BIOCRYST PHARMACEUTICALS INC BCRX
COM · Common Stock · CUSIP 09058V103
American pharmaceutical company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersDurham, NC
- Founded1986
- Websitebiocryst.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($593.7k this quarter). Holder counts are more reliable. Shares outstanding: 255.5m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $10.00. Options: 11 managers hold calls ($31.5m notional), 10 hold puts ($7.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 234 |
| Q4 2022 | 230 |
| Q1 2023 | 243 |
| Q2 2023 | 237 |
| Q3 2023 | 234 |
| Q4 2023 | 235 |
| Q1 2024 | 238 |
| Q2 2024 | 243 |
| Q3 2024 | 258 |
| Q4 2024 | 259 |
| Q1 2025 | 276 |
| Q2 2025 | 295 |
| Q3 2025 | 286 |
| Q4 2025 | 273 |
| Q1 2026 | 302 |
| Q2 2026 | 318 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 127 | 109 |
| Q4 2024 | 99 | 122 |
| Q1 2025 | 146 | 94 |
| Q2 2025 | 163 | 116 |
| Q3 2025 | 131 | 143 |
| Q4 2025 | 135 | 158 |
| Q1 2026 | 178 | 119 |
| Q2 2026 | 187 | 122 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $6.8m | $4.9m | 0.72 |
| Q4 2025 | $12.0m | $7.3m | 0.61 |
| Q1 2026 | $14.2m | $6.1m | 0.43 |
| Q2 2026 | $31.5m | $7.6m | 0.24 |
Biggest buyers
| MILLENNIUM MANAGEMENT LLC | Added | +3.2m |
| STATE STREET CORP | Added | +3.0m |
| PERCEPTIVE ADVISORS LLC | Added | +2.9m |
| JANE STREET GROUP, LLC | Added | +2.1m |
| GOLDMAN SACHS GROUP INC | Added | +2.1m |
| Nantahala Capital Management, LLC | Added | +1.8m |
| AQR CAPITAL MANAGEMENT LLC | Added | +1.8m |
| RENAISSANCE TECHNOLOGIES LLC | Added | +1.8m |
| Vestal Point Capital, LP | Added | +1.3m |
| BlackRock, Inc. | Added | +1.2m |
Biggest sellers
| Royalty Pharma Sub-Manager, LLC | Sold out | -3.8m |
| Kynam Capital Management, LP | Reduced | -3.2m |
| RFG Advisory, LLC | Sold out | -2.9m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -1.6m |
| Pacer Advisors, Inc. | Reduced | -1.6m |
| Eversept Partners, LP | Reduced | -1.2m |
| JPMORGAN CHASE & CO | Reduced | -1.0m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Sold out | -1.0m |
| Hillsdale Investment Management Inc. | Sold out | -639.1k |
| Schonfeld Strategic Advisors LLC | Reduced | -626.9k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $9.9m994.4k shares |
| SIMPLEX TRADING, LLC | Added | $7.5m750.2k shares |
| GROUP ONE TRADING LLC | Added | $4.0m395.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.2m323.8k shares |
| CITADEL ADVISORS LLC | Added | $2.3m232.2k shares |
| IMC-Chicago, LLC | New | $1.7m166.9k shares |
| CITIGROUP INC | Unchanged | $950.0k95.0k shares |
| TUDOR INVESTMENT CORP ET AL | Reduced | $899.0k89.9k shares |
| Walleye Capital LLC | Added | $665.0k66.5k shares |
| NOMURA HOLDINGS INC | Reduced | $361.0k36.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.9m185.3k shares |
| CITADEL ADVISORS LLC | Added | $1.4m145.0k shares |
| CITIGROUP INC | Unchanged | $950.0k95.0k shares |
| IMC-Chicago, LLC | New | $938.0k93.8k shares |
| JANE STREET GROUP, LLC | Added | $590.0k59.0k shares |
| JPMORGAN CHASE & CO | New | $548.2k57.4k shares |
| NOMURA HOLDINGS INC | Reduced | $500.0k50.0k shares |
| GROUP ONE TRADING LLC | Reduced | $492.0k49.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $260.0k26.0k shares |
| Walleye Capital LLC | Added | $12.0k1.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 8.4% |
| Flynn James E 13G · passive investor +1.0 pts · filed 2026-02-12 | 6.8% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -1.1 pts · filed 2026-08-14 | 6.2% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.0% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.2% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 1 | $52.8k | $52.8k |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 1 | $595.7k | — |
| Q4 2025 | 0 | — | 2 | $1.6m | $1.6m |
| Q1 2026 | 0 | — | 2 | $1.9m | $1.4m |
| Q2 2026 | 0 | — | 2 | $696.5k | $596.2k |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-05-18 | McKee Amy E Director | Sold | $100.3k11.2k shares |
