Vault-13

ASCENDIS PHARMA A/S

SPONSORED ADR · CUSIP 04351P101 · ISIN US04351P1012

165 institutional holders -22 vs Q4 2022
66,152,76966.2m shares reported held*
$7.1bnreported value*
16 new 59 added 64 reduced 36 sold out net bought ≈ $37.5m (+354.8k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($775.4k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $107.16. Options: 14 managers hold calls ($117.0m notional), 11 hold puts ($22.8m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 183Q4 22: 187Q1 23: 165165Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022183
Q4 2022187
Q1 2023165

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 94 bought or addedQ4 22: 91 cut or sold outQ4 22Q1 23: 75 bought or addedQ1 23: 100 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20229491
Q1 202375100

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ3 22 calls: $224.7mQ3 22 puts: $20.5mQ3 22P/C 0.09Q4 22 calls: $109.7mQ4 22 puts: $23.3mQ4 22P/C 0.21Q1 23 calls: $117.0mQ1 23 puts: $22.8mQ1 23P/C 0.19
Numbers
QuarterCallsPutsP/C
Q3 2022$224.7m$20.5m0.09
Q4 2022$109.7m$23.3m0.21
Q1 2023$117.0m$22.8m0.19

Biggest buyers

FMR LLC Added +5,075,260+5.1m
T. Rowe Price Investment Management, Inc. Added +645,199+645.2k
Capital International Investors Added +421,109+421.1k
Point72 Asset Management, L.P. Added +396,400+396.4k
Avoro Capital Advisors LLC Added +225,000+225.0k
Woodline Partners LP Added +209,683+209.7k
PFM Health Sciences, LP New +202,115+202.1k
Logos Global Management LP New +150,000+150.0k
Nicholas Investment Partners, LP Added +85,450+85.5k
TimesSquare Capital Management, LLC Added +60,835+60.8k

Biggest sellers

BAKER BROS. ADVISORS LP Sold out -4,954,855-5.0m
Deep Track Capital, LP Sold out -700,000-700.0k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -339,898-339.9k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -140,000-140.0k
CITADEL ADVISORS LLC Reduced -135,284-135.3k
Sofinnova Investments, Inc. Reduced -126,768-126.8k
WELLINGTON MANAGEMENT GROUP LLP Reduced -119,813-119.8k
JANUS HENDERSON GROUP PLC Reduced -111,125-111.1k
J.P. Morgan Private Wealth Advisors LLC Reduced -104,394-104.4k
Tri Locum Partners LP Sold out -99,215-99.2k

Biggest calls

Caption Management, LLC Added $49.3m459.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $30.0m279.6k shares
JPMORGAN CHASE & CO New $8.0m75.0k shares
SIMPLEX TRADING, LLC Added $6.4m60.0k shares
GROUP ONE TRADING LLC Added $5.9m54.8k shares
CITADEL ADVISORS LLC Reduced $5.7m52.8k shares
JANE STREET GROUP, LLC Reduced $4.4m40.7k shares
GOLDMAN SACHS GROUP INC Added $2.9m27.0k shares
CITIGROUP INC Added $2.7m25.0k shares
Walleye Trading LLC Added $932.8k8.7k shares

Biggest puts

GOLDMAN SACHS GROUP INC New $5.4m50.0k shares
JANE STREET GROUP, LLC Added $4.4m40.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $3.3m30.8k shares
CITIGROUP INC Added $2.7m25.0k shares
Caption Management, LLC Unchanged $2.7m25.0k shares
Walleye Trading LLC Added $1.4m13.1k shares
SIMPLEX TRADING, LLC Added $1.3m12.5k shares
CITADEL ADVISORS LLC Reduced $1.1m10.1k shares
Walleye Capital LLC Reduced $471.8k4.4k shares
WOLVERINE ASSET MANAGEMENT LLC Added $107.2k1.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +0.6 pts · filed 2026-05-07 10.5% +0.6 pts 6.5m 2026-05-07
WESTFIELD CAPITAL MANAGEMENT CO LP 13G · institution -0.7 pts · filed 2026-02-11 8.5% -0.7 pts 5.2m 2026-02-11
FMR LLC 13G · institution filed 2025-05-12 8.0% 4.6m 2025-05-12
JANUS HENDERSON GROUP PLC 13G · institution -1.8 pts · filed 2026-05-15 6.0% -1.8 pts 3.7m 2026-05-15
Artisan Partners Limited Partnership 13G · institution filed 2026-02-03 5.2% 3.2m 2026-02-03

Fell to 5% or below in the last year: Capital International Investors (3.2%, 2026-05-14)

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.05% of their portfolio BOSTON, MA 10,304,33010.3m $1.1bn $1.1bn 0.05% Added +5.1m +5,075,260
2 RA CAPITAL MANAGEMENT, L.P. 16.89% of their portfolio BOSTON, MA 6,957,1797.0m $745.9m $745.9m 16.89% Unchanged
3 Artisan Partners Limited Partnership 1.22% of their portfolio Milwaukee, WI 6,844,7416.8m $733.9m $733.9m 1.22% Reduced -75.6k -75,615
4 JANUS HENDERSON GROUP PLC 0.25% of their portfolio LONDON, X0 3,532,8303.5m $378.8m $378.8m 0.25% Reduced -111.1k -111,125
5 T. Rowe Price Investment Management, Inc. 0.27% of their portfolio BALTIMORE, MD 3,473,4663.5m $372.4m $372.4m 0.27% Added +645.2k +645,199
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.05% of their portfolio BALTIMORE, MD 3,369,9433.4m $361.3m $361.3m 0.05% Reduced -339.9k -339,898
7 Avoro Capital Advisors LLC 5.29% of their portfolio NEW YORK, NY 3,325,0003.3m $356.5m $356.5m 5.29% Added +225.0k +225,000
8 WESTFIELD CAPITAL MANAGEMENT CO LP 2.38% of their portfolio BOSTON, MA 3,146,1263.1m $337.3m $337.3m 2.38% Reduced -12.0k -12,042
9 WELLINGTON MANAGEMENT GROUP LLP 0.06% of their portfolio Boston, MA 2,933,7922.9m $314.6m $314.6m 0.06% Reduced -119.8k -119,813
10 GOLDMAN SACHS GROUP INC 0.07% of their portfolio NEW YORK, NY 2,548,1452.5m $273.2m $273.2m 0.07% Added +28.6k +28,633
11 Capital International Investors 0.05% of their portfolio Los Angeles, CA 1,989,1062.0m $213.3m $213.3m 0.05% Added +421.1k +421,109
12 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.05% of their portfolio Boston, MA 1,357,5741.4m $145.6m $145.6m 0.05% Added +14.0k +13,972
13 FRANKLIN RESOURCES INC 0.07% of their portfolio San Mateo, CA 1,345,9041.3m $144.3m $144.3m 0.07% Reduced -31.6k -31,618
14 TimesSquare Capital Management, LLC 1.33% of their portfolio NEW YORK, NY 852,080852.1k $91.4m $91.4m 1.33% Added +60.8k +60,835
15 EVENTIDE ASSET MANAGEMENT, LLC 1.54% of their portfolio Boston, MA 782,840782.8k $83.9m $83.9m 1.54% Added +131 +131
16 Point72 Asset Management, L.P. 0.29% of their portfolio STAMFORD, CT 771,110771.1k $82.7m $82.7m 0.29% Added +396.4k +396,400
17 Sofinnova Investments, Inc. 5.48% of their portfolio Menlo Park, CA 754,032754.0k $80.8m $80.8m 5.48% Reduced -126.8k -126,768
18 PUTNAM INVESTMENTS LLC 0.13% of their portfolio BOSTON, MA 740,862740.9k $79.4m $79.4m 0.13% Added +34.5k +34,453
19 Spyglass Capital Management LLC 5.77% of their portfolio Greenbrae, CA 713,966714.0k $76.6m $76.6m 5.77% Reduced -495 -495
20 Invesco Ltd. 0.02% of their portfolio ATLANTA, GA 646,560646.6k $69.3m $69.3m 0.02% Reduced -14.2k -14,226
21 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 515,058515.1k $55.2m $55.2m 0.02% Added +25.1k +25,112
22 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.12% of their portfolio Boston, MA 500,000500.0k $53.6m $53.6m 0.12% Reduced -140.0k -140,000
