TCG Crossover Management, LLC

PALO ALTO, CA · CIK 1839948 · 13F filing filed 2026-08-14

No investment adviser registration (Form ADV) found for this filer. It may be a parent company whose subsidiaries are the registered advisers, a bank or insurer, or a manager based outside the US.

Others nearbyPalo Alto, CA

$4.2bn reported value +19.0% vs Q1 2026

54positions

57.4%in top 10

12 new 2 added 9 reduced 7 sold out vs Q1 2026

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	ABIVAX SA SPONSORED ADS ABVX	ABVX	6,007,834	$800.6m19.24%	19.24%	Reduced -473.3k	-473,251 -7.3%
2	TANGO THERAPEUTICS INC COM TNGX	TNGX	9,081,201	$283.9m6.82%	6.82%	Reduced -1.4m	-1,449,870 -13.8%
3	CG ONCOLOGY INC COM CGON	CGON	3,670,206	$260.8m6.27%	6.27%	Unchanged
4	COGENT BIOSCIENCES INC COM COGT	COGT	4,854,436	$187.9m4.52%	4.52%	Reduced -92.5k	-92,458 -1.9%
5	IMMUNOVANT INC COM IMVT	IMVT	4,457,988	$171.8m4.13%	4.13%	Unchanged
6	SPYRE THERAPEUTICS INC COM NEW SYRE	SYRE	1,900,582	$168.7m4.06%	4.06%	Unchanged
7	DIANTHUS THERAPEUTICS INC COM DNTH	DNTH	1,676,624	$163.4m3.93%	3.93%	Unchanged
8	MIRUM PHARMACEUTICALS INC COM MIRM	MIRM	1,062,049	$124.3m2.99%	2.99%	Unchanged
9	ZAI LAB LTD ADR ZLAB	ZLAB	6,137,627	$116.6m2.80%	2.80%	New
10	AMYLYX PHARMACEUTICALS INC COM AMLX	AMLX	6,243,812	$112.1m2.70%	2.70%	Unchanged
11	MONTE ROSA THERAPEUTICS INC COM GLUE	GLUE	4,622,151	$111.9m2.69%	2.69%	Unchanged
12	BIOCRYST PHARMACEUTICALS INC COM BCRX	BCRX	11,020,968	$110.2m2.65%	2.65%	Unchanged
13	VOR BIOPHARMA INC COM NEW VOR	VOR	5,673,078	$104.4m2.51%	2.51%	Unchanged
14	TYRA BIOSCIENCES INC COM TYRA	TYRA	3,248,980	$103.8m2.49%	2.49%	Unchanged
15	DYNE THERAPEUTICS INC COM DYN	DYN	4,615,144	$102.5m2.46%	2.46%	Unchanged
16	DISC MEDICINE INC COM IRON	IRON	1,341,862	$98.1m2.36%	2.36%	Unchanged
17	RELAY THERAPEUTICS INC COM RLAY	RLAY	4,273,356	$80.0m1.92%	1.92%	Unchanged
18	SAVARA INC COM SVRA	SVRA	12,362,205	$76.2m1.83%	1.83%	Unchanged
19	AURA BIOSCIENCES INC COM AURA	AURA	9,533,333	$67.7m1.63%	1.63%	New
20	REVOLUTION MEDICINES INC COM RVMD	RVMD	340,899	$63.8m1.53%	1.53%	Reduced -235.6k	-235,574 -40.9%
21	FIRST TRACKS BIOTHERAPEUTICS ORD SHS TRAX	TRAX	2,895,304	$58.3m1.40%	1.40%	New
22	KODIAK SCIENCES INC COM KOD	KOD	1,445,538	$56.3m1.35%	1.35%	Unchanged
23	AVALO THERAPEUTICS INC COM NEW AVTX	AVTX	3,017,120	$55.8m1.34%	1.34%	Added +2.3m	+2,278,737 308.6%
24	LB PHARMACEUTICALS INC COM SHS LBRX	LBRX	1,447,310	$47.0m1.13%	1.13%	Reduced -392.2k	-392,179 -21.3%
25	CENTURY THERAPEUTICS INC COM IPSC	IPSC	17,754,430	$43.4m1.04%	1.04%	Unchanged
26	TECTONIC THERAPEUTIC INC COM TECX	TECX	1,204,891	$41.4m1.00%	1.00%	Unchanged
