Tekla Capital Management LLC

Boston, MA · CIK 1300336 · 13F filing filed 2023-08-10

No investment adviser registration (Form ADV) found for this filer. It may be a parent company whose subsidiaries are the registered advisers, a bank or insurer, or a manager based outside the US.

Legal entityTEKLA CAPITAL MANAGEMENT LLC (US)

Others nearbyBoston, MA

$2.6bn reported value -2.7% vs Q1 2023

166positions

40.3%in top 10

9 new 28 added 31 reduced 20 sold out vs Q1 2023

Holdings, Q2 2023

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	AMGEN INC COM AMGN	AMGN	616,539	$136.9m5.36%	5.36%	Added +60.6k	+60,600 10.9%
2	JOHNSON & JOHNSON COM JNJ	JNJ	721,779	$119.5m4.68%	4.68%	Unchanged
3	GILEAD SCIENCES INC COM GILD	GILD	1,533,884	$118.2m4.63%	4.63%	Reduced -26.0k	-26,000 -1.7%
4	REGENERON PHARMACEUTICALS COM REGN	REGN	161,418	$116.0m4.54%	4.54%	Added +18.4k	+18,365 12.8%
5	VERTEX PHARMACEUTICALS INC COM VRTX	VRTX	318,043	$111.9m4.38%	4.38%	Reduced -12.3k	-12,300 -3.7%
6	ELI LILLY & CO COM LLY	LLY	213,352	$100.1m3.92%	3.92%	Reduced -75.6k	-75,565 -26.1%
7	UNITEDHEALTH GROUP INC COM UNH	UNH	206,961	$99.5m3.89%	3.89%	Reduced -27.2k	-27,212 -11.6%
8	MERCK & CO INC COM MRK	MRK	728,154	$84.0m3.29%	3.29%	Added +176.0k	+176,032 31.9%
9	ABBVIE INC COM ABBV	ABBV	545,629	$73.5m2.88%	2.88%	Added +34.0k	+34,030 6.7%
10	BIOGEN INC COM BIIB	BIIB	247,943	$70.6m2.76%	2.76%	Added +7.0k	+7,017 2.9%
11	ASTRAZENECA PLC SPONSORED ADR SPONSORED ADR		976,676	$69.9m2.74%	2.74%	Reduced -16.0k	-15,988 -1.6%
12	ILLUMINA INC COM ILMN	ILMN	336,979	$63.2m2.47%	2.47%	Reduced -11.1k	-11,100 -3.2%
13	ABBOTT LABS COM ABT	ABT	552,455	$60.2m2.36%	2.36%	Reduced -71.4k	-71,400 -11.4%
14	PFIZER INC COM PFE	PFE	1,624,476	$59.6m2.33%	2.33%	Reduced -150.6k	-150,600 -8.5%
15	THERMO FISHER SCIENTIFIC INC COM TMO	TMO	98,987	$51.6m2.02%	2.02%	Added +5.3k	+5,282 5.6%
16	ELEVANCE HEALTH INC COM ELV	ELV	114,070	$50.7m1.98%	1.98%	Unchanged
17	MODERNA INC COM MRNA	MRNA	343,695	$41.8m1.63%	1.63%	Added +21.5k	+21,478 6.7%
18	BOSTON SCIENTIFIC CORP COM BSX	BSX	657,790	$35.6m1.39%	1.39%	Added +91.8k	+91,800 16.2%
19	DANAHER CORPORATION COM DHR	DHR	142,813	$34.3m1.34%	1.34%	Added +37.1k	+37,123 35.1%
20	MEDTRONIC PLC SHS MDT	MDT	344,417	$30.3m1.19%	1.19%	Reduced -100	-100 -0.0%
21	IDEXX LABS INC COM IDXX	IDXX	58,595	$29.4m1.15%	1.15%	Unchanged
22	DEXCOM INC COM DXCM	DXCM	228,747	$29.4m1.15%	1.15%	Unchanged
23	BRISTOL-MYERS SQUIBB CO COM BMY	BMY	458,498	$29.3m1.15%	1.15%	Reduced -205.3k	-205,298 -30.9%
24	INTUITIVE SURGICAL INC COM NEW ISRG	ISRG	83,980	$28.7m1.12%	1.12%	Reduced -28.7k	-28,700 -25.5%
25	ALNYLAM PHARMACEUTICALS INC COM ALNY	ALNY	143,214	$27.2m1.06%	1.06%	Unchanged
26	THE CIGNA GROUP COM CI	CI	96,339	$27.0m1.06%	1.06%	Reduced -86.3k	-86,292 -47.2%
27	MCKESSON CORP COM MCK	MCK	61,955	$26.5m1.04%	1.04%	Reduced -4.5k	-4,500 -6.8%
28	ARGENX SE SPONSORED ADR ARGX	ARGX	65,553	$25.5m1.00%	1.00%	Reduced -22.8k	-22,757 -25.8%
29	HCA HEALTHCARE INC COM HCA	HCA	82,403	$25.0m0.98%	0.98%	Reduced -6.3k	-6,300 -7.1%
30	STRYKER CORPORATION COM SYK	SYK	81,128	$24.8m0.97%	0.97%	Added +9.6k	+9,550 13.3%
31	IQVIA HLDGS INC COM IQV	IQV	109,129	$24.5m0.96%	0.96%	Added +46.0k	+46,012 72.9%
32	ZOETIS INC CL A ZTS	ZTS	136,914	$23.6m0.92%	0.92%	Unchanged
33	CHARLES RIV LABS INTL INