Paradigm Biocapital Advisors LP

NEW YORK, NY · CIK 1855655 · 13F filing filed 2023-05-15

SEC-registered investment adviser since 2021 · limited partnership

Assets managed$4.5bn
Staff11 · 6 in investment roles
Main clients (by assets)Private funds 90%
Private funds2 (2 hedge) · $4.1bn gross assets
Form ADV · 2026-08-27SEC adviser record

Legal entityPARADIGM BIOCAPITAL ADVISORS LP (US)

Kindhedge funds, futures
Others nearbyNew York, NY

As an employer

Offices in1 country
Private fundshedge 2

$1.1bn reported value +23.9% vs Q4 2022

25positions

61.5%in top 10

7 new 14 added 3 reduced 5 sold out vs Q4 2022

Holdings, Q1 2023

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	BIOGEN INC COM BIIB	BIIB	349,593	$97.2m9.21%	9.21%	Added +110.8k	+110,821 46.4%
2	INCYTE CORP COM INCY	INCY	1,261,711	$91.2m8.64%	8.64%	Added +408.9k	+408,881 47.9%
3	LEGEND BIOTECH CORP SPONSORED ADS LEGN	LEGN	1,510,324	$72.8m6.90%	6.90%	Added +455.5k	+455,454 43.2%
4	ARGENX SE SPONSORED ADR ARGX	ARGX	181,172	$67.5m6.40%	6.40%	Added +91.6k	+91,616 102.3%
5	SEAGEN INC COM SGEN	SGEN	281,969	$57.1m5.41%	5.41%	Reduced -4.3k	-4,319 -1.5%
6	IMMUNOCORE HLDGS PLC ADS IMCR	IMCR	1,126,256	$55.7m5.28%	5.28%	Added +268.3k	+268,331 31.3%
7	ARCELLX INC COMMON STOCK ACLX	ACLX	1,757,779	$54.2m5.13%	5.13%	Added +875.7k	+875,678 99.3%
8	VIRIDIAN THERAPEUTICS INC COM VRDN	VRDN	2,085,698	$53.1m5.03%	5.03%	Added +334.5k	+334,531 19.1%
9	MIRATI THERAPEUTICS INC COM MRTX	MRTX	1,396,779	$51.9m4.92%	4.92%	Added +128.8k	+128,809 10.2%
10	SYNDAX PHARMACEUTICALS INC COM SNDX	SNDX	2,274,512	$48.0m4.55%	4.55%	Added +320.0k	+320,000 16.4%
11	UNITED THERAPEUTICS CORP DEL COM UTHR	UTHR	211,892	$47.5m4.50%	4.50%	Added +63.0k	+63,000 42.3%
12	KEROS THERAPEUTICS INC COM KROS	KROS	930,752	$39.7m3.77%	3.77%	New
13	BEIGENE LTD SPONSORED ADR ONC	ONC	184,012	$39.7m3.76%	3.76%	New
14	CEREVEL THERAPEUTICS HLDNG I COM CERE	CERE	1,595,199	$38.9m3.69%	3.69%	New
15	BICYCLE THERAPEUTICS PLC SPONSORED ADS BCYC	BCYC	1,816,781	$38.6m3.66%	3.66%	Added +583.5k	+583,501 47.3%
16	ASCENDIS PHARMA A/S SPONSORED ADR SPONSORED ADR		350,866	$37.6m3.57%	3.57%	Reduced -1.9k	-1,942 -0.6%
17	VOR BIOPHARMA INC COM COM		6,477,999	$34.9m3.30%	3.30%	Added +35.2k	+35,174 0.6%
18	ZAI LAB LTD ADR ZLAB	ZLAB	780,558	$26.0m2.46%	2.46%	Added +265.3k	+265,284 51.5%
19	XENON PHARMACEUTICALS INC COM XENE	XENE	651,068	$23.3m2.21%	2.21%	New
20	VERONA PHARMA PLC SPONSORED ADS VRNA	VRNA	962,361	$19.3m1.83%	1.83%	New
21	CRINETICS PHARMACEUTICALS IN COM CRNX	CRNX	1,133,782	$18.2m1.73%	1.73%	Added +243.7k	+243,677 27.4%
22	ALPINE IMMUNE SCIENCES INC COM NVLS	NVLS	2,317,634	$17.9m1.70%	1.70%	Unchanged
23	THESEUS PHARMACEUTICALS INC COM COM		1,505,327	$13.4m1.27%	1.27%	New
24	OLEMA PHARMACEUTICALS INC COM OLMA	OLMA	2,382,377	$8.3m0.78%	0.78%	New
25	POSEIDA THERAPEUTICS INC COM PSTX	PSTX	1,072,410	$3.3m0.31%	0.31%	Reduced -1.4m	-1,362,406 -56.0%

Sold out since Q4 2022

Security	Ticker	Shares held before	Value then
HORIZON THERAPEUTICS PUB L HZNP	HZNP	477,585	$54.3m477.6k shares
AKERO THERAPEUTICS INC AKRO	AKRO	604,544	$33.1m604.5k shares
KARUNA THERAPEUTICS INC		106,210	$20.9m106.2k shares
ARVINAS INC ARVN	ARVN	599,599	$20.5m599.6k shares
PROTHENA CORP PLC PRTA	PRTA	75,000	$4.5m75.0k shares

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
OLEMA PHARMACEUTICALS INC OLMA · 13G · filed 2025-02-14	OLMA	10.0%≈ $92.9m		13G	2025-02-14
EDGEWISE THERAPEUTICS INC EWTX · 13G · filed 2026-08-14	EWTX	9.5%≈ $415.1m	+3.3 pts	13G	2026-08-14
ACHIEVE LIFE SCIENCES INC ACHV · 13G · filed 2026-04-24	ACHV	9.2%≈ $64.7m	new	13G	2026-04-24
ASSEMBLY BIOSCIENCES INC ASMB · 13G · filed 2026-08-14	ASMB	7.8%≈ $42.7m	+2.4 pts	13G	2026-08-14
VIRIDIAN THERAPEUTICS INC VRDN · 13G · filed 2026-08-14	VRDN	6.1%≈ $123.5m	+1.0 pts	13G	2026-08-14
TYRA BIOSCIENCES INC TYRA · 13G · filed 2026-09-17	TYRA	5.8%≈ $110.9m	new	13G	2026-09-17
LEXEO THERAPEUTICS INC LXEO · 13G · filed 2026-08-14	LXEO	5.3%≈ $19.4m	-3.0 pts	13G	2026-08-14
MBX BIOSCIENCES INC MBX · 13G · filed 2026-06-24	MBX	5.2%≈ $137.6m	new	13G	2026-06-24
SPYRE THERAPEUTICS INC SYRE · 13G · filed 2026-10-01	SYRE	5.1%≈ $395.7m	new	13G	2026-10-01
JADE BIOSCIENCES INC JBIO · 13G · filed 2026-07-17	JBIO	5.1%≈ $69.0m	new	13G	2026-07-17