23 SEI INVESTMENTS CO 0.09% of their portfolio OAKS, PA 476,021476.0k $51.0m $51.0m 0.09% Added +38.8k +38,770
24 BROWN ADVISORY INC 0.08% of their portfolio BALTIMORE, MD 466,372466.4k $50.0m $50.0m 0.08% Added +26.1k +26,080
25 Rock Springs Capital Management LP 1.09% of their portfolio Baltimore, MD 425,500425.5k $45.6m $45.6m 1.09% Unchanged
26 BlackRock Inc. 0.00% of their portfolio New York, NY 381,099381.1k $40.9m $40.9m 0.00% Reduced -13.7k -13,671
27 DEUTSCHE BANK AG\ 0.02% of their portfolio FRANKFURT AM MAIN, 2M 365,488365.5k $39.2m $39.2m 0.02% Reduced -650 -650
28 AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio KANSAS CITY, MO 356,637356.6k $36.9m $36.9m 0.03% Added +12.9k +12,943
29 Paradigm Biocapital Advisors LP 3.57% of their portfolio NEW YORK, NY 350,866350.9k $37.6m $37.6m 3.57% Reduced -1.9k -1,942
30 Woodline Partners LP 0.46% of their portfolio San Francisco, CA 304,796304.8k $32.7m $32.7m 0.46% Added +209.7k +209,683
31 Nicholas Investment Partners, LP 2.05% of their portfolio RANCHO SANTA FE, CA 251,387251.4k $27.0m $27.0m 2.05% Added +85.5k +85,450
32 Candriam S.C.A. 0.17% of their portfolio STRASSEN, N4 250,375250.4k $24.7m $24.7m 0.17% Added +60.0k +60,000
33 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 248,521248.5k $26.6m $26.6m 0.04% Reduced -7.0k -6,985
34 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 245,419245.4k $26.3m $26.3m 0.01% Reduced -5.2k -5,231
35 Allspring Global Investments Holdings, LLC 0.04% of their portfolio CHARLOTTE, NC 240,215240.2k $25.8m $25.8m 0.04% Reduced -10.4k -10,355
36 ARS Investment Partners, LLC 3.08% of their portfolio New York, NY 239,038239.0k $25.6m $25.6m 3.08% Added +417 +417
37 TD Asset Management Inc 0.03% of their portfolio Toronto, A6 236,194236.2k $25.3m $25.3m 0.03% Added +39.9k +39,894
38 PFM Health Sciences, LP 1.00% of their portfolio SAN FRANCISCO, CA 202,115202.1k $21.7m $21.7m 1.00% New
39 Driehaus Capital Management LLC 0.27% of their portfolio Chicago, IL 180,234180.2k $19.3m $19.3m 0.27% Added +7 +7
40 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.02% of their portfolio Boston, MA 169,693169.7k $18.2m $18.2m 1.02% Reduced -3.1k -3,058
41 Finepoint Capital LP 6.39% of their portfolio BOSTON, MA 156,072156.1k $16.7m $16.7m 6.39% Added +22.0k +22,036
42 RICE HALL JAMES & ASSOCIATES, LLC 0.94% of their portfolio San Diego, CA 154,928154.9k $16.6m $16.6m 0.94% Added +9.2k +9,189
43 Logos Global Management LP 2.30% of their portfolio San Francisco, CA 150,000150.0k $16.1m $16.1m 2.30% New
44 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 139,216139.2k $14.9m $14.9m 0.02% Added +22.5k +22,512
45 DAFNA Capital Management LLC 4.35% of their portfolio LOS ANGELES, CA 135,212135.2k $14.5m $14.5m 4.35% Added +5.0k +5,000
46 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 133,218133.2k $14.3m $14.3m 0.00% Added +50.3k +50,275
47 Thrivent Financial for Lutherans 0.03% of their portfolio Minneapolis, MN 127,116127.1k $13.6m $13.6m 0.03% Added +1.9k +1,918
48 Tekla Capital Management LLC 0.51% of their portfolio Boston, MA 123,791123.8k $13.3m $13.3m 0.51% Unchanged
49 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 121,002121.0k $13.0m $13.0m 0.01% Reduced -135.3k -135,284
50 Ghost Tree Capital, LLC 4.46% of their portfolio NEW YORK, NY 110,000110.0k $11.8m $11.8m 4.46% Reduced -20.0k -20,000
51 MARSHALL WACE, LLP 0.03% of their portfolio LONDON, X0 108,326108.3k $11.6m $11.6m 0.03% Added +4.9k +4,900
52 Q Global Advisors, LLC 7.40% of their portfolio FORT WORTH, TX 98,57198.6k $10.6m $10.6m 7.40% Reduced -52.8k -52,838
53 Boxer Capital, LLC 0.50% of their portfolio San Diego, CA 95,00095.0k $10.2m $10.2m 0.50% Unchanged
54 BAILLIE GIFFORD & CO 0.01% of their portfolio EDINBURGH, X0 91,69391.7k $9.8m $9.8m 0.01% Added +11 +11
55 Saturn V Capital Management LP 6.18% of their portfolio AUSTIN, TX 77,21077.2k $8.3m $8.3m 6.18% Added +8.8k +8,806
56 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 75,99776.0k $8.1m $8.1m 0.00% Reduced -747 -747
57 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 68,90268.9k $7.4m $7.4m 0.01% Added +12.2k +12,195
58 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 67,69367.7k $7.3m $7.3m 0.02% Unchanged
59 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 60,22160.2k $6.5m $6.5m 0.01% Unchanged
60 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 59,08259.1k $6.3m $6.3m 0.00% Reduced -27.0k -26,967
61 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 54,20354.2k $5.8m $5.8m 0.01% Reduced -4.8k -4,760
62 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 54,03354.0k $5.8m $5.8m 0.00% Reduced -103 -103
63 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 53,03553.0k $5.7m $5.7m 0.01% Added +28.1k +28,060
64 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 51,73351.7k $5.5m $5.5m 0.00% Added +541 +541
65 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 51,02851.0k $5.5m $5.5m 0.00% Unchanged
66 Alberta Investment Management Corp 0.05% of their portfolio EDMONTON, A0 50,03150.0k $5.4m $5.4m 0.05% Reduced -10.5k -10,454
67 SG Americas Securities, LLC 0.07% of their portfolio NEW YORK, NY 46,34746.3k $5.0m $5.0m 0.07% Added +25.4k +25,417
68 FIL Ltd 0.01% of their portfolio HAMILTON, D0 45,00045.0k $4.8m $4.8m 0.01% Reduced -65 -65
69 Alyeska Investment Group, L.P. 0.04% of their portfolio CHICAGO, IL 45,00045.0k $4.8m $4.8m 0.04% New
70 Affinity Asset Advisors, LLC 1.65% of their portfolio NEW YORK, NY 40,00040.0k $4.3m $4.3m 1.65% Reduced -31.0k -30,997
71 Resolute Capital Asset Partners LLC 2.94% of their portfolio DENVER, CO 37,50037.5k $4.0m $4.0m 2.94% Unchanged
72 BAMCO INC /NY/ 0.01% of their portfolio NEW YORK, NY 35,30635.3k $3.8m $3.8m 0.01% Unchanged
73 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 33,68833.7k $3.6m $3.6m 0.00% Added +14.9k +14,913
74 INTERNATIONAL BIOTECHNOLOGY TRUST PLC 0.88% of their portfolio London, X0 29,40029.4k $3.2m $3.2m 0.88% Unchanged
75 Matisse Capital 1.95% of their portfolio PORTLAND, OR 28,15028.1k $3.0m $3.0m 1.95% Reduced -32.9k -32,890
76 WESTPAC BANKING CORP 0.04% of their portfolio SYDNEY, C3 27,12827.1k $2.9m $2.9m 0.04% Reduced -9.6k -9,614
77 Henry James International Management Inc. 1.18% of their portfolio NEW YORK, NY 26,01726.0k $2.8m $2.8m 1.18% Reduced -6 -6
78 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 20,90020.9k $2.2m $2.2m 0.02% Reduced -47.0k -46,958
79 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 20,00020.0k $2.2m $2.2m 0.01% Unchanged
80 Tamarack Advisers, LP 1.64% of their portfolio CARLSBAD, CA 20,00020.0k $2.1m $2.1m 1.64% Reduced -25.0k -25,000
81 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 19,99120.0k $2.1m $2.1m 0.00% Reduced -9.8k -9,817
82 Parkwood LLC 0.37% of their portfolio CLEVELAND, OH 18,67818.7k $2.0m $2.0m 0.37% Added +1.1k +1,125
83 Erste Asset Management GmbH 0.04% of their portfolio VIENNA, C4 18,50018.5k $2.0m $2.0m 0.04% Unchanged
84 CM WEALTH ADVISORS LLC 0.26% of their portfolio BEACHWOOD, OH 17,25417.3k $1.3m $1.3m 0.26% New
85 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 16,88716.9k $1.8m $1.8m 0.00% Reduced -2.8k -2,847
86 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 14,69414.7k $1.6m $1.6m 0.00% Reduced -633 -633
87 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 14,33314.3k $1.5m $1.5m 0.00% Reduced -38.6k -38,560
88 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 13,84713.8k $1.5m $1.5m 0.00% Added +1.5k +1,526
89 BERYLSON CAPITAL PARTNERS, LLC 3.67% of their portfolio Boston, MA 13,60013.6k $1.5m $1.5m 3.67% New
90 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 13,39413.4k $1.4m $1.4m 0.00% Reduced -40.1k -40,103
91 NOMURA ASSET MANAGEMENT CO LTD 0.01% of their portfolio TOKYO, M0 13,31813.3k $1.4m $1.4m 0.01% Added +648 +648
92 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 13,08013.1k $1.4m $1.4m 0.00% Reduced -580 -580
93 J.P. Morgan Private Wealth Advisors LLC 0.00% of their portfolio SAN FRANCISCO, CA 12,92912.9k $1.4m $1.4m 0.00% Reduced -104.4k -104,394
94 CAPTRUST FINANCIAL ADVISORS 0.01% of their portfolio RALEIGH, NC 12,32512.3k $1.3m $1.3m 0.01% Unchanged
95 HARBOR CAPITAL ADVISORS, INC. 0.38% of their portfolio CHICAGO, IL 12,20112.2k $1.3m $1.3m 0.38% Reduced -1.0k -1,009
96 Allianz Asset Management GmbH 0.00% of their portfolio MUNICH, 2M 11,20011.2k $1.2m $1.2m 0.00% New
97 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 10,73210.7k $1.2m $1.2m 0.00% Reduced -28 -28
98 Evolutionary Tree Capital Management, LLC 1.58% of their portfolio ALEXANDRIA, VA 10,65210.7k $1.1m $1.1m 1.58% Reduced -11.7k -11,695
99 STIFEL FINANCIAL CORP 0.00% of their portfolio ST. LOUIS, MO 9,1689.2k $983.0k $983.0k 0.00% Reduced -205 -205
100 Handelsbanken Fonder AB 0.01% of their portfolio STOCKHOLM, V7 8,5008.5k $911.0k $911.0k 0.01% Added +1.4k +1,400