ALPINE IMMUNE SCIENCES INC NVLS
COM · Common Stock · CUSIP 02083G100
64
institutional holders
-6 vs Q3 2022
34.2m
shares reported held*
$251.5mreported value*
8 new
32 added
9 reduced
15 sold out
net sold ≈ $38.5m (-5.2m shares)
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $7.35. Options: 2 managers hold calls ($8.1k notional), 2 hold puts ($735).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 70 |
| Q4 2022 | 64 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
CallsPuts
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $1.0k | — |
| Q4 2022 | $8.1k | $735 | 0.09 |
Biggest buyers
| BlackRock Inc. | Added | +509.1k |
| VANGUARD GROUP INC | Added | +237.7k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +234.2k |
| GREAT POINT PARTNERS LLC | Added | +189.2k |
| Cheyne Capital Management (UK) LLP | New | +181.9k |
| Affinity Asset Advisors, LLC | Added | +137.9k |
| Paradigm Biocapital Advisors LP | Added | +102.9k |
| Lynx1 Capital Management LP | Added | +69.8k |
| NORTHERN TRUST CORP | Added | +67.1k |
| DIMENSIONAL FUND ADVISORS LP | Added | +47.4k |
Biggest sellers
| Decheng Capital Management III (Cayman), LLC | Sold out | -6.7m |
| Allspring Global Investments Holdings, LLC | Reduced | -125.7k |
| Monashee Investment Management LLC | Sold out | -100.0k |
| Walleye Capital LLC | Sold out | -71.4k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Sold out | -70.6k |
| Alberta Investment Management Corp | Sold out | -45.9k |
| CAAS CAPITAL MANAGEMENT LP | Sold out | -45.4k |
| MARSHALL WACE, LLP | Sold out | -45.1k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -25.8k |
| TWO SIGMA INVESTMENTS, LP | Sold out | -21.9k |
Biggest calls
| CITADEL ADVISORS LLC | New | $8.1k1.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | New | $735100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.66% of their portfolio | 4.4m $32.3m | Added +40.7k |
| ORBIMED ADVISORS LLC 0.57% of their portfolio | 4.1m $30.0m | Unchanged |
| GREAT POINT PARTNERS LLC 5.53% of their portfolio | 3.6m $26.7m | Added +189.2k |
| Lynx1 Capital Management LP 19.87% of their portfolio | 3.1m $23.0m | Added +69.8k |
| Frazier Life Sciences Management, L.P. 1.36% of their portfolio | 3.0m $21.9m | Unchanged |
| Paradigm Biocapital Advisors LP 2.00% of their portfolio | 2.3m $17.0m | Added +102.9k |
| Omega Fund Management, LLC 5.03% of their portfolio | 2.0m $14.9m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 1.4m $10.6m | Added +509.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $10.0m | Added +237.7k |
| Commodore Capital LP 1.47% of their portfolio | 1.3m $9.7m | Unchanged |
| Octagon Capital Advisors LP 1.40% of their portfolio | 1.2m $9.0m | Unchanged |
| Artal Group S.A. 0.51% of their portfolio | 1.2m $8.8m | Unchanged |
| BVF INC/IL 0.35% of their portfolio | 1.1m $8.3m | Unchanged |
| Avidity Partners Management LP 0.18% of their portfolio | 1.0m $7.6m | Added +29.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 485.8k $3.6m | Added +234.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 332.9k $2.4m | Reduced -25.8k |
| STATE STREET CORP 0.00% of their portfolio | 303.4k $2.2m | Added +24.4k |
| TCG Crossover Management, LLC 0.33% of their portfolio | 253.1k $1.9m | Reduced -1.5k |
| Affinity Asset Advisors, LLC 0.84% of their portfolio | 247.9k $1.8m | Added +137.9k |
| SPHERA FUNDS MANAGEMENT LTD. 0.46% of their portfolio | 200.0k $1.5m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 191.6k $1.4m | Added +67.1k |
| Cheyne Capital Management (UK) LLP 2.36% of their portfolio | 181.9k $1.3m | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 98.8k $725.0k | Added +47.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 83.6k $614.4k | Added +19.1k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 65.2k $479.0k | Reduced -3.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 64.5k $474.0k | Added +24.7k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 58.3k $428.6k | Added +802 |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 31.7k $233.0k | Added +3.0k |
| PURA VIDA INVESTMENTS, LLC 0.04% of their portfolio | 30.9k $227.3k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 30.5k $224.1k | Added +6.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 26.2k $193.0k | Added +4.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 23.7k $173.9k | Added +17.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 22.2k $162.9k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 21.2k $155.8k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 19.4k $143.0k | Added +6.8k |
| MORGAN STANLEY 0.00% of their portfolio | 17.6k $129.1k | Added +6.0k |
| Trexquant Investment LP 0.00% of their portfolio | 16.8k $123.2k | Added +6.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 15.5k $114.0k | Added +8.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 14.2k $105.0k | Added +3.7k |
| Hikari Power Ltd 0.01% of their portfolio | 12.4k $91.0k | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 12.0k $88.4k | New |
| Western Wealth Management, LLC 0.01% of their portfolio | 12.0k $88.2k | Reduced -12.0k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 10.7k $78.7k | Added +3.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 9.0k $66.4k | Added +2.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.2k $59.9k | Added +106 |
| BARCLAYS PLC 0.00% of their portfolio | 6.1k $44.7k | First filing |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 5.4k $40.0k | Unchanged |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 4.5k $32.7k | Reduced -125.7k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 3.2k $23.0k | Added +3.0k |
| Legal & General Group Plc 0.00% of their portfolio | 2.5k $18.2k | Added +1.0k |
| AMALGAMATED BANK 0.00% of their portfolio | 2.4k $18.0k | Added +355 |
| UBS Group AG 0.00% of their portfolio | 2.3k $16.7k | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 1.7k $12.6k | Reduced -331 |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 1.4k $10.4k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.0k $8.0k | Reduced -583 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 911 $7.5k | Unchanged |
| FMR LLC 0.00% of their portfolio | 680 $5.0k | Added +478 |
| CITIGROUP INC 0.00% of their portfolio | 594 $4.4k | Reduced -25 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 467 $3.4k | Added +182 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 85 $1.0k | Unchanged |
| Tradewinds Capital Management, LLC 0.00% of their portfolio | 15 $110 | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 12 $0 | New |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 1 $7 | Reduced -84 |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |