Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

288 institutional holders +63 vs Q1 2026
67,498,31267.5m shares reported held*
$8.9bnreported value*
112 new 85 added 66 reduced 48 sold out net sold ≈ $1.4bn (-10.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.7m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $132.13. Options: 11 managers hold calls ($37.3m notional), 15 hold puts ($162.1m).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140Q3 24: 140Q4 24: 159Q1 25: 170Q2 25: 184Q3 25: 174Q4 25: 208Q1 26: 225Q2 26: 288288Q3 23Q2 24Q1 25Q4 25Q2 26
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140
Q3 2024140
Q4 2024159
Q1 2025170
Q2 2025184
Q3 2025174
Q4 2025208
Q1 2026225
Q2 2026288

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 24: 71 bought or addedQ3 24: 70 cut or sold outQ4 24: 84 bought or addedQ4 24: 62 cut or sold outQ4 24Q1 25: 83 bought or addedQ1 25: 78 cut or sold outQ2 25: 91 bought or addedQ2 25: 87 cut or sold outQ2 25Q3 25: 86 bought or addedQ3 25: 89 cut or sold outQ4 25: 129 bought or addedQ4 25: 65 cut or sold outQ4 25Q1 26: 146 bought or addedQ1 26: 82 cut or sold outQ2 26: 197 bought or addedQ2 26: 114 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20247170
Q4 20248462
Q1 20258378
Q2 20259187
Q3 20258689
Q4 202512965
Q1 202614682
Q2 2026197114

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ3 25 calls: $12.8mQ3 25 puts: $5.3mQ3 25P/C 0.41Q4 25 calls: $27.8mQ4 25 puts: $13.5mQ4 25P/C 0.49Q1 26 calls: $78.5mQ1 26 puts: $36.7mQ1 26P/C 0.47Q2 26 calls: $37.3mQ2 26 puts: $162.1mQ2 26P/C 4.35
Numbers
QuarterCallsPutsP/C
Q3 2025$12.8m$5.3m0.41
Q4 2025$27.8m$13.5m0.49
Q1 2026$78.5m$36.7m0.47
Q2 2026$37.3m$162.1m4.35

Biggest buyers

HBK INVESTMENTS L P New +2,850,000+2.9m
GLAZER CAPITAL, LLC New +1,641,042+1.6m
Pentwater Capital Management LP New +1,425,000+1.4m
BlackRock, Inc. Added +1,421,381+1.4m
MILLENNIUM MANAGEMENT LLC Added +1,398,812+1.4m
Balyasny Asset Management L.P. Added +1,226,448+1.2m
VANGUARD PORTFOLIO MANAGEMENT LLC Added +1,132,420+1.1m
GOLDMAN SACHS GROUP INC Added +1,040,751+1.0m
MORGAN STANLEY Added +826,649+826.6k
Kryger Capital LLC New +742,555+742.6k

Biggest sellers

T. Rowe Price Investment Management, Inc. Reduced -9,538,801-9.5m
FMR LLC Reduced -6,769,154-6.8m
WELLINGTON MANAGEMENT GROUP LLP Reduced -3,811,377-3.8m
RTW INVESTMENTS, LP Sold out -2,782,097-2.8m
Vestal Point Capital, LP Sold out -1,100,000-1.1m
UBS Group AG Reduced -942,497-942.5k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -905,942-905.9k
FRONTIER CAPITAL MANAGEMENT CO LLC Reduced -760,744-760.7k
JPMORGAN CHASE & CO Reduced -751,220-751.2k
JENNISON ASSOCIATES LLC Reduced -577,751-577.8k

Biggest calls

ExodusPoint Capital Management, LP New $11.6m87.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $9.8m73.6k shares
Symmetry Investments LP New $6.6m50.0k shares
JANE STREET GROUP, LLC Reduced $3.6m26.8k shares
SIMPLEX TRADING, LLC Added $1.4m10.7k shares
MILLENNIUM MANAGEMENT LLC New $1.3m10.1k shares
Twin Tree Management, LP New $1.1m8.0k shares
CITADEL ADVISORS LLC Reduced $929.1k7.0k shares
Schonfeld Strategic Advisors LLC New $663.6k5.0k shares
Verition Fund Management LLC New $265.5k2.0k shares

Biggest puts

Balyasny Asset Management L.P. New $66.4m500.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $26.9m202.8k shares
PICTON MAHONEY ASSET MANAGEMENT New $26.5m200.0k shares
Caption Management, LLC Added $15.4m115.7k shares
TUDOR INVESTMENT CORP ET AL New $13.4m100.6k shares
JANE STREET GROUP, LLC Reduced $3.9m29.5k shares
SIMPLEX TRADING, LLC Reduced $3.1m23.5k shares
WATER ISLAND CAPITAL LLC New $2.3m17.5k shares
JPMORGAN CHASE & CO Unchanged $2.0m14.9k shares
CITADEL ADVISORS LLC Reduced $1.1m8.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 34.18% of their portfolio NEW YORK, NY 8,493,3218.5m $1.1bn $1.1bn 34.18% Unchanged
2 BlackRock, Inc. 0.01% of their portfolio New York, NY 5,507,0325.5m $730.9m $730.9m 0.01% Added +1.4m +1,421,381
3 HBK INVESTMENTS L P 4.43% of their portfolio DALLAS, TX 2,850,0002.9m $378.3m $378.3m 4.43% New
4 VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 2,572,1192.6m $341.4m $341.4m 0.01% Added +70.0k +70,024
5 FMR LLC 0.01% of their portfolio BOSTON, MA 2,493,1372.5m $330.9m $330.9m 0.01% Reduced -6.8m -6,769,154
6 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,297,7432.3m $305.0m $305.0m 0.01% Added +134.8k +134,779
7 Driehaus Capital Management LLC 1.34% of their portfolio Chicago, IL 1,740,1011.7m $231.0m $231.0m 1.34% Reduced -180.7k -180,699
8 GOLDMAN SACHS GROUP INC 0.02% of their portfolio NEW YORK, NY 1,693,3411.7m $224.8m $224.8m 0.02% Added +1.0m +1,040,751
9 Balyasny Asset Management L.P. 0.40% of their portfolio Chicago, IL 1,665,1021.7m $221.0m $221.0m 0.40% Added +1.2m +1,226,448
10 GLAZER CAPITAL, LLC 5.37% of their portfolio New York, NY 1,641,0421.6m $217.8m $217.8m 5.37% New
11 Paradigm Biocapital Advisors LP 3.92% of their portfolio NEW YORK, NY 1,576,3851.6m $209.2m $209.2m 3.92% Added +228.1k +228,142
12 VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 1,528,7501.5m $202.9m $202.9m 0.01% Added +1.1m +1,132,420
13 MILLENNIUM MANAGEMENT LLC 0.13% of their portfolio NEW YORK, NY 1,491,4041.5m $198.0m $198.0m 0.13% Added +1.4m +1,398,812
14 Pentwater Capital Management LP 1.51% of their portfolio Naples, FL 1,425,0001.4m $189.1m $189.1m 1.51% New
15 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,421,6811.4m $188.7m $188.7m 0.01% Added +826.6k +826,649
16 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,314,8681.3m $174.6m $174.6m 0.01% Added +97.6k +97,579
17 PERCEPTIVE ADVISORS LLC 2.70% of their portfolio NEW YORK, NY 1,308,1131.3m $173.6m $173.6m 2.70% Reduced -232.3k -232,271
18 Jupiter Topco LLC 0.06% of their portfolio NEW YORK, NY 1,193,6261.2m $158.4m $158.4m 0.06% First filing
19 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 1,126,1391.1m $149.5m $149.5m 0.01% Added +225.3k +225,268
20 Affinity Asset Advisors, LLC 6.41% of their portfolio NEW YORK, NY 987,000987.0k $131.0m $131.0m 6.41% Reduced -297.9k -297,926
21 MERCER GLOBAL ADVISORS INC /ADV 0.15% of their portfolio DENVER, CO 941,283941.3k $124.9m $124.9m 0.15% Added +109.9k +109,855
22 First Light Asset Management, LLC 7.50% of their portfolio Edina, MN 930,289930.3k $123.5m $123.5m 7.50% Added +353.6k +353,605
23 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 775,058775.1k $65.2m $65.2m 0.02% Reduced -215.2k -215,239
24 T. Rowe Price Investment Management, Inc. 0.07% of their portfolio BALTIMORE, MD 762,183762.2k $101.2m $101.2m 0.07% Reduced -9.5m -9,538,801
25 Kryger Capital LLC 5.62% of their portfolio HAMILTON, D0 742,555742.6k $98.6m $98.6m 5.62% New
26 Qube Research & Technologies Ltd 0.10% of their portfolio LONDON, X0 659,678659.7k $87.6m $87.6m 0.10% New
27 First Trust Capital Management L.P. 4.83% of their portfolio CHICAGO, IL 625,182625.2k $83.0m $83.0m 4.83% New
28 Remedium Capital Partners, LLC 17.24% of their portfolio WEST PALM BEACH, FL 586,691586.7k $77.9m $77.9m 17.24% Added +3.1k +3,100
29 SOROS FUND MANAGEMENT LLC 0.98% of their portfolio NEW YORK, NY 564,500564.5k $74.9m $74.9m 0.98% New
30 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 564,326564.3k $74.9m $74.9m 0.01% Reduced -3.8m -3,811,377
31 Woodline Partners LP 0.19% of their portfolio San Francisco, CA 464,622464.6k $61.7m $61.7m 0.19% Added +203.5k +203,502
32 WHITEBOX ADVISORS LLC 0.96% of their portfolio MINNEAPOLIS, MN 450,001450.0k $59.7m $59.7m 0.96% New
33 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 445,154445.2k $59.1m $59.1m 0.01% Added +54.3k +54,275
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 443,658443.7k $58.9m $58.9m 0.01% Added +23.0k +22,974
35 AQR Arbitrage LLC 0.81% of their portfolio Greenwich, CT 429,900429.9k $57.1m $57.1m 0.81% New
36 Magnetar Financial LLC 0.48% of their portfolio EVANSTON, IL 399,123399.1k $53.0m $53.0m 0.48% New
37 Man Group plc 0.10% of their portfolio LONDON, X0 397,000397.0k $52.7m $52.7m 0.10% Added +355.2k +355,185
38 VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio MALVERN, PA 393,180393.2k $52.2m $52.2m 0.01% Added +24.2k +24,219
39 Opaleye Management Inc. 4.69% of their portfolio BOSTON, MA 390,000390.0k $51.8m $51.8m 4.69% Unchanged
40 TIG Advisors, LLC 2.22% of their portfolio New York, NY 364,250364.2k $48.3m $48.3m 2.22% New
41 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 363,379363.4k $48.2m $48.2m 0.01% Reduced -42.2k -42,159
42 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 359,250359.2k $47.9m $47.9m 0.00% Reduced -751.2k -751,220
43 Cinctive Capital Management LP 1.85% of their portfolio New York, NY 350,165350.2k $46.5m $46.5m 1.85% New
44 LOOMIS SAYLES & CO L P 0.06% of their portfolio BOSTON, MA 338,664338.7k $45.0m $45.0m 0.06% Reduced -24.1k -24,117
45 Polar Asset Management Partners Inc. 0.78% of their portfolio TORONTO, A6 322,467322.5k $42.8m $42.8m 0.78% New
46 FRONTIER CAPITAL MANAGEMENT CO LLC 0.38% of their portfolio Boston, MA 303,739303.7k $40.3m $40.3m 0.38% Reduced -760.7k -760,744
47 NEXPOINT ASSET MANAGEMENT, L.P. 2.66% of their portfolio Dallas, TX 299,940299.9k $39.8m $39.8m 2.66% New
48 Fairmount Funds Management LLC 2.62% of their portfolio WEST CONSHOHOCKEN, PA 298,647298.6k $39.6m $39.6m 2.62% Unchanged
49 Squarepoint Ops LLC 0.07% of their portfolio NEW YORK, NY 290,713290.7k $38.6m $38.6m 0.07% Added +252.4k +252,365
50 CITIGROUP INC 0.02% of their portfolio NEW YORK, NY 289,464289.5k $38.4m $38.4m 0.02% Added +275.5k +275,476
51 Slotnik Capital, LLC 9.63% of their portfolio DALLAS, TX 260,740260.7k $34.6m $34.6m 9.63% New
52 EVENTIDE ASSET MANAGEMENT, LLC 0.46% of their portfolio Boston, MA 260,000260.0k $34.5m $34.5m 0.46% Reduced -297.4k -297,423
53 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio Boston, MA 250,000250.0k $33.2m $33.2m 0.05% Unchanged
54 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 246,086246.1k $32.7m $32.7m 0.02% Added +187.3k +187,251
55 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 237,210237.2k $31.5m $31.5m 0.00% Reduced -905.9k -905,942
56 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 210,212210.2k $27.9m $27.9m 0.01% Reduced -9.9k -9,887
57 Absolute Gestao de Investimentos Ltda. 7.50% of their portfolio SAO PAULO, D5 205,000205.0k $27.2m $27.2m 7.50% New
58 UBS Group AG 0.00% of their portfolio ZURICH, V8 201,831201.8k $26.8m $26.8m 0.00% Reduced -942.5k -942,497
59 MUFG Securities EMEA plc 0.25% of their portfolio LONDON, X0 180,500180.5k $24.0m $24.0m 0.25% New
60 Allianz Asset Management GmbH 0.02% of their portfolio MUNICH, 2M 179,500179.5k $23.7m $23.7m 0.02% Added +177.0k +177,000
61 PICTON MAHONEY ASSET MANAGEMENT 0.20% of their portfolio Toronto, A6 165,000165.0k $21.9m $21.9m 0.20% New
62 Verition Fund Management LLC 0.15% of their portfolio GREENWICH, CT 159,256159.3k $21.1m $21.1m 0.15% New
63 HIGHBRIDGE CAPITAL MANAGEMENT LLC 0.70% of their portfolio NEW YORK, NY 155,857155.9k $20.7m $20.7m 0.70% New
64 Sagefield Capital LP 1.53% of their portfolio DALLAS, TX 155,135155.1k $20.6m $20.6m 1.53% New
65 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 152,815152.8k $20.3m $20.3m 0.00% Added +26.1k +26,058
66 RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio NEW YORK, NY 146,800146.8k $19.5m $19.5m 0.03% New
67 First Turn Management, LLC 1.97% of their portfolio DEL MAR, CA 138,822138.8k $18.4m $18.4m 1.97% Reduced -374.9k -374,948
68 Grantham, Mayo, Van Otterloo & Co. LLC 0.04% of their portfolio Boston, MA 137,395137.4k $18.2m $18.2m 0.04% New
69 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 131,634131.6k $17.5m $17.5m 0.00% Added +3.5k +3,519
70 GABELLI FUNDS LLC 0.11% of their portfolio Rye, NY 127,281127.3k $16.9m $16.9m 0.11% New
71 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 121,258121.3k $16.1m $16.1m 0.02% Reduced -6.8k -6,757
72 Twin Securities, Inc. 8.13% of their portfolio New York, NY 120,000120.0k $15.9m $15.9m 8.13% New
73 CAPSTONE INVESTMENT ADVISORS, LLC 0.11% of their portfolio NEW YORK, NY 120,000120.0k $15.9m $15.9m 0.11% New
74 Melqart Asset Management (UK) Ltd 1.48% of their portfolio London, X0 117,249117.2k $15.6m $15.6m 1.48% New
75 Maven Securities LTD 1.48% of their portfolio ST HELIER, Y9 115,018115.0k $15.3m $15.3m 1.48% Added +90.0k +90,018
76 SEVEN GRAND MANAGERS, LLC 0.53% of their portfolio BRONXVILLE, NY 100,000100.0k $13.3m $13.3m 0.53% Unchanged
77 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 98,97999.0k $13.1m $13.1m 0.00% Added +7.6k +7,558
78 Chicago Capital Management, LLC 8.73% of their portfolio CHICAGO, IL 97,10097.1k $9.8m $9.8m 8.73% New
79 WATER ISLAND CAPITAL LLC 1.33% of their portfolio NEW YORK, NY 94,90094.9k $12.6m $12.6m 1.33% New
80 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 94,75994.8k $12.6m $12.6m 0.01% Reduced -186.6k -186,627
81 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 87,95388.0k $11.7m $11.7m 0.01% Reduced -7.2k -7,184
82 Handelsbanken Fonder AB 0.03% of their portfolio STOCKHOLM, V7 86,30086.3k $11.5m $11.5m 0.03% Added +65.2k +65,200
83 Groupe la Francaise 0.14% of their portfolio PARIS, I0 84,07284.1k $11.2m $11.2m 0.14% New
84 GABELLI & Co INVESTMENT ADVISERS, INC. 1.58% of their portfolio Rye, NY 81,64581.6k $10.8m $10.8m 1.58% New
85 GARDNER LEWIS ASSET MANAGEMENT L P 2.37% of their portfolio CHADDS FORD, PA 80,00080.0k $10.6m $10.6m 2.37% New
86 Candriam S.C.A. 0.05% of their portfolio STRASSEN, N4 79,68479.7k $10.6m $10.6m 0.05% Reduced -143.9k -143,857
87 HARVEST MANAGEMENT LLC 4.65% of their portfolio New York, NY 79,00079.0k $10.5m $10.5m 4.65% New
88 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 77,47577.5k $10.3m $10.3m 0.01% Reduced -2.7k -2,726
89 Swiss National Bank 0.01% of their portfolio ZURICH, V8 76,70076.7k $10.2m $10.2m 0.01% Added +1.1k +1,100
90 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 76,62076.6k $10.2m $10.2m 0.01% Added +12.7k +12,720
91 WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio LAGUNA BEACH, CA 75,97476.0k $10.1m $10.1m 0.02% Reduced -56 -56
92 Alberta Investment Management Corp 0.06% of their portfolio EDMONTON, A0 75,00075.0k $10.0m $10.0m 0.06% New
93 Westchester Capital Management, LLC 0.49% of their portfolio VALHALLA, NY 72,96273.0k $9.7m $9.7m 0.49% New
94 Boxer Capital Management, LLC 0.70% of their portfolio San Diego, CA 70,00070.0k $9.3m $9.3m 0.70% Unchanged
95 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 66,43366.4k $8.8m $8.8m 0.00% Added +10.1k +10,081
96 KENNEDY CAPITAL MANAGEMENT LLC 0.15% of their portfolio ST LOUIS, MO 63,98164.0k $8.5m $8.5m 0.15% Reduced -58.7k -58,688
97 CREDIT INDUSTRIEL ET COMMERCIAL 0.91% of their portfolio PARIS FRANCE, I0 63,42463.4k $8.4m $8.4m 0.91% New
98 ALPS ADVISORS INC 0.04% of their portfolio Denver, CO 62,52362.5k $8.3m $8.3m 0.04% Added +16.9k +16,937
99 Beryl Capital Management LLC 7.04% of their portfolio REDONDO BEACH, CA 58,67658.7k $7.8m $7.8m 7.04% New
100 PRELUDE CAPITAL MANAGEMENT, LLC 0.57% of their portfolio NEW YORK, NY 58,59058.6k $7.8m $7.8m 0.57% Added +52.6k +52,590