27	XENCOR INC COM XNCR	XNCR	2,452,138	$39.5m0.95%	0.95%	Unchanged
28	SURROZEN INC COM NEW SRZN	SRZN	1,473,101	$38.2m0.92%	0.92%	Unchanged
29	EDITAS MEDICINE INC COM EDIT	EDIT	11,111,111	$36.0m0.87%	0.87%	New
30	MBX BIOSCIENCES INC COM MBX	MBX	650,000	$35.9m0.86%	0.86%	Unchanged
31	PHARVARIS N V COM PHVS	PHVS	1,008,229	$34.9m0.84%	0.84%	New
32	SILENCE THERAPEUTICS PLC ADS SLN	SLN	3,033,560	$33.3m0.80%	0.80%	Unchanged
33	INFLARX NV COM IFRX	IFRX	14,500,000	$32.5m0.78%	0.78%	New
34	ALTIMMUNE INC COM NEW ALT	ALT	10,000,000	$30.4m0.73%	0.73%	New
35	JANUX THERAPEUTICS INC COM JANX	JANX	1,789,617	$27.5m0.66%	0.66%	Unchanged
36	PERSPECTIVE THERAPEUTICS INC COM NEW CATX	CATX	7,915,567	$27.0m0.65%	0.65%	Unchanged
37	AGOMAB THERAPEUTICS NV SPONSORED ADS AGMB	AGMB	2,053,233	$26.7m0.64%	0.64%	Unchanged
38	BIOHAVEN LTD COM BHVN	BHVN	1,779,952	$26.5m0.64%	0.64%	Reduced -2.9m	-2,851,365 -61.6%
39	AKTIS ONCOLOGY INC COM AKTS	AKTS	696,560	$22.5m0.54%	0.54%	New
40	ALECTOR INC COM ALEC	ALEC	10,000,000	$20.1m0.48%	0.48%	Unchanged
41	FORTE BIOSCIENCES INC COM NEW FBRX	FBRX	920,000	$19.6m0.47%	0.47%	New
42	MONOPAR THERAPEUTICS INC COM NEW MNPR	MNPR	203,327	$18.8m0.45%	0.45%	Added +71.2k	+71,224 53.9%
43	OCULAR THERAPEUTIX INC COM OCUL	OCUL	1,647,752	$16.2m0.39%	0.39%	Unchanged
44	ADC THERAPEUTICS SA SHS ADCT	ADCT	11,390,175	$12.2m0.29%	0.29%	Unchanged
45	ALX ONCOLOGY HLDGS INC COM ALXO	ALXO	5,655,487	$11.7m0.28%	0.28%	Reduced -7.4m	-7,356,362 -56.5%
46	ENTRADA THERAPEUTICS INC COM TRDA	TRDA	1,060,230	$7.8m0.19%	0.19%	Reduced -1.2m	-1,227,270 -53.6%
47	CULLINAN THERAPEUTICS INC COM CGEM	CGEM	406,786	$7.4m0.18%	0.18%	Unchanged
48	ARVINAS INC COM ARVN	ARVN	707,098	$5.9m0.14%	0.14%	Reduced -1.7m	-1,680,363 -70.4%
49	KORRO BIO INC COM KRRO	KRRO	416,301	$5.5m0.13%	0.13%	Unchanged
50	RESEARCH ALLIANCE CORP III ORD SHS CL A RACC	RACC	500,000	$5.3m0.13%	0.13%	New
51	LEONABIO INC COM LONA	LONA	464,398	$4.3m0.10%	0.10%	Unchanged
52	JATT II ACQUISITION CORP ORD SHS JATT	JATT	200,000	$2.3m0.05%	0.05%	New
53	CONTEXT THERAPEUTICS INC COM CNTX	CNTX	2,682,696	$1.5m0.04%	0.04%	Unchanged
54	EIKON THERAPEUTICS INC COM EIKN	EIKN	37,902	$494.6k0.01%	0.01%	New

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
CENTESSA PHARMACEUTICALS PLC		4,286,480	$170.3m4.3m shares
FULCRUM THERAPEUTICS INC FULC	FULC	5,250,000	$40.3m5.2m shares
LIQUIDIA CORPORATION LQDA	LQDA	403,048	$15.2m403.0k shares
UROGEN PHARMA LTD URGN	URGN	405,365	$7.3m405.4k shares
STRUCTURE THERAPEUTICS INC GPCR	GPCR	140,411	$6.8m140.4k shares
UPSTREAM BIO INC UPB	UPB	181,063	$1.6m181.1k shares
VISTAGEN THERAPEUTICS INC VTGN	VTGN	2,676,580	$1.5m2.7m shares