Vault-13

AKERO THERAPEUTICS INC AKRO

COM · Common Stock · CUSIP 00973Y108

162 institutional holders +16 vs Q3 2022
48,636,66148.6m shares reported held*
$2.7bnreported value*
35 new 68 added 41 reduced 19 sold out net sold ≈ $146.8m (-2.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($477.3k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $54.71. Options: 14 managers hold calls ($54.4m notional), 16 hold puts ($55.7m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 146Q4 22: 162162Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022146
Q4 2022162

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 22 calls: $24.0mQ3 22 puts: $42.4mQ3 22P/C 1.77Q4 22 calls: $54.4mQ4 22 puts: $55.7mQ4 22P/C 1.02
Numbers
QuarterCallsPutsP/C
Q3 2022$24.0m$42.4m1.77
Q4 2022$54.4m$55.7m1.02

Biggest buyers

STATE STREET CORP Added +1,953,347+2.0m
Redmile Group, LLC Added +1,041,827+1.0m
PRICE T ROWE ASSOCIATES INC /MD/ Added +938,613+938.6k
MARSHALL WACE, LLP Added +752,524+752.5k
Avidity Partners Management LP Added +703,000+703.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +452,477+452.5k
DEUTSCHE BANK AG\ Added +414,957+415.0k
BlackRock Inc. Added +413,052+413.1k
VANGUARD GROUP INC Added +375,978+376.0k
D. E. Shaw & Co., Inc. Added +254,821+254.8k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -5,210,744-5.2m
GOLDMAN SACHS GROUP INC Reduced -1,932,885-1.9m
Skorpios Trust Reduced -1,636,000-1.6m
Deep Track Capital, LP Sold out -790,926-790.9k
Yiheng Capital Management, L.P. Reduced -630,241-630.2k
venBio Partners LLC Sold out -596,483-596.5k
Atlas Venture Life Science Advisors, LLC Reduced -400,000-400.0k
HHLR ADVISORS, LTD. Reduced -364,498-364.5k
Paradigm Biocapital Advisors LP Reduced -228,721-228.7k
Commodore Capital LP Reduced -206,396-206.4k

Biggest calls

Yiheng Capital Management, L.P. Added $17.9m326.5k shares
SILVERARC CAPITAL MANAGEMENT, LLC New $8.2m150.0k shares
JANE STREET GROUP, LLC Added $7.0m127.3k shares
CITADEL ADVISORS LLC Added $6.8m123.4k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $6.3m114.9k shares
GROUP ONE TRADING LLC Reduced $1.8m32.0k shares
SG3 Management, LLC Added $1.6m30.0k shares
SIMPLEX TRADING, LLC Reduced $1.3m23.9k shares
WOLVERINE TRADING, LLC New $954.0k17.4k shares
Walleye Trading LLC Reduced $926.1k16.9k shares

Biggest puts

GROUP ONE TRADING LLC Added $12.7m231.0k shares
JANE STREET GROUP, LLC Added $11.3m205.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $8.2m150.1k shares
SILVERARC CAPITAL MANAGEMENT, LLC New $8.2m150.0k shares
UBS Group AG New $3.7m66.9k shares
CITADEL ADVISORS LLC Reduced $2.6m47.5k shares
SIMPLEX TRADING, LLC Reduced $2.5m46.3k shares
Jefferies Financial Group Inc. New $1.6m30.0k shares
SG3 Management, LLC Added $1.6m30.0k shares
Caption Management, LLC Reduced $1.6m30.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GENERAL ATLANTIC, L.P. 13G · passive investor filed 2025-05-15 8.4% 6.8m 2025-05-15

Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (4.1%, 2026-02-17), RTW INVESTMENTS, LP (0.0%, 2026-02-17), Deep Track Capital, LP (0.0%, 2026-02-13), WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-02-10), PRICE T ROWE ASSOCIATES INC /MD/ (4.8%, 2025-11-14)

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Avidity Partners Management LP 4.90% of their portfolio DALLAS, TX 3,825,0003.8m $209.6m $209.6m 4.90% Added +703.0k +703,000
2 JANUS HENDERSON GROUP PLC 0.13% of their portfolio LONDON, X0 3,340,1743.3m $183.0m $183.0m 0.13% Reduced -5.2m -5,210,744
3 Skorpios Trust 57.03% of their portfolio LIMASSOL, G4 3,271,8293.3m $179.3m $179.3m 57.03% Reduced -1.6m -1,636,000
4 ALKEON CAPITAL MANAGEMENT LLC 1.32% of their portfolio New York, NY 3,243,9153.2m $177.8m $177.8m 1.32% Added +81.7k +81,656
5 BlackRock Inc. 0.00% of their portfolio New York, NY 2,758,5292.8m $151.2m $151.2m 0.00% Added +413.1k +413,052
6 Redmile Group, LLC 5.90% of their portfolio LARKSPUR, CA 2,632,9122.6m $144.3m $144.3m 5.90% Added +1.0m +1,041,827
7 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,500,9692.5m $137.1m $137.1m 0.01% Added +2.0m +1,953,347
8 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 2,401,0372.4m $131.6m $131.6m 0.02% Added +938.6k +938,613
9 BAKER BROS. ADVISORS LP 0.78% of their portfolio NEW YORK, NY 2,368,3782.4m $129.8m $129.8m 0.78% Unchanged
10 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,116,5712.1m $116.0m $116.0m 0.00% Added +376.0k +375,978
11 MARSHALL WACE, LLP 0.21% of their portfolio LONDON, X0 1,503,3641.5m $82.4m $82.4m 0.21% Added +752.5k +752,524
12 Yiheng Capital Management, L.P. 6.24% of their portfolio SAN FRANCISCO, CA 1,468,9051.5m $80.5m $80.5m 6.24% Reduced -630.2k -630,241
13 Rock Springs Capital Management LP 1.85% of their portfolio Baltimore, MD 1,400,6541.4m $76.8m $76.8m 1.85% Added +30.7k +30,681
14 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.17% of their portfolio Boston, MA 1,324,9771.3m $72.6m $72.6m 0.17% Added +452.5k +452,477
15 RA CAPITAL MANAGEMENT, L.P. 1.07% of their portfolio BOSTON, MA 958,980959.0k $52.6m $52.6m 1.07% Unchanged
16 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 876,099876.1k $48.0m $48.0m 0.01% Added +79.6k +79,600
17 Boxer Capital, LLC 2.40% of their portfolio San Diego, CA 831,495831.5k $45.6m $45.6m 2.40% Unchanged
18 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 633,380633.4k $34.7m $34.7m 0.00% Added +110.1k +110,091
19 Paradigm Biocapital Advisors LP 3.89% of their portfolio NEW YORK, NY 604,544604.5k $33.1m $33.1m 3.89% Reduced -228.7k -228,721
20 Atlas Venture Life Science Advisors, LLC 3.92% of their portfolio CAMBRIDGE, MA 594,251594.3k $32.6m $32.6m 3.92% Reduced -400.0k -400,000
21 Commodore Capital LP 4.44% of their portfolio NEW YORK, NY 537,076537.1k $29.4m $29.4m 4.44% Reduced -206.4k -206,396
22 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 427,683427.7k $23.4m $23.4m 0.01% Added +415.0k +414,957
23 Logos Global Management LP 2.57% of their portfolio San Francisco, CA 400,000400.0k $21.9m $21.9m 2.57% Unchanged
24 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 360,277360.3k $19.7m $19.7m 0.00% Added +95.8k +95,767
25 PERCEPTIVE ADVISORS LLC 0.55% of their portfolio NEW YORK, NY 350,525350.5k $19.2m $19.2m 0.55% Reduced -79.5k -79,475
26 HHLR ADVISORS, LTD. 0.36% of their portfolio GRAND CAYMAN, E9 315,502315.5k $17.3m $17.3m 0.36% Reduced -364.5k -364,498
27 D. E. Shaw & Co., Inc. 0.03% of their portfolio New York, NY 293,844293.8k $16.1m $16.1m 0.03% Added +254.8k +254,821
28 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 290,606290.6k $15.9m $15.9m 0.01% Reduced -785 -785
29 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 261,717261.7k $14.3m $14.3m 0.02% Added +84.6k +84,556
30 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 247,017247.0k $13.5m $13.5m 0.02% New
31 Artisan Partners Limited Partnership 0.02% of their portfolio Milwaukee, WI 238,465238.5k $13.1m $13.1m 0.02% New
32 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 236,597236.6k $13.0m $13.0m 0.00% Added +23.6k +23,578
