Vault-13

BICYCLE THERAPEUTICS PLC BCYC

SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088

Company in Cambridge, United Kingdom

90 institutional holders +3 vs Q4 2022
23,802,16123.8m shares reported held*
$504.1mreported value*
18 new 35 added 16 reduced 13 sold out net bought ≈ $55.3m (+2.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($931.8k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $21.18. Options: 8 managers hold calls ($9.7m notional), 6 hold puts ($2.5m).

Trends to Q1 2023

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 80Q4 22: 87Q1 23: 9090Q3 22Q4 22Q1 23
Numbers
QuarterHolders
Q3 202280
Q4 202287
Q1 202390

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 32 bought or addedQ4 22: 43 cut or sold outQ4 22Q1 23: 53 bought or addedQ1 23: 29 cut or sold outQ1 23
Numbers
QuarterBought or addedCut or sold out
Q4 20223243
Q1 20235329

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2.5m$5m$7.5m$10mQ3 22 calls: $18.0kQ3 22 puts: $18.0kQ3 22P/C 1.00Q4 22 calls: $538.2kQ4 22 puts: $3.3mQ4 22P/C 6.12Q1 23 calls: $9.7mQ1 23 puts: $2.5mQ1 23P/C 0.26
Numbers
QuarterCallsPutsP/C
Q3 2022$18.0k$18.0k1.00
Q4 2022$538.2k$3.3m6.12
Q1 2023$9.7m$2.5m0.26

Biggest buyers

Jefferies Financial Group Inc. New +1,948,000+1.9m
MORGAN STANLEY Added +786,190+786.2k
ARMISTICE CAPITAL, LLC New +736,000+736.0k
Paradigm Biocapital Advisors LP Added +583,501+583.5k
TYBOURNE CAPITAL MANAGEMENT (HK) LTD Added +503,109+503.1k
Sio Capital Management, LLC Added +283,922+283.9k
Polar Capital Holdings Plc Added +259,500+259.5k
BNP PARIBAS ASSET MANAGEMENT Holding S.A. Added +218,605+218.6k
Ikarian Capital, LLC New +207,112+207.1k
Rubric Capital Management LP New +205,423+205.4k

Biggest sellers

RTW INVESTMENTS, LP Sold out -1,258,587-1.3m
SAMLYN CAPITAL, LLC Sold out -987,888-987.9k
EVENTIDE ASSET MANAGEMENT, LLC Sold out -853,800-853.8k
Logos Global Management LP Reduced -685,000-685.0k
PURA VIDA INVESTMENTS, LLC Sold out -239,015-239.0k
Point72 Asset Management, L.P. Reduced -205,578-205.6k
MILLENNIUM MANAGEMENT LLC Reduced -151,887-151.9k
ALLIANCEBERNSTEIN L.P. Sold out -72,549-72.5k
GOLDMAN SACHS GROUP INC Reduced -70,005-70.0k
L & S Advisors Inc Sold out -34,950-35.0k

Biggest calls

Ikarian Capital, LLC New $4.3m200.0k shares
SIMPLEX TRADING, LLC Added $2.1m97.8k shares
Caption Management, LLC New $2.0m95.7k shares
BOOTHBAY FUND MANAGEMENT, LLC New $852.9k40.1k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $385.0k18.1k shares
CITADEL ADVISORS LLC Reduced $87.2k4.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares
Cutler Group LLC / CA New $0400 shares

Biggest puts

GROUP ONE TRADING LLC Unchanged $821.0k38.6k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $787.0k37.0k shares
CITADEL ADVISORS LLC Added $574.3k27.0k shares
SIMPLEX TRADING, LLC Reduced $280.0k13.2k shares
Cutler Group LLC / CA Added $12.0k1.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 7.3% new 3.5m 2024-12-19
ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 6.7% no change 3.4m 2026-08-14
Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 6.6% new 3.3m 2026-05-15

Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)

Insider purchases and sales in Q1 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
10010Q2 21: 0 buyingQ2 21: 0 sellingQ3 21: 0 buyingQ3 21: 0 sellingQ3 21Q4 21: 0 buyingQ4 21: 3 sellingQ1 22: 0 buyingQ1 22: 0 sellingQ1 22Q2 22: 0 buyingQ2 22: 0 sellingQ3 22: 0 buyingQ3 22: 0 sellingQ3 22Q4 22: 0 buyingQ4 22: 0 sellingQ1 23: 0 buyingQ1 23: 7 sellingQ1 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q2 20210—0——
Q3 20210—0——
Q4 20210—3$9.4m—
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——
Q1 20230—7$332.2k—
DateInsiderTradeSharesPrice ValueTheir holding
2023-01-03 Lee Kevin Chief Executive Officer, director Sold 6,000 $29.06 $174.4k6.0k shares -2%
2023-01-03 Keen Nicholas Chief Scientific Officer Sold 1,817 $29.06 $52.8k1.8k shares -4%
2023-01-03 Kalowski Lee President and CFO Sold 1,815 $29.06 $52.7k1.8k shares -6%
2023-01-03 Crockett Nigel Chief Business Officer Sold 1,801 $29.06 $52.3k1.8k shares -6%
2023-01-03 Skynner Michael Chief Technology Officer Sold 1,801 $29.06 $52.3k1.8k shares -2%
2023-01-03 Smethurst Dominic Chief Medical Officer Sold 1,801 $29.06 $52.3k1.8k shares -5%
2023-01-03 Milnes Alistair Chief Operating Officer Sold 1,801 $29.06 $52.3k1.8k shares -4%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q1 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Deep Track Capital, LP 2.55% of their portfolio GREENWICH, CT 2,819,0452.8m $60.0m $60.0m 2.55% Unchanged
2 Jefferies Financial Group Inc. 0.88% of their portfolio NEW YORK, NY 1,948,0001.9m $41.4m $41.4m 0.88% New
3 Paradigm Biocapital Advisors LP 3.66% of their portfolio NEW YORK, NY 1,816,7811.8m $38.6m $38.6m 3.66% Added +583.5k +583,501
4 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,507,7491.5m $32.1m $32.1m 0.00% Added +786.2k +786,190
5 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 1,474,3781.5m $31.4m $31.4m 0.02% Reduced -29.1k -29,069
6 TYBOURNE CAPITAL MANAGEMENT (HK) LTD 3.02% of their portfolio HONG KONG, K3 1,408,8311.4m $30.0m $30.0m 3.02% Added +503.1k +503,109
7 Candriam S.C.A. 0.18% of their portfolio STRASSEN, N4 1,303,2111.3m $25.5m $25.5m 0.18% Added +128.0k +128,000
8 Polar Capital Holdings Plc 0.16% of their portfolio London, X0 1,009,5001.0m $21.5m $21.5m 0.16% Added +259.5k +259,500
9 Sio Capital Management, LLC 10.17% of their portfolio NEW YORK, NY 967,347967.3k $20.6m $20.6m 10.17% Added +283.9k +283,922
10 BAKER BROS. ADVISORS LP 0.10% of their portfolio NEW YORK, NY 843,814843.8k $17.9m $17.9m 0.10% Unchanged
11 Point72 Asset Management, L.P. 0.06% of their portfolio STAMFORD, CT 802,400802.4k $17.1m $17.1m 0.06% Reduced -205.6k -205,578
12 Logos Global Management LP 2.28% of their portfolio San Francisco, CA 750,000750.0k $16.0m $16.0m 2.28% Reduced -685.0k -685,000
13 ARMISTICE CAPITAL, LLC 0.36% of their portfolio NEW YORK, NY 736,000736.0k $15.7m $15.7m 0.36% New
14 First Light Asset Management, LLC 1.34% of their portfolio Edina, MN 699,328699.3k $14.9m $14.9m 1.34% Added +2.9k +2,896
15 Verition Fund Management LLC 0.20% of their portfolio GREENWICH, CT 582,558582.6k $12.4m $12.4m 0.20% Added +201.7k +201,709
16 FMR LLC 0.00% of their portfolio BOSTON, MA 574,294574.3k $12.2m $12.2m 0.00% Added +196.6k +196,647
17 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio Paris, I0 519,573519.6k $11.1m $11.1m 0.04% Added +218.6k +218,605
18 AXA S.A. 0.03% of their portfolio PARIS, I0 460,125460.1k $9.8m $9.8m 0.03% Added +79.6k +79,570
19 Soleus Capital Management, L.P. 1.09% of their portfolio GREENWICH, CT 411,800411.8k $8.8m $8.8m 1.09% Added +153.4k +153,400
20 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 318,076318.1k $6.8m $6.8m 0.00% Reduced -20.7k -20,657
