HighVista Strategies LLC

BOSTON, MA · CIK 1335325 · 13F filing filed 2026-08-14

SEC-registered investment adviser since 2012 · limited liability company

Assets managed$9.1bn
Staff80 · 30 in investment roles
Main clients (by assets)Private funds 83%, State and local governments 17%
Private funds40 (23 hedge) · $7.6bn gross assets
Websitehighvistastrategies.com
Form ADV · 2026-03-31SEC adviser record

Legal entityHIGHVISTA STRATEGIES LLC (US)

Kindhedge funds, private equity, real estate, futures
Others nearbyBoston, MA
FamilyHighVista Strategies LLC · 2 related pages

As an employer

Offices in1 country
Private fundshedge 23, real estate 2, private equity 4, other private 11

US visa salary filings

Filings FY2024–20254
Median salary offered$100,000
Middle half$100,000 – $107,500
Job titles3

Job title	Filings	Median
Associate Accounting And Performance ReportingBoston, MA	2	$100,000
Quantitative AnalystBoston, MA	1	$130,000
Investment AnalystBoston, MA	1	$100,000

Source: US Department of Labor, Labor Condition Application disclosure data (certified, full-time, yearly equivalent). These are the salaries the employer committed to pay the visa roles it filed for, at least the prevailing wage for the job and place; they are not the pay of all its staff. Filed by: HighVista Strategies LLC..

$438.6m reported value +21.1% vs Q1 2026

147positions

28.2%in top 10

29 new 50 added 66 reduced 38 sold out vs Q1 2026

This report includes the holdings of 1 other manager that shares the investment decisions:

HighVista Private Capital Management LLC – no 13F of its own this quarter

Shares in two reports are counted once in each security's totals.

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	INVESCO DB COMMDY INDX TRCK UNIT DBC	DBC	1,057,238	$28.2m6.43%	6.43%	Unchanged
2	ABIVAX SA SPONSORED ADS ABVX	ABVX	113,031	$15.1m3.43%	3.43%	Reduced -223	-223 -0.2%
3	REVOLUTION MEDICINES INC COM RVMD	RVMD	66,983	$12.5m2.86%	2.86%	Reduced -2.3k	-2,326 -3.4%
4	DEFINIUM THERAPEUTICS INC COM SHS DFTX	DFTX	242,884	$11.4m2.60%	2.60%	Added +57.0k	+57,028 30.7%
5	IMMUNOVANT INC COM IMVT	IMVT	277,873	$10.7m2.44%	2.44%	Added +52.7k	+52,734 23.4%
6	PRAXIS PRECISION MEDICINES I COM NEW PRAX	PRAX	30,210	$10.1m2.31%	2.31%	Added +3.9k	+3,887 14.8%
7	RELAY THERAPEUTICS INC COM RLAY	RLAY	506,235	$9.5m2.16%	2.16%	Added +84.4k	+84,354 20.0%
8	ALKERMES PLC SHS ALKS	ALKS	179,256	$9.4m2.14%	2.14%	Added +106.1k	+106,067 144.9%
9	VAXCYTE INC COM PCVX	PCVX	149,739	$8.7m1.98%	1.98%	Added +25.1k	+25,092 20.1%
10	TANGO THERAPEUTICS INC COM TNGX	TNGX	260,070	$8.1m1.85%	1.85%	Added +155.9k	+155,877 149.6%
11	LIQUIDIA CORPORATION COM NEW LQDA	LQDA	97,896	$7.8m1.78%	1.78%	Reduced -1.8k	-1,848 -1.9%
12	COGENT BIOSCIENCES INC COM COGT	COGT	188,780	$7.3m1.67%	1.67%	Reduced -8.3k	-8,271 -4.2%
13	STRUCTURE THERAPEUTICS INC SPONSORED ADS GPCR	GPCR	130,784	$7.0m1.60%	1.60%	Added +6.9k	+6,875 5.5%
14	ENLIVEN THERAPEUTICS INC COM ELVN	ELVN	137,866	$7.0m1.60%	1.60%	Added +64.8k	+64,764 88.6%
15	AMYLYX PHARMACEUTICALS INC COM AMLX	AMLX	386,080	$6.9m1.58%	1.58%	Added +34.0k	+33,995 9.7%
16	SPYRE THERAPEUTICS INC COM NEW SYRE	SYRE	77,807	$6.9m1.57%	1.57%	Reduced -68.5k	-68,457 -46.8%
17	LB PHARMACEUTICALS INC COM SHS LBRX	LBRX	211,511	$6.9m1.57%	1.57%	Added +37.9k	+37,916 21.8%
18	CYTOKINETICS INC COM NEW CYTK	CYTK	78,003	$6.6m1.52%	1.52%	Added +19.4k	+19,360 33.0%
19	C4 THERAPEUTICS INC COM STK CCCC	CCCC	1,348,136	$6.3m1.44%	1.44%	New
20	TYRA BIOSCIENCES INC COM TYRA	TYRA	184,774	$5.9m1.35%	1.35%	Added +53.5k	+53,470 40.7%
21	ALUMIS INC COM ALMS	ALMS	199,968	$5.6m1.28%	1.28%	Added +87.0k	+87,039 77.1%
22	PHARVARIS N V COM PHVS	PHVS	160,494	$5.5m1.27%	1.27%	Added +62.6k	+62,628 64.0%
23	TARSUS PHARMACEUTICALS INC COM TARS	TARS	87,060	$5.5m1.25%	1.25%	Added +34.6k	+34,596 65.9%
24	COMPASS PATHWAYS PLC SPONSORED ADS CMPS	CMPS	371,120	$5.3m1.20%	1.20%	Added +6.8k	+6,760 1.9%
25	DIANTHUS THERAPEUTICS INC COM DNTH	DNTH	51,125	$5.0m1.14%	1.14%	Added +15.5k	+15,538 43.7%
26	NURIX THERAPEUTICS INC COM NRIX	NRIX	203,739	$4.9m1.13%	1.13%	Reduced -22.8k	-22,807 -10.1%
27	AXSOME THERAPEUTICS INC COM AXSM	AXSM	20,183	$4.9m1.13%	1.13%	Reduced -254	-254 -1.2%
28	TRAVERE THERAPEUTICS INC COM TVTX	TVTX	86,233	$4.9m1.12%	1.12%	Added +49.9k	+49,908 137.4%
29	VERA THERAPEUTICS INC CL A VERA	VERA	105,907	$4.5m1.04%	1.04%	Added +36.7k	+36,666 53.0%
30	NVIDIA CORPORATION COM NVDA	NVDA	21,792	$4.4m0.99%	0.99%	Reduced -628	-628 -2.8%
31	GH RESEARCH PLC ORDINARY SHARES GHRS	GHRS	158,770	$4.3m0.97%	0.97%	Reduced -54.4k	-54,442 -25.5%
32	PALISADE BIO INC COM PALI	PALI	2,030,927	$4.2m0.97%	0.97%	Added +11.6k	+11,601 0.6%
33	ARGENX SE SPONSORED ADR ARGX	ARGX	4,561	$4.2m0.96%	0.96%	Reduced -357	-357 -7.3%
34	MAZE THERAPEUTICS INC COM MAZE	MAZE	136,572	$4.1m0.93%	0.93%	Added +36.7k	+36,722 36.8%
35	OCULAR THERAPEUTIX INC COM OCUL	OCUL	408,534	$4.0m0.91%	0.91%	Reduced -33.0k	-33,039 -7.5%
36	ORUKA THERAPEUTICS INC COM ORKA	ORKA	41,902	$4.0m0.91%	0.91%	Reduced -37.0k	-37,009 -46.9%
37	DYNE THERAPEUTICS INC COM DYN	DYN	171,961	$3.8m0.87%	0.87%	Reduced -11.0k	-10,968 -6.0%
38	EDGEWISE THERAPEUTICS INC COM EWTX	EWTX	90,996	$3.7m0.84%	0.84%	Reduced -935	-935 -1.0%
39	MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD MLTX	MLTX	187,946	$3.7m0.83%	0.83%	Reduced -6.0k	-6,009 -3.1%
40	INSMED INC COM PAR $.01 INSM	INSM	31,256	$3.3m0.76%	0.76%	Added +6.9k	+6,940 28.5%
41	CELLDEX THERAPEUTICS INC NEW COM NEW CLDX	CLDX	86,964	$3.2m0.74%	0.74%	Reduced -2.4k	-2,433 -2.7%
42	AMAZON COM INC COM AMZN	AMZN	13,397	$3.2m0.73%	0.73%	Reduced -9.0k	-9,000 -40.2%
43	INVENTIVA SA ADS IVA	IVA	831,442	$3.1m0.72%	0.72%	Added +215.8k	+215,776 35.0%
44	TALEN ENERGY CORP COM TLN	TLN	8,148	$3.1m0.71%	0.71%	Added +5.0k	+5,030 161.3%
45	RELMADA THERAPEUTICS INC COM RLMD	RLMD	445,799	$3.1m0.70%	0.70%	New
46	PROTAGONIST THERAPEUTICS INC COM PTGX	PTGX	24,460	$3.0m0.68%	0.68%	Reduced -9.4k	-9,392 -27.7%
47	ERASCA INC COM ERAS	ERAS	160,328	$2.9m0.67%	0.67%	Reduced -20.7k	-20,741 -11.4%
48	VIRIDIAN THERAPEUTICS INC COM VRDN	VRDN	159,885	$2.9m0.67%	0.67%	Added +25.7k	+25,656 19.1%
49	HEWLETT PACKARD ENTERPRISE C COM HPE	HPE	59,081	$2.7m0.61%	0.61%	Reduced -30.9k	-30,900 -34.3%
50	MINERALYS THERAPEUTICS INC COM MLYS	MLYS	86,085	$2.3m0.53%	0.53%	Added +39.3k	+39,307 84.0%
51	GUARDANT HEALTH INC COM GH	GH	15,419	$2.3m0.53%	0.53%	Reduced -7.9k	-7,938 -34.0%
52	AVALO THERAPEUTICS INC COM NEW AVTX	AVTX	122,610	$2.3m0.52%	0.52%	Added +64.0k	+63,988 109.2%
53	JAMES HARDIE INDS PLC ORD SHS JHX	JHX	85,198	$2.2m0.51%	0.51%	Added +19.6k	+19,600 29.9%
54	EYEPOINT PHARMACEUTICALS INC COM NEW EYPT	EYPT	155,704	$2.2m0.51%	0.51%	Reduced -27.3k	-27,333 -14.9%
55	MASTEC INC COM MTZ	MTZ	5,137	$2.1m0.49%	0.49%	Added +1.5k	+1,510 41.6%
56	XENON PHARMACEUTICALS INC COM XENE	XENE	35,318	$2.1m0.49%	0.49%	Reduced -13.7k	-13,732 -28.0%
57	RBC BEARINGS INC COM RBC	RBC	3,223	$2.1m0.47%	0.47%	Added +560	+560 21.0%
58	VISA INC COM CL A V	V	5,961	$2.0m0.47%	0.47%	Reduced -1.2k	-1,180 -16.5%
59	ASSEMBLY BIOSCIENCES INC COM NEW ASMB	ASMB	73,405	$2.0m0.46%	0.46%	Reduced -1.3k	-1,330 -1.8%
60	STOKE THERAPEUTICS INC COM STOK	STOK	61,316	$2.0m0.46%	0.46%	Reduced -1.3k	-1,301 -2.1%
61	OLEMA PHARMACEUTICALS INC COM OLMA	OLMA	160,167	$2.0m0.46%	0.46%	Added +42.6k	+42,566 36.2%
62	ROCKET COS INC COM CL A RKT	RKT	125,530	$2.0m0.45%	0.45%	Added +33.1k	+33,100 35.8%
63	XPO INC COM XPO	XPO	9,623	$2.0m0.45%	0.45%	Added +700	+700 7.8%
64	WESTERN DIGITAL CORP COM WDC	WDC	3,050	$1.9m0.44%	0.44%	Reduced -1.1k	-1,050 -25.6%
65	CORE SCIENTIFIC INC NEW COM CORZ	CORZ	75,712	$1.9m0.44%	0.44%	Reduced -27.7k	-27,700 -26.8%
66	TEXAS INSTRS INC COM TXN	TXN	6,500	$1.9m0.44%	0.44%	New
67	KBR INC COM KBR	KBR	54,206	$1.9m0.43%	0.43%	Added +14.8k	+14,800 37.6%
68	FLOWSERVE CORP COM FLS	FLS	24,958	$1.9m0.42%	0.42%	Unchanged
69	ALPHABET INC CAP STK CL C GOOG	GOOG	5,127	$1.8m0.41%	0.41%	Reduced -350	-350 -6.4%
70	SEAGATE TECHNOLOGY HLDNGS PL ORD SHS STX	STX	1,870	$1.8m0.41%	0.41%	Reduced -1.0k	-1,030 -35.5%
71	MIRUM PHARMACEUTICALS INC COM MIRM	MIRM	14,892	$1.7m0.40%	0.40%	Reduced -671	-671 -4.3%
72	DNOW INC COM DNOW	DNOW	132,900	$1.7m0.39%	0.39%	New
73	ON SEMICONDUCTOR CORP COM ON	ON	18,200	$1.7m0.39%	0.39%	Reduced -9.8k	-9,800 -35.0%
74	NUCOR CORP COM NUE	NUE	7,600	$1.7m0.39%	0.39%	New
75	GANNETT CO INC COM TDAY	TDAY	188,500	$1.6m0.37%	0.37%	New
76	BROADCOM INC COM AVGO	AVGO	4,199	$1.6m0.36%	0.36%	Reduced -1.4k	-1,400 -25.0%
77	CALUMET INC COM CLMT	CLMT	44,000	$1.6m0.36%	0.36%	New
78	QNITY ELECTRONICS INC COMMON STOCK Q	Q	9,700	$1.6m0.36%	0.36%	New
79	KODIAK SCIENCES INC COM KOD	KOD	40,590	$1.6m0.36%	0.36%	Reduced -3.0k	-2,979 -6.8%
80	CREDO TECHNOLOGY GROUP HOLDI ORDINARY SHARES CRDO	CRDO	5,800	$1.6m0.36%	0.36%	New
81	KNIGHT-SWIFT TRANSN HLDGS IN CL A KNX	KNX	20,100	$1.6m0.36%	0.36%	Reduced -2.8k	-2,800 -12.2%
82	BRINKS CO COM BCO	BCO	16,414	$1.6m0.35%	0.35%	New
83	ASTERA LABS INC COM ALAB	ALAB	3,198	$1.5m0.35%	0.35%	New
84	S&P GLOBAL INC COM SPGI	SPGI	3,782	$1.5m0.35%	0.35%	New
85	MADRIGAL PHARMACEUTICALS INC COM MDGL	MDGL	2,852	$1.5m0.35%	0.35%	Added +254	+254 9.8%
86	EQUIFAX INC COM EFX	EFX	9,572	$1.5m0.35%	0.35%	New
87	RHYTHM PHARMACEUTICALS INC COM RYTM	RYTM	13,657	$1.5m0.35%	0.35%	Reduced -3.1k	-3,139 -18.7%
88	SAVARA INC COM SVRA	SVRA	242,379	$1.5m0.34%	0.34%	Reduced -8.6k	-8,620 -3.4%
89	DOMINOS PIZZA INC COM DPZ	DPZ	4,991	$1.5m0.34%	0.34%	New
90	BELITE BIO INC SPONSORED ADS BLTE	BLTE	9,554	$1.5m0.34%	0.34%	Added +1.5k	+1,521 18.9%
91	MICRON TECHNOLOGY INC COM MU	MU	1,260	$1.5m0.33%	0.33%	Reduced -2.5k	-2,540 -66.8%
92	CIENA CORP COM NEW CIEN	CIEN	2,925	$1.4m0.33%	0.33%	Reduced -2.4k	-2,360 -44.6%
93	CELCUITY INC COM CELC	CELC	13,472	$1.4m0.32%	0.32%	Added +367	+367 2.8%
94	QXO INC COM NEW QXO	QXO	81,420	$1.4m0.32%	0.32%	Added +55.1k	+55,100 209.3%
95	IMMUNOCORE HLDGS PLC ADS IMCR	IMCR	43,185	$1.4m0.31%	0.31%	Reduced -15.5k	-15,512 -26.4%
96	CG ONCOLOGY INC COM CGON	CGON	18,867	$1.3m0.31%	0.31%	Reduced -1.0k	-1,047 -5.3%
97	US FOODS HLDG CORP COM USFD	USFD	13,000	$1.3m0.30%	0.30%	New
98	TRANSDIGM GROUP INC COM TDG	TDG	985	$1.3m0.30%	0.30%	Reduced -160	-160 -14.0%
99	LUMENTUM HLDGS INC COM LITE	LITE	1,517	$1.3m0.30%	0.30%	Reduced -1.6k	-1,600 -51.3%
100	FIRSTENERGY CORP COM FE	FE	26,100	$1.2m0.28%	0.28%	New

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
TERNS PHARMACEUTICALS INC		114,307	$6.0m114.3k shares
NUVALENT INC		56,602	$5.8m56.6k shares
SOLENO THERAPEUTICS INC SLNO	SLNO	165,227	$5.5m165.2k shares
APOGEE THERAPEUTICS INC		35,761	$3.0m35.8k shares
JAZZ PHARMACEUTICALS PLC JAZZ	JAZZ	10,838	$2.0m10.8k shares
NCR ATLEOS CORPORATION NATL	NATL	40,100	$1.7m40.1k shares
CLEAN HARBORS INC CLH	CLH	5,543	$1.6m5.5k shares
SALESFORCE INC CRM	CRM	8,313	$1.6m8.3k shares
XOMA ROYALTY CORPORATION XOMA	XOMA	46,814	$1.5m46.8k shares
AVANTOR INC AVTR	AVTR	186,500	$1.5m186.5k shares
ASCENDIS PHARMA A/S		5,781	$1.3m5.8k shares
INTUIT INTU	INTU	3,003	$1.3m3.0k shares
BOOKING HOLDINGS INC BKNG	BKNG	7,075	$1.2m7.1k shares
KILROY RLTY CORP KRC	KRC	41,997	$1.2m42.0k shares
EQT CORP EQT	EQT	18,290	$1.2m18.3k shares
PETROLEO BRASILEIRO SA PETRO PBR.A	PBR.A	59,400	$1.1m59.4k shares
WORKDAY INC WDAY	WDAY	8,286	$1.1m8.3k shares
PTC INC PTC	PTC	7,474	$1.1m7.5k shares
GE VERNOVA INC GEV	GEV	1,218	$1.1m1.2k shares
ARGAN INC AGX	AGX	1,896	$1.0m1.9k shares
AMRIZE LTD AMRZ	AMRZ	17,068	$956.1k17.1k shares
REDDIT INC RDDT	RDDT	6,900	$929.1k6.9k shares
3M CO MMM	MMM	6,150	$893.2k6.2k shares
UNION PAC CORP UNP	UNP	3,658	$887.5k3.7k shares
COUPANG INC CPNG	CPNG	46,036	$869.2k46.0k shares