PROTAGONIST THERAPEUTICS INC PTGX
COM · Common Stock · CUSIP 74366E102 · ISIN US74366E1029
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNewark, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($12.6m this quarter). Holder counts are more reliable. Shares outstanding: 64.7m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $122.56. Options: 9 managers hold calls ($51.0m notional), 7 hold puts ($29.4m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 132 |
| Q4 2022 | 138 |
| Q1 2023 | 138 |
| Q2 2023 | 168 |
| Q3 2023 | 145 |
| Q4 2023 | 157 |
| Q1 2024 | 186 |
| Q2 2024 | 189 |
| Q3 2024 | 241 |
| Q4 2024 | 243 |
| Q1 2025 | 277 |
| Q2 2025 | 276 |
| Q3 2025 | 276 |
| Q4 2025 | 318 |
| Q1 2026 | 322 |
| Q2 2026 | 346 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 153 | 86 |
| Q4 2024 | 130 | 116 |
| Q1 2025 | 150 | 125 |
| Q2 2025 | 169 | 125 |
| Q3 2025 | 123 | 145 |
| Q4 2025 | 161 | 141 |
| Q1 2026 | 159 | 153 |
| Q2 2026 | 201 | 124 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $12.2m | $3.4m | 0.28 |
| Q4 2025 | $85.2m | $4.6m | 0.05 |
| Q1 2026 | $36.4m | $11.1m | 0.31 |
| Q2 2026 | $51.0m | $29.4m | 0.58 |
Biggest buyers
| BlackRock, Inc. | Added | +528.5k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +484.2k |
| FRANKLIN RESOURCES INC | Added | +382.2k |
| Alyeska Investment Group, L.P. | Added | +296.1k |
| Stephens Investment Management Group LLC | New | +281.8k |
| LORD, ABBETT & CO. LLC | Added | +235.5k |
| STATE STREET CORP | Added | +204.8k |
| Invesco Ltd. | Added | +176.0k |
| NEUBERGER BERMAN GROUP LLC | Added | +161.0k |
| Nuveen, LLC | Added | +156.2k |
Biggest sellers
| UBS Group AG | Reduced | -1.8m |
| CITADEL ADVISORS LLC | Sold out | -1.6m |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | Sold out | -571.8k |
| MARSHALL WACE, LLP | Reduced | -519.1k |
| Rubric Capital Management LP | Sold out | -428.0k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -330.0k |
| Vestal Point Capital, LP | Sold out | -326.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -282.4k |
| PERCEPTIVE ADVISORS LLC | Reduced | -249.0k |
| Holocene Advisors, LP | Reduced | -201.4k |
Biggest calls
| ORBIMED ADVISORS LLC | New | $18.4m150.0k shares |
| Caption Management, LLC | Added | $18.4m150.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.6m45.4k shares |
| CITADEL ADVISORS LLC | Reduced | $4.0m32.4k shares |
| GROUP ONE TRADING LLC | Reduced | $2.0m16.2k shares |
| JANE STREET GROUP, LLC | Reduced | $1.3m10.2k shares |
| Walleye Capital LLC | Reduced | $539.4k4.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $502.6k4.1k shares |
| TUDOR INVESTMENT CORP ET AL | Reduced | $453.5k3.7k shares |
Biggest puts
| Caption Management, LLC | Added | $19.8m161.8k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.8m55.4k shares |
| CITADEL ADVISORS LLC | Added | $1.6m13.4k shares |
| SIMPLEX TRADING, LLC | New | $563.9k4.6k shares |
| JANE STREET GROUP, LLC | New | $281.9k2.3k shares |
| TUDOR INVESTMENT CORP ET AL | Reduced | $257.4k2.1k shares |
| Walleye Capital LLC | Reduced | $12.3k100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-10-27 | 15.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 10.0% |
| Farallon Capital Partners, L.P. 13G · passive investor no change · filed 2026-02-06 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution filed 2026-02-17 | 8.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.5% |
| STATE STREET CORP 13G · institution +0.3 pts · filed 2026-08-07 | 5.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-02-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), BIOTECHNOLOGY VALUE FUND L P (4.1%, 2025-11-14), Deep Track Capital, LP (2.8%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 3 | $11.8m | — |
| Q1 2025 | 0 | — | 4 | $3.6m | $217.0k |
| Q2 2025 | 0 | — | 2 | $1.2m | — |
| Q3 2025 | 0 | — | 2 | $3.9m | $494.0k |
| Q4 2025 | 0 | — | 2 | $1.2m | $979.5k |
| Q1 2026 | 0 | — | 6 | $29.5m | — |
| Q2 2026 | 0 | — | 4 | $16.5m | $10.4m |
| Q3 2026 | 0 | — | 1 | $33.1m | $33.1m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-10 | PATEL DINESH V PH D President and CEO, director | Sold plan | $1.0m7.3k shares |
| 2026-09-09 | PATEL DINESH V PH D President and CEO, director | Sold plan | $9.3m63.5k shares |
| 2026-09-08 | PATEL DINESH V PH D President and CEO, director | Sold plan | $7.9m54.2k shares |
| 2026-08-11 | PATEL DINESH V PH D President and CEO, director | Sold plan | $5.1m34.2k shares |
| 2026-08-10 | PATEL DINESH V PH D President and CEO, director | Sold plan | $9.8m65.8k shares |
