BICYCLE THERAPEUTICS PLC BCYC
SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088
Company in Cambridge, United Kingdom
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, United Kingdom
- Founded2009
- Websitebicycletherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($931.8k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $21.18. Options: 8 managers hold calls ($9.7m notional), 6 hold puts ($2.5m).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 80 |
| Q4 2022 | 87 |
| Q1 2023 | 90 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 32 | 43 |
| Q1 2023 | 53 | 29 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $18.0k | $18.0k | 1.00 |
| Q4 2022 | $538.2k | $3.3m | 6.12 |
| Q1 2023 | $9.7m | $2.5m | 0.26 |
Biggest buyers
| Jefferies Financial Group Inc. | New | +1.9m |
| MORGAN STANLEY | Added | +786.2k |
| ARMISTICE CAPITAL, LLC | New | +736.0k |
| Paradigm Biocapital Advisors LP | Added | +583.5k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD | Added | +503.1k |
| Sio Capital Management, LLC | Added | +283.9k |
| Polar Capital Holdings Plc | Added | +259.5k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added | +218.6k |
| Ikarian Capital, LLC | New | +207.1k |
| Rubric Capital Management LP | New | +205.4k |
Biggest sellers
| RTW INVESTMENTS, LP | Sold out | -1.3m |
| SAMLYN CAPITAL, LLC | Sold out | -987.9k |
| EVENTIDE ASSET MANAGEMENT, LLC | Sold out | -853.8k |
| Logos Global Management LP | Reduced | -685.0k |
| PURA VIDA INVESTMENTS, LLC | Sold out | -239.0k |
| Point72 Asset Management, L.P. | Reduced | -205.6k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -151.9k |
| ALLIANCEBERNSTEIN L.P. | Sold out | -72.5k |
| GOLDMAN SACHS GROUP INC | Reduced | -70.0k |
| L & S Advisors Inc | Sold out | -35.0k |
Biggest calls
| Ikarian Capital, LLC | New | $4.3m200.0k shares |
| SIMPLEX TRADING, LLC | Added | $2.1m97.8k shares |
| Caption Management, LLC | New | $2.0m95.7k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $852.9k40.1k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $385.0k18.1k shares |
| CITADEL ADVISORS LLC | Reduced | $87.2k4.1k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
| Cutler Group LLC / CA | New | $0400 shares |
Biggest puts
| GROUP ONE TRADING LLC | Unchanged | $821.0k38.6k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $787.0k37.0k shares |
| CITADEL ADVISORS LLC | Added | $574.3k27.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $280.0k13.2k shares |
| Cutler Group LLC / CA | Added | $12.0k1.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 | 7.3% |
| ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 | 6.7% |
| Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 | 6.6% |
Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 3 | $9.4m | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 7 | $332.2k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-01-03 | Lee Kevin Chief Executive Officer, director | Sold | $174.4k6.0k shares |
| 2023-01-03 | Keen Nicholas Chief Scientific Officer | Sold | $52.8k1.8k shares |
| 2023-01-03 | Kalowski Lee President and CFO | Sold | $52.7k1.8k shares |
| 2023-01-03 | Crockett Nigel Chief Business Officer | Sold | $52.3k1.8k shares |
| 2023-01-03 | Skynner Michael Chief Technology Officer | Sold | $52.3k1.8k shares |
| 2023-01-03 | Smethurst Dominic Chief Medical Officer | Sold | $52.3k1.8k shares |
| 2023-01-03 | Milnes Alistair Chief Operating Officer | Sold | $52.3k1.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| Deep Track Capital, LP 2.55% of their portfolio | 2.8m $60.0m | Unchanged |
| Jefferies Financial Group Inc. 0.88% of their portfolio | 1.9m $41.4m | New |
| Paradigm Biocapital Advisors LP 3.66% of their portfolio | 1.8m $38.6m | Added +583.5k |
| MORGAN STANLEY 0.00% of their portfolio | 1.5m $32.1m | Added +786.2k |
| JANUS HENDERSON GROUP PLC 0.02% of their portfolio | 1.5m $31.4m | Reduced -29.1k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 3.02% of their portfolio | 1.4m $30.0m | Added +503.1k |
| Candriam S.C.A. 0.18% of their portfolio | 1.3m $25.5m | Added +128.0k |
| Polar Capital Holdings Plc 0.16% of their portfolio | 1.0m $21.5m | Added +259.5k |
| Sio Capital Management, LLC 10.17% of their portfolio | 967.3k $20.6m | Added +283.9k |
| BAKER BROS. ADVISORS LP 0.10% of their portfolio | 843.8k $17.9m | Unchanged |
| Point72 Asset Management, L.P. 0.06% of their portfolio | 802.4k $17.1m | Reduced -205.6k |
| Logos Global Management LP 2.28% of their portfolio | 750.0k $16.0m | Reduced -685.0k |
| ARMISTICE CAPITAL, LLC 0.36% of their portfolio | 736.0k $15.7m | New |
| First Light Asset Management, LLC 1.34% of their portfolio | 699.3k $14.9m | Added +2.9k |
| Verition Fund Management LLC 0.20% of their portfolio | 582.6k $12.4m | Added +201.7k |
| FMR LLC 0.00% of their portfolio | 574.3k $12.2m | Added +196.6k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio | 519.6k $11.1m | Added +218.6k |
| AXA S.A. 0.03% of their portfolio | 460.1k $9.8m | Added +79.6k |
| Soleus Capital Management, L.P. 1.09% of their portfolio | 411.8k $8.8m | Added +153.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 318.1k $6.8m | Reduced -20.7k |
| Ikarian Capital, LLC 1.83% of their portfolio | 207.1k $4.4m | New |
| Rubric Capital Management LP 0.17% of their portfolio | 205.4k $4.4m | New |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 187.9k $4.0m | Added +26.1k |
| BlackRock Inc. 0.00% of their portfolio | 178.9k $3.8m | Reduced -10.9k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 160.6k $3.4m | New |
| Parkman Healthcare Partners LLC 0.68% of their portfolio | 147.8k $3.1m | Added +56.5k |
| Handelsbanken Fonder AB 0.02% of their portfolio | 131.8k $2.8m | Unchanged |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 122.8k $2.6m | Added +17.9k |
| DAFNA Capital Management LLC 0.78% of their portfolio | 122.2k $2.6m | Unchanged |
| HighVista Strategies LLC 1.60% of their portfolio | 92.4k $2.0m | Unchanged |
| Tekla Capital Management LLC 0.07% of their portfolio | 88.7k $1.9m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 87.1k $1.9m | Added +3.9k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.04% of their portfolio | 80.7k $1.7m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 80.6k $1.7m | Added +14.6k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 76.6k $1.6m | Added +67.4k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 67.2k $1.4m | Added +34.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 61.9k $1.3m | New |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 60.1k $1.3m | Reduced -19.6k |
| Bellevue Group AG 0.02% of their portfolio | 53.2k $1.1m | Reduced -17.0k |
| J. Goldman & Co LP 0.06% of their portfolio | 49.9k $1.1m | New |
| GROUP ONE TRADING LLC 0.05% of their portfolio | 48.4k $1.0m | Added +9.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 44.6k $948.1k | Added +7.5k |
| Cubist Systematic Strategies, LLC 0.01% of their portfolio | 43.8k $931.8k | Added +30.6k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.02% of their portfolio | 43.0k $914.2k | New |
| Jump Financial, LLC 0.03% of their portfolio | 37.7k $802.7k | Added +30.3k |
| Caption Management, LLC 0.12% of their portfolio | 26.0k $553.0k | New |
| SIMPLEX TRADING, LLC 0.02% of their portfolio | 25.9k $550.0k | Added +11.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 25.1k $534.6k | Unchanged |
| Vident Investment Advisory, LLC 0.02% of their portfolio | 24.3k $516.6k | Added +330 |
| TD Asset Management Inc 0.00% of their portfolio | 23.6k $501.7k | Unchanged |
| Eagle Health Investments LP 0.10% of their portfolio | 23.5k $499.8k | Unchanged |
| Allianz Asset Management GmbH 0.00% of their portfolio | 21.1k $448.8k | Added +5.9k |
| HARBOR CAPITAL ADVISORS, INC. 0.12% of their portfolio | 19.1k $406.9k | Reduced -5.0k |
| WOODSTOCK CORP 0.05% of their portfolio | 18.6k $396.3k | Added +3.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 17.1k $364.7k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 16.8k $358.0k | Reduced -151.9k |
| AtonRa Partners 0.47% of their portfolio | 15.2k $322.6k | Reduced -1.9k |
| HORIZON KINETICS ASSET MANAGEMENT LLC 0.01% of their portfolio | 15.0k $319.1k | New |
| Erste Asset Management GmbH 0.01% of their portfolio | 14.0k $304.8k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 13.9k $295.5k | Added +950 |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 13.2k $275.0k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 13.2k $280.1k | Added +2.6k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 12.6k $268.7k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 10.5k $224.4k | Reduced -70.0k |
| FISHMAN JAY A LTD/MI 0.03% of their portfolio | 10.5k $223.3k | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 9.8k $208.4k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.4k $178.0k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 7.3k $154.8k | Added +7.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.9k $125.9k | Added +406 |
| HighMark Wealth Management LLC 0.07% of their portfolio | 4.2k $90.1k | Unchanged |
| NATIXIS 0.00% of their portfolio | 3.4k $73.7k | Reduced -213 |
| VIRTUS ADVISERS, LLC 0.04% of their portfolio | 3.1k $66.9k | Reduced -1.2k |
| Cutler Group LLC / CA 0.01% of their portfolio | 2.9k $62.0k | Added +902 |
| Values First Advisors, Inc. 0.03% of their portfolio | 2.4k $50.9k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.3k $27.0k | Added +99 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.1k $22.5k | Reduced -250 |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 853 $18.1k | Added +458 |
| Aquatic Capital Management LLC 0.00% of their portfolio | 800 $17.0k | New |
| CITIGROUP INC 0.00% of their portfolio | 455 $9.7k | Reduced -56 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 349 $7.4k | Added +90 |
| Quantbot Technologies LP 0.00% of their portfolio | 300 $6.4k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 193 $4.0k | Reduced -18 |
| Advisory Services Network, LLC 0.00% of their portfolio | 115 $2.4k | Unchanged |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 103 $2.0k | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 84 $1.8k | New |
| Crewe Advisors LLC 0.00% of their portfolio | 83 $1.8k | Unchanged |
| NFSG Corp 0.00% of their portfolio | 40 $851 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 19 $404 | New |
| Parallel Advisors, LLC 0.00% of their portfolio | 5 $106 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |