Vault-13

AKERO THERAPEUTICS INC AKRO

COM · Common Stock · CUSIP 00973Y108

157 institutional holders -5 vs Q4 2022
49,207,56749.2m shares reported held*
$1.9bnreported value*
18 new 57 added 56 reduced 21 sold out net bought ≈ $22.5m (+579.9k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($169.2k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $38.26. Options: 14 managers hold calls ($25.3m notional), 14 hold puts ($16.9m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 146Q4 22: 162Q1 23: 157157Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 2022146
Q4 2022162
Q1 2023157

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 103 bought or addedQ4 22: 60 cut or sold outQ4 22Q1 23: 75 bought or addedQ1 23: 77 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 202210360
Q1 20237577

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 22 calls: $24.0mQ3 22 puts: $42.4mQ3 22P/C 1.77Q4 22 calls: $54.4mQ4 22 puts: $55.7mQ4 22P/C 1.02Q1 23 calls: $25.3mQ1 23 puts: $16.9mQ1 23P/C 0.67
Numbers
QuarterCallsPutsP/C
Q3 2022$24.0m$42.4m1.77
Q4 2022$54.4m$55.7m1.02
Q1 2023$25.3m$16.9m0.67

Biggest buyers

FMR LLC Added +2,262,159+2.3m
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +1,064,914+1.1m
CITADEL ADVISORS LLC Added +593,991+594.0k
JANUS HENDERSON GROUP PLC Added +471,502+471.5k
EVENTIDE ASSET MANAGEMENT, LLC New +379,120+379.1k
WELLINGTON MANAGEMENT GROUP LLP Added +284,443+284.4k
Commodore Capital LP Added +252,924+252.9k
PRICE T ROWE ASSOCIATES INC /MD/ Added +222,643+222.6k
VICTORY CAPITAL MANAGEMENT INC Added +199,495+199.5k
Ghost Tree Capital, LLC Added +190,000+190.0k

Biggest sellers

Avidity Partners Management LP Reduced -1,378,000-1.4m
RA CAPITAL MANAGEMENT, L.P. Sold out -958,980-959.0k
Paradigm Biocapital Advisors LP Sold out -604,544-604.5k
Redmile Group, LLC Reduced -588,523-588.5k
MARSHALL WACE, LLP Reduced -421,639-421.6k
Yiheng Capital Management, L.P. Reduced -343,114-343.1k
STATE STREET CORP Reduced -270,162-270.2k
MILLENNIUM MANAGEMENT LLC Reduced -236,851-236.9k
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Sold out -234,000-234.0k
Public Sector Pension Investment Board Sold out -214,000-214.0k

Biggest calls

Yiheng Capital Management, L.P. Reduced $6.3m163.8k shares
JANE STREET GROUP, LLC Reduced $4.7m122.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $4.2m110.0k shares
MILLENNIUM MANAGEMENT LLC New $2.7m70.0k shares
CITADEL ADVISORS LLC Reduced $2.0m52.9k shares
Walleye Trading LLC Added $1.5m40.1k shares
Caption Management, LLC New $1.1m30.0k shares
SIMPLEX TRADING, LLC Reduced $803.0k21.0k shares
GROUP ONE TRADING LLC Reduced $700.2k18.3k shares
JPMORGAN CHASE & CO Unchanged $574.0k15.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $5.4m141.6k shares
JANE STREET GROUP, LLC Reduced $2.9m75.9k shares
UBS Group AG Unchanged $2.6m66.9k shares
Caption Management, LLC Added $2.3m60.0k shares
Jefferies Financial Group Inc. Reduced $1.1m29.1k shares
CITADEL ADVISORS LLC Reduced $937.4k24.5k shares
SIMPLEX TRADING, LLC Reduced $581.0k15.2k shares
JPMORGAN CHASE & CO New $425.0k11.1k shares
WOLVERINE TRADING, LLC Reduced $333.0k8.8k shares
Walleye Trading LLC Added $267.8k7.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GENERAL ATLANTIC, L.P. 13G · passive investor filed 2025-05-15 8.4% 6.8m 2025-05-15

Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (4.1%, 2026-02-17), RTW INVESTMENTS, LP (0.0%, 2026-02-17), Deep Track Capital, LP (0.0%, 2026-02-13), WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-02-10)

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.10% of their portfolio LONDON, X0 3,811,6763.8m $145.8m $145.8m 0.10% Added +471.5k +471,502
2 Skorpios Trust 50.58% of their portfolio LIMASSOL, G4 3,271,8293.3m $125.2m $125.2m 50.58% Unchanged
3 ALKEON CAPITAL MANAGEMENT LLC 0.79% of their portfolio New York, NY 3,220,7303.2m $123.2m $123.2m 0.79% Reduced -23.2k -23,185
4 BlackRock Inc. 0.00% of their portfolio New York, NY 2,783,3772.8m $106.5m $106.5m 0.00% Added +24.8k +24,848
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 2,623,6802.6m $100.4m $100.4m 0.02% Added +222.6k +222,643
6 Avidity Partners Management LP 3.11% of their portfolio DALLAS, TX 2,447,0002.4m $93.6m $93.6m 3.11% Reduced -1.4m -1,378,000
7 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.21% of their portfolio Boston, MA 2,389,8912.4m $91.4m $91.4m 0.21% Added +1.1m +1,064,914
8 BAKER BROS. ADVISORS LP 0.49% of their portfolio NEW YORK, NY 2,368,3782.4m $90.6m $90.6m 0.49% Unchanged
9 FMR LLC 0.00% of their portfolio BOSTON, MA 2,282,5702.3m $87.3m $87.3m 0.00% Added +2.3m +2,262,159
10 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,230,8072.2m $85.4m $85.4m 0.00% Reduced -270.2k -270,162
11 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,138,8932.1m $81.8m $81.8m 0.00% Added +22.3k +22,322
12 Redmile Group, LLC 3.39% of their portfolio LARKSPUR, CA 2,044,3892.0m $78.2m $78.2m 3.39% Reduced -588.5k -588,523
13 Rock Springs Capital Management LP 1.33% of their portfolio Baltimore, MD 1,454,2541.5m $55.6m $55.6m 1.33% Added +53.6k +53,600
14 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 1,160,5421.2m $44.4m $44.4m 0.01% Added +284.4k +284,443
15 Yiheng Capital Management, L.P. 3.36% of their portfolio SAN FRANCISCO, CA 1,125,7911.1m $43.1m $43.1m 3.36% Reduced -343.1k -343,114
16 MARSHALL WACE, LLP 0.10% of their portfolio LONDON, X0 1,081,7251.1m $41.4m $41.4m 0.10% Reduced -421.6k -421,639
17 CITADEL ADVISORS LLC 0.04% of their portfolio MIAMI, FL 855,708855.7k $32.7m $32.7m 0.04% Added +594.0k +593,991
18 Boxer Capital, LLC 1.56% of their portfolio San Diego, CA 831,495831.5k $31.8m $31.8m 1.56% Unchanged
19 Commodore Capital LP 4.60% of their portfolio NEW YORK, NY 790,000790.0k $30.2m $30.2m 4.60% Added +252.9k +252,924
20 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 665,927665.9k $25.5m $25.5m 0.00% Added +32.5k +32,547
21 Atlas Venture Life Science Advisors, LLC 3.08% of their portfolio CAMBRIDGE, MA 594,251594.3k $22.7m $22.7m 3.08% Unchanged
22 PERCEPTIVE ADVISORS LLC 0.59% of their portfolio NEW YORK, NY 523,525523.5k $20.0m $20.0m 0.59% Added +173.0k +173,000
23 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 519,575519.6k $19.9m $19.9m 0.01% Added +91.9k +91,892
24 Logos Global Management LP 2.19% of their portfolio San Francisco, CA 400,000400.0k $15.3m $15.3m 2.19% Unchanged
25 EVENTIDE ASSET MANAGEMENT, LLC 0.27% of their portfolio Boston, MA 379,120379.1k $14.5m $14.5m 0.27% New
26 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 368,011368.0k $14.1m $14.1m 0.02% Added +74.2k +74,167
27 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 357,767357.8k $13.7m $13.7m 0.00% Reduced -2.5k -2,510
28 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 357,593357.6k $13.7m $13.7m 0.00% Added +150.6k +150,593
29 HHLR ADVISORS, LTD. 0.20% of their portfolio GRAND CAYMAN, E9 295,502295.5k $11.3m $11.3m 0.20% Reduced -20.0k -20,000
30 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 283,516283.5k $10.8m $10.8m 0.00% Reduced -7.1k -7,090
31 Ghost Tree Capital, LLC 3.98% of their portfolio NEW YORK, NY 275,000275.0k $10.5m $10.5m 3.98% Added +190.0k +190,000
32 NORGES BANK 0.00% of their portfolio OSLO, Q8 270,576270.6k $10.4m $10.4m 0.00% Added +95.7k +95,676
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 238,347238.3k $9.1m $9.1m 0.00% Added +1.8k +1,750
34 Artisan Partners Limited Partnership 0.02% of their portfolio Milwaukee, WI 237,863237.9k $9.1m $9.1m 0.02% Reduced -602 -602
35 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 231,421231.4k $8.9m $8.9m 0.00% Added +29.0k +29,032
36 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 223,291223.3k $8.5m $8.5m 0.00% Added +37.4k +37,379
37 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 211,468211.5k $8.1m $8.1m 0.00% Added +28.2k +28,153
38 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 203,582203.6k $7.8m $7.8m 0.01% Added +199.5k +199,495
39 SILVERARC CAPITAL MANAGEMENT, LLC 3.48% of their portfolio BOSTON, MA 202,561202.6k $7.7m $7.7m 3.48% Added +30.5k +30,461
40 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 175,564175.6k $6.7m $6.7m 0.01% Added +12.3k +12,300
41 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 168,900168.9k $6.5m $6.5m 0.01% Added +101.3k +101,300
42 Rafferty Asset Management, LLC 0.04% of their portfolio New York, NY 164,503164.5k $6.3m $6.3m 0.04% Reduced -23.3k -23,296
43 Long Focus Capital Management, LLC 1.01% of their portfolio SAN JUAN, PR 164,000164.0k $6.3m $6.3m 1.01% Unchanged
44 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 133,517133.5k $5.1m $5.1m 0.01% Added +50.5k +50,458
45 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 122,592122.6k $4.7m $4.7m 0.00% Reduced -17.9k -17,890
46 Walleye Capital LLC 0.08% of their portfolio NEW YORK, NY 105,432105.4k $4.0m $4.0m 0.08% Added +15.9k +15,864
47 Candriam S.C.A. 0.03% of their portfolio STRASSEN, N4 105,000105.0k $3.7m $3.7m 0.03% Reduced -105.0k -105,000
48 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 98,70398.7k $3.8m $3.8m 0.01% Added +63.1k +63,149
49 UBS Group AG 0.00% of their portfolio ZURICH, V8 93,43293.4k $3.6m $3.6m 0.00% Reduced -45.5k -45,548
50 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 92,37992.4k $3.5m $3.5m 0.00% Reduced -8.1k -8,139
51 Tri Locum Partners LP 1.03% of their portfolio NEW YORK, NY 88,52488.5k $3.4m $3.4m 1.03% Reduced -40.3k -40,327
52 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio JUPITER, FL 84,90784.9k $3.2m $3.2m 0.02% Reduced -134.2k -134,165
53 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 77,22477.2k $3.0m $3.0m 0.00% Reduced -26.3k -26,328
54 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 73,89073.9k $2.8m $2.8m 0.00% Added +39.3k +39,310
55 Integral Health Asset Management, LLC 0.56% of their portfolio New York, NY 70,00070.0k $2.7m $2.7m 0.56% Unchanged
56 Swiss National Bank 0.00% of their portfolio ZURICH, V8 65,60065.6k $2.5m $2.5m 0.00% Reduced -5.4k -5,400
57 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 64,51764.5k $2.5m $2.5m 0.01% Added +26.8k +26,757
58 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 60,63660.6k $2.3m $2.3m 0.00% Added +26.5k +26,496
59 Simplify Asset Management Inc. 0.41% of their portfolio Las Vegas, NV 59,77759.8k $2.3m $2.3m 0.41% New
60 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 59,67859.7k $2.3m $2.3m 0.02% Reduced -38.5k -38,478
61 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 58,02258.0k $2.2m $2.2m 0.00% Added +5.6k +5,600
62 FEDERATED HERMES, INC. 0.01% of their portfolio PITTSBURGH, PA 58,00458.0k $2.2m $2.2m 0.01% Reduced -20 -20
63 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 57,65857.7k $2.2m $2.2m 0.00% Added +2.4k +2,415
64 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 54,87154.9k $2.1m $2.1m 0.00% Added +3.2k +3,158
65 Ikarian Capital, LLC 0.79% of their portfolio DALLAS, TX 50,00050.0k $1.9m $1.9m 0.79% New
66 Informed Momentum Co LLC 0.34% of their portfolio SOLANA BEACH, CA 44,68744.7k $1.7m $1.7m 0.34% Reduced -8.8k -8,825
67 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 39,67439.7k $1.5m $1.5m 0.00% Added +158 +158
68 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 38,09038.1k $1.5m $1.5m 0.00% Added +2.1k +2,121
69 TUDOR INVESTMENT CORP ET AL 0.03% of their portfolio STAMFORD, CT 36,88536.9k $1.4m $1.4m 0.03% Added +13.9k +13,887
70 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 36,61736.6k $1.4m $1.4m 0.00% Added +34.8k +34,800
71 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 34,00034.0k $1.3m $1.3m 0.00% Reduced -8.3k -8,322
72 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 30,81430.8k $1.2m $1.2m 0.01% Reduced -911 -911
73 PROFUND ADVISORS LLC 0.07% of their portfolio BETHESDA, MD 30,57830.6k $1.2m $1.2m 0.07% New
74 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 30,11930.1k $1.2m $1.2m 0.00% Added +1.5k +1,451
75 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 29,99630.0k $1.1m $1.1m 0.00% Added +16.3k +16,313
76 Legal & General Group Plc 0.00% of their portfolio London, X0 29,38729.4k $1.1m $1.1m 0.00% Added +16.2k +16,158
77 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 28,08128.1k $1.1m $1.1m 0.00% Added +1.4k +1,442
78 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 27,68227.7k $1.1m $1.1m 0.00% Reduced -4.9k -4,947
79 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 26,40526.4k $1.0m $1.0m 0.00% Reduced -10.4k -10,360
80 Chicago Partners Investment Group LLC 0.07% of their portfolio CHICAGO, IL 26,34626.3k $1.2m $1.2m 0.07% Added +352 +352
81 Bellevue Group AG 0.01% of their portfolio ZURICH, V8 26,10026.1k $998.6k $998.6k 0.01% Reduced -16.6k -16,550
82 ALGERT GLOBAL LLC 0.04% of their portfolio SAN FRANCISCO, CA 22,56422.6k $863.3k $863.3k 0.04% Added +8.7k +8,656
83 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 22,48722.5k $860.4k $860.4k 0.00% Added +6.2k +6,203
84 Caption Management, LLC 0.18% of their portfolio OKLAHOMA CITY, OK 22,16022.2k $847.8k $847.8k 0.18% Added +17.1k +17,060
85 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 21,60021.6k $812.0k $812.0k 0.00% Added +7.6k +7,600
86 TWINBEECH CAPITAL LP 0.02% of their portfolio PURCHASE, NY 20,59520.6k $788.0k $788.0k 0.02% New
87 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 20,09120.1k $768.7k $768.7k 0.01% Reduced -6.9k -6,945
88 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 19,77819.8k $756.7k $756.7k 0.01% Reduced -95.7k -95,706
89 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 18,65318.7k $713.7k $713.7k 0.00% Reduced -184.4k -184,375
90 HighVista Strategies LLC 0.58% of their portfolio BOSTON, MA 18,62918.6k $712.7k $712.7k 0.58% Unchanged
91 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 18,27918.3k $699.4k $699.4k 0.01% Unchanged
92 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 18,20018.2k $696.3k $696.3k 0.00% Reduced -2.9k -2,900
93 Hillsdale Investment Management Inc. 0.06% of their portfolio Toronto, A6 17,90017.9k $684.9k $684.9k 0.06% New
94 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 16,82516.8k $643.7k $643.7k 0.00% Added +334 +334
95 HRT FINANCIAL LP 0.01% of their portfolio NEW YORK, NY 16,48916.5k $630.0k $630.0k 0.01% New
96 Ergoteles LLC 0.02% of their portfolio NEW YORK, NY 15,82215.8k $605.4k $605.4k 0.02% New
97 CAPITAL FUND MANAGEMENT S.A. 0.01% of their portfolio PARIS, I0 15,23115.2k $582.7k $582.7k 0.01% New
98 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 11,60011.6k $443.8k $443.8k 0.00% Reduced -3.7k -3,678
99 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 10,66010.7k $407.9k $407.9k 0.00% Added +1.3k +1,313
100 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 10,16610.2k $389.0k $389.0k 0.00% Reduced -236.9k -236,851