21 Ikarian Capital, LLC 1.83% of their portfolio DALLAS, TX 207,112207.1k $4.4m $4.4m 1.83% New
22 Rubric Capital Management LP 0.17% of their portfolio NEW YORK, NY 205,423205.4k $4.4m $4.4m 0.17% New
23 TWO SIGMA ADVISERS, LP 0.01% of their portfolio NEW YORK, NY 187,900187.9k $4.0m $4.0m 0.01% Added +26.1k +26,100
24 BlackRock Inc. 0.00% of their portfolio New York, NY 178,932178.9k $3.8m $3.8m 0.00% Reduced -10.9k -10,886
25 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 160,576160.6k $3.4m $3.4m 0.01% New
26 Parkman Healthcare Partners LLC 0.68% of their portfolio STAMFORD, CT 147,799147.8k $3.1m $3.1m 0.68% Added +56.5k +56,467
27 Handelsbanken Fonder AB 0.02% of their portfolio STOCKHOLM, V7 131,800131.8k $2.8m $2.8m 0.02% Unchanged
28 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 122,781122.8k $2.6m $2.6m 0.03% Added +17.9k +17,915
29 DAFNA Capital Management LLC 0.78% of their portfolio LOS ANGELES, CA 122,200122.2k $2.6m $2.6m 0.78% Unchanged
30 HighVista Strategies LLC 1.60% of their portfolio BOSTON, MA 92,43492.4k $2.0m $2.0m 1.60% Unchanged
31 Tekla Capital Management LLC 0.07% of their portfolio Boston, MA 88,67688.7k $1.9m $1.9m 0.07% Unchanged
32 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 87,13887.1k $1.9m $1.9m 0.00% Added +3.9k +3,932
33 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.04% of their portfolio CHICAGO, IL 80,71980.7k $1.7m $1.7m 0.04% New
34 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 80,59580.6k $1.7m $1.7m 0.00% Added +14.6k +14,555
35 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 76,64976.6k $1.6m $1.6m 0.00% Added +67.4k +67,378
36 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 67,20067.2k $1.4m $1.4m 0.00% Added +34.2k +34,210
37 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 61,90061.9k $1.3m $1.3m 0.00% New
38 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 60,10060.1k $1.3m $1.3m 0.01% Reduced -19.6k -19,646
39 Bellevue Group AG 0.02% of their portfolio ZURICH, V8 53,20053.2k $1.1m $1.1m 0.02% Reduced -17.0k -17,000
40 J. Goldman & Co LP 0.06% of their portfolio NEW YORK, NY 49,94449.9k $1.1m $1.1m 0.06% New
41 GROUP ONE TRADING LLC 0.05% of their portfolio CHICAGO, IL 48,43948.4k $1.0m $1.0m 0.05% Added +9.7k +9,655
42 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 44,57344.6k $948.1k $948.1k 0.00% Added +7.5k +7,518
43 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 43,80743.8k $931.8k $931.8k 0.01% Added +30.6k +30,617
44 BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 42,97943.0k $914.2k $914.2k 0.02% New
45 Jump Financial, LLC 0.03% of their portfolio Chicago, IL 37,73737.7k $802.7k $802.7k 0.03% Added +30.3k +30,337
46 Caption Management, LLC 0.12% of their portfolio OKLAHOMA CITY, OK 26,00026.0k $553.0k $553.0k 0.12% New
47 SIMPLEX TRADING, LLC 0.02% of their portfolio CHICAGO, IL 25,88825.9k $550.0k $550.0k 0.02% Added +11.6k +11,554
48 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 25,13625.1k $534.6k $534.6k 0.00% Unchanged
49 Vident Investment Advisory, LLC 0.02% of their portfolio Alpharetta, GA 24,28724.3k $516.6k $516.6k 0.02% Added +330 +330
50 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 23,58623.6k $501.7k $501.7k 0.00% Unchanged
51 Eagle Health Investments LP 0.10% of their portfolio Greenwich, CT 23,50023.5k $499.8k $499.8k 0.10% Unchanged
52 Allianz Asset Management GmbH 0.00% of their portfolio MUNICH, 2M 21,10021.1k $448.8k $448.8k 0.00% Added +5.9k +5,900
53 HARBOR CAPITAL ADVISORS, INC. 0.12% of their portfolio CHICAGO, IL 19,13219.1k $406.9k $406.9k 0.12% Reduced -5.0k -5,015
54 WOODSTOCK CORP 0.05% of their portfolio BOSTON, MA 18,63018.6k $396.3k $396.3k 0.05% Added +3.8k +3,790
55 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 17,14417.1k $364.7k $364.7k 0.00% Unchanged
56 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 16,83616.8k $358.0k $358.0k 0.00% Reduced -151.9k -151,887
57 AtonRa Partners 0.47% of their portfolio GENEVA, V8 15,16915.2k $322.6k $322.6k 0.47% Reduced -1.9k -1,898
58 HORIZON KINETICS ASSET MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 15,00015.0k $319.1k $319.1k 0.01% New
59 Erste Asset Management GmbH 0.01% of their portfolio VIENNA, C4 14,00014.0k $304.8k $304.8k 0.01% Unchanged
60 UBS Group AG 0.00% of their portfolio ZURICH, V8 13,89213.9k $295.5k $295.5k 0.00% Added +950 +950
61 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 13,20013.2k $275.0k $275.0k 0.00% Unchanged
62 Legal & General Group Plc 0.00% of their portfolio London, X0 13,15913.2k $280.1k $280.1k 0.00% Added +2.6k +2,626
63 PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio NEW YORK, NY 12,63412.6k $268.7k $268.7k 0.02% New
64 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 10,54810.5k $224.4k $224.4k 0.00% Reduced -70.0k -70,005
65 FISHMAN JAY A LTD/MI 0.03% of their portfolio TROY, MI 10,50010.5k $223.3k $223.3k 0.03% Unchanged
66 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 9,8009.8k $208.4k $208.4k 0.00% New
67 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 8,3708.4k $178.0k $178.0k 0.00% Unchanged
68 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 7,2797.3k $154.8k $154.8k 0.00% Added +7.1k +7,117
69 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 5,9195.9k $125.9k $125.9k 0.00% Added +406 +406
70 HighMark Wealth Management LLC 0.07% of their portfolio ST. PAUL, MN 4,2354.2k $90.1k $90.1k 0.07% Unchanged
71 NATIXIS 0.00% of their portfolio PARIS, I0 3,4003.4k $73.7k $73.7k 0.00% Reduced -213 -213
72 VIRTUS ADVISERS, LLC 0.04% of their portfolio HARTFORD, CT 3,1453.1k $66.9k $66.9k 0.04% Reduced -1.2k -1,216
73 Cutler Group LLC / CA 0.01% of their portfolio SAN FRANCISCO, CA 2,9422.9k $62.0k $62.0k 0.01% Added +902 +902
74 Values First Advisors, Inc. 0.03% of their portfolio JOHNSON CITY, TN 2,3922.4k $50.9k $50.9k 0.03% New
75 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,2631.3k $27.0k $27.0k 0.00% Added +99 +99
76 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 1,0601.1k $22.5k $22.5k 0.00% Reduced -250 -250
77 Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio ZURICH, V8 853853 $18.1k $18.1k 0.00% Added +458 +458
78 Aquatic Capital Management LLC 0.00% of their portfolio CHICAGO, IL 800800 $17.0k $17.0k 0.00% New
79 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 455455 $9.7k $9.7k 0.00% Reduced -56 -56
80 China Universal Asset Management Co., Ltd. 0.00% of their portfolio SHANGHAI, F4 349349 $7.4k $7.4k 0.00% Added +90 +90
81 Quantbot Technologies LP 0.00% of their portfolio NEW YORK, NY 300300 $6.4k $6.4k 0.00% New
82 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 193193 $4.0k $4.0k 0.00% Reduced -18 -18
83 Advisory Services Network, LLC 0.00% of their portfolio ATLANTA, GA 115115 $2.4k $2.4k 0.00% Unchanged
84 Daiwa Securities Group Inc. 0.00% of their portfolio CHIYODA-KU,TOKYO, M0 103103 $2.0k $2.0k 0.00% Unchanged
85 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 8484 $1.8k $1.8k 0.00% New
86 Crewe Advisors LLC 0.00% of their portfolio SALT LAKE CITY, UT 8383 $1.8k $1.8k 0.00% Unchanged
87 NFSG Corp 0.00% of their portfolio BOCA RATON, FL 4040 $851 $851 0.00% Unchanged
88 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 1919 $404 $404 0.00% New
89 Parallel Advisors, LLC 0.00% of their portfolio SAN FRANCISCO, CA 55 $106 $106 0.00% Unchanged
90 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged