Soleus Capital Management, L.P.

GREENWICH, CT · CIK 1802630 · 13F filing filed 2026-08-11

No investment adviser registration (Form ADV) found for this filer. It may be a parent company whose subsidiaries are the registered advisers, a bank or insurer, or a manager based outside the US.

Legal entitySOLEUS CAPITAL MANAGEMENT, L.P. (US)

Others nearbyGreenwich, CT

$2.9bn reported value +17.5% vs Q1 2026

97positions

48.9%in top 10

22 new 25 added 41 reduced 18 sold out vs Q1 2026

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	KRYSTAL BIOTECH INC COM KRYS	KRYS	939,254	$349.1m12.03%	12.03%	Reduced -213.8k	-213,833 -18.5%
2	CELCUITY INC COM CELC	CELC	1,704,318	$178.3m6.14%	6.14%	Added +419.9k	+419,940 32.7%
3	TG THERAPEUTICS INC COM TGTX	TGTX	2,927,895	$160.9m5.54%	5.54%	Reduced -1.1m	-1,101,424 -27.3%
4	INSULET CORP COM PODD	PODD	1,049,000	$159.7m5.50%	5.50%	Added +486.5k	+486,500 86.5%
5	NOVOCURE LTD ORD SHS NVCR	NVCR	9,913,401	$150.2m5.18%	5.18%	Reduced -579.0k	-578,990 -5.5%
6	UNITED THERAPEUTICS CORP DEL COM UTHR	UTHR	225,587	$122.2m4.21%	4.21%	Added +38.4k	+38,400 20.5%
7	INSPIRE MED SYS INC COM INSP	INSP	1,931,436	$86.2m2.97%	2.97%	Added +1.4m	+1,355,137 235.1%
8	RIGEL PHARMACEUTICALS INC COM RIGL	RIGL	1,843,504	$72.1m2.49%	2.49%	Added +1.8m	+1,833,504 18335.0%
9	ANI PHARMACEUTICALS INC COM ANIP	ANIP	867,760	$71.8m2.48%	2.48%	Added +47.5k	+47,517 5.8%
10	BETA BIONICS INC COM BBNX	BBNX	4,393,714	$68.8m2.37%	2.37%	Added +39.2k	+39,213 0.9%
11	VERICEL CORP COM VCEL	VCEL	1,459,152	$64.9m2.24%	2.24%	Reduced -1.1m	-1,089,927 -42.8%
12	PRAXIS PRECISION MEDICINES I COM NEW PRAX	PRAX	177,517	$59.4m2.05%	2.05%	Reduced -153.0k	-153,000 -46.3%
13	GERON CORP COM GERN	GERN	42,808,659	$54.8m1.89%	1.89%	Added +1.3m	+1,300,000 3.1%
14	ALKERMES PLC SHS ALKS	ALKS	1,029,252	$53.9m1.86%	1.86%	Reduced -941.6k	-941,612 -47.8%
15	ERASCA INC COM ERAS	ERAS	2,700,000	$49.5m1.70%	1.70%	New
16	NEUROPACE INC COM NPCE	NPCE	2,911,122	$46.3m1.59%	1.59%	Reduced -21.1k	-21,085 -0.7%
17	PROGYNY INC COM PGNY	PGNY	1,602,000	$46.2m1.59%	1.59%	Reduced -465.0k	-465,000 -22.5%
18	INDIVIOR PHARMACEUTICALS INC COM INDV	INDV	1,064,000	$43.7m1.50%	1.50%	Reduced -210.0k	-210,000 -16.5%
19	PARABILIS MEDICINES INC COM PBLS	PBLS	1,465,070	$40.1m1.38%	1.38%	New
20	EDAP TMS S A SPONSORED ADR FOCL	FOCL	7,309,254	$37.9m1.30%	1.30%	Unchanged
21	GLOBUS MED INC CL A GMED	GMED	468,922	$37.0m1.28%	1.28%	Reduced -260.5k	-260,545 -35.7%
22	ARCUS BIOSCIENCES INC COM RCUS	RCUS	1,168,738	$36.0m1.24%	1.24%	Added +716.8k	+716,755 158.6%
23	SYNDAX PHARMACEUTICALS INC COM SNDX	SNDX	1,628,039	$35.6m1.23%	1.23%	Reduced -98.9k	-98,869 -5.7%
24	NURIX THERAPEUTICS INC COM NRIX	NRIX	1,465,163	$35.5m1.22%	1.22%	Added +527.0k	+527,000 56.2%
25	LEGEND BIOTECH CORP SPONSORED ADS LEGN	LEGN	1,205,000	$34.8m1.20%	1.20%	New
26	JADE BIOSCIENCES INC COM NEW JBIO	JBIO	1,550,690	$34.5m1.19%	1.19%	Added +753.9k	+753,946 94.6%
27	UNITEDHEALTH GROUP INC COM UNH	UNH	80,000	$33.3m1.15%	1.15%	New
28	AVALO THERAPEUTICS INC COM NEW AVTX	AVTX	1,654,978	$30.6m1.05%	1.05%	Added +1.2m	+1,213,000 274.4%
29	UROGEN PHARMA LTD COM URGN	URGN	829,810	$30.5m1.05%	1.05%	Added +102.8k	+102,810 14.1%
30	MBX BIOSCIENCES INC COM MBX	MBX	515,279	$28.4m0.98%	0.98%	Added +336.4k	+336,382 188.0%
31	PALISADE BIO INC COM PALI	PALI	13,063,687	$27.3m0.94%	0.94%	New
32	PHARVARIS N V COM PHVS	PHVS	730,907	$25.3m0.87%	0.87%	Added +28.9k	+28,855 4.1%
33	ORGANOGENESIS HLDGS INC COM ORGO	ORGO	10,140,951	$24.6m0.85%	0.85%	Added +55.0k	+55,000 0.6%
34	SUPERNUS PHARMACEUTICALS INC COM SUPN	SUPN	520,000	$24.2m0.83%	0.83%	New
35	PROCEPT BIOROBOTICS CORP COM PRCT	PRCT	1,003,000	$22.6m0.78%	0.78%	Added +843.0k	+843,000 526.9%
36	TANGO THERAPEUTICS INC COM TNGX	TNGX	709,000	$22.2m0.76%	0.76%	Added +259.0k	+259,000 57.6%
37	INHIBIKASE THERAPEUTICS INC COM NEW IKT	IKT	10,875,000	$22.1m0.76%	0.76%	Unchanged
38	TREVI THERAPEUTICS INC COM TRVI	TRVI	1,179,618	$22.0m0.76%	0.76%	Reduced -440.4k	-440,382 -27.2%
39	BIOMARIN PHARMACEUTICAL INC COM BMRN	BMRN	375,572	$21.5m0.74%	0.74%	Reduced -275.0k	-275,000 -42.3%
40	LIVANOVA PLC SHS LIVN	LIVN	254,957	$21.0m0.72%	0.72%	Reduced -327.5k	-327,543 -56.2%
41	ARGENX SE SPONSORED ADR ARGX	ARGX	19,955	$18.5m0.64%	0.64%	Added +16.5k	+16,455 470.1%
42	NUVECTIS PHARMA INC COM NVCT	NVCT	1,000,000	$18.4m0.63%	0.63%	New
43	CAPRICOR THERAPEUTICS INC COM NEW CAPR	CAPR	761,737	$18.3m0.63%	0.63%	New
44	EDGEWISE THERAPEUTICS INC COM EWTX	EWTX	450,889	$18.3m0.63%	0.63%	Reduced -999.0k	-999,026 -68.9%
45	PRELUDE THERAPEUTICS INC COM PRLD	PRLD	3,378,378	$18.0m0.62%	0.62%	New
46	XENON PHARMACEUTICALS INC COM XENE	XENE	267,000	$16.1m0.56%	0.56%	Reduced -25.0k	-25,000 -8.6%
47	C4 THERAPEUTICS INC COM STK CCCC	CCCC	3,377,981	$15.8m0.54%	0.54%	Reduced -426.0k	-425,961 -11.2%
48	KINIKSA PHARMACEUTICALS INTL ORD SHS CL A KNSA	KNSA	246,353	$15.8m0.54%	0.54%	Reduced -275.0k	-275,000 -52.8%
49	ORTHOPEDIATRICS CORP COM KIDS	KIDS	732,144	$14.0m0.48%	0.48%	Added +116.7k	+116,697 19.0%
50	AVALYN PHARMACEUTICALS INC COM SHS AVLN	AVLN	419,000	$13.8m0.48%	0.48%	New
51	BIODESIX INC COM BDSX	BDSX	585,958	$13.2m0.46%	0.46%	Added +169.4k	+169,359 40.6%
52	SPYRE THERAPEUTICS INC COM NEW SYRE	SYRE	147,000	$13.1m0.45%	0.45%	New
53	TWIST BIOSCIENCE CORP COM TWST	TWST	104,629	$10.8m0.37%	0.37%	Reduced -1.1m	-1,122,000 -91.5%
54	VIR BIOTECHNOLOGY INC COM VIR	VIR	1,000,000	$10.2m0.35%	0.35%	Reduced -1.0m	-1,002,000 -50.0%
55	ALNYLAM PHARMACEUTICALS INC COM ALNY	ALNY	33,050	$9.9m0.34%	0.34%	Reduced -98.6k	-98,600 -74.9%
56	IMMUNOVANT INC COM IMVT	IMVT	252,000	$9.7m0.33%	0.33%	Added +22.0k	+22,000 9.6%
57	INSMED INC COM PAR $.01 INSM	INSM	90,250	$9.6m0.33%	0.33%	Added +80.0k	+80,000 780.5%
58	SEPTERNA INC COM SEPN	SEPN	275,000	$9.2m0.32%	0.32%	Unchanged
59	SOPHIA GENETICS SA ORDINARY SHARES SOPH	SOPH	1,565,000	$9.0m0.31%	0.31%	Reduced -285.0k	-285,000 -15.4%
60	NEKTAR THERAPEUTICS COM NEW NKTR	NKTR	128,362	$9.0m0.31%	0.31%	New
61	MIRUM PHARMACEUTICALS INC COM MIRM	MIRM	75,000	$8.8m0.30%	0.30%	Reduced -325.3k	-325,306 -81.3%
62	ARTIVION INC COM AORT	AORT	388,000	$8.7m0.30%	0.30%	New
63	TANDEM DIABETES CARE INC COM NEW TNDM	TNDM	575,000	$8.7m0.30%	0.30%	Reduced -208.0k	-208,000 -26.6%
64	ENLIVEN THERAPEUTICS INC COM ELVN	ELVN	165,677	$8.4m0.29%	0.29%	Reduced -65.2k	-65,192 -28.2%
65	SIONNA THERAPEUTICS INC COM SION	SION	177,687	$7.8m0.27%	0.27%	Reduced -115.8k	-115,813 -39.5%
66	BELITE BIO INC SPONSORED ADS BLTE	BLTE	50,524	$7.8m0.27%	0.27%	New
67	CERUS CORP COM CERS	CERS	2,500,000	$7.3m0.25%	0.25%	Reduced -8.3m	-8,253,700 -76.8%
68	SILENCE THERAPEUTICS PLC ADS SLN	SLN	630,000	$6.9m0.24%	0.24%	New
69	IMMUNIC INC COM NEW IMUX	IMUX	450,000	$6.9m0.24%	0.24%	New
70	INVIVYD INC COM IVVD	IVVD	7,708,727	$6.7m0.23%	0.23%	Unchanged
71	MERCK & CO INC COM MRK	MRK	50,000	$6.4m0.22%	0.22%	Reduced -153.0k	-153,000 -75.4%
72	RELMADA THERAPEUTICS INC COM RLMD	RLMD	842,106	$5.8m0.20%	0.20%	Unchanged
73	STRUCTURE THERAPEUTICS INC SPONSORED ADS GPCR	GPCR	107,000	$5.7m0.20%	0.20%	Added +27.0k	+27,000 33.8%
74	EVOLUS INC COM EOLS	EOLS	822,428	$5.7m0.20%	0.20%	Reduced -1.4m	-1,422,932 -63.4%
75	ADLAI NORTYE LTD SPONSORED ADS ANL	ANL	405,523	$4.7m0.16%	0.16%	New
76	ZENTALIS PHARMACEUTICALS INC COM ZNTL	ZNTL	950,000	$4.6m0.16%	0.16%	New
77	KARYOPHARM THERAPEUTICS INC COM NEW KPTI	KPTI	440,000	$4.3m0.15%	0.15%	Unchanged
78	CONTEXT THERAPEUTICS INC COM CNTX	CNTX	7,063,141	$3.9m0.13%	0.13%	Added +100.0k	+100,000 1.4%
79	PULMONX CORP COM LUNG	LUNG	2,788,323	$3.6m0.12%	0.12%	Unchanged
80	SAB BIOTHERAPEUTICS INC COM NEW SABS	SABS	900,000	$3.5m0.12%	0.12%	Reduced -150.0k	-150,000 -14.3%
81	TECTONIC THERAPEUTIC INC COM TECX	TECX	101,684	$3.5m0.12%	0.12%	Reduced -20.0k	-20,000 -16.4%
82	AXOGEN INC COM AXGN	AXGN	57,036	$2.6m0.09%	0.09%	Reduced -622.1k	-622,134 -91.6%
83	SATELLOS BIOSCIENCE INC COM MSLE	MSLE	314,359	$2.4m0.08%	0.08%	Reduced -100.0k	-100,000 -24.1%
84	ARRIVENT BIOPHARMA INC COM AVBP	AVBP	50,000	$1.7m0.06%	0.06%	New
85	CORCEPT THERAPEUTICS INC COM CORT	CORT	19,653	$1.7m0.06%	0.06%	Reduced -265.9k	-265,878 -93.1%
86	SOLID BIOSCIENCES INC COM NEW SLDB	SLDB	150,000	$1.5m0.05%	0.05%	New
87	VERACYTE INC COM VCYT	VCYT	25,000	$1.5m0.05%	0.05%	Reduced -294.9k	-294,912 -92.2%
88	CULLINAN THERAPEUTICS INC COM CGEM	CGEM	50,000	$910.5k0.03%	0.03%	Reduced -360.2k	-360,200 -87.8%
89	INSPIREMD INC COM NSPR	NSPR	1,045,708	$732.1k0.03%	0.03%	Unchanged
90	GENEDX HOLDINGS CORP COM CL A WGS	WGS	10,000	$686.5k0.02%	0.02%	New
91	IOVANCE BIOTHERAPEUTICS INC COM IOVA	IOVA	150,000	$624.0k0.02%	0.02%	Reduced -850.0k	-850,000 -85.0%
92	LARIMAR THERAPEUTICS INC COM LRMR	LRMR	188,102	$573.7k0.02%	0.02%	Reduced -878.9k	-878,858 -82.4%
93	CG ONCOLOGY INC COM CGON	CGON	5,000	$355.2k0.01%	0.01%	Reduced -15.0k	-15,000 -75.0%
94	QUOIN PHARMACEUTICALS LTD SPONSORED ADS QNRX	QNRX	72,730	$352.0k0.01%	0.01%	Unchanged
95	EQUILLIUM INC COM EQ	EQ	90,000	$288.0k0.01%	0.01%	New
96	NATERA INC COM NTRA	NTRA	1,000	$271.4k0.01%	0.01%	Reduced -118.0k	-118,000 -99.2%
97	NEOGENOMICS INC COM NEW NEO	NEO	10,000	$145.9k0.01%	0.01%	Reduced -165.0k	-165,000 -94.3%

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
VAXCYTE INC PCVX	PCVX	385,472	$22.4m385.5k shares
ICON PLC ICLR	ICLR	192,000	$21.2m192.0k shares
TRAVERE THERAPEUTICS INC TVTX	TVTX	546,000	$16.2m546.0k shares
INHIBRX BIOSCIENCES INC INBX	INBX	131,000	$8.8m131.0k shares
DEXCOM INC DXCM	DXCM	140,000	$8.8m140.0k shares
IMMUNIC INC		4,500,000	$5.0m4.5m shares
ETON PHARMACEUTICALS INC ETON	ETON	166,381	$4.1m166.4k shares
ARROWHEAD PHARMACEUTICALS IN ARWR	ARWR	28,479	$1.8m28.5k shares
CYTOMX THERAPEUTICS INC CTMX	CTMX	300,000	$1.4m300.0k shares
COGENT BIOSCIENCES INC COGT	COGT	10,000	$384.9k10.0k shares
TYRA BIOSCIENCES INC TYRA	TYRA	10,000	$383.0k10.0k shares
STAAR SURGICAL CO STAA	STAA	20,000	$374.0k20.0k shares
ANAPTYSBIO INC ANAB	ANAB	6,000	$332.8k6.0k shares
RAPPORT THERAPEUTICS INC RAPP	RAPP	10,000	$312.9k10.0k shares
ZYMEWORKS INC ZYME	ZYME	10,000	$250.4k10.0k shares
LB PHARMACEUTICALS INC LBRX	LBRX	10,000	$246.6k10.0k shares
ORUKA THERAPEUTICS INC ORKA	ORKA	5,000	$245.2k5.0k shares
JASPER THERAPEUTICS INC JSPR	JSPR	276,312	$242.1k276.3k shares

Trades reported as a company insider since 1 Apr 2026

Owning 10% or more of a company, or having someone on its board, makes this manager an insider there: it reports its trades in that company's shares on Form 4 within two business days. Open-market and private purchases and sales only.

Date	Company	Ticker	Trade	Shares	Value	Their holding
2026-06-11	PARABILIS MEDICINES INC 10% owner · See footnote	PBLS	Bought	500,000	$10.0m500.0k shares	+329%