XENCOR INC XNCR
COM · Common Stock · CUSIP 98401F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersPasadena, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($202.7k this quarter). Holder counts are more reliable. Shares outstanding: 74.4m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $16.12. Options: 1 managers hold calls ($4.8k notional), 1 hold puts ($1.6k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 186 |
| Q4 2022 | 197 |
| Q1 2023 | 189 |
| Q2 2023 | 183 |
| Q3 2023 | 179 |
| Q4 2023 | 196 |
| Q1 2024 | 202 |
| Q2 2024 | 199 |
| Q3 2024 | 211 |
| Q4 2024 | 194 |
| Q1 2025 | 203 |
| Q2 2025 | 195 |
| Q3 2025 | 206 |
| Q4 2025 | 208 |
| Q1 2026 | 203 |
| Q2 2026 | 208 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 92 | 108 |
| Q4 2024 | 101 | 95 |
| Q1 2025 | 102 | 91 |
| Q2 2025 | 115 | 69 |
| Q3 2025 | 88 | 98 |
| Q4 2025 | 86 | 105 |
| Q1 2026 | 89 | 92 |
| Q2 2026 | 114 | 80 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $115.9k | $0 | 0.00 |
| Q4 2025 | $1.1m | $12.2k | 0.01 |
| Q1 2026 | $60.3k | $1.2k | 0.02 |
| Q2 2026 | $4.8k | $1.6k | 0.33 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +796.0k |
| BlackRock, Inc. | Added | +615.3k |
| STATE STREET CORP | Added | +602.0k |
| Deep Track Capital, LP | New | +593.6k |
| RA CAPITAL MANAGEMENT, L.P. | Added | +377.0k |
| AQR CAPITAL MANAGEMENT LLC | Added | +321.4k |
| Seven Fleet Capital Management LP | Added | +288.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Added | +260.8k |
| MILLENNIUM MANAGEMENT LLC | Added | +243.9k |
| UBS Group AG | Added | +223.8k |
Biggest sellers
| EcoR1 Capital, LLC | Sold out | -2.2m |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Reduced | -1.3m |
| Lynx1 Capital Management LP | Reduced | -518.2k |
| Erste Asset Management GmbH | Reduced | -338.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Sold out | -293.1k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -283.8k |
| Hudson Bay Capital Management LP | Reduced | -277.3k |
| Nantahala Capital Management, LLC | Sold out | -264.6k |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -223.8k |
| CITADEL ADVISORS LLC | Reduced | -186.9k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $4.8k300 shares |
Biggest puts
| SIMPLEX TRADING, LLC | New | $1.6k100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| PRIMECAP MANAGEMENT CO/CA/ 13G · institution filed 2025-08-14 | 14.8% |
| BlackRock, Inc. 13G · institution -1.3 pts · filed 2026-10-27 | 14.5% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor +3.5 pts · filed 2026-02-17 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2025-11-14 | 8.7% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-03-30 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-02-09 | 6.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: EcoR1 Capital, LLC (2.9%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), PRICE T ROWE ASSOCIATES INC /MD/ (2.4%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 3 | $3.3m | $3.3m |
| Q1 2025 | 0 | — | 4 | $513.0k | — |
| Q2 2025 | 0 | — | 7 | $158.4k | $77.3k |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 2 | $3.0m | — |
| Q1 2026 | 0 | — | 4 | $528.1k | — |
| Q2 2026 | 0 | — | 6 | $354.8k | $311.7k |
| Q3 2026 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-06-18 | Feigal Ellen Director | Sold plan | $89.4k6.8k shares |
| 2026-06-15 | GORMAN KEVIN CHARLES Director | Sold plan | $92.7k7.5k shares |
| 2026-06-15 | RANIERI RICHARD J Director | Sold plan | $67.4k5.5k shares |
| 2026-06-15 | GUSTAFSON KURT A Director | Sold plan | $67.4k5.5k shares |
| 2026-06-15 | Montgomery Alan Bruce Director | Sold plan | $62.3k5.1k shares |
| 2026-04-10 | Cornelissen Bart Jan SR. VICE PRESIDENT & CFO | Sold | $43.0k3.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 13.7m $219.8m | Added +615.3k |
| PRIMECAP MANAGEMENT CO/CA/ 0.10% of their portfolio | 10.2m $163.9m | Reduced -156.7k |
| BVF INC/IL 2.94% of their portfolio | 7.1m $114.9m | Unchanged |
| RTW INVESTMENTS, LP 0.93% of their portfolio | 6.8m $109.1m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.74% of their portfolio | 5.3m $84.9m | Added +377.0k |
| STATE STREET CORP 0.00% of their portfolio | 5.0m $79.8m | Added +602.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 3.3m $52.8m | Added +177.2k |
| TCG Crossover Management, LLC 0.95% of their portfolio | 2.5m $39.5m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.4m $37.9m | Added +796.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 2.2m $35.7m | Reduced -1.3m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.9m $30.9m | Added +105.3k |
| MORGAN STANLEY 0.00% of their portfolio | 1.8m $28.2m | Added +194.3k |
| UBS Group AG 0.00% of their portfolio | 1.3m $21.0m | Added +223.8k |
| BAKER BROS. ADVISORS LP 0.09% of their portfolio | 1.1m $17.7m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 1.1m $17.6m | Added +24.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 1.0m $16.3m | Reduced -283.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 968.8k $15.6m | Added +205.0k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 853.7k $13.7m | Added +243.9k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 819.5k $13.2m | Added +14.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 794.3k $12.8m | Added +49.8k |
| JOHNSON & JOHNSON 1.51% of their portfolio | 748.1k $12.0m | Unchanged |
| Jefferies Financial Group Inc. 0.11% of their portfolio | 720.4k $11.6m | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 707.2k $11.4m | Added +10.4k |
| PANAGORA ASSET MANAGEMENT INC 0.03% of their portfolio | 680.2k $11.0m | Added +59.4k |
| Deep Track Capital, LP 0.14% of their portfolio | 593.6k $9.6m | New |
| TORONTO DOMINION BANK 0.01% of their portfolio | 491.0k $7.9m | Unchanged |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 487.1k $7.8m | Added +16.0k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 483.8k $7.8m | Added +321.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 410.8k $6.6m | Added +14.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 382.1k $6.2m | Added +260.8k |
| Seven Fleet Capital Management LP 1.29% of their portfolio | 368.3k $7.8m | Added +288.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 360.4k $5.8m | Reduced -5.7k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 358.2k $5.8m | Added +11.2k |
| Invesco Ltd. 0.00% of their portfolio | 260.6k $4.2m | Reduced -3.2k |
| Velan Capital Investment Management LP 2.52% of their portfolio | 255.0k $4.1m | Added +5.0k |
| Public Sector Pension Investment Board 0.01% of their portfolio | 254.7k $4.1m | Reduced -731 |
| ADAR1 Capital Management, LLC 0.18% of their portfolio | 232.6k $3.7m | Added +138.9k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 210.0k $3.4m | Reduced -277.3k |
| BARCLAYS PLC 0.00% of their portfolio | 203.6k $3.3m | Reduced -14.7k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.00% of their portfolio | 200.0k $3.2m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 190.8k $3.1m | Reduced -186.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 181.6k $2.9m | Added +11.2k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 180.2k $2.9m | Added +5.0k |
| CITIGROUP INC 0.00% of their portfolio | 167.2k $2.7m | Added +62.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 167.1k $2.6m | Reduced -34.8k |
| Susquehanna Portfolio Strategies, LLC 0.04% of their portfolio | 159.6k $2.6m | Added +21.5k |
| KORNITZER CAPITAL MANAGEMENT INC /KS 0.05% of their portfolio | 151.4k $2.4m | New |
| Trexquant Investment LP 0.01% of their portfolio | 144.6k $2.3m | Added +100.1k |
| Nuveen, LLC 0.00% of their portfolio | 139.4k $2.2m | Added +4.6k |
| Jump Financial, LLC 0.02% of their portfolio | 131.0k $2.1m | Added +120.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 125.5k $2.1m | Added +66.9k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 124.4k $2.0m | Reduced -4.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 119.8k $1.9m | Reduced -103.8k |
| FMR LLC 0.00% of their portfolio | 119.7k $1.9m | Added +7.9k |
| OP Asset Management Ltd 0.02% of their portfolio | 110.1k $1.8m | Added +55.0k |
| XTX Topco Ltd 0.02% of their portfolio | 107.4k $1.7m | Added +15.3k |
| WINTON GROUP Ltd 0.06% of their portfolio | 106.2k $1.7m | Added +1.5k |
| DCF Advisers, LLC 0.44% of their portfolio | 103.7k $1.7m | Unchanged |
| Essex LLC 0.24% of their portfolio | 98.7k $1.6m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 97.8k $1.2m | Added +25.7k |
| Erste Asset Management GmbH 0.01% of their portfolio | 92.2k $1.4m | Reduced -338.0k |
| Swiss National Bank 0.00% of their portfolio | 92.0k $1.5m | Reduced -6.8k |
| Quinn Opportunity Partners LLC 0.07% of their portfolio | 90.0k $1.4m | Added +60.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 80.7k $1.3m | Reduced -22.3k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 75.1k $1.2m | Added +47.2k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 74.9k $1.2m | Added +680 |
| ALPS ADVISORS INC 0.01% of their portfolio | 74.6k $1.2m | Added +14.9k |
| HRT FINANCIAL LP 0.00% of their portfolio | 74.6k $1.2m | Added +14.9k |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 72.9k $1.2m | Added +29.1k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 71.6k $1.2m | New |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 70.5k $1.1m | Added +2.3k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 70.2k $1.1m | Added +48.5k |
| SG Americas Securities, LLC 0.00% of their portfolio | 68.2k $1.1m | Added +602 |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 67.9k $1.1m | Reduced -223.8k |
| TD Asset Management Inc 0.00% of their portfolio | 62.2k $1.0m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 60.8k $979.5k | Added +33.6k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 59.7k $961.0k | Reduced -1.6k |
| Man Group plc 0.00% of their portfolio | 58.4k $939.9k | Reduced -35.3k |
| CANADA LIFE ASSURANCE Co 0.00% of their portfolio | 57.2k $921.0k | Unchanged |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 53.9k $868.1k | Reduced -21.7k |
| Quantinno Capital Management LP 0.00% of their portfolio | 53.5k $861.3k | Reduced -3.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 50.5k $812.6k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 49.7k $800.1k | Reduced -31.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 46.3k $745.9k | Added +5.3k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 45.4k $730.6k | Reduced -37.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 44.4k $714.9k | Added +16.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 43.8k $705.8k | Added +2.7k |
| Inspire Investing, LLC 0.03% of their portfolio | 41.6k $670.4k | Reduced -887 |
| MetLife Investment Management, LLC 0.00% of their portfolio | 40.6k $653.9k | Added +899 |
| Cerity Partners LLC 0.00% of their portfolio | 39.9k $642.9k | Added +9.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 38.2k $611.8k | Reduced -91 |
| Palumbo Wealth Management LLC 0.13% of their portfolio | 37.5k $604.4k | Added +19.7k |
| GSA CAPITAL PARTNERS LLP 0.04% of their portfolio | 34.5k $556.0k | Reduced -72.2k |
| EntryPoint Capital, LLC 0.13% of their portfolio | 32.8k $527.3k | Added +7.5k |
| Louisiana State Employees Retirement System 0.01% of their portfolio | 32.5k $523.2k | Added +800 |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 31.4k $505.4k | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 30.8k $496.5k | Added +10.2k |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 29.6k $476.8k | Reduced -7.2k |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 29.4k $472.7k | Added +1.4k |
| Squarepoint Ops LLC 0.00% of their portfolio | 28.5k $459.0k | New |