Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

130 institutional holders +8 vs Q4 2022
55,982,69356.0m shares reported held*
$899.1mreported value*
21 new 59 added 28 reduced 12 sold out net bought ≈ $21.1m (+1.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($17.7k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $16.06. Options: 3 managers hold calls ($472.0k notional), 2 hold puts ($1.6k).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 122Q4 22: 122Q1 23: 130130Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 55 bought or addedQ4 22: 50 cut or sold outQ4 22Q1 23: 80 bought or addedQ1 23: 40 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20225550
Q1 20238040

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ3 22 calls: $2.5mQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $43.1kQ4 22 puts: $20.1kQ4 22P/C 0.47Q1 23 calls: $472.0kQ1 23 puts: $1.6kQ1 23P/C 0.00
Numbers
QuarterCallsPutsP/C
Q3 2022$2.5m$00.00
Q4 2022$43.1k$20.1k0.47
Q1 2023$472.0k$1.6k0.00

Biggest buyers

T. Rowe Price Investment Management, Inc. New +929,369+929.4k
WELLINGTON MANAGEMENT GROUP LLP Added +831,041+831.0k
ORBIMED ADVISORS LLC Added +753,920+753.9k
GW&K Investment Management, LLC New +536,880+536.9k
MORGAN STANLEY Added +500,328+500.3k
EVENTIDE ASSET MANAGEMENT, LLC New +434,768+434.8k
GOLDMAN SACHS GROUP INC Added +386,882+386.9k
NOVO HOLDINGS A/S Added +362,943+362.9k
VANGUARD GROUP INC Added +306,675+306.7k
First Light Asset Management, LLC Added +289,812+289.8k

Biggest sellers

BRAIDWELL LP Reduced -1,449,960-1.4m
Point72 Asset Management, L.P. Reduced -1,134,600-1.1m
Deep Track Capital, LP Sold out -1,048,829-1.0m
SPHERA FUNDS MANAGEMENT LTD. Reduced -588,897-588.9k
PERCEPTIVE ADVISORS LLC Reduced -484,389-484.4k
MILLENNIUM MANAGEMENT LLC Reduced -480,681-480.7k
Driehaus Capital Management LLC Reduced -335,225-335.2k
SILVERARC CAPITAL MANAGEMENT, LLC Sold out -152,747-152.7k
BANK OF MONTREAL /CAN/ Sold out -147,000-147.0k
Atom Investors LP Reduced -68,580-68.6k

Biggest calls

CITADEL ADVISORS LLC Added $363.0k22.6k shares
SIMPLEX TRADING, LLC Added $109.0k6.8k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Reduced $1.6k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Driehaus Capital Management LLC 1.19% of their portfolio Chicago, IL 5,289,5195.3m $84.9m $84.9m 1.19% Reduced -335.2k -335,225
2 BlackRock Inc. 0.00% of their portfolio New York, NY 3,956,3584.0m $63.5m $63.5m 0.00% Added +38.9k +38,869
3 ORBIMED ADVISORS LLC 1.26% of their portfolio New York, NY 3,950,7964.0m $63.4m $63.4m 1.26% Added +753.9k +753,920
4 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 3,635,5263.6m $58.4m $58.4m 0.01% Added +831.0k +831,041
5 PERCEPTIVE ADVISORS LLC 1.69% of their portfolio NEW YORK, NY 3,554,8873.6m $57.1m $57.1m 1.69% Reduced -484.4k -484,389
6 BVF INC/IL 1.61% of their portfolio San Francisco, CA 2,736,6132.7m $44.0m $44.0m 1.61% Unchanged
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,693,0622.7m $43.3m $43.3m 0.00% Added +306.7k +306,675
8 Bain Capital Life Sciences Investors, LLC 4.63% of their portfolio Boston, MA 2,305,5582.3m $37.0m $37.0m 4.63% Unchanged
9 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,218,7942.2m $35.6m $35.6m 0.00% Added +214.0k +214,010
10 BRAIDWELL LP 1.07% of their portfolio STAMFORD, CT 2,019,7142.0m $32.4m $32.4m 1.07% Reduced -1.4m -1,449,960
11 FMR LLC 0.00% of their portfolio BOSTON, MA 1,841,9161.8m $29.6m $29.6m 0.00% Reduced -41.2k -41,202
12 First Light Asset Management, LLC 2.34% of their portfolio Edina, MN 1,619,1251.6m $26.0m $26.0m 2.34% Added +289.8k +289,812
13 Frazier Life Sciences Management, L.P. 1.65% of their portfolio PALO ALTO, CA 1,414,8231.4m $22.7m $22.7m 1.65% Unchanged
14 EcoR1 Capital, LLC 0.69% of their portfolio San Francisco, CA 1,330,2631.3m $21.4m $21.4m 0.69% Unchanged
15 Paradigm Biocapital Advisors LP 1.73% of their portfolio NEW YORK, NY 1,133,7821.1m $18.2m $18.2m 1.73% Added +243.7k +243,677
16 NOVO HOLDINGS A/S 1.17% of their portfolio HELLERUP, G7 1,100,0001.1m $17.7m $17.7m 1.17% Added +362.9k +362,943
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 954,860954.9k $15.3m $15.3m 0.00% Added +33.6k +33,630
18 T. Rowe Price Investment Management, Inc. 0.01% of their portfolio BALTIMORE, MD 929,369929.4k $14.9m $14.9m 0.01% New
19 Finepoint Capital LP 5.33% of their portfolio BOSTON, MA 868,427868.4k $13.9m $13.9m 5.33% Added +45.7k +45,682
20 5AM Venture Management, LLC 3.54% of their portfolio SAN FRANCISCO, CA 862,286862.3k $13.8m $13.8m 3.54% Unchanged
21 Opaleye Management Inc. 3.78% of their portfolio BOSTON, MA 785,794785.8k $12.6m $12.6m 3.78% Added +53.8k +53,794
22 Saturn V Capital Management LP 8.89% of their portfolio AUSTIN, TX 741,043741.0k $11.9m $11.9m 8.89% Added +117.2k +117,224
23 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio Paris, I0 691,201691.2k $11.1m $11.1m 0.04% Added +80.5k +80,511
24 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 652,916652.9k $10.5m $10.5m 0.00% Added +500.3k +500,328
25 GW&K Investment Management, LLC 0.08% of their portfolio BOSTON, MA 536,880536.9k $8.6m $8.6m 0.08% New
26 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 520,198520.2k $8.4m $8.4m 0.00% Added +386.9k +386,882
27 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 477,288477.3k $7.7m $7.7m 0.00% Reduced -3.5k -3,512
28 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 449,605449.6k $7.2m $7.2m 0.00% Reduced -59.2k -59,243
29 EVENTIDE ASSET MANAGEMENT, LLC 0.13% of their portfolio Boston, MA 434,768434.8k $7.0m $7.0m 0.13% New
30 Walleye Capital LLC 0.14% of their portfolio NEW YORK, NY 433,695433.7k $7.0m $7.0m 0.14% Added +28.1k +28,136
31 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 422,789422.8k $6.8m $6.8m 0.00% Added +71.0k +71,030
32 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 416,252416.3k $6.7m $6.7m 0.00% Added +10.0k +9,988
33 MPM BIOIMPACT LLC 1.50% of their portfolio BOSTON, MA 360,392360.4k $5.8m $5.8m 1.50% Reduced -11.2k -11,247
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 345,567345.6k $5.5m $5.5m 0.00% Added +2.5k +2,512
35 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 285,595285.6k $4.6m $4.6m 0.01% Added +248.2k +248,239
36 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 270,269270.3k $4.3m $4.3m 0.01% Unchanged
37 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 226,400226.4k $3.6m $3.6m 0.01% Reduced -1.1m -1,134,600
38 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 176,473176.5k $2.8m $2.8m 0.00% Added +52.4k +52,406
39 FIRST MANHATTAN CO. LLC. 0.01% of their portfolio NEW YORK, NY 152,200152.2k $2.4m $2.4m 0.01% Unchanged
40 NORGES BANK 0.00% of their portfolio OSLO, Q8 149,100149.1k $2.4m $2.4m 0.00% New
41 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 147,116147.1k $2.4m $2.4m 0.03% New
42 New Leaf Venture Partners, L.L.C. 1.87% of their portfolio New York, NY 141,000141.0k $2.3m $2.3m 1.87% Unchanged
43 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 138,530138.5k $2.2m $2.2m 0.00% New
44 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 128,708128.7k $2.1m $2.1m 0.01% Added +22.2k +22,210
45 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 124,309124.3k $2.0m $2.0m 0.00% Reduced -13.4k -13,384
46 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 109,273109.3k $1.8m $1.8m 0.00% Added +40.4k +40,430
47 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 103,817103.8k $1.7m $1.7m 0.00% Added +54.9k +54,946
48 Altium Capital Management LLC 0.96% of their portfolio NEW YORK, NY 100,000100.0k $1.6m $1.6m 0.96% New
49 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 94,80794.8k $1.5m $1.5m 0.00% Reduced -480.7k -480,681