| 2026-06-23 | Waddill William D. Director | Sold plan | $1.1m9.0k shares |
| 2026-06-10 | Waddill William D. Director | Sold plan | $969.1k9.0k shares |
| 2026-05-29 | Waddill William D. Director | Sold plan | $896.8k9.0k shares |
| 2026-05-12 | PATEL DINESH V PH D President and CEO, director | Sold plan | $7.5m75.0k shares |
| 2026-05-08 | Giraudo Bryan Director | Sold | $600.0k6.0k shares |
| 2026-05-08 | Giraudo Bryan Director | Sold | $513.0k5.1k shares |
| 2026-05-07 | Giraudo Bryan Director | Sold | $3.6m36.0k shares |
| 2026-05-07 | Giraudo Bryan Director | Sold | $1.2m12.0k shares |
| 2026-04-20 | Ali Asif Chief Financial Officer | Sold | $184.6k1.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.02% of their portfolio | 10.3m $1.3bn | Added +528.5k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 4.56% of their portfolio | 6.3m $778.2m | Unchanged |
| RTW INVESTMENTS, LP 5.30% of their portfolio | 5.1m $620.4m | Added +2.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio | 3.6m $444.9m | Added +148.1k |
| WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio | 3.4m $418.8m | Reduced -182.9k |
| UBS Group AG 0.07% of their portfolio | 3.4m $416.7m | Reduced -1.8m |
| STATE STREET CORP 0.01% of their portfolio | 3.3m $407.2m | Added +204.8k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.9m $349.8m | Added +47.5k |
| JOHNSON & JOHNSON 37.59% of their portfolio | 2.4m $300.2m | Unchanged |
| Invesco Ltd. 0.02% of their portfolio | 2.3m $286.9m | Added +176.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio | 2.1m $263.5m | Added +484.2k |
| Jupiter Topco LLC 0.11% of their portfolio | 2.1m $261.0m | First filing |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.7m $213.5m | Added +71.8k |
| Woodline Partners LP 0.54% of their portfolio | 1.4m $173.3m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 1.3m $162.4m | Added +29.1k |
| JENNISON ASSOCIATES LLC 0.08% of their portfolio | 1.2m $141.2m | Added +79.7k |
| PERCEPTIVE ADVISORS LLC 1.87% of their portfolio | 981.9k $120.4m | Reduced -249.0k |
| ADAR1 Capital Management, LLC 5.54% of their portfolio | 960.9k $117.8m | Reduced -33.3k |
| MORGAN STANLEY 0.01% of their portfolio | 906.0k $111.1m | Reduced -112.2k |
| Alyeska Investment Group, L.P. 0.28% of their portfolio | 889.3k $109.0m | Added +296.1k |
| Hood River Capital Management LLC 0.78% of their portfolio | 882.7k $108.2m | Added +53.5k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 812.9k $99.6m | Added +33.9k |
| Driehaus Capital Management LLC 0.52% of their portfolio | 731.1k $89.6m | Added +10.1k |
| Clearbridge Investments, LLC 0.07% of their portfolio | 725.3k $88.9m | Added +103.5k |
| FMR LLC 0.00% of their portfolio | 672.2k $82.4m | Added +10.2k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 666.1k $81.7m | Added +78.1k |
| AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio | 598.6k $73.4m | Added +61.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 583.8k $71.6m | Added +30.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.06% of their portfolio | 571.6k $70.1m | Added +117.2k |
| Pictet Asset Management Holding SA 0.07% of their portfolio | 568.0k $69.6m | Reduced -13.1k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 520.0k $63.7m | Added +382.2k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 437.7k $53.7m | Added +25.0k |
| LORD, ABBETT & CO. LLC 0.14% of their portfolio | 399.0k $48.9m | Added +235.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.02% of their portfolio | 385.3k $47.2m | Added +17.4k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 358.3k $43.9m | Added +16.8k |
| NEUBERGER BERMAN GROUP LLC 0.02% of their portfolio | 302.4k $37.1m | Added +161.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio | 301.5k $37.0m | Added +106.9k |
| 683 Capital Management, LLC 3.27% of their portfolio | 290.0k $35.5m | Reduced -65.0k |
| Nuveen, LLC 0.01% of their portfolio | 284.1k $34.8m | Added +156.2k |
| Stephens Investment Management Group LLC 0.37% of their portfolio | 281.8k $34.5m | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio | 260.0k $31.9m | Reduced -46.1k |
| Eagle Health Investments LP 5.05% of their portfolio | 248.3k $30.4m | Added +69.0k |
| NEXTBio Capital Management LP 12.37% of their portfolio | 219.3k $26.9m | Reduced -10.3k |
| SEGALL BRYANT & HAMILL, LLC 0.31% of their portfolio | 214.7k $26.3m | Added +2.0k |
| SEB Asset Management AB 0.10% of their portfolio | 210.0k $25.7m | Reduced -22.5k |
| Duquesne Family Office LLC 0.59% of their portfolio | 208.9k $25.6m | Added +49.2k |
| Public Sector Pension Investment Board 0.07% of their portfolio | 207.7k $25.5m | Reduced -2.6k |
| CITIGROUP INC 0.01% of their portfolio | 198.7k $24.4m | Added +40.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 183.1k $22.6m | Added +10.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 178.2k $21.8m | Reduced -330.0k |
| Affinity Asset Advisors, LLC 1.03% of their portfolio | 172.1k $21.1m | Unchanged |
| Fisher Asset Management, LLC 0.01% of their portfolio | 170.5k $20.9m | Reduced -3.4k |
| Boxer Capital Management, LLC 1.57% of their portfolio | 170.0k $20.8m | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 168.3k $20.6m | Reduced -9.1k |
| NAN FUNG TRINITY (HK) LTD 1.94% of their portfolio | 160.7k $19.7m | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 143.8k $17.6m | Reduced -1.9k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 141.8k $17.4m | Added +16.4k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 141.3k $17.3m | Reduced -16.1k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.03% of their portfolio | 141.1k $17.3m | New |
| TD Asset Management Inc 0.01% of their portfolio | 134.9k $16.5m | Reduced -48.8k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.29% of their portfolio | 134.0k $16.4m | Reduced -3.1k |
| Legal & General Group Plc 0.00% of their portfolio | 132.4k $16.2m | Reduced -3.0k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 115.4k $14.1m | Added +75.0k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 109.0k $13.4m | Reduced -519.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 108.6k $13.3m | Reduced -19.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 107.1k $13.1m | Reduced -343 |
| Catalio Capital Management, LP 2.46% of their portfolio | 106.8k $13.1m | New |
| Swiss National Bank 0.01% of their portfolio | 102.4k $12.6m | Added +3.5k |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 102.0k $12.5m | Reduced -3.5k |
| Opaleye Management Inc. 1.11% of their portfolio | 100.0k $12.3m | Unchanged |
| ASSETMARK, INC 0.02% of their portfolio | 98.7k $12.1m | Added +52.2k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 92.7k $11.4m | Added +9.6k |
| ALGERT GLOBAL LLC 0.13% of their portfolio | 87.7k $10.8m | Added +9.2k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 85.2k $10.4m | Reduced -10.1k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 83.9k $10.3m | Added +339 |
| AXIOM INVESTORS LLC /DE 0.09% of their portfolio | 81.7k $10.0m | Reduced -3.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 79.6k $8.4m | Added +5.8k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 71.9k $8.8m | Added +41.9k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 65.0k $7.9m | New |
| NORDEA INVESTMENT MANAGEMENT AB 0.01% of their portfolio | 65.0k $7.9m | Added +13.1k |
| Knott David M Jr 4.08% of their portfolio | 63.0k $7.7m | Unchanged |
| Atika Capital Management LLC 0.76% of their portfolio | 62.1k $7.6m | Unchanged |
| Moody Aldrich Partners LLC 1.31% of their portfolio | 59.6k $7.3m | Added +5.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 59.0k $7.2m | Added +284 |
| Eversept Partners, LP 0.39% of their portfolio | 58.5k $7.2m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 57.1k $7.0m | Reduced -110.5k |
| GREAT LAKES ADVISORS, LLC 0.05% of their portfolio | 56.9k $7.0m | Reduced -14.1k |
| Creative Planning 0.00% of their portfolio | 56.2k $6.9m | Added +8.2k |
| Bellevue Group AG 0.14% of their portfolio | 55.7k $6.8m | Added +41.2k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 54.9k $6.7m | Reduced -33.0k |
| KVP Capital Advisors, LP 4.77% of their portfolio | 53.0k $6.5m | Unchanged |
| BESSEMER GROUP INC 0.01% of their portfolio | 52.1k $6.4m | Reduced -2.1k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 51.6k $6.3m | Added +5.3k |
| CASTLEARK MANAGEMENT LLC 0.17% of their portfolio | 50.6k $6.2m | New |
| Granahan Investment Management, LLC 0.22% of their portfolio | 49.8k $6.1m | Added +22.4k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 49.5k $6.1m | Added +2.1k |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 48.9k $6.0m | Reduced -126 |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 48.0k $5.9m | Added +605 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.04% of their portfolio | 45.7k $5.6m | Reduced -2.3k |
| Seven Fleet Capital Management LP 0.92% of their portfolio | 45.4k $5.6m | Added +41.4k |