AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($16.8m this quarter). Holder counts are more reliable. Shares outstanding: 52.4m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $244.56. Options: 21 managers hold calls ($246.8m notional), 17 hold puts ($286.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
| Q1 2023 | 198 |
| Q2 2023 | 233 |
| Q3 2023 | 229 |
| Q4 2023 | 247 |
| Q1 2024 | 261 |
| Q2 2024 | 258 |
| Q3 2024 | 281 |
| Q4 2024 | 293 |
| Q1 2025 | 355 |
| Q2 2025 | 350 |
| Q3 2025 | 356 |
| Q4 2025 | 401 |
| Q1 2026 | 412 |
| Q2 2026 | 506 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 127 | 117 |
| Q4 2024 | 141 | 129 |
| Q1 2025 | 194 | 141 |
| Q2 2025 | 203 | 149 |
| Q3 2025 | 191 | 142 |
| Q4 2025 | 203 | 156 |
| Q1 2026 | 209 | 194 |
| Q2 2026 | 290 | 197 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $87.3m | $81.5m | 0.93 |
| Q4 2025 | $166.8m | $116.5m | 0.70 |
| Q1 2026 | $140.4m | $109.9m | 0.78 |
| Q2 2026 | $246.8m | $286.6m | 1.16 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +535.3k |
| JANE STREET GROUP, LLC | Added | +399.9k |
| Invesco Ltd. | Added | +374.0k |
| TWO SIGMA INVESTMENTS, LP | Added | +346.7k |
| MORGAN STANLEY | Added | +327.4k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Added | +275.5k |
| Integral Health Asset Management, LLC | Added | +265.0k |
| AMERIPRISE FINANCIAL INC | Added | +251.8k |
| SAMLYN CAPITAL, LLC | New | +246.0k |
| FRANKLIN RESOURCES INC | Added | +229.9k |
Biggest sellers
| BlackRock, Inc. | Reduced | -809.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -674.2k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -491.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -478.5k |
| Deep Track Capital, LP | Reduced | -400.0k |
| UBS Group AG | Reduced | -395.3k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | Reduced | -273.4k |
| EVENTIDE ASSET MANAGEMENT, LLC | Reduced | -202.7k |
| STATE STREET CORP | Reduced | -201.1k |
| GEODE CAPITAL MANAGEMENT, LLC | Reduced | -195.8k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $81.8m334.2k shares |
| JANE STREET GROUP, LLC | Added | $42.9m175.1k shares |
| CITADEL ADVISORS LLC | Reduced | $25.2m103.0k shares |
| GROUP ONE TRADING LLC | Added | $23.5m95.9k shares |
| Caption Management, LLC | Reduced | $14.7m60.0k shares |
| PEAK6 LLC | Reduced | $13.8m56.2k shares |
| Tetragon Partners GP Ltd | Unchanged | $8.6m35.0k shares |
| Point72 Asset Management, L.P. | New | $7.1m28.9k shares |
| DLD Asset Management, LP | New | $6.1m25.0k shares |
| NOMURA HOLDINGS INC | New | $4.9m20.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $118.8m485.4k shares |
| JANE STREET GROUP, LLC | Added | $41.8m170.7k shares |
| CITADEL ADVISORS LLC | Added | $38.3m156.3k shares |
| GROUP ONE TRADING LLC | Added | $26.4m107.8k shares |
| Caption Management, LLC | Reduced | $13.1m53.5k shares |
| IMC-Chicago, LLC | Added | $10.7m43.7k shares |
| SIMPLEX TRADING, LLC | Added | $10.2m41.5k shares |
| D. E. Shaw & Co., Inc. | New | $9.8m40.0k shares |
| Point72 Asset Management, L.P. | New | $8.4m34.4k shares |
| NOMURA HOLDINGS INC | New | $4.9m20.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 1 | $2.0m | $2.0m |
| Q2 2025 | 0 | — | 3 | $11.7m | $11.4m |
| Q3 2025 | 1 | $200.5k | 4 | $28.3m | $28.3m |
| Q4 2025 | 0 | — | 2 | $45.1m | $45.1m |
| Q1 2026 | 0 | — | 5 | $43.3m | $43.3m |
| Q2 2026 | 0 | — | 7 | $26.8m | $26.8m |
| Q3 2026 | 0 | — | 2 | $24.6m | $24.6m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-03 | Jacobson Mark L. Chief Operating Officer | Sold plan | $2.1m10.0k shares |
| 2026-08-06 | TABUTEAU HERRIOT Chief Executive Officer, director | Sold plan | $997.0k4.7k shares |
| 2026-08-05 | TABUTEAU HERRIOT Chief Executive Officer, director | Sold plan | $9.5m45.0k shares |
| 2026-07-01 | TABUTEAU HERRIOT Chief Executive Officer, director | Sold plan | $11.9m49.7k shares |
| 2026-06-11 | JEFFS ROGER Director | Sold plan | $71.2k286 shares |
| 2026-06-10 | Coleman Mark Director | Sold plan | $160.1k643 shares |
| 2026-06-10 | Mahony Susan Director | Sold plan | $73.9k300 shares |
| 2026-06-10 | JEFFS ROGER Director | Sold plan | $70.4k286 shares |
| 2026-06-09 | TABUTEAU HERRIOT Chief Executive Officer, director | Sold plan | $12.0m49.7k shares |
| 2026-06-09 | Pizzie Nick Chief Financial Officer | Sold plan | $7.9m33.0k shares |
| 2026-06-09 | Mahony Susan Director | Sold plan | $71.2k300 shares |
| 2026-06-02 | Coleman Mark Director | Sold plan | $1.2m5.5k shares |
| 2026-06-01 | Coleman Mark Director | Sold plan | $1.4m6.0k shares |
| 2026-05-29 | Coleman Mark Director | Sold plan | $1.4m6.0k shares |
| 2026-05-05 | Jacobson Mark L. Chief Operating Officer | Sold plan | $53.2k233 shares |
| 2026-05-04 | Jacobson Mark L. Chief Operating Officer | Sold plan | $1.0m4.5k shares |
| 2026-04-22 | Maizel Ari Chief Commercial Officer | Sold plan | $1.4m7.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 3.1m $759.7m | Reduced -809.1k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.02% of their portfolio | 2.0m $485.5m | Reduced -74.7k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.0m $481.0m | Added +27.3k |
| Invesco Ltd. 0.03% of their portfolio | 1.7m $409.2m | Added +374.0k |
| FMR LLC 0.02% of their portfolio | 1.5m $376.7m | Reduced -27.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 967.2k $236.8m | Reduced -195.8k |
| Assenagon Asset Management S.A. 0.14% of their portfolio | 909.4k $222.6m | Added +43.4k |
| MORGAN STANLEY 0.01% of their portfolio | 804.1k $196.8m | Added +327.4k |
| STATE STREET CORP 0.01% of their portfolio | 785.7k $192.3m | Reduced -201.1k |
| Deep Track Capital, LP 2.52% of their portfolio | 700.0k $171.3m | Reduced -400.0k |
| TWO SIGMA INVESTMENTS, LP 0.12% of their portfolio | 669.5k $163.9m | Added +346.7k |
| FRANKLIN RESOURCES INC 0.04% of their portfolio | 668.4k $163.6m | Added +229.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 653.9k $160.1m | Reduced -491.4k |
| ALETHEA CAPITAL MANAGEMENT, LLC 65.78% of their portfolio | 648.8k $158.8m | Reduced -358 |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 642.9k $157.4m | Reduced -674.2k |
| D. E. Shaw & Co., Inc. 0.09% of their portfolio | 604.8k $148.0m | Added +1.3k |
| MILLENNIUM MANAGEMENT LLC 0.09% of their portfolio | 556.1k $136.1m | Added +535.3k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.20% of their portfolio | 539.4k $132.0m | Reduced -273.4k |
| NORGES BANK 0.01% of their portfolio | 514.3k $125.9m | Not comparable |
| FIRST TRUST ADVISORS LP 0.07% of their portfolio | 482.1k $118.0m | Reduced -95.4k |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 452.5k $110.8m | Reduced -145.6k |
| AMERIPRISE FINANCIAL INC 0.02% of their portfolio | 428.1k $104.8m | Added +251.8k |
| Pictet Asset Management Holding SA 0.10% of their portfolio | 426.5k $104.4m | Added +10.5k |
| Qube Research & Technologies Ltd 0.12% of their portfolio | 426.3k $104.4m | Added +91.0k |
| Point72 Asset Management, L.P. 0.16% of their portfolio | 416.5k $102.0m | Reduced -8.2k |
| JANE STREET GROUP, LLC 0.06% of their portfolio | 404.0k $98.9m | Added +399.9k |
| Hood River Capital Management LLC 0.71% of their portfolio | 402.7k $98.6m | Added +31.2k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.13% of their portfolio | 373.1k $91.3m | Added +275.5k |
| Driehaus Capital Management LLC 0.53% of their portfolio | 372.5k $91.2m | Added +80.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.04% of their portfolio | 332.6k $81.4m | Reduced -17.8k |
| EVENTIDE ASSET MANAGEMENT, LLC 1.04% of their portfolio | 316.8k $77.5m | Reduced -202.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 316.1k $77.4m | Reduced -79.0k |
| Integral Health Asset Management, LLC 3.01% of their portfolio | 300.0k $73.4m | Added +265.0k |
| VANGUARD FIDUCIARY TRUST CO 0.02% of their portfolio | 279.7k $68.5m | Reduced -15.4k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 270.2k $66.1m | Reduced -131.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.09% of their portfolio | 262.0k $64.1m | Added +97.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.09% of their portfolio | 259.0k $63.4m | Reduced -478.5k |
| CITADEL ADVISORS LLC 0.04% of their portfolio | 255.9k $62.6m | Reduced -25.6k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.58% of their portfolio | 254.3k $62.2m | Added +51.2k |
| SAMLYN CAPITAL, LLC 1.00% of their portfolio | 246.0k $60.2m | New |
| Clearbridge Investments, LLC 0.05% of their portfolio | 245.6k $60.1m | Added +200.6k |
| LOOMIS SAYLES & CO L P 0.07% of their portfolio | 239.5k $58.6m | Reduced -17.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.03% of their portfolio | 231.0k $56.5m | Added +42.8k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 229.7k $56.2m | Reduced -191.8k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.03% of their portfolio | 225.4k $55.2m | Added +134.0k |
| MARSHALL WACE, LLP 0.05% of their portfolio | 223.4k $54.7m | Added +82.2k |
| PFM Health Sciences, LP 4.67% of their portfolio | 219.6k $53.8m | Reduced -44.7k |
| Tri Locum Partners LP 6.60% of their portfolio | 219.3k $53.7m | Added +157.2k |
| First Turn Management, LLC 5.72% of their portfolio | 218.4k $53.5m | Added +29.6k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 197.2k $48.3m | Reduced -9.4k |
| Nuveen, LLC 0.01% of their portfolio | 190.1k $46.5m | Reduced -145.7k |
| HRT FINANCIAL LP 0.10% of their portfolio | 178.5k $43.7m | New |
| FEDERATED HERMES, INC. 0.06% of their portfolio | 177.8k $43.5m | Added +69.3k |
| Woodline Partners LP 0.12% of their portfolio | 162.2k $39.7m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 162.1k $39.5m | Reduced -108.1k |
| Sofinnova Investments, Inc. 2.10% of their portfolio | 160.4k $39.3m | Reduced -52.3k |
| NEUBERGER BERMAN GROUP LLC 0.03% of their portfolio | 156.5k $38.3m | Added +95.8k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 155.9k $38.1m | Added +8.1k |
| Squarepoint Ops LLC 0.07% of their portfolio | 154.6k $37.8m | Added +40.5k |
| UBS Group AG 0.01% of their portfolio | 151.9k $37.2m | Reduced -395.3k |
| WESTFIELD CAPITAL MANAGEMENT CO LP 0.12% of their portfolio | 145.1k $35.5m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 142.1k $34.8m | Reduced -41.9k |
| CITIGROUP INC 0.02% of their portfolio | 136.9k $33.5m | Reduced -48.8k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 135.2k $33.1m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 127.2k $31.1m | Added +32.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.02% of their portfolio | 119.0k $29.1m | Added +1.9k |
| PERCEPTIVE ADVISORS LLC 0.45% of their portfolio | 118.5k $29.0m | Reduced -31.5k |
| ORBIMED ADVISORS LLC 0.55% of their portfolio | 117.6k $28.8m | Reduced -96.3k |
| Public Sector Pension Investment Board 0.07% of their portfolio | 116.0k $28.4m | New |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 114.0k $27.9m | Added +10.0k |
| EMERALD ADVISERS, LLC 0.60% of their portfolio | 104.2k $25.5m | Reduced -3.4k |
| Nicholas Investment Partners, LP 1.36% of their portfolio | 99.0k $24.2m | Added +17.5k |
| Connor, Clark & Lunn Investment Management Ltd. 0.05% of their portfolio | 97.7k $23.9m | Reduced -37.1k |
| ALGERT GLOBAL LLC 0.28% of their portfolio | 95.3k $23.3m | Reduced -40.1k |
| ROYCE & ASSOCIATES LP 0.18% of their portfolio | 91.0k $22.3m | Reduced -3.0k |
| MetLife Investment Management, LLC 0.10% of their portfolio | 89.7k $21.9m | Reduced -63.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 87.8k $21.5m | Added +40.6k |
| DEUTSCHE BANK AG\ 0.01% of their portfolio | 86.5k $21.2m | Reduced -17.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 85.7k $14.5m | Added +22.9k |
| Voleon Capital Management LP 0.38% of their portfolio | 84.4k $20.7m | Reduced -63.4k |
| Cannell & Spears LLC 0.37% of their portfolio | 84.2k $20.6m | Unchanged |
| Trexquant Investment LP 0.13% of their portfolio | 83.7k $20.5m | Added +77.7k |
| Man Group plc 0.04% of their portfolio | 82.5k $20.2m | Reduced -59.7k |
| Granite Investment Partners, LLC 1.00% of their portfolio | 80.1k $19.6m | Reduced -175 |
| Weiss Asset Management LP 0.22% of their portfolio | 80.0k $19.6m | Not comparable |
| Swiss National Bank 0.01% of their portfolio | 79.5k $19.5m | Added +10.4k |
| Aberdeen Group plc 0.03% of their portfolio | 78.2k $19.1m | Reduced -71.5k |
| SEI INVESTMENTS CO 0.02% of their portfolio | 76.5k $18.7m | Added +6.4k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 76.2k $18.7m | New |
| WCM INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 75.7k $18.3m | Reduced -32.1k |
| California Public Employees Retirement System 0.01% of their portfolio | 74.8k $18.3m | Added +23.9k |
| LORD, ABBETT & CO. LLC 0.05% of their portfolio | 74.0k $18.1m | New |
| Science & Technology Partners, L.P. 3.01% of their portfolio | 73.0k $17.9m | New |
| TimesSquare Capital Management, LLC 0.26% of their portfolio | 71.5k $17.5m | New |
| EMERALD MUTUAL FUND ADVISERS TRUST 0.58% of their portfolio | 67.2k $16.4m | Added +141 |
| US BANCORP \DE\ 0.02% of their portfolio | 66.6k $16.3m | Reduced -64.8k |
| DNB Asset Management AS 0.04% of their portfolio | 65.2k $16.0m | Reduced -24.9k |
| Eagle Health Investments LP 2.64% of their portfolio | 65.1k $15.9m | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio | 63.6k $15.6m | Reduced -7.2k |
| Rhenman & Partners Asset Management AB 1.46% of their portfolio | 63.0k $15.4m | Reduced -750 |