ARGENX SE ARGX
SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $372.52. Options: 15 managers hold calls ($208.4m notional), 14 hold puts ($162.6m).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 255 |
| Q4 2022 | 271 |
| Q1 2023 | 273 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 114 | 139 |
| Q1 2023 | 123 | 139 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $77.6m | $45.3m | 0.58 |
| Q4 2022 | $108.3m | $72.4m | 0.67 |
| Q1 2023 | $208.4m | $162.6m | 0.78 |
Biggest buyers
| FMR LLC | Added | +5.3m |
| JANUS HENDERSON GROUP PLC | Added | +820.1k |
| Artisan Partners Limited Partnership | Added | +416.8k |
| Capital World Investors | Added | +316.6k |
| BANK OF AMERICA CORP /DE/ | Added | +193.4k |
| STATE STREET CORP | Added | +129.4k |
| SEI INVESTMENTS CO | Added | +95.5k |
| Paradigm Biocapital Advisors LP | Added | +91.6k |
| MILLENNIUM MANAGEMENT LLC | Added | +82.9k |
| Hudson Bay Capital Management LP | New | +82.5k |
Biggest sellers
| JENNISON ASSOCIATES LLC | Reduced | -344.9k |
| Avidity Partners Management LP | Reduced | -344.3k |
| Holocene Advisors, LP | Reduced | -174.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -135.7k |
| T. Rowe Price Investment Management, Inc. | Reduced | -120.1k |
| BAMCO INC /NY/ | Reduced | -115.3k |
| CITADEL ADVISORS LLC | Reduced | -95.6k |
| BlackRock Inc. | Reduced | -90.6k |
| Assenagon Asset Management S.A. | Reduced | -88.3k |
| MORGAN STANLEY | Reduced | -83.8k |
Biggest calls
| Holocene Advisors, LP | New | $79.5m213.3k shares |
| JPMORGAN CHASE & CO | Added | $39.2m105.3k shares |
| GROUP ONE TRADING LLC | Added | $28.1m75.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $16.8m45.2k shares |
| Optiver Holding B.V. | Reduced | $16.7m44.9k shares |
| CITADEL ADVISORS LLC | Added | $14.2m38.2k shares |
| Caption Management, LLC | New | $5.4m14.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $3.9m10.6k shares |
| JANE STREET GROUP, LLC | Added | $1.7m4.5k shares |
| UBS Group AG | New | $1.1m3.0k shares |
Biggest puts
| Deep Track Capital, LP | New | $37.3m100.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $34.9m93.7k shares |
| Caption Management, LLC | New | $24.6m66.0k shares |
| CITADEL ADVISORS LLC | Added | $18.7m50.3k shares |
| JPMORGAN CHASE & CO | New | $14.8m39.8k shares |
| GROUP ONE TRADING LLC | Added | $8.3m22.2k shares |
| Optiver Holding B.V. | Reduced | $7.7m20.6k shares |
| SIMPLEX TRADING, LLC | Added | $6.7m18.1k shares |
| Walleye Trading LLC | Added | $4.1m10.9k shares |
| Walleye Capital LLC | Added | $2.7m7.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
No one currently above 5% in the filings since 19 Dec 2024.
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q1 2023.
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.18% of their portfolio | 10.5m $3.9bn | Added +5.3m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.21% of their portfolio | 3.8m $1.4bn | Reduced -135.7k |
| Artisan Partners Limited Partnership 1.87% of their portfolio | 3.0m $1.1bn | Added +416.8k |
| JANUS HENDERSON GROUP PLC 0.44% of their portfolio | 1.8m $668.7m | Added +820.1k |
| Avoro Capital Advisors LLC 7.12% of their portfolio | 1.3m $479.7m | Added +21.9k |
| JENNISON ASSOCIATES LLC 0.39% of their portfolio | 1.1m $424.0m | Reduced -344.9k |
| T. Rowe Price Investment Management, Inc. 0.30% of their portfolio | 1.1m $412.4m | Reduced -120.1k |
| Capital World Investors 0.08% of their portfolio | 1.1m $394.0m | Added +316.6k |
| Bellevue Group AG 4.80% of their portfolio | 886.9k $330.5m | Reduced -24.2k |
| BlackRock Inc. 0.01% of their portfolio | 670.7k $249.9m | Reduced -90.6k |
| MORGAN STANLEY 0.02% of their portfolio | 546.5k $203.6m | Reduced -83.8k |
| RTW INVESTMENTS, LP 3.74% of their portfolio | 482.2k $179.7m | Unchanged |
| PICTET ASSET MANAGEMENT SA 0.21% of their portfolio | 440.2k $164.0m | Reduced -9.6k |
| DEUTSCHE BANK AG\ 0.09% of their portfolio | 431.2k $160.7m | Reduced -25 |
| Rock Springs Capital Management LP 3.11% of their portfolio | 350.0k $130.4m | Unchanged |
| FEDERATED HERMES, INC. 0.32% of their portfolio | 346.2k $129.0m | Reduced -32.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.28% of their portfolio | 336.4k $125.3m | Added +49.0k |
| Holocene Advisors, LP 0.63% of their portfolio | 335.7k $125.1m | Reduced -174.9k |
| EVENTIDE ASSET MANAGEMENT, LLC 2.25% of their portfolio | 328.9k $122.5m | Added +49 |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 297.8k $111.0m | Added +193.4k |
| Darwin Global Management, Ltd. 29.06% of their portfolio | 285.2k $106.3m | Reduced -12.5k |
| Avidity Partners Management LP 3.47% of their portfolio | 280.7k $104.6m | Reduced -344.3k |
| BAKER BROS. ADVISORS LP 0.57% of their portfolio | 280.2k $104.4m | Unchanged |
| SEI INVESTMENTS CO 0.18% of their portfolio | 266.9k $99.4m | Added +95.5k |
| LORD, ABBETT & CO. LLC 0.18% of their portfolio | 263.4k $98.1m | Reduced -26.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 258.3k $96.2m | Added +37.6k |
| BAMCO INC /NY/ 0.28% of their portfolio | 249.0k $92.8m | Reduced -115.3k |
| FRANKLIN RESOURCES INC 0.05% of their portfolio | 246.7k $91.9m | Added +35.6k |
| ARMISTICE CAPITAL, LLC 1.94% of their portfolio | 224.0k $83.5m | Added +54.0k |
| 1832 Asset Management L.P. 0.17% of their portfolio | 220.2k $82.0m | Reduced -1.0k |
| AMERICAN CENTURY COMPANIES INC 0.06% of their portfolio | 206.3k $73.6m | Reduced -6.6k |
| D. E. Shaw & Co., Inc. 0.12% of their portfolio | 197.9k $73.7m | Reduced -59.2k |
| MARSHALL WACE, LLP 0.17% of their portfolio | 187.9k $70.0m | Added +57.3k |
| MILLENNIUM MANAGEMENT LLC 0.08% of their portfolio | 182.4k $67.9m | Added +82.9k |
| Paradigm Biocapital Advisors LP 6.40% of their portfolio | 181.2k $67.5m | Added +91.6k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 168.9k $62.9m | Reduced -21.0k |
| Fiera Capital Corp 0.18% of their portfolio | 161.4k $60.2m | Reduced -2.7k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.07% of their portfolio | 133.2k $49.6m | Added +15.2k |
| Clearbridge Investments, LLC 0.05% of their portfolio | 132.6k $49.4m | Reduced -9.5k |
| STATE STREET CORP 0.00% of their portfolio | 132.0k $48.8m | Added +129.4k |
| Redmile Group, LLC 2.11% of their portfolio | 130.5k $48.6m | Reduced -18.0k |
| Nicholas Investment Partners, LP 3.36% of their portfolio | 118.6k $44.2m | Added +52.5k |
| TD Asset Management Inc 0.05% of their portfolio | 117.1k $43.6m | Reduced -12.0k |
| PFM Health Sciences, LP 1.80% of their portfolio | 104.7k $39.0m | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.05% of their portfolio | 99.6k $37.1m | Added +15.5k |
| Balyasny Asset Management L.P. 0.12% of their portfolio | 97.5k $36.3m | Added +27.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 96.3k $35.9m | Added +45.7k |
| TimesSquare Capital Management, LLC 0.51% of their portfolio | 93.2k $34.7m | Reduced -37.6k |
| Tekla Capital Management LLC 1.25% of their portfolio | 88.3k $32.9m | Added +4.3k |
