

Polar Capital Holdings Plc New +750,000+750.0k
BNP PARIBAS ASSET MANAGEMENT Holding S.A. New +300,968+301.0k
Soleus Capital Management, L.P. New +258,400+258.4k
Paradigm Biocapital Advisors LP Added +74,594+74.6k
Schonfeld Strategic Advisors LLC Added +58,946+58.9k
GROUP ONE TRADING LLC New +38,784+38.8k
SUSQUEHANNA INTERNATIONAL GROUP, LLP New +37,055+37.1k
ExodusPoint Capital Management, LP Added +26,184+26.2k
PURA VIDA INVESTMENTS, LLC Added +25,894+25.9k
MILLENNIUM MANAGEMENT LLC Added +25,677+25.7k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -1,858,251-1.9m
Logos Global Management LP Reduced -565,000-565.0k
AXA S.A. Reduced -440,725-440.7k
Verition Fund Management LLC Reduced -316,177-316.2k
SAMLYN CAPITAL, LLC Reduced -306,197-306.2k
FMR LLC Reduced -287,159-287.2k
Point72 Asset Management, L.P. Reduced -247,440-247.4k
MORGAN STANLEY Reduced -138,292-138.3k
TYBOURNE CAPITAL MANAGEMENT (HK) LTD Reduced -135,609-135.6k
TWO SIGMA ADVISERS, LP Reduced -100,900-100.9k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $313.8k10.6k shares
CITADEL ADVISORS LLC New $186.5k6.3k shares
SIMPLEX TRADING, LLC Added $38.0k1.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

GROUP ONE TRADING LLC New $1.1m38.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $1.1m36.4k shares
CITADEL ADVISORS LLC New $657.1k22.2k shares
SIMPLEX TRADING, LLC Added $411.0k13.9k shares
Cutler Group LLC / CA New $7.0k800 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 7.3% new 3.5m 2024-12-19
ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 6.7% no change 3.4m 2026-08-14
Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 6.6% new 3.3m 2026-05-15

Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)

Insider purchases and sales in Q4 2022

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q1 21: 0 buyingQ1 21: 0 sellingQ2 21: 0 buyingQ2 21: 0 sellingQ2 21Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 3 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20210—0——
Q2 20210—0——
Q3 20210—0——
Q4 20210—3$9.4m—
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——

None reported in Q4 2022.

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Deep Track Capital, LP 3.64% of their portfolio GREENWICH, CT 2,819,0452.8m $83.4m $83.4m 3.64% Reduced -81.0k -80,955
2 Ridgeback Capital Investments L.P. 80.44% of their portfolio MIAMI BEACH, FL 2,264,8012.3m $67.0m $67.0m 80.44% Not comparable
3 JANUS HENDERSON GROUP PLC 0.03% of their portfolio LONDON, X0 1,503,4471.5m $44.5m $44.5m 0.03% Reduced -1.9m -1,858,251
4 Logos Global Management LP 4.98% of their portfolio San Francisco, CA 1,435,0001.4m $42.5m $42.5m 4.98% Reduced -565.0k -565,000
5 RTW INVESTMENTS, LP 0.76% of their portfolio NEW YORK, NY 1,258,5871.3m $37.3m $37.3m 0.76% Reduced -17.7k -17,689
6 Paradigm Biocapital Advisors LP 4.29% of their portfolio NEW YORK, NY 1,233,2801.2m $36.5m $36.5m 4.29% Added +74.6k +74,594
7 Candriam S.C.A. 0.23% of their portfolio STRASSEN, N4 1,175,2111.2m $34.8m $34.8m 0.23% Reduced -57.0k -57,043
8 Point72 Asset Management, L.P. 0.11% of their portfolio STAMFORD, CT 1,007,9781.0m $29.8m $29.8m 0.11% Reduced -247.4k -247,440
9 SAMLYN CAPITAL, LLC 0.57% of their portfolio New York, NY 987,888987.9k $29.2m $29.2m 0.57% Reduced -306.2k -306,197
10 TYBOURNE CAPITAL MANAGEMENT (HK) LTD 2.67% of their portfolio HONG KONG, K3 905,722905.7k $26.8m $26.8m 2.67% Reduced -135.6k -135,609
11 EVENTIDE ASSET MANAGEMENT, LLC 0.50% of their portfolio Boston, MA 853,800853.8k $25.3m $25.3m 0.50% Unchanged
12 BAKER BROS. ADVISORS LP 0.15% of their portfolio NEW YORK, NY 843,814843.8k $25.0m $25.0m 0.15% Unchanged
13 Polar Capital Holdings Plc 0.18% of their portfolio London, X0 750,000750.0k $22.2m $22.2m 0.18% New
14 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 721,559721.6k $21.4m $21.4m 0.00% Reduced -138.3k -138,292
15 First Light Asset Management, LLC 1.91% of their portfolio Edina, MN 696,432696.4k $20.6m $20.6m 1.91% Reduced -8.3k -8,289
16 Sio Capital Management, LLC 10.78% of their portfolio NEW YORK, NY 683,425683.4k $20.2m $20.2m 10.78% Unchanged
17 Verition Fund Management LLC 0.22% of their portfolio GREENWICH, CT 380,849380.8k $11.3m $11.3m 0.22% Reduced -316.2k -316,177
18 AXA S.A. 0.04% of their portfolio PARIS, I0 380,555380.6k $11.3m $11.3m 0.04% Reduced -440.7k -440,725
19 FMR LLC 0.00% of their portfolio BOSTON, MA 377,647377.6k $11.2m $11.2m 0.00% Reduced -287.2k -287,159
20 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 338,733338.7k $10.0m $10.0m 0.00% Reduced -78.6k -78,607
21 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio Paris, I0 300,968301.0k $8.9m $8.9m 0.03% New
22 Soleus Capital Management, L.P. 1.10% of their portfolio GREENWICH, CT 258,400258.4k $7.6m $7.6m 1.10% New
23 PURA VIDA INVESTMENTS, LLC 1.19% of their portfolio NEW YORK, NY 239,015239.0k $7.1m $7.1m 1.19% Added +25.9k +25,894
24 BlackRock Inc. 0.00% of their portfolio New York, NY 189,818189.8k $5.6m $5.6m 0.00% Added +8.8k +8,771
25 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 168,723168.7k $5.0m $5.0m 0.01% Added +25.7k +25,677
26 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 161,800161.8k $4.8m $4.8m 0.01% Reduced -100.9k -100,900
27 Handelsbanken Fonder AB 0.02% of their portfolio STOCKHOLM, V7 131,800131.8k $3.9m $3.9m 0.02% Added +1.8k +1,800
28 DAFNA Capital Management LLC 1.02% of their portfolio LOS ANGELES, CA 122,200122.2k $3.6m $3.6m 1.02% Unchanged
29 ExodusPoint Capital Management, LP 0.05% of their portfolio NEW YORK, NY 104,866104.9k $3.1m $3.1m 0.05% Added +26.2k +26,184
30 HighVista Strategies LLC 1.62% of their portfolio BOSTON, MA 92,43492.4k $2.7m $2.7m 1.62% Reduced -44.3k -44,325
31 Parkman Healthcare Partners LLC 0.72% of their portfolio STAMFORD, CT 91,33291.3k $2.7m $2.7m 0.72% Added +10.0k +9,968
32 Tekla Capital Management LLC 0.10% of their portfolio Boston, MA 88,67688.7k $2.6m $2.6m 0.10% Unchanged
33 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 83,20683.2k $2.5m $2.5m 0.00% Reduced -42.5k -42,483
34 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 80,55380.6k $2.4m $2.4m 0.00% Reduced -24.7k -24,738
35 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 79,74679.7k $2.4m $2.4m 0.02% Added +58.9k +58,946
36 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 72,54972.5k $2.1m $2.1m 0.00% Added +9.1k +9,111
37 Bellevue Group AG 0.03% of their portfolio ZURICH, V8 70,20070.2k $2.1m $2.1m 0.03% Reduced -27.9k -27,900
38 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 66,04066.0k $2.0m $2.0m 0.00% Reduced -1.7k -1,707
39 GROUP ONE TRADING LLC 0.04% of their portfolio CHICAGO, IL 38,78438.8k $1.1m $1.1m 0.04% New
40 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 37,05537.1k $1.1m $1.1m 0.00% New
41 L & S Advisors Inc 0.19% of their portfolio Los Angeles, CA 34,95035.0k $1.0m $1.0m 0.19% Reduced -7.8k -7,815
42 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 32,99033.0k $976.5k $976.5k 0.00% Reduced -15.4k -15,414
43 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 25,13625.1k $743.0k $743.0k 0.00% Unchanged
44 HARBOR CAPITAL ADVISORS, INC. 0.69% of their portfolio CHICAGO, IL 24,14724.1k $714.8k $714.8k 0.69% Reduced -21.5k -21,520
45 Vident Investment Advisory, LLC 0.03% of their portfolio Alpharetta, GA 23,95724.0k $709.1k $709.1k 0.03% New
46 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 23,58623.6k $698.1k $698.1k 0.00% Added +8.0k +8,000
47 Eagle Health Investments LP 0.16% of their portfolio Greenwich, CT 23,50023.5k $695.6k $695.6k 0.16% Unchanged
48 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 17,14417.1k $507.0k $507.0k 0.00% Reduced -4.3k -4,276
49 AtonRa Partners 0.64% of their portfolio GENEVA, V8 17,06717.1k $505.2k $505.2k 0.64% Reduced -4.5k -4,527
50 Allianz Asset Management GmbH 0.00% of their portfolio MUNICH, 2M 15,20015.2k $449.9k $449.9k 0.00% Unchanged
51 WOODSTOCK CORP 0.06% of their portfolio BOSTON, MA 14,84014.8k $439.3k $439.3k 0.06% Unchanged
52 SIMPLEX TRADING, LLC 0.02% of their portfolio CHICAGO, IL 14,33414.3k $424.0k $424.0k 0.02% Added +14.1k +14,092
53 Erste Asset Management GmbH 0.01% of their portfolio VIENNA, C4 14,00014.0k $413.8k $413.8k 0.01% Unchanged
54 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 13,20013.2k $375.0k $375.0k 0.00% Unchanged
55 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 13,19013.2k $390.4k $390.4k 0.00% New
56 UBS Group AG 0.00% of their portfolio ZURICH, V8 12,94212.9k $383.1k $383.1k 0.00% Reduced -15.5k -15,533
57 Legal & General Group Plc 0.00% of their portfolio London, X0 10,53310.5k $311.8k $311.8k 0.00% Added +1.4k +1,400
58 FISHMAN JAY A LTD/MI 0.04% of their portfolio TROY, MI 10,50010.5k $310.8k $310.8k 0.04% New
59 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 9,2719.3k $274.4k $274.4k 0.00% Unchanged
60 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 8,8618.9k $262.3k $262.3k 0.00% Added +39 +39
61 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 8,3708.4k $247.8k $247.8k 0.00% Reduced -6.5k -6,480
62 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 8,0378.0k $237.9k $237.9k 0.00% Reduced -27.8k -27,820
63 Jump Financial, LLC 0.01% of their portfolio Chicago, IL 7,4007.4k $219.0k $219.0k 0.01% New
64 Twelve Points Wealth Management LLC 0.15% of their portfolio CONCORD, MA 7,2007.2k $213.1k $213.1k 0.15% New
65 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 5,5135.5k $163.2k $163.2k 0.00% Reduced -3.6k -3,613
66 VIRTUS ADVISERS, LLC 0.07% of their portfolio HARTFORD, CT 4,3614.4k $129.1k $129.1k 0.07% Reduced -3.6k -3,648
67 HighMark Wealth Management LLC 0.09% of their portfolio ST. PAUL, MN 4,2354.2k $125.4k $125.4k 0.09% Unchanged
68 NATIXIS 0.00% of their portfolio PARIS, I0 3,6133.6k $106.9k $106.9k 0.00% New
69 Cutler Group LLC / CA 0.01% of their portfolio SAN FRANCISCO, CA 2,0402.0k $60.0k $60.0k 0.01% Reduced -60 -60
70 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 1,3101.3k $38.0k $38.0k 0.00% Reduced -100 -100
71 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,1641.2k $35.0k $35.0k 0.00% Reduced -1.1k -1,099
72 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 511511 $15.1k $15.1k 0.00% Reduced -23 -23
73 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 395395 $11.7k $11.7k 0.00% Reduced -140 -140
74 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 259259 $7.7k $7.7k 0.00% Added +20 +20
75 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 234234 $6.9k $6.9k 0.00% Unchanged
76 Atle Fund Management AB 0.01% of their portfolio STOCKHOLM, V7 226226 $6.7k $6.7k 0.01% New
77 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 211211 $7.0k $7.0k 0.00% Added +3 +3
78 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 162162 $4.8k $4.8k 0.00% New
79 Advisory Services Network, LLC 0.00% of their portfolio ATLANTA, GA 115115 $3.4k $3.4k 0.00% New
80 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 103103 $3.0k $3.0k 0.00% Added +45 +45
81 Crewe Advisors LLC 0.00% of their portfolio SALT LAKE CITY, UT 8383 $2.5k $2.5k 0.00% Unchanged
82 TCI Wealth Advisors, Inc. 0.00% of their portfolio Tucson, AZ 7373 $2.2k $2.2k 0.00% New
83 Zullo Investment Group, Inc. 0.00% of their portfolio SCRANTON, PA 5050 $1.5k $1.5k 0.00% Unchanged
84 NFSG Corp 0.00% of their portfolio BOCA RATON, FL 4040 $1.2k $1.2k 0.00% Unchanged
85 Blue Trust, Inc. 0.00% of their portfolio BRENTWOOD, TN 2020 $0 $0 0.00% New
86 Parallel Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 55 $148 $148 0.00% Unchanged
87 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged