AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.3m this quarter). Holder counts are more reliable. Shares outstanding: 43.4m as of 2022-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $77.12. Options: 21 managers hold calls ($179.1m notional), 18 hold puts ($132.8m).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $113.6m | $113.3m | 1.00 |
| Q4 2022 | $179.1m | $132.8m | 0.74 |
Biggest buyers
| BVF INC/IL | New | +1.8m |
| RTW INVESTMENTS, LP | Added | +1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +915.0k |
| Venrock Adviser, LLC | New | +670.7k |
| Hood River Capital Management LLC | New | +460.3k |
| Boxer Capital, LLC | New | +400.0k |
| FMR LLC | Added | +385.5k |
| Cormorant Asset Management, LP | New | +325.0k |
| Cannell & Co. | Added | +320.7k |
| BlackRock Inc. | Added | +310.7k |
Biggest sellers
| Avidity Partners Management LP | Reduced | -868.6k |
| Nuveen Asset Management, LLC | Reduced | -571.6k |
| PFM Health Sciences, LP | Reduced | -566.9k |
| Paradigm Biocapital Advisors LP | Sold out | -520.1k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -351.1k |
| GOLDMAN SACHS GROUP INC | Reduced | -253.4k |
| CITADEL ADVISORS LLC | Reduced | -167.6k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -160.1k |
| TWO SIGMA INVESTMENTS, LP | Sold out | -141.3k |
| MORGAN STANLEY | Reduced | -122.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $40.8m528.7k shares |
| CITADEL ADVISORS LLC | Reduced | $37.4m484.4k shares |
| PFM Health Sciences, LP | New | $23.1m299.0k shares |
| JANE STREET GROUP, LLC | Added | $19.5m253.1k shares |
| GROUP ONE TRADING LLC | Added | $18.1m235.1k shares |
| SIMPLEX TRADING, LLC | Added | $14.3m185.1k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $11.0m142.5k shares |
| Walleye Trading LLC | Added | $3.7m48.3k shares |
| Caption Management, LLC | New | $2.7m35.0k shares |
| WOLVERINE TRADING, LLC | Added | $2.5m32.0k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $53.2m689.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $24.9m322.3k shares |
| JANE STREET GROUP, LLC | Added | $12.3m159.9k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | $10.9m140.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $7.5m97.1k shares |
| GROUP ONE TRADING LLC | Reduced | $7.1m92.3k shares |
| JPMORGAN CHASE & CO | Added | $4.6m59.2k shares |
| CSS LLC/IL | Added | $2.9m37.1k shares |
| Caption Management, LLC | New | $2.7m35.0k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.8m23.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2021 | 0 | — | 0 | — | — |
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 4 | $345.1k | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
None reported in Q4 2022.
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| VANGUARD GROUP INC 0.01% of their portfolio | 3.4m $263.6m | Added +306.1k |
| RTW INVESTMENTS, LP 4.69% of their portfolio | 3.0m $229.9m | Added +1.1m |
| BlackRock Inc. 0.01% of their portfolio | 2.5m $193.1m | Added +310.7k |
| Fairmount Funds Management LLC 24.61% of their portfolio | 2.0m $155.2m | Added +115.0k |
| BVF INC/IL 5.71% of their portfolio | 1.8m $135.4m | New |
| PFM Health Sciences, LP 3.56% of their portfolio | 1.1m $84.3m | Reduced -566.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.20% of their portfolio | 1.1m $82.1m | Added +915.0k |
| ALETHEA CAPITAL MANAGEMENT, LLC 58.09% of their portfolio | 785.7k $60.6m | Reduced -2.6k |
| STATE STREET CORP 0.00% of their portfolio | 756.9k $58.4m | Added +45.5k |
| FMR LLC 0.01% of their portfolio | 734.4k $56.6m | Added +385.5k |
| Venrock Adviser, LLC 8.71% of their portfolio | 670.7k $51.7m | New |
| Avidity Partners Management LP 1.21% of their portfolio | 670.0k $51.7m | Reduced -868.6k |
| Point72 Asset Management, L.P. 0.19% of their portfolio | 650.1k $50.1m | Added +32.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 624.6k $48.2m | Added +62.0k |
| MORGAN STANLEY 0.00% of their portfolio | 477.3k $36.8m | Reduced -122.3k |
| Hood River Capital Management LLC 1.29% of their portfolio | 460.3k $35.5m | New |
| Bellevue Group AG 0.45% of their portfolio | 436.7k $33.7m | Reduced -59.9k |
| Boxer Capital, LLC 1.63% of their portfolio | 400.0k $30.9m | New |
| Cannell & Co. 1.03% of their portfolio | 370.0k $28.5m | Added +320.7k |
| CITADEL ADVISORS LLC 0.03% of their portfolio | 363.7k $28.1m | Reduced -167.6k |
| Cormorant Asset Management, LP 1.68% of their portfolio | 325.0k $25.1m | New |
| TANG CAPITAL MANAGEMENT LLC 3.59% of their portfolio | 320.0k $24.7m | Added +250.0k |
| IRIDIAN ASSET MANAGEMENT LLC/CT 2.37% of their portfolio | 318.6k $24.6m | Reduced -82.5k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 311.9k $24.1m | Added +24.0k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 265.8k $20.5m | Reduced -253.4k |
| NORGES BANK 0.00% of their portfolio | 256.4k $19.8m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 249.8k $19.3m | Added +23.4k |
| Ghost Tree Capital, LLC 7.74% of their portfolio | 235.0k $18.1m | Reduced -65.0k |
| Driehaus Capital Management LLC 0.27% of their portfolio | 233.1k $18.0m | New |
| Atika Capital Management LLC 2.67% of their portfolio | 226.5k $17.5m | Reduced -37.8k |
| Woodline Partners LP 0.24% of their portfolio | 223.7k $17.3m | New |
| Nicholas Investment Partners, LP 1.35% of their portfolio | 200.3k $15.4m | New |
| Tri Locum Partners LP 6.82% of their portfolio | 200.1k $15.4m | New |
| WMS Partners, LLC 1.48% of their portfolio | 193.3k $14.9m | Reduced -711 |
| JANE STREET GROUP, LLC 0.03% of their portfolio | 175.9k $13.6m | Reduced -7.0k |
| Candriam S.C.A. 0.09% of their portfolio | 171.5k $13.2m | Added +61.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 167.6k $12.9m | Reduced -4.3k |
| Invesco Ltd. 0.00% of their portfolio | 139.5k $10.8m | Reduced -31.6k |
| US BANCORP \DE\ 0.02% of their portfolio | 138.8k $10.7m | Reduced -11.6k |
| SEI INVESTMENTS CO 0.02% of their portfolio | 137.5k $10.6m | Reduced -11.3k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 128.5k $9.9m | Reduced -6.6k |
| GROUP ONE TRADING LLC 0.33% of their portfolio | 126.6k $9.8m | Reduced -7.2k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 121.9k $9.4m | Reduced -571.6k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 120.9k $9.3m | New |
| 1832 Asset Management L.P. 0.02% of their portfolio | 118.2k $9.1m | New |
| Man Group plc 0.03% of their portfolio | 116.5k $9.0m | New |
| PUTNAM INVESTMENTS LLC 0.02% of their portfolio | 114.2k $8.8m | Added +1.7k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.23% of their portfolio | 96.4k $7.4m | Reduced -10.5k |
| Hennion & Walsh Asset Management, Inc. 0.44% of their portfolio | 93.2k $7.2m | Reduced -13.4k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.08% of their portfolio | 89.4k $6.9m | New |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 88.7k $6.8m | Reduced -45.0k |
| Lindbrook Capital, LLC 0.80% of their portfolio | 84.5k $6.5m | Added +84.5k |
| Schonfeld Strategic Advisors LLC 0.05% of their portfolio | 84.4k $6.5m | Added +35.0k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 77.0k $5.9m | Added +3.1k |
| Swiss National Bank 0.00% of their portfolio | 73.0k $5.6m | Added +3.8k |
| HighVista Strategies LLC 2.52% of their portfolio | 55.1k $4.3m | Added +38.2k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 53.7k $4.1m | Reduced -160.1k |
| Moody Aldrich Partners LLC 0.81% of their portfolio | 52.1k $4.0m | Reduced -70.1k |
| MPM BIOIMPACT LLC 1.04% of their portfolio | 52.0k $4.0m | New |
| Soleus Capital Management, L.P. 0.55% of their portfolio | 50.0k $3.9m | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 48.0k $3.7m | Added +2.6k |
| BALDWIN WEALTH PARTNERS LLC/MA 0.33% of their portfolio | 47.5k $3.7m | Reduced -5.3k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 45.1k $3.5m | Reduced -16.5k |
| Squarepoint Ops LLC 0.02% of their portfolio | 44.6k $3.4m | Reduced -88.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 42.9k $3.3m | Added +4.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 40.7k $3.1m | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 40.6k $3.1m | Reduced -7.8k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.04% of their portfolio | 39.3k $3.0m | Added +17.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 39.1k $3.0m | Added +2.2k |
| SVB FINANCIAL GROUP 7.14% of their portfolio | 33.8k $2.6m | First filing |
| Jump Financial, LLC 0.13% of their portfolio | 32.8k $2.5m | Reduced -4.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 31.2k $2.4m | Reduced -7.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 30.4k $2.3m | Added +8.9k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 30.3k $2.3m | Added +1.2k |
| DekaBank Deutsche Girozentrale 0.01% of their portfolio | 30.0k $2.3m | Unchanged |
| ALPS ADVISORS INC 0.02% of their portfolio | 29.4k $2.3m | New |
| Legal & General Group Plc 0.00% of their portfolio | 27.0k $2.1m | Added +250 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 27.0k $2.1m | Added +2.0k |
| Trexquant Investment LP 0.05% of their portfolio | 24.0k $1.8m | New |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 23.8k $1.8m | Reduced -98.0k |
| Global IMC LLC 0.42% of their portfolio | 21.3k $1.6m | Reduced -16.9k |
| CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio | 19.3k $1.5m | New |
| Dana Investment Advisors, Inc. 0.08% of their portfolio | 18.9k $1.5m | Added +4.1k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 18.4k $1.4m | Reduced -9.3k |
| OLD NATIONAL BANCORP /IN/ 0.04% of their portfolio | 17.4k $1.3m | Reduced -35.8k |
| CIBC Private Wealth Group LLC 0.00% of their portfolio | 17.4k $1.3m | Reduced -1.9k |
| MetLife Investment Management, LLC 0.01% of their portfolio | 16.9k $1.3m | Added +558 |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 16.4k $1.3m | Added +490 |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 16.4k $1.3m | Added +863 |
| SIMPLEX TRADING, LLC 0.06% of their portfolio | 16.4k $1.3m | Reduced -21.7k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio | 15.2k $1.2m | Added +1.0k |
| Meridian Wealth Management, LLC 0.11% of their portfolio | 14.9k $1.2m | Added +1.9k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 14.9k $1.2m | Added +1.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 14.5k $1.1m | Added +380 |
| Informed Momentum Co LLC 0.23% of their portfolio | 14.5k $1.1m | Reduced -37.6k |
| DAVENPORT & Co LLC 0.01% of their portfolio | 14.2k $1.1m | New |
| Lion Street Advisors, LLC 0.27% of their portfolio | 13.2k $507.3k | Reduced -135 |
| UBS Group AG 0.00% of their portfolio | 13.1k $1.0m | Reduced -5.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 13.0k $1.0m | Added +1.2k |
| SEVEN EIGHT CAPITAL, LP 0.26% of their portfolio | 12.9k $994.2k | Added +6.2k |