| Hudson Bay Capital Management LP 0.18% of their portfolio | 82.5k $30.8m | New |
| Allspring Global Investments Holdings, LLC 0.05% of their portfolio | 78.7k $29.3m | Added +5.2k |
| Public Sector Pension Investment Board 0.22% of their portfolio | 77.4k $28.8m | Reduced -12.4k |
| Thrivent Financial for Lutherans 0.07% of their portfolio | 77.2k $28.7m | Added +1.0k |
| Fairmount Funds Management LLC 4.71% of their portfolio | 73.5k $27.4m | Unchanged |
| Eagle Health Investments LP 4.67% of their portfolio | 64.4k $24.0m | Added +4.1k |
| VAN ECK ASSOCIATES CORP 0.05% of their portfolio | 59.4k $22.1m | Added +9.9k |
| Invesco Ltd. 0.01% of their portfolio | 57.3k $21.3m | Reduced -15.6k |
| Legal & General Group Plc 0.01% of their portfolio | 51.2k $19.1m | Added +1.8k |
| AWM Investment Company, Inc. 2.52% of their portfolio | 50.0k $18.6m | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.04% of their portfolio | 48.1k $17.9m | Reduced -27.6k |
| Assenagon Asset Management S.A. 0.07% of their portfolio | 46.9k $17.5m | Reduced -88.3k |
| PGGM Investments 0.28% of their portfolio | 44.6k $16.6m | New |
| ORBIMED ADVISORS LLC 0.33% of their portfolio | 44.5k $16.6m | Added +28.3k |
| BARCLAYS PLC 0.02% of their portfolio | 39.4k $14.7m | Added +39.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 37.9k $14.1m | Reduced -3.2k |
| Artia Global Partners LP 5.46% of their portfolio | 36.4k $13.6m | Reduced -48.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 34.5k $12.8m | Reduced -5.7k |
| Driehaus Capital Management LLC 0.18% of their portfolio | 33.9k $12.6m | Added +231 |
| QVT Financial LP 0.71% of their portfolio | 32.5k $12.1m | Unchanged |
| ExodusPoint Capital Management, LP 0.13% of their portfolio | 31.4k $11.7m | Added +14.0k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 29.9k $11.2m | Reduced -33.8k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 27.5k $10.3m | Reduced -95.6k |
| Decheng Capital Management III (Cayman), LLC 4.12% of their portfolio | 27.4k $10.2m | Added +21.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 26.9k $10.0m | Added +759 |
| DCF Advisers, LLC 7.06% of their portfolio | 25.7k $9.6m | Added +700 |
| Senator Investment Group LP 0.51% of their portfolio | 25.0k $9.3m | Reduced -15.0k |
| Atika Capital Management LLC 1.43% of their portfolio | 24.7k $9.2m | Reduced -2.8k |
| BRAIDWELL LP 0.30% of their portfolio | 24.6k $9.2m | Reduced -24.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 24.3k $9.1m | Added +132 |
| Aquilo Capital Management, LLC 5.24% of their portfolio | 24.0k $8.9m | Unchanged |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 23.7k $8.8m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 21.8k $8.1m | Added +740 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 20.3k $7.5m | Added +567 |
| Varma Mutual Pension Insurance Co 0.09% of their portfolio | 20.0k $7.5m | New |
| Handelsbanken Fonder AB 0.04% of their portfolio | 19.2k $7.2m | Reduced -767 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio | 19.1k $7.1m | Added +2.8k |
| Lombard Odier Asset Management (Switzerland) SA 0.62% of their portfolio | 19.0k $7.1m | New |
| PINEBRIDGE INVESTMENTS, L.P. 0.08% of their portfolio | 18.6k $6.9m | Added +5.1k |
| AXA S.A. 0.02% of their portfolio | 17.5k $6.5m | Reduced -46.7k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 17.4k $6.5m | Unchanged |
| Brookfield Corp /ON/ 0.02% of their portfolio | 16.8k $6.3m | Reduced -3.5k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 16.7k $6.2m | Reduced -15.9k |
| SG Americas Securities, LLC 0.08% of their portfolio | 16.6k $6.2m | Reduced -1.9k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 15.5k $5.8m | Added +294 |
| Alyeska Investment Group, L.P. 0.05% of their portfolio | 15.0k $5.6m | New |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP 0.24% of their portfolio | 14.7k $5.5m | Reduced -1.4k |
| Jump Financial, LLC 0.22% of their portfolio | 14.2k $5.3m | Added +8.5k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 13.7k $5.1m | Added +678 |
| Verition Fund Management LLC 0.08% of their portfolio | 13.7k $5.1m | Added +1.4k |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 13.6k $5.1m | Reduced -21.0k |