50 SPHERA FUNDS MANAGEMENT LTD. 0.29% of their portfolio TEL AVIV, L3 82,74782.7k $1.3m $1.3m 0.29% Reduced -588.9k -588,897
51 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 81,90481.9k $1.3m $1.3m 0.00% Added +2.9k +2,916
52 Swiss National Bank 0.00% of their portfolio ZURICH, V8 81,30081.3k $1.3m $1.3m 0.00% Reduced -9.5k -9,500
53 Tekla Capital Management LLC 0.05% of their portfolio Boston, MA 78,52978.5k $1.3m $1.3m 0.05% Added +32.7k +32,668
54 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 73,89073.9k $1.2m $1.2m 0.01% New
55 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 68,27168.3k $1.1m $1.1m 0.00% Reduced -8.7k -8,653
56 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 61,98762.0k $995.5k $995.5k 0.00% Added +51.8k +51,752
57 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 60,30060.3k $968.4k $968.4k 0.00% Reduced -39.1k -39,100
58 UBS Group AG 0.00% of their portfolio ZURICH, V8 59,16859.2k $950.2k $950.2k 0.00% Reduced -21.5k -21,526
59 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 58,78858.8k $944.1k $944.1k 0.00% Added +31.1k +31,144
60 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 52,65652.7k $845.7k $845.7k 0.00% Reduced -1.0k -1,022
61 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 51,20051.2k $822.3k $822.3k 0.00% Unchanged
62 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 48,35548.4k $777.0k $777.0k 0.01% Added +3.4k +3,366
63 HighVista Strategies LLC 0.63% of their portfolio BOSTON, MA 48,24548.2k $774.8k $774.8k 0.63% Reduced -45.6k -45,648
64 MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio BOSTON, MA 48,18048.2k $773.8k $773.8k 0.01% Added +2.5k +2,500
65 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 41,78341.8k $672.0k $672.0k 0.00% Reduced -10.1k -10,148
66 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 40,51340.5k $651.0k $651.0k 0.00% Added +5.8k +5,819
67 BIT Capital GmbH 0.10% of their portfolio BERLIN, 2M 40,06240.1k $643.4k $643.4k 0.10% Added +17.9k +17,925
68 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 38,41038.4k $616.9k $616.9k 0.00% Added +20.1k +20,129
69 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 38,31938.3k $615.4k $615.4k 0.00% Added +9.1k +9,062
70 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 35,52035.5k $570.5k $570.5k 0.01% Reduced -957 -957
71 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 34,76734.8k $558.4k $558.4k 0.00% Reduced -1.0k -1,027
72 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.01% of their portfolio CHICAGO, IL 33,42133.4k $536.7k $536.7k 0.01% New
73 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 32,20032.2k $517.1k $517.1k 0.00% Added +7.6k +7,588
74 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 31,72031.7k $509.4k $509.4k 0.00% Added +2.0k +2,038
75 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 30,98431.0k $497.6k $497.6k 0.00% Added +30.6k +30,567
76 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 30,11030.1k $483.6k $483.6k 0.00% Added +4.8k +4,841
77 GSA CAPITAL PARTNERS LLP 0.05% of their portfolio LONDON, X0 29,45529.5k $473.0k $473.0k 0.05% New
78 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 28,76428.8k $461.9k $461.9k 0.00% Reduced -10.4k -10,356
79 WESTWOOD HOLDINGS GROUP INC 0.00% of their portfolio DALLAS, TX 28,40228.4k $456.0k $456.0k 0.00% Added +3.0k +3,031
80 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 28,04728.0k $450.4k $450.4k 0.00% Unchanged
81 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 27,60027.6k $443.3k $443.3k 0.00% New
82 SG Americas Securities, LLC 0.01% of their portfolio NEW YORK, NY 26,16626.2k $420.0k $420.0k 0.01% Added +16.4k +16,399
83 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 25,39925.4k $407.9k $407.9k 0.00% Added +506 +506
84 Walleye Trading LLC 0.01% of their portfolio NEW YORK, NY 25,15425.2k $404.0k $404.0k 0.01% Added +7.3k +7,326
85 PROFUND ADVISORS LLC 0.02% of their portfolio BETHESDA, MD 24,40324.4k $391.9k $391.9k 0.02% New
86 Legal & General Group Plc 0.00% of their portfolio London, X0 22,54722.5k $362.1k $362.1k 0.00% Added +6.6k +6,601
87 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 20,60620.6k $330.9k $330.9k 0.00% Unchanged
88 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 20,41520.4k $327.9k $327.9k 0.00% Unchanged
89 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 20,22220.2k $325.0k $325.0k 0.00% Added +8.5k +8,458
90 J.P. Morgan Private Wealth Advisors LLC 0.00% of their portfolio SAN FRANCISCO, CA 19,76119.8k $317.4k $317.4k 0.00% Added +545 +545
91 ALGERT GLOBAL LLC 0.01% of their portfolio SAN FRANCISCO, CA 18,71018.7k $300.5k $300.5k 0.01% Added +1.3k +1,304
92 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 17,03817.0k $273.6k $273.6k 0.00% Unchanged
93 Ergoteles LLC 0.01% of their portfolio NEW YORK, NY 16,15716.2k $259.5k $259.5k 0.01% Reduced -2.9k -2,927
94 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 13,98814.0k $224.6k $224.6k 0.00% Added +1.7k +1,654
95 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 13,74513.7k $220.7k $220.7k 0.00% Reduced -12.3k -12,321
96 Connacht Asset Management LP 0.62% of their portfolio New York, NY 13,39113.4k $215.1k $215.1k 0.62% Added +1.1k +1,054
97 Atom Investors LP 0.11% of their portfolio AUSTIN, TX 12,88612.9k $206.9k $206.9k 0.11% Reduced -68.6k -68,580
98 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 12,70312.7k $204.0k $204.0k 0.01% New
99 MBB PUBLIC MARKETS I LLC 0.01% of their portfolio CHICAGO, IL 11,70211.7k $187.9k $187.9k 0.01% New
100 TEACHER RETIREMENT SYSTEM OF TEXAS 0.00% of their portfolio AUSTIN, TX 11,60311.6k $186.0k $186.0k 0.00% Added +253 +253