MBX BIOSCIENCES INC MBX
COM · Common Stock · CUSIP 55287L101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarmel, IN
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($150.6k this quarter). Holder counts are more reliable. Shares outstanding: 48.2m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $55.18. Options: 5 managers hold calls ($19.6m notional), 4 hold puts ($13.0m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 46 |
| Q4 2024 | 64 |
| Q1 2025 | 80 |
| Q2 2025 | 89 |
| Q3 2025 | 118 |
| Q4 2025 | 138 |
| Q1 2026 | 157 |
| Q2 2026 | 173 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 42 | 21 |
| Q1 2025 | 49 | 23 |
| Q2 2025 | 60 | 26 |
| Q3 2025 | 68 | 38 |
| Q4 2025 | 92 | 49 |
| Q1 2026 | 76 | 65 |
| Q2 2026 | 99 | 68 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $15.3m | $29.0m | 1.89 |
| Q4 2025 | $4.1m | $14.0m | 3.42 |
| Q1 2026 | $3.7m | $1.5m | 0.40 |
| Q2 2026 | $19.6m | $13.0m | 0.66 |
Biggest buyers
| Paradigm Biocapital Advisors LP | New | +2.5m |
| FMR LLC | Added | +2.4m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.8m |
| BlackRock, Inc. | Added | +382.3k |
| MARSHALL WACE, LLP | Added | +339.2k |
| Soleus Capital Management, L.P. | Added | +336.4k |
| BANK OF AMERICA CORP /DE/ | Added | +270.2k |
| FRANKLIN RESOURCES INC | New | +252.7k |
| MORGAN STANLEY | Added | +217.0k |
| DIMENSIONAL FUND ADVISORS LP | Added | +186.9k |
Biggest sellers
| Deep Track Capital, LP | Reduced | -1.0m |
| STEMPOINT CAPITAL LP | Sold out | -998.9k |
| CITADEL ADVISORS LLC | Sold out | -932.8k |
| BRAIDWELL LP | Reduced | -781.6k |
| Caligan Partners LP | Reduced | -648.6k |
| Cormorant Asset Management, LP | Reduced | -570.0k |
| EcoR1 Capital, LLC | Reduced | -388.5k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -338.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -214.2k |
| ORBIMED ADVISORS LLC | Reduced | -209.2k |
Biggest calls
| Caption Management, LLC | New | $11.0m200.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.2m94.4k shares |
| JANE STREET GROUP, LLC | Added | $2.1m37.6k shares |
| CITADEL ADVISORS LLC | Added | $1.2m22.4k shares |
| SIMPLEX TRADING, LLC | Unchanged | $27.6k500 shares |
Biggest puts
| Caption Management, LLC | New | $11.0m200.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $1.7m31.0k shares |
| CITADEL ADVISORS LLC | Reduced | $209.8k3.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $16.6k300 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
Frazier Life Sciences Public Fund, L.P.
13D · may seek influence
no change · filed 2026-08-10
Stated purposeItem 4 is hereby amended to remove references to "FLSPOF" and the "FLSPOF Shares" from the first paragraph. Full filing |
11.7% |
| FMR LLC 13G · institution +5.0 pts · filed 2026-07-08 | 11.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution +3.0 pts · filed 2026-07-08 | 10.5% |
New Enterprise Associates 17, L.P.
13D · may seek influence
filed 2025-11-10
Stated purposeNEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount of assets of the Issuer or any of its subsidiaries; (d) Any change in the present board of dire… Full filing |
8.1% |
ORBIMED ADVISORS LLC
13D · may seek influence
-1.3 pts · filed 2026-08-10
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
6.4% |
| BlackRock, Inc. 13G · institution +0.7 pts · filed 2026-07-29 | 5.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-06-24 | 5.2% |
Fell to 5% or below in the last year: Deep Track Capital, LP (3.6%, 2026-08-14), Hawryluk P. Kent (4.3%, 2025-11-14), Wellington Biomedical Innovation Master Investors (Cayman) I (4.5%, 2025-11-12; now reported by WELLINGTON MANAGEMENT GROUP LLP)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 3 | $2.6m | 0 | — | — |
| Q2 2025 | 1 | $45.3k | 0 | — | — |
| Q3 2025 | 1 | $12.0m | 0 | — | — |
| Q4 2025 | 2 | $537.8k | 0 | — | — |
| Q1 2026 | 1 | $525.6k | 0 | — | — |
| Q2 2026 | 0 | — | 2 | $2.7m | $2.7m |
| Q3 2026 | 0 | — | 1 | $24.3k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-04 | Azoulay Salomon Chief Medical Officer | Sold | $24.3k370 shares |
| 2026-05-08 | Azoulay Salomon Chief Medical Officer | Sold plan | $2.7m70.0k shares |
| 2026-05-06 | Hawryluk P. Kent President & CEO, director | Sold | $17.9k607 shares |
| 2026-05-06 | Azoulay Salomon Chief Medical Officer | Sold | $6.8k231 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 8.00% of their portfolio | 6.7m $367.2m | Unchanged |
| FMR LLC 0.01% of their portfolio | 5.3m $293.8m | Added +2.4m |
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 5.0m $274.8m | Added +1.8m |
| NEA Management Company, LLC 12.56% of their portfolio | 3.6m $199.5m | Unchanged |
| ORBIMED ADVISORS LLC 3.58% of their portfolio | 3.4m $189.3m | Reduced -209.2k |
| BlackRock, Inc. 0.00% of their portfolio | 3.3m $183.5m | Added +382.3k |
| Paradigm Biocapital Advisors LP 2.59% of their portfolio | 2.5m $138.4m | New |
| NVP ASSOCIATES, LLC 35.93% of their portfolio | 2.1m $117.9m | Unchanged |
| Deep Track Capital, LP 1.41% of their portfolio | 1.7m $95.6m | Reduced -1.0m |
| Polar Capital Holdings Plc 0.25% of their portfolio | 1.6m $88.8m | Reduced -13.7k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 1.5m $81.6m | Reduced -204 |
| Aaron Wealth Advisors LLC 3.27% of their portfolio | 1.2m $64.5m | Reduced -377 |
| Driehaus Capital Management LLC 0.34% of their portfolio | 1.1m $58.3m | Added +38.4k |
| Kynam Capital Management, LP 2.85% of their portfolio | 934.8k $51.6m | Unchanged |
| Woodline Partners LP 0.15% of their portfolio | 900.1k $49.7m | Added +29 |
| EVENTIDE ASSET MANAGEMENT, LLC 0.64% of their portfolio | 873.5k $48.2m | Reduced -16.5k |
| STATE STREET CORP 0.00% of their portfolio | 864.5k $47.7m | Added +77.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 814.8k $45.0m | Reduced -214.2k |
| Parkman Healthcare Partners LLC 4.54% of their portfolio | 800.2k $44.2m | Added +136 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 773.1k $42.7m | Added +102.7k |
| BRAIDWELL LP 1.45% of their portfolio | 710.9k $39.2m | Reduced -781.6k |
| TCG Crossover Management, LLC 0.86% of their portfolio | 650.0k $35.9m | Unchanged |
| Cormorant Asset Management, LP 1.56% of their portfolio | 550.0k $30.4m | Reduced -570.0k |
| Soleus Capital Management, L.P. 0.98% of their portfolio | 515.3k $28.4m | Added +336.4k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 459.0k $25.3m | Added +1.1k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 401.9k $22.2m | Added +339.2k |
| EcoR1 Capital, LLC 1.06% of their portfolio | 388.5k $21.4m | Reduced -388.5k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 346.7k $19.1m | Added +53.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 298.9k $16.5m | Added +270.2k |
| Rock Springs Capital Management LP 0.80% of their portfolio | 298.2k $16.5m | Added +10.3k |
| Candriam S.C.A. 0.07% of their portfolio | 289.9k $16.0m | Reduced -4.5k |
| UBS Group AG 0.00% of their portfolio | 272.7k $15.1m | Reduced -74.2k |
| Opaleye Management Inc. 1.30% of their portfolio | 260.0k $14.4m | Unchanged |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 252.7k $13.9m | New |
| Schonfeld Strategic Advisors LLC 0.07% of their portfolio | 248.7k $13.7m | Added +124.9k |
| MORGAN STANLEY 0.00% of their portfolio | 248.6k $13.7m | Added +217.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 246.7k $13.6m | Added +36.1k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 233.7k $12.9m | Added +186.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 233.1k $12.9m | Added +18.2k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 226.2k $12.5m | Reduced -338.3k |
| Tetragon Partners GP Ltd 1.83% of their portfolio | 203.5k $11.2m | Added +58.1k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 201.4k $11.1m | Added +31.3k |
| Caligan Partners LP 0.53% of their portfolio | 200.0k $11.0m | Reduced -648.6k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 182.8k $10.1m | Reduced -106.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 139.6k $7.5m | Reduced -7.4k |
| KVP Capital Advisors, LP 4.92% of their portfolio | 121.5k $6.7m | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 113.5k $6.3m | Reduced -1.6k |
| Burkehill Global Management, LP 0.20% of their portfolio | 100.0k $5.5m | Unchanged |
| Nuveen, LLC 0.00% of their portfolio | 98.7k $5.5m | Added +16.9k |
| TD Asset Management Inc 0.00% of their portfolio | 95.6k $5.3m | Reduced -20.4k |
| Elmind Capital, LP 1.26% of their portfolio | 91.0k $5.0m | Reduced -120.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 88.9k $4.9m | Added +8.7k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 88.0k $4.9m | New |
| BARCLAYS PLC 0.00% of their portfolio | 87.9k $4.8m | Added +76.0k |
| Affinity Asset Advisors, LLC 0.20% of their portfolio | 75.0k $4.1m | Reduced -75.0k |
| PFM Health Sciences, LP 0.34% of their portfolio | 71.0k $3.9m | Reduced -923 |
| BOOTHBAY FUND MANAGEMENT, LLC 0.07% of their portfolio | 70.4k $3.9m | Reduced -137.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 66.1k $3.6m | Reduced -24.5k |
| MOORE CAPITAL MANAGEMENT, LP 0.08% of their portfolio | 64.9k $3.6m | New |
| Rhenman & Partners Asset Management AB 0.32% of their portfolio | 62.0k $3.4m | New |
| Invesco Ltd. 0.00% of their portfolio | 50.7k $2.8m | Added +23.2k |
| ALPS ADVISORS INC 0.01% of their portfolio | 48.0k $2.7m | Added +11.5k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.59% of their portfolio | 43.6k $2.4m | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 42.9k $2.4m | Reduced -1.5k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 42.2k $2.3m | New |
| ALGERT GLOBAL LLC 0.03% of their portfolio | 42.1k $2.3m | Added +6.0k |
| Creative Planning 0.00% of their portfolio | 39.5k $2.2m | Added +3.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 37.2k $2.1m | Added +3.3k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 31.7k $1.7m | Added +8.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 31.0k $925.4k | Added +500 |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 28.3k $1.6m | Added +17.6k |
| EXCHANGE TRADED CONCEPTS, LLC 0.01% of their portfolio | 27.4k $1.5m | Reduced -6.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 26.7k $1.5m | Added +17.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 26.1k $1.4m | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH 0.00% of their portfolio | 25.8k $1.4m | New |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 25.4k $1.4m | New |
| CITIGROUP INC 0.00% of their portfolio | 25.1k $1.4m | Added +11.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 23.4k $1.3m | Added +611 |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 22.7k $1.3m | Added +14.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 22.6k $1.2m | Reduced -4.8k |
| Legal & General Group Plc 0.00% of their portfolio | 21.6k $1.2m | Added +2.2k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 21.3k $1.2m | Added +14.1k |
| Cerity Partners LLC 0.00% of their portfolio | 21.0k $1.2m | Reduced -166 |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 19.0k $1.0m | Added +2.9k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 18.2k $1.0m | Added +2.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 18.2k $1.0m | Added +14.3k |
| Koa Wealth Management, LLC 0.64% of their portfolio | 17.1k $944.6k | Reduced -800 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 16.0k $881.6k | Reduced -3.3k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 14.8k $814.3k | Unchanged |
| OPTIMIZE FINANCIAL INC. 0.29% of their portfolio | 14.5k $798.1k | Reduced -50 |
| Sound Capital Solutions LLC 0.19% of their portfolio | 14.5k $798.1k | First filing |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 14.3k $788.9k | Added +967 |
| DAFNA Capital Management LLC 0.12% of their portfolio | 11.8k $651.9k | Reduced -163.7k |
| HighVista Strategies LLC 0.15% of their portfolio | 11.6k $642.2k | Added +162 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 11.0k $607.2k | Added +2.0k |
| Jupiter Topco LLC 0.00% of their portfolio | 10.3k $568.3k | First filing |
| FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio | 9.9k $545.2k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 9.9k $544.3k | Reduced -524 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 9.8k $539.7k | New |
| Virtus Investment Advisers, LLC 0.12% of their portfolio | 9.2k $508.7k | Added +84 |