Vault-13

AXSOME THERAPEUTICS INC AXSM

COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043

American biopharmaceutical company

219 institutional holders +30 vs Q3 2022
30,038,62130.0m shares reported held*
69.2% of all shares outstanding*
$2.3bnreported value*
54 new 56 added 75 reduced 26 sold out net bought ≈ $341.6m (+4.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.3m this quarter). Holder counts are more reliable. Shares outstanding: 43.4m as of 2022-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $77.12. Options: 21 managers hold calls ($179.1m notional), 18 hold puts ($132.8m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 189Q4 22: 219219Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022189
Q4 2022219

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ3 22 calls: $113.6mQ3 22 puts: $113.3mQ3 22P/C 1.00Q4 22 calls: $179.1mQ4 22 puts: $132.8mQ4 22P/C 0.74
Numbers
QuarterCallsPutsP/C
Q3 2022$113.6m$113.3m1.00
Q4 2022$179.1m$132.8m0.74

Biggest buyers

BVF INC/IL New +1,755,000+1.8m
RTW INVESTMENTS, LP Added +1,098,318+1.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +915,000+915.0k
Venrock Adviser, LLC New +670,718+670.7k
Hood River Capital Management LLC New +460,295+460.3k
Boxer Capital, LLC New +400,000+400.0k
FMR LLC Added +385,541+385.5k
Cormorant Asset Management, LP New +325,000+325.0k
Cannell & Co. Added +320,680+320.7k
BlackRock Inc. Added +310,722+310.7k

Biggest sellers

Avidity Partners Management LP Reduced -868,600-868.6k
Nuveen Asset Management, LLC Reduced -571,579-571.6k
PFM Health Sciences, LP Reduced -566,902-566.9k
Paradigm Biocapital Advisors LP Sold out -520,080-520.1k
MILLENNIUM MANAGEMENT LLC Sold out -351,140-351.1k
GOLDMAN SACHS GROUP INC Reduced -253,425-253.4k
CITADEL ADVISORS LLC Reduced -167,596-167.6k
VOLORIDGE INVESTMENT MANAGEMENT, LLC Reduced -160,113-160.1k
TWO SIGMA INVESTMENTS, LP Sold out -141,312-141.3k
MORGAN STANLEY Reduced -122,275-122.3k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $40.8m528.7k shares
CITADEL ADVISORS LLC Reduced $37.4m484.4k shares
PFM Health Sciences, LP New $23.1m299.0k shares
JANE STREET GROUP, LLC Added $19.5m253.1k shares
GROUP ONE TRADING LLC Added $18.1m235.1k shares
SIMPLEX TRADING, LLC Added $14.3m185.1k shares
BOOTHBAY FUND MANAGEMENT, LLC New $11.0m142.5k shares
Walleye Trading LLC Added $3.7m48.3k shares
Caption Management, LLC New $2.7m35.0k shares
WOLVERINE TRADING, LLC Added $2.5m32.0k shares

Biggest puts

CITADEL ADVISORS LLC Reduced $53.2m689.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $24.9m322.3k shares
JANE STREET GROUP, LLC Added $12.3m159.9k shares
BOOTHBAY FUND MANAGEMENT, LLC Reduced $10.9m140.9k shares
SIMPLEX TRADING, LLC Reduced $7.5m97.1k shares
GROUP ONE TRADING LLC Reduced $7.1m92.3k shares
JPMORGAN CHASE & CO Added $4.6m59.2k shares
CSS LLC/IL Added $2.9m37.1k shares
Caption Management, LLC New $2.7m35.0k shares
WOLVERINE TRADING, LLC Reduced $1.8m23.9k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2026-07-27 5.3% 2.7m≈ $669.8m 2026-07-27

Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)

Insider purchases and sales in Q4 2022

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q1 21: 0 buyingQ1 21: 0 sellingQ2 21: 0 buyingQ2 21: 0 sellingQ2 21Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 4 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20210—0——
Q2 20210—0——
Q3 20210—0——
Q4 20214$345.1k0——
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——

None reported in Q4 2022.

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 3,417,6283.4m $263.6m $263.6m 0.01% Added +306.1k +306,128
2 RTW INVESTMENTS, LP 4.69% of their portfolio NEW YORK, NY 2,980,4823.0m $229.9m $229.9m 4.69% Added +1.1m +1,098,318
3 BlackRock Inc. 0.01% of their portfolio New York, NY 2,502,9772.5m $193.1m $193.1m 0.01% Added +310.7k +310,722
4 Fairmount Funds Management LLC 24.61% of their portfolio WEST CONSHOHOCKEN, PA 2,011,6472.0m $155.2m $155.2m 24.61% Added +115.0k +115,000
5 BVF INC/IL 5.71% of their portfolio San Francisco, CA 1,755,0001.8m $135.4m $135.4m 5.71% New
6 PFM Health Sciences, LP 3.56% of their portfolio SAN FRANCISCO, CA 1,092,8311.1m $84.3m $84.3m 3.56% Reduced -566.9k -566,902
7 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.20% of their portfolio Boston, MA 1,065,0001.1m $82.1m $82.1m 0.20% Added +915.0k +915,000
8 ALETHEA CAPITAL MANAGEMENT, LLC 58.09% of their portfolio MERCER ISLAND, WA 785,683785.7k $60.6m $60.6m 58.09% Reduced -2.6k -2,580
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 756,870756.9k $58.4m $58.4m 0.00% Added +45.5k +45,538
10 FMR LLC 0.01% of their portfolio BOSTON, MA 734,437734.4k $56.6m $56.6m 0.01% Added +385.5k +385,541
11 Venrock Adviser, LLC 8.71% of their portfolio NEW YORK, NY 670,718670.7k $51.7m $51.7m 8.71% New
12 Avidity Partners Management LP 1.21% of their portfolio DALLAS, TX 670,000670.0k $51.7m $51.7m 1.21% Reduced -868.6k -868,600
13 Point72 Asset Management, L.P. 0.19% of their portfolio STAMFORD, CT 650,065650.1k $50.1m $50.1m 0.19% Added +32.2k +32,165
14 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 624,589624.6k $48.2m $48.2m 0.01% Added +62.0k +62,000
15 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 477,256477.3k $36.8m $36.8m 0.00% Reduced -122.3k -122,275
16 Hood River Capital Management LLC 1.29% of their portfolio PALM BEACH GARDENS, FL 460,295460.3k $35.5m $35.5m 1.29% New
17 Bellevue Group AG 0.45% of their portfolio ZURICH, V8 436,658436.7k $33.7m $33.7m 0.45% Reduced -59.9k -59,866
18 Boxer Capital, LLC 1.63% of their portfolio San Diego, CA 400,000400.0k $30.9m $30.9m 1.63% New
19 Cannell & Co. 1.03% of their portfolio New York, NY 370,020370.0k $28.5m $28.5m 1.03% Added +320.7k +320,680
20 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 363,741363.7k $28.1m $28.1m 0.03% Reduced -167.6k -167,596
21 Cormorant Asset Management, LP 1.68% of their portfolio BOSTON, MA 325,000325.0k $25.1m $25.1m 1.68% New
22 TANG CAPITAL MANAGEMENT LLC 3.59% of their portfolio SAN DIEGO, CA 320,000320.0k $24.7m $24.7m 3.59% Added +250.0k +250,000
23 IRIDIAN ASSET MANAGEMENT LLC/CT 2.37% of their portfolio WESTPORT, CT 318,611318.6k $24.6m $24.6m 2.37% Reduced -82.5k -82,497
24 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 311,945311.9k $24.1m $24.1m 0.01% Added +24.0k +23,993
25 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 265,839265.8k $20.5m $20.5m 0.01% Reduced -253.4k -253,425
26 NORGES BANK 0.00% of their portfolio OSLO, Q8 256,397256.4k $19.8m $19.8m 0.00% Unchanged
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 249,770249.8k $19.3m $19.3m 0.01% Added +23.4k +23,417
28 Ghost Tree Capital, LLC 7.74% of their portfolio NEW YORK, NY 235,000235.0k $18.1m $18.1m 7.74% Reduced -65.0k -65,000
29 Driehaus Capital Management LLC 0.27% of their portfolio Chicago, IL 233,095233.1k $18.0m $18.0m 0.27% New
30 Atika Capital Management LLC 2.67% of their portfolio NEW YORK, NY 226,535226.5k $17.5m $17.5m 2.67% Reduced -37.8k -37,795
31 Woodline Partners LP 0.24% of their portfolio San Francisco, CA 223,652223.7k $17.3m $17.3m 0.24% New
32 Nicholas Investment Partners, LP 1.35% of their portfolio RANCHO SANTA FE, CA 200,254200.3k $15.4m $15.4m 1.35% New
33 Tri Locum Partners LP 6.82% of their portfolio NEW YORK, NY 200,054200.1k $15.4m $15.4m 6.82% New
34 WMS Partners, LLC 1.48% of their portfolio TOWSON, MD 193,289193.3k $14.9m $14.9m 1.48% Reduced -711 -711
35 JANE STREET GROUP, LLC 0.03% of their portfolio NEW YORK, NY 175,899175.9k $13.6m $13.6m 0.03% Reduced -7.0k -6,971
36 Candriam S.C.A. 0.09% of their portfolio STRASSEN, N4 171,474171.5k $13.2m $13.2m 0.09% Added +61.1k +61,094
37 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 167,577167.6k $12.9m $12.9m 0.00% Reduced -4.3k -4,301
38 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 139,459139.5k $10.8m $10.8m 0.00% Reduced -31.6k -31,591
39 US BANCORP \DE\ 0.02% of their portfolio MINNEAPOLIS, MN 138,792138.8k $10.7m $10.7m 0.02% Reduced -11.6k -11,614
40 SEI INVESTMENTS CO 0.02% of their portfolio OAKS, PA 137,467137.5k $10.6m $10.6m 0.02% Reduced -11.3k -11,322
41 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 128,498128.5k $9.9m $9.9m 0.00% Reduced -6.6k -6,632
42 GROUP ONE TRADING LLC 0.33% of their portfolio CHICAGO, IL 126,555126.6k $9.8m $9.8m 0.33% Reduced -7.2k -7,243
43 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 121,945121.9k $9.4m $9.4m 0.00% Reduced -571.6k -571,579
44 Balyasny Asset Management L.P. 0.03% of their portfolio Chicago, IL 120,874120.9k $9.3m $9.3m 0.03% New
45 1832 Asset Management L.P. 0.02% of their portfolio TORONTO, A6 118,200118.2k $9.1m $9.1m 0.02% New
46 Man Group plc 0.03% of their portfolio LONDON, X0 116,492116.5k $9.0m $9.0m 0.03% New
47 PUTNAM INVESTMENTS LLC 0.02% of their portfolio BOSTON, MA 114,239114.2k $8.8m $8.8m 0.02% Added +1.7k +1,667
48 PEREGRINE CAPITAL MANAGEMENT LLC 0.23% of their portfolio MINNEAPOLIS, MN 96,38696.4k $7.4m $7.4m 0.23% Reduced -10.5k -10,453
49 Hennion & Walsh Asset Management, Inc. 0.44% of their portfolio Parsippany, NJ 93,19093.2k $7.2m $7.2m 0.44% Reduced -13.4k -13,392
50 FRONTIER CAPITAL MANAGEMENT CO LLC 0.08% of their portfolio Boston, MA 89,41189.4k $6.9m $6.9m 0.08% New
51 WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio LAGUNA BEACH, CA 88,73988.7k $6.8m $6.8m 0.02% Reduced -45.0k -44,966
52 Lindbrook Capital, LLC 0.80% of their portfolio CALABASAS, CA 84,55084.5k $6.5m $6.5m 0.80% Added +84.5k +84,498
53 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 84,35584.4k $6.5m $6.5m 0.05% Added +35.0k +34,955
54 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 76,96677.0k $5.9m $5.9m 0.00% Added +3.1k +3,144
55 Swiss National Bank 0.00% of their portfolio ZURICH, V8 73,00073.0k $5.6m $5.6m 0.00% Added +3.8k +3,800
56 HighVista Strategies LLC 2.52% of their portfolio BOSTON, MA 55,12455.1k $4.3m $4.3m 2.52% Added +38.2k +38,238
57 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 53,68053.7k $4.1m $4.1m 0.02% Reduced -160.1k -160,113
58 Moody Aldrich Partners LLC 0.81% of their portfolio MARBLEHEAD, MA 52,14652.1k $4.0m $4.0m 0.81% Reduced -70.1k -70,115
59 MPM BIOIMPACT LLC 1.04% of their portfolio BOSTON, MA 51,97552.0k $4.0m $4.0m 1.04% New
60 Soleus Capital Management, L.P. 0.55% of their portfolio GREENWICH, CT 50,00050.0k $3.9m $3.9m 0.55% New
61 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 48,04448.0k $3.7m $3.7m 0.00% Added +2.6k +2,623
62 BALDWIN WEALTH PARTNERS LLC/MA 0.33% of their portfolio Marion, MA 47,49547.5k $3.7m $3.7m 0.33% Reduced -5.3k -5,350
63 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 45,14245.1k $3.5m $3.5m 0.00% Reduced -16.5k -16,474
64 Squarepoint Ops LLC 0.02% of their portfolio NEW YORK, NY 44,61644.6k $3.4m $3.4m 0.02% Reduced -88.0k -87,977
65 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 42,93942.9k $3.3m $3.3m 0.00% Added +4.1k +4,083
66 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 40,70040.7k $3.1m $3.1m 0.00% Unchanged
67 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 40,59840.6k $3.1m $3.1m 0.00% Reduced -7.8k -7,807
68 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.04% of their portfolio New York, NY 39,25239.3k $3.0m $3.0m 0.04% Added +17.5k +17,456
69 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 39,09639.1k $3.0m $3.0m 0.00% Added +2.2k +2,238
70 SVB FINANCIAL GROUP 7.14% of their portfolio Dallas, TX 33,84933.8k $2.6m $2.6m 7.14% First filing
71 Jump Financial, LLC 0.13% of their portfolio Chicago, IL 32,75032.8k $2.5m $2.5m 0.13% Reduced -4.6k -4,636
72 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 31,22631.2k $2.4m $2.4m 0.00% Reduced -7.0k -7,023
73 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 30,43930.4k $2.3m $2.3m 0.00% Added +8.9k +8,866
74 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 30,26830.3k $2.3m $2.3m 0.01% Added +1.2k +1,229
75 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 30,00030.0k $2.3m $2.3m 0.01% Unchanged
76 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 29,42329.4k $2.3m $2.3m 0.02% New
77 Legal & General Group Plc 0.00% of their portfolio London, X0 27,01127.0k $2.1m $2.1m 0.00% Added +250 +250
78 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 26,95427.0k $2.1m $2.1m 0.00% Added +2.0k +1,951
79 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 23,95524.0k $1.8m $1.8m 0.05% New
80 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 23,78623.8k $1.8m $1.8m 0.01% Reduced -98.0k -98,024
81 Global IMC LLC 0.42% of their portfolio SOLANA BEACH, CA 21,28821.3k $1.6m $1.6m 0.42% Reduced -16.9k -16,930
82 CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio PARIS, I0 19,28319.3k $1.5m $1.5m 0.03% New
83 Dana Investment Advisors, Inc. 0.08% of their portfolio BROOKFIELD, WI 18,92618.9k $1.5m $1.5m 0.08% Added +4.1k +4,061
84 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 18,40618.4k $1.4m $1.4m 0.00% Reduced -9.3k -9,301
85 OLD NATIONAL BANCORP /IN/ 0.04% of their portfolio EVANSVILLE, IN 17,44517.4k $1.3m $1.3m 0.04% Reduced -35.8k -35,791
86 CIBC Private Wealth Group LLC 0.00% of their portfolio ATLANTA, GA 17,42217.4k $1.3m $1.3m 0.00% Reduced -1.9k -1,901
87 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 16,90016.9k $1.3m $1.3m 0.01% Added +558 +558
88 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 16,43216.4k $1.3m $1.3m 0.00% Added +490 +490
89 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 16,36216.4k $1.3m $1.3m 0.00% Added +863 +863
90 SIMPLEX TRADING, LLC 0.06% of their portfolio CHICAGO, IL 16,36216.4k $1.3m $1.3m 0.06% Reduced -21.7k -21,689
91 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 15,16015.2k $1.2m $1.2m 0.01% Added +1.0k +1,040
92 Meridian Wealth Management, LLC 0.11% of their portfolio LEXINGTON, KY 14,94814.9k $1.2m $1.2m 0.11% Added +1.9k +1,878
93 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 14,94214.9k $1.2m $1.2m 0.00% Added +1.8k +1,794
94 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 14,47914.5k $1.1m $1.1m 0.00% Added +380 +380
95 Informed Momentum Co LLC 0.23% of their portfolio SOLANA BEACH, CA 14,45814.5k $1.1m $1.1m 0.23% Reduced -37.6k -37,634
96 DAVENPORT & Co LLC 0.01% of their portfolio RICHMOND, VA 14,20014.2k $1.1m $1.1m 0.01% New
97 Lion Street Advisors, LLC 0.27% of their portfolio Austin, TX 13,17713.2k $507.3k $507.3k 0.27% Reduced -135 -135
98 UBS Group AG 0.00% of their portfolio ZURICH, V8 13,05713.1k $1.0m $1.0m 0.00% Reduced -5.2k -5,244
99 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 12,98813.0k $1.0m $1.0m 0.00% Added +1.2k +1,157
100 SEVEN EIGHT CAPITAL, LP 0.26% of their portfolio New York, NY 12,89012.9k $994.2k $994.2k 0.26% Added +6.2k +6,225