ALPINE IMMUNE SCIENCES INC NVLS
COM · Common Stock · CUSIP 02083G100
61
institutional holders
-3 vs Q4 2022
34.7m
shares reported held*
$267.7mreported value*
5 new
26 added
13 reduced
7 sold out
net bought ≈ $4.9m (+637.3k shares)
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $7.72. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 70 |
| Q4 2022 | 64 |
| Q1 2023 | 61 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Bought or addedCut or sold out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 40 | 24 |
| Q1 2023 | 31 | 20 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
CallsPuts
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $1.0k | — |
| Q4 2022 | $8.1k | $735 | 0.09 |
| Q1 2023 | $0 | $0 | — |
Biggest buyers
| RA CAPITAL MANAGEMENT, L.P. | Added | +290.7k |
| Ghost Tree Capital, LLC | New | +200.0k |
| BlackRock Inc. | Added | +116.1k |
| GREAT POINT PARTNERS LLC | Added | +103.0k |
| HighVista Strategies LLC | New | +90.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +70.5k |
| STATE STREET CORP | Added | +43.3k |
| DIMENSIONAL FUND ADVISORS LP | Added | +40.9k |
| Walleye Capital LLC | New | +34.1k |
| JPMORGAN CHASE & CO | Added | +33.9k |
Biggest sellers
| BVF INC/IL | Reduced | -277.6k |
| Avidity Partners Management LP | Reduced | -38.7k |
| PURA VIDA INVESTMENTS, LLC | Sold out | -30.9k |
| TWO SIGMA ADVISERS, LP | Reduced | -24.2k |
| Octagon Capital Advisors LP | Reduced | -23.0k |
| CITADEL ADVISORS LLC | Sold out | -21.2k |
| Trexquant Investment LP | Sold out | -16.8k |
| Bank of New York Mellon Corp | Reduced | -11.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -11.5k |
| Allspring Global Investments Holdings, LLC | Sold out | -4.5k |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.82% of their portfolio | 4.7m $36.2m | Added +290.7k |
| ORBIMED ADVISORS LLC 0.62% of their portfolio | 4.1m $31.5m | Unchanged |
| GREAT POINT PARTNERS LLC 5.71% of their portfolio | 3.7m $28.9m | Added +103.0k |
| Lynx1 Capital Management LP 20.18% of their portfolio | 3.1m $24.2m | Added +10.0k |
| Frazier Life Sciences Management, L.P. 1.67% of their portfolio | 3.0m $23.1m | Unchanged |
| Paradigm Biocapital Advisors LP 1.70% of their portfolio | 2.3m $17.9m | Unchanged |
| Omega Fund Management, LLC 10.22% of their portfolio | 2.0m $15.7m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 1.6m $12.0m | Added +116.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $10.6m | Added +9.2k |
| Commodore Capital LP 1.56% of their portfolio | 1.3m $10.2m | Unchanged |
| Octagon Capital Advisors LP 1.34% of their portfolio | 1.2m $9.3m | Reduced -23.0k |
| Artal Group S.A. 0.55% of their portfolio | 1.2m $9.2m | Unchanged |
| Avidity Partners Management LP 0.25% of their portfolio | 989.5k $7.6m | Reduced -38.7k |
| BVF INC/IL 0.24% of their portfolio | 858.3k $6.6m | Reduced -277.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 556.2k $4.3m | Added +70.5k |
| STATE STREET CORP 0.00% of their portfolio | 346.7k $2.7m | Added +43.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 330.3k $2.5m | Reduced -2.6k |
| TCG Crossover Management, LLC 0.38% of their portfolio | 253.1k $2.0m | Unchanged |
| Affinity Asset Advisors, LLC 0.74% of their portfolio | 247.9k $1.9m | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. 0.33% of their portfolio | 200.0k $1.5m | Unchanged |
| Ghost Tree Capital, LLC 0.58% of their portfolio | 200.0k $1.5m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 194.0k $1.5m | Added +2.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 139.7k $1.1m | Added +40.9k |
| HighVista Strategies LLC 0.57% of their portfolio | 90.3k $697.0k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 71.8k $554.3k | Reduced -11.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 67.3k $519.3k | Added +2.8k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 54.2k $418.7k | Reduced -4.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 48.1k $372.0k | Added +33.9k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 41.0k $316.3k | Reduced -24.2k |
| Walleye Capital LLC 0.01% of their portfolio | 34.1k $263.4k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 32.8k $254.0k | Added +6.6k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 31.7k $245.0k | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 30.9k $238.2k | Added +368 |
| MORGAN STANLEY 0.00% of their portfolio | 27.9k $215.5k | Added +10.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 23.5k $181.4k | Reduced -166 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 20.5k $158.4k | Added +5.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 19.6k $152.0k | Added +224 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 14.8k $113.9k | Added +6.6k |
| Hikari Power Ltd 0.01% of their portfolio | 12.4k $96.0k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 12.1k $93.2k | Added +6.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 12.0k $92.9k | Unchanged |
| Western Wealth Management, LLC 0.01% of their portfolio | 12.0k $92.6k | Unchanged |
| SG Americas Securities, LLC 0.00% of their portfolio | 11.9k $92.0k | New |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 11.4k $88.1k | Added +708 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 10.6k $82.1k | Reduced -11.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 8.8k $67.9k | Reduced -242 |
| UBS Group AG 0.00% of their portfolio | 8.0k $61.7k | Added +5.7k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 5.5k $42.5k | Added +68 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 4.4k $33.9k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 2.8k $22.0k | Added +448 |
| FMR LLC 0.00% of their portfolio | 2.5k $19.4k | Added +1.8k |
| Legal & General Group Plc 0.00% of their portfolio | 2.5k $19.1k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 1.9k $14.7k | Added +989 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.5k $12.0k | Added +478 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.3k $10.0k | Reduced -1.8k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 623 $4.8k | Added +156 |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 537 $4.1k | Reduced -881 |
| CITIGROUP INC 0.00% of their portfolio | 523 $4.0k | Reduced -71 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 85 $1.0k | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 12 $0 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |