IOVANCE BIOTHERAPEUTICS INC IOVA
COM · Common Stock · CUSIP 462260100 · ISIN US4622601007
American biopharmaceutical startup
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersSan Carlos, CA
- Founded2007
- Websiteiovance.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($174.3k this quarter). Holder counts are more reliable. Shares outstanding: 453.0m as of 2026-07-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $4.16. Options: 10 managers hold calls ($24.0m notional), 7 hold puts ($20.8m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 243 |
| Q4 2022 | 219 |
| Q1 2023 | 230 |
| Q2 2023 | 221 |
| Q3 2023 | 230 |
| Q4 2023 | 238 |
| Q1 2024 | 274 |
| Q2 2024 | 297 |
| Q3 2024 | 288 |
| Q4 2024 | 304 |
| Q1 2025 | 304 |
| Q2 2025 | 256 |
| Q3 2025 | 253 |
| Q4 2025 | 263 |
| Q1 2026 | 286 |
| Q2 2026 | 292 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 141 | 130 |
| Q4 2024 | 137 | 122 |
| Q1 2025 | 154 | 146 |
| Q2 2025 | 130 | 156 |
| Q3 2025 | 123 | 117 |
| Q4 2025 | 147 | 99 |
| Q1 2026 | 176 | 96 |
| Q2 2026 | 172 | 99 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $7.5m | $4.5m | 0.60 |
| Q4 2025 | $12.0m | $5.9m | 0.49 |
| Q1 2026 | $15.1m | $14.6m | 0.96 |
| Q2 2026 | $24.0m | $20.8m | 0.86 |
Biggest buyers
| STATE STREET CORP | Added | +7.0m |
| BlackRock, Inc. | Added | +5.9m |
| TWO SIGMA INVESTMENTS, LP | Added | +5.3m |
| JUPITER ASSET MANAGEMENT LTD | New | +4.5m |
| DIMENSIONAL FUND ADVISORS LP | Added | +3.8m |
| AQR CAPITAL MANAGEMENT LLC | Added | +3.2m |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +2.7m |
| Xcelsior Advisor Partners LLC | Added | +1.8m |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +1.8m |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +1.6m |
Biggest sellers
| Invenomic Capital Management LP | Reduced | -7.0m |
| D. E. Shaw & Co., Inc. | Reduced | -5.9m |
| GOLDMAN SACHS GROUP INC | Reduced | -3.7m |
| BANK OF AMERICA CORP /DE/ | Reduced | -3.5m |
| MARSHALL WACE, LLP | Reduced | -2.3m |
| MORGAN STANLEY | Reduced | -1.2m |
| Palo Alto Investors LP | Reduced | -1.1m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -888.4k |
| Soleus Capital Management, L.P. | Reduced | -850.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -751.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $11.1m2.7m shares |
| GROUP ONE TRADING LLC | Added | $4.0m957.0k shares |
| CITADEL ADVISORS LLC | Added | $3.4m813.9k shares |
| JANE STREET GROUP, LLC | Added | $3.0m730.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.3m319.0k shares |
| Walleye Capital LLC | Added | $923.1k221.9k shares |
| TUDOR INVESTMENT CORP ET AL | New | $208.0k50.0k shares |
| IMC-Chicago, LLC | New | $47.4k11.4k shares |
| Raiffeisen Bank International AG | Unchanged | $8.3k2.0k shares |
| Walleye Trading LLC | Added | $5.8k1.4k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $10.0m2.4m shares |
| CITADEL ADVISORS LLC | Added | $3.0m720.4k shares |
| 683 Capital Management, LLC | Unchanged | $2.7m644.3k shares |
| GROUP ONE TRADING LLC | Added | $2.0m485.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.5m369.6k shares |
| JANE STREET GROUP, LLC | Added | $1.4m345.2k shares |
| Walleye Capital LLC | Added | $130.2k31.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.1 pts · filed 2026-07-28 | 7.5% |
| STATE STREET CORP 13G · institution +1.3 pts · filed 2026-08-07 | 5.5% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 1 | $503.0k | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 3 | $107.2k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 37.0m $153.7m | Added +5.9m |
| MHR FUND MANAGEMENT LLC 6.28% of their portfolio | 29.0m $120.5m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 24.5m $101.8m | Added +7.0m |
| TWO SIGMA INVESTMENTS, LP 0.06% of their portfolio | 19.0m $79.1m | Added +5.3m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 18.2m $75.7m | Added +1.6m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 14.4m $59.9m | Added +2.7m |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 10.3m $43.0m | Added +1.8m |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 8.5m $35.5m | Reduced -888.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 6.5m $26.9m | Added +3.8m |
| Palo Alto Investors LP 3.04% of their portfolio | 5.3m $22.0m | Reduced -1.1m |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 5.1m $21.2m | Reduced -3.7m |
| Nuveen, LLC 0.00% of their portfolio | 5.0m $20.8m | Added +1.3m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 5.0m $20.8m | Reduced -3.5m |
| MORGAN STANLEY 0.00% of their portfolio | 5.0m $20.7m | Reduced -1.2m |
| JUPITER ASSET MANAGEMENT LTD 0.09% of their portfolio | 4.5m $18.9m | New |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 4.4m $18.3m | Added +220.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 4.2m $17.3m | Added +1.3m |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 3.9m $16.1m | Added +3.2m |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 3.2m $13.5m | Added +1.2m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 3.2m $13.4m | Added +435.9k |
| HRT FINANCIAL LP 0.03% of their portfolio | 3.1m $12.9m | Reduced -388.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 2.7m $11.1m | Reduced -340.0k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 2.5m $10.6m | Added +358.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.4m $10.2m | Reduced -69.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 2.4m $10.1m | Reduced -751.4k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 2.1m $8.9m | Reduced -5.9m |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 2.1m $8.8m | Reduced -506.4k |
| Long Focus Capital Management, LLC 0.36% of their portfolio | 2.1m $8.7m | Unchanged |
| Orion Investment Co 2.52% of their portfolio | 2.1m $8.6m | Added +7.5k |
| Xcelsior Advisor Partners LLC 0.98% of their portfolio | 1.8m $7.4m | Added +1.8m |
| Rhenman & Partners Asset Management AB 0.67% of their portfolio | 1.7m $7.1m | Reduced -350.0k |
| Knott David M Jr 3.52% of their portfolio | 1.6m $6.7m | Unchanged |
| RICE HALL JAMES & ASSOCIATES, LLC 0.31% of their portfolio | 1.5m $6.4m | Added +24.9k |
| B Group, Inc. 3.54% of their portfolio | 1.5m $6.2m | Unchanged |
| Invenomic Capital Management LP 0.37% of their portfolio | 1.5m $6.2m | Reduced -7.0m |
| Woodline Partners LP 0.02% of their portfolio | 1.4m $5.7m | Added +71.2k |
| FMR LLC 0.00% of their portfolio | 1.4m $5.6m | Added +1.3m |
| UBS Group AG 0.00% of their portfolio | 1.3m $5.4m | Reduced -625.0k |
| Invesco Ltd. 0.00% of their portfolio | 1.3m $5.3m | Reduced -137.1k |
| C WorldWide Group Holding A/S 0.13% of their portfolio | 1.3m $5.2m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 1.2m $4.8m | Added +205.3k |
| Mirador Capital Partners LP 0.55% of their portfolio | 1.1m $4.5m | Added +7.1k |
| Susquehanna Portfolio Strategies, LLC 0.07% of their portfolio | 1.1m $4.4m | Added +141.1k |
| SECTOR GAMMA AS 0.87% of their portfolio | 968.5k $4.0m | Added +68.5k |
| CITIGROUP INC 0.00% of their portfolio | 882.1k $3.7m | Added +800.4k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 855.0k $3.6m | Added +120.0k |
| Jump Financial, LLC 0.03% of their portfolio | 825.9k $3.4m | Added +801.7k |
| Hennion & Walsh Asset Management, Inc. 0.10% of their portfolio | 818.9k $3.4m | Added +409.4k |
| Swiss National Bank 0.00% of their portfolio | 702.6k $2.9m | Added +96.1k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 688.1k $2.9m | Reduced -334.6k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 684.7k $2.8m | Added +328.9k |
| QVT Financial LP 0.18% of their portfolio | 678.6k $2.8m | Unchanged |
| LPL Financial LLC 0.00% of their portfolio | 661.1k $2.8m | Added +91.8k |
| GSA CAPITAL PARTNERS LLP 0.17% of their portfolio | 655.3k $2.7m | Added +98.2k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 628.2k $2.6m | Added +3.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 594.2k $2.5m | Added +74.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 526.6k $2.2m | Added +52.5k |
| Mariner, LLC 0.00% of their portfolio | 505.2k $2.1m | Added +390.9k |
| ALGERT GLOBAL LLC 0.02% of their portfolio | 474.9k $2.0m | Added +182.0k |
| CM Management, LLC 1.19% of their portfolio | 450.0k $1.9m | Unchanged |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 436.1k $1.8m | Added +10.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 421.0k $1.5m | Added +99.4k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 402.9k $1.7m | Reduced -30.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 397.0k $1.7m | Added +101.6k |
| Cresset Asset Management, LLC 0.01% of their portfolio | 383.8k $1.6m | Unchanged |
| Raiffeisen Bank International AG 0.02% of their portfolio | 380.0k $1.6m | Unchanged |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 373.3k $1.6m | Added +124.5k |
| CORSAIR CAPITAL MANAGEMENT, L.P. 0.19% of their portfolio | 370.0k $1.5m | Added +20.0k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 335.1k $1.4m | Added +166.3k |
| Squarepoint Ops LLC 0.00% of their portfolio | 325.6k $1.4m | Reduced -706.6k |
| Kennondale Capital Management LLC 0.88% of their portfolio | 318.2k $1.3m | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 294.0k $1.2m | Added +78.0k |
| IEQ CAPITAL, LLC 0.01% of their portfolio | 293.0k $1.2m | Added +273.8k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 285.1k $1.2m | Added +174.9k |
| Virtus Investment Advisers, LLC 0.28% of their portfolio | 285.0k $1.2m | Reduced -98.7k |
| Creative Planning 0.00% of their portfolio | 281.7k $1.2m | Added +76.2k |
| Tidal Investments LLC 0.00% of their portfolio | 280.0k $1.2m | Added +95.9k |
| Tema ETFs LLC 0.04% of their portfolio | 280.0k $1.2m | First filing |
| Quadrature Capital Ltd 0.01% of their portfolio | 278.9k $1.2m | Added +120.0k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 270.7k $1.1m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 262.1k $1.1m | Reduced -103.3k |
| Legal & General Group Plc 0.00% of their portfolio | 259.5k $1.1m | Added +39.3k |
| Man Group plc 0.00% of their portfolio | 253.0k $1.1m | Added +179.9k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 246.5k $1.0m | Added +57.1k |
| TD Asset Management Inc 0.00% of their portfolio | 245.1k $1.0m | Reduced -95.2k |
| GROUP ONE TRADING LLC 0.03% of their portfolio | 237.7k $988.7k | Reduced -358.1k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 232.2k $965.7k | Added +47.8k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 230.1k $959.4k | Added +41.1k |
| Baird Financial Group, Inc. 0.00% of their portfolio | 222.3k $924.9k | Added +23.8k |
| Virtu Financial LLC 0.03% of their portfolio | 221.5k $921.0k | Reduced -64.3k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 216.4k $900.2k | Added +82.6k |
| SG Americas Securities, LLC 0.00% of their portfolio | 211.6k $880.0k | Added +43.7k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 210.5k $875.7k | Reduced -239.1k |
| PROFUND ADVISORS LLC 0.02% of their portfolio | 204.2k $849.5k | Added +9.4k |
| Parametrica Management Ltd 0.64% of their portfolio | 195.9k $814.9k | Unchanged |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 193.1k $803.1k | Added +30.0k |
| Engineers Gate Manager LP 0.01% of their portfolio | 190.0k $790.5k | Added +82.3k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 164.1k $682.7k | Added +57.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 160.7k $668.6k | Added +149.4k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 155.5k $646.9k | Added +92.1k |