33 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.06% of their portfolio TORONTO, A6 234,000234.0k $12.8m $12.8m 0.06% New
34 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio JUPITER, FL 219,072219.1k $12.0m $12.0m 0.07% New
35 Public Sector Pension Investment Board 0.09% of their portfolio MONTREAL, A8 214,000214.0k $11.7m $11.7m 0.09% New
36 Candriam S.C.A. 0.08% of their portfolio STRASSEN, N4 210,000210.0k $11.5m $11.5m 0.08% New
37 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 207,000207.0k $11.3m $11.3m 0.00% Added +13.7k +13,747
38 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 203,028203.0k $11.1m $11.1m 0.00% Reduced -34.9k -34,858
39 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 202,389202.4k $11.1m $11.1m 0.00% Added +132.1k +132,069
40 Rafferty Asset Management, LLC 0.09% of their portfolio New York, NY 187,799187.8k $10.3m $10.3m 0.09% New
41 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 185,912185.9k $10.2m $10.2m 0.00% Reduced -1.9m -1,932,885
42 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 183,315183.3k $10.0m $10.0m 0.00% Reduced -52.2k -52,214
43 NORGES BANK 0.00% of their portfolio OSLO, Q8 174,900174.9k $9.6m $9.6m 0.00% Not comparable
44 SILVERARC CAPITAL MANAGEMENT, LLC 3.25% of their portfolio BOSTON, MA 172,100172.1k $9.4m $9.4m 3.25% Reduced -127.9k -127,900
45 Long Focus Capital Management, LLC 1.48% of their portfolio SAN JUAN, PR 164,000164.0k $9.0m $9.0m 1.48% Reduced -128.0k -128,000
46 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 163,264163.3k $8.9m $8.9m 0.02% Reduced -6.8k -6,770
47 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 140,482140.5k $7.7m $7.7m 0.00% Added +27.6k +27,592
48 UBS Group AG 0.00% of their portfolio ZURICH, V8 138,980139.0k $7.6m $7.6m 0.00% Added +135.3k +135,262
49 Tri Locum Partners LP 3.12% of their portfolio NEW YORK, NY 128,851128.9k $7.1m $7.1m 3.12% Reduced -80.4k -80,397
50 Altium Capital Management LLC 3.50% of their portfolio NEW YORK, NY 125,000125.0k $6.8m $6.8m 3.50% Reduced -15.0k -15,000
51 GROUP ONE TRADING LLC 0.23% of their portfolio CHICAGO, IL 124,628124.6k $6.8m $6.8m 0.23% Added +124.6k +124,573
52 Cubist Systematic Strategies, LLC 0.05% of their portfolio STAMFORD, CT 115,484115.5k $6.3m $6.3m 0.05% Reduced -1.7k -1,691
53 MUFG Securities EMEA plc 0.11% of their portfolio LONDON, X0 115,000115.0k $6.3m $6.3m 0.11% New
54 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 103,552103.6k $5.7m $5.7m 0.00% First filing
55 NISA INVESTMENT ADVISORS, LLC 0.04% of their portfolio ST. LOUIS, MO 103,021103.0k $5.6m $5.6m 0.04% Added +103.0k +103,000
56 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 100,518100.5k $1.2m $1.2m 0.00% Reduced -31.7k -31,727
57 Ghisallo Capital Management LLC 0.98% of their portfolio BOSTON, MA 100,000100.0k $5.5m $5.5m 0.98% Added +50.0k +50,000
58 Schonfeld Strategic Advisors LLC 0.04% of their portfolio NEW YORK, NY 98,15698.2k $5.4m $5.4m 0.04% Added +89.3k +89,256
59 Walleye Capital LLC 0.11% of their portfolio NEW YORK, NY 89,56889.6k $4.9m $4.9m 0.11% Reduced -114.5k -114,475
60 Ghost Tree Capital, LLC 1.99% of their portfolio NEW YORK, NY 85,00085.0k $4.7m $4.7m 1.99% New
61 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 83,05983.1k $4.6m $4.6m 0.01% Added +80.9k +80,860
62 Swiss National Bank 0.00% of their portfolio ZURICH, V8 71,00071.0k $3.9m $3.9m 0.00% Added +1.8k +1,800
63 Integral Health Asset Management, LLC 0.86% of their portfolio New York, NY 70,00070.0k $3.8m $3.8m 0.86% Reduced -160.0k -160,000
64 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 67,60067.6k $3.7m $3.7m 0.01% Added +3.5k +3,500
65 NATIONAL BANK OF CANADA /FI/ 0.01% of their portfolio MONTREAL, A8 59,00059.0k $3.2m $3.2m 0.01% New
66 FEDERATED HERMES, INC. 0.01% of their portfolio PITTSBURGH, PA 58,02458.0k $3.2m $3.2m 0.01% Not comparable
67 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 55,24355.2k $3.0m $3.0m 0.00% Added +31.4k +31,417
68 Informed Momentum Co LLC 0.61% of their portfolio SOLANA BEACH, CA 53,51253.5k $2.9m $2.9m 0.61% Reduced -31.1k -31,095
69 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 52,42252.4k $2.9m $2.9m 0.00% Added +33.3k +33,300
70 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 51,71351.7k $2.8m $2.8m 0.00% Added +9.5k +9,452
71 Bellevue Group AG 0.03% of their portfolio ZURICH, V8 42,65042.6k $2.3m $2.3m 0.03% Added +1.0k +1,016
72 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 42,32242.3k $2.3m $2.3m 0.01% Reduced -91.2k -91,225
73 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 39,51639.5k $2.2m $2.2m 0.00% Added +3.1k +3,130
74 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 37,76037.8k $2.1m $2.1m 0.01% Added +23.1k +23,142
75 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 36,76536.8k $2.0m $2.0m 0.00% Added +25.8k +25,818
76 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 35,96936.0k $2.0m $2.0m 0.00% Added +11.4k +11,360
77 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 35,55435.6k $1.9m $1.9m 0.00% Reduced -37.4k -37,423
78 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 34,58034.6k $1.9m $1.9m 0.00% Added +10.1k +10,052
79 Walleye Trading LLC 0.05% of their portfolio NEW YORK, NY 34,28834.3k $1.9m $1.9m 0.05% Added +21.5k +21,455
80 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 34,14034.1k $1.9m $1.9m 0.00% Added +26.2k +26,236
81 Global IMC LLC 0.47% of their portfolio SOLANA BEACH, CA 33,50933.5k $1.8m $1.8m 0.47% Reduced -22.1k -22,051
82 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 32,62932.6k $1.8m $1.8m 0.00% Added +12.4k +12,392
83 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 31,72531.7k $1.7m $1.7m 0.02% Added +11.2k +11,177
84 Jump Financial, LLC 0.09% of their portfolio Chicago, IL 30,14930.1k $1.7m $1.7m 0.09% Added +19.9k +19,853
85 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 28,66828.7k $1.6m $1.6m 0.01% Added +10.1k +10,087
86 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 27,03627.0k $1.5m $1.5m 0.01% New
87 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 26,63926.6k $1.5m $1.5m 0.00% Added +13.7k +13,663
88 SIMPLEX TRADING, LLC 0.07% of their portfolio CHICAGO, IL 26,28626.3k $1.4m $1.4m 0.07% Reduced -52.1k -52,085
89 Chicago Partners Investment Group LLC 0.07% of their portfolio CHICAGO, IL 25,99426.0k $1.2m $1.2m 0.07% Reduced -4.2k -4,206
90 TUDOR INVESTMENT CORP ET AL 0.03% of their portfolio STAMFORD, CT 22,99823.0k $1.3m $1.3m 0.03% Added +10.9k +10,852
91 Trexquant Investment LP 0.04% of their portfolio STAMFORD, CT 22,83022.8k $1.3m $1.3m 0.04% Reduced -18.3k -18,337
92 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 21,10021.1k $1.2m $1.2m 0.00% New
93 FMR LLC 0.00% of their portfolio BOSTON, MA 20,41120.4k $1.1m $1.1m 0.00% Reduced -18.5k -18,460
94 Moody Aldrich Partners LLC 0.22% of their portfolio MARBLEHEAD, MA 19,99420.0k $1.1m $1.1m 0.22% New
95 Quantbot Technologies LP 0.07% of their portfolio NEW YORK, NY 18,81818.8k $1.0m $1.0m 0.07% New
96 HighVista Strategies LLC 0.61% of their portfolio BOSTON, MA 18,62918.6k $1.0m $1.0m 0.61% New
97 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 18,27918.3k $1.0m $1.0m 0.01% Added +2.7k +2,699
98 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 16,49116.5k $903.7k $903.7k 0.01% Added +3.2k +3,193
99 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 16,28416.3k $892.4k $892.4k 0.00% Added +3.3k +3,307
100 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 15,27815.3k $837.2k $837.2k 0.00% Reduced -673 -673