| 2026-05-13 | Barnes Alane P Chief Legal Officer | Sold plan | $596.2k62.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 23.9m $238.9m | Added +1.2m |
| RA CAPITAL MANAGEMENT, L.P. 1.38% of their portfolio | 15.8m $158.3m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 15.2m $151.9m | Added +3.0m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 1.57% of their portfolio | 15.1m $151.0m | Added +58.4k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 11.4m $113.6m | Added +228.5k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 11.1m $111.4m | Reduced -105.5k |
| TCG Crossover Management, LLC 2.65% of their portfolio | 11.0m $110.2m | Unchanged |
| PERCEPTIVE ADVISORS LLC 1.60% of their portfolio | 10.3m $103.1m | Added +2.9m |
| Jupiter Topco LLC 0.04% of their portfolio | 9.5m $95.3m | First filing |
| Vestal Point Capital, LP 1.94% of their portfolio | 8.3m $83.0m | Added +1.3m |
| TWO SIGMA INVESTMENTS, LP 0.05% of their portfolio | 6.8m $67.8m | Added +382.7k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 6.2m $62.5m | Added +465.3k |
| Aberdeen Group plc 0.07% of their portfolio | 5.3m $53.1m | Added +270.2k |
| UBS Group AG 0.01% of their portfolio | 5.1m $50.8m | Added +134.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 4.8m $48.0m | Reduced -290.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 4.5m $44.8m | Added +2.1m |
| Frazier Life Sciences Management, L.P. 0.87% of their portfolio | 4.0m $40.1m | Unchanged |
| Nuveen, LLC 0.01% of their portfolio | 4.0m $40.1m | Added +188.0k |
| Nantahala Capital Management, LLC 1.15% of their portfolio | 3.8m $38.0m | Added +1.8m |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 3.4m $33.9m | Added +3.2m |
| GW&K Investment Management, LLC 0.25% of their portfolio | 3.2m $31.7m | Reduced -69.3k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 2.8m $27.6m | Added +2.1m |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 2.7m $27.2m | Added +28.1k |
| Fisher Asset Management, LLC 0.01% of their portfolio | 2.6m $26.0m | Reduced -129.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio | 2.5m $25.3m | Added +1.8m |
| Kynam Capital Management, LP 1.39% of their portfolio | 2.5m $25.2m | Reduced -3.2m |
| Candriam S.C.A. 0.11% of their portfolio | 2.5m $25.1m | Added +228.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 2.4m $23.5m | Added +2.9k |
| RICE HALL JAMES & ASSOCIATES, LLC 1.13% of their portfolio | 2.3m $23.3m | Added +101.9k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 2.3m $22.6m | Added +151.0k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.2m $22.1m | Added +1.8m |
| MORGAN STANLEY 0.00% of their portfolio | 2.0m $20.0m | Reduced -23.3k |
| Eversept Partners, LP 1.02% of their portfolio | 1.9m $18.7m | Reduced -1.2m |
| ORBIMED ADVISORS LLC 0.35% of their portfolio | 1.9m $18.5m | Added +426.8k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.03% of their portfolio | 1.8m $18.4m | Added +617.9k |
| STIFEL FINANCIAL CORP 0.02% of their portfolio | 1.8m $18.3m | Added +1.1k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 1.8m $17.6m | Added +95.3k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 1.8m $17.6m | Added +740.4k |
| JUPITER ASSET MANAGEMENT LTD 0.08% of their portfolio | 1.6m $16.4m | Added +446.5k |
| IMC-Chicago, LLC 0.15% of their portfolio | 1.6m $16.3m | Added +1.0m |
| Parkman Healthcare Partners LLC 1.67% of their portfolio | 1.6m $16.2m | Reduced -83.8k |
| Legal & General Group Plc 0.00% of their portfolio | 1.5m $14.6m | Added +44.3k |
| OP Asset Management Ltd 0.14% of their portfolio | 1.3m $13.4m | Added +88.1k |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 1.2m $12.0m | Added +778.2k |
| Invesco Ltd. 0.00% of their portfolio | 1.2m $12.3m | Reduced -75.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 1.2m $12.0m | Reduced -1.6m |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 1.2m $11.7m | Reduced -128.2k |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 1.1m $11.2m | Added +319.6k |
| HRT FINANCIAL LP 0.03% of their portfolio | 1.1m $10.8m | New |
| MOORE CAPITAL MANAGEMENT, LP 0.19% of their portfolio | 848.3k $8.5m | New |
| FMR LLC 0.00% of their portfolio | 808.9k $8.1m | Added +175.8k |
| ExodusPoint Capital Management, LP 0.07% of their portfolio | 744.9k $7.4m | Added +554.9k |
| Man Group plc 0.01% of their portfolio | 732.9k $7.3m | Reduced -560.4k |
| Rosalind Advisors, Inc. 2.71% of their portfolio | 721.5k $7.2m | Reduced -201.6k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 710.8k $7.1m | Reduced -626.9k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 706.1k $7.1m | Added +473.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 680.5k $6.8m | Added +42.8k |
| Jump Financial, LLC 0.05% of their portfolio | 570.0k $5.7m | Added +460.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 563.4k $5.6m | Reduced -258.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 538.8k $5.4m | Added +2.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 525.4k $5.1m | Reduced -1.0m |
| Elmind Capital, LP 1.31% of their portfolio | 520.0k $5.2m | Reduced -480.0k |
| Bridgewater Associates, LP 0.02% of their portfolio | 491.1k $4.9m | Reduced -147.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 480.4k $4.8m | Reduced -42.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 468.8k $4.7m | Added +38.2k |
| NAN FUNG TRINITY (HK) LTD 0.44% of their portfolio | 450.0k $4.5m | New |
| SPHERA FUNDS MANAGEMENT LTD. 0.60% of their portfolio | 422.1k $4.2m | Reduced -444.4k |
| Swiss National Bank 0.00% of their portfolio | 415.3k $4.2m | Added +6.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 408.5k $4.1m | Added +106.4k |
| Susquehanna Portfolio Strategies, LLC 0.06% of their portfolio | 404.7k $4.0m | Added +30.7k |
| DAFNA Capital Management LLC 0.76% of their portfolio | 400.2k $4.0m | Reduced -30.0k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 400.0k $4.0m | Reduced -90.4k |
| WEDGE CAPITAL MANAGEMENT L L P/NC 0.06% of their portfolio | 380.8k $3.8m | New |
| DOLIVER ADVISORS, LP 0.85% of their portfolio | 374.3k $3.7m | Unchanged |
| Aquatic Capital Management LLC 0.12% of their portfolio | 362.9k $3.6m | New |
| CITIGROUP INC 0.00% of their portfolio | 360.2k $3.6m | Added +289.0k |
| MACKENZIE FINANCIAL CORP 0.00% of their portfolio | 347.3k $3.5m | Added +103.9k |
| Phocas Financial Corp. 0.47% of their portfolio | 340.5k $3.4m | Added +145.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 327.9k $3.1m | Added +64.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 320.6k $3.2m | Reduced -48.4k |
| ALPS ADVISORS INC 0.01% of their portfolio | 318.0k $3.2m | Added +257.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 305.9k $3.1m | Added +74.9k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 293.9k $2.9m | Added +195.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 279.8k $2.8m | Added +13.7k |
| NFJ INVESTMENT GROUP, LLC 0.09% of their portfolio | 278.8k $2.8m | New |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 265.6k $2.7m | Reduced -88.6k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 260.9k $2.6m | New |
| WINTON GROUP Ltd 0.08% of their portfolio | 255.6k $2.6m | Added +202.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 252.8k $2.5m | Added +6.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 251.2k $2.5m | Reduced -7.1k |
| MARTINGALE ASSET MANAGEMENT L P 0.06% of their portfolio | 242.5k $2.4m | Added +186.0k |
| IEQ CAPITAL, LLC 0.01% of their portfolio | 227.4k $2.3m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 222.9k $2.2m | Reduced -14.0k |
| HUSSMAN STRATEGIC ADVISORS, INC. 0.48% of their portfolio | 210.0k $2.1m | New |
| PFM Health Sciences, LP 0.18% of their portfolio | 207.4k $2.1m | New |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 196.3k $2.0m | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 195.1k $2.0m | New |
| Engineers Gate Manager LP 0.02% of their portfolio | 175.0k $1.8m | Reduced -19.5k |
| Squarepoint Ops LLC 0.00% of their portfolio | 174.7k $1.7m | Added +134.9k |
| Janney Montgomery Scott LLC 0.00% of their portfolio | 163.3k $1.6m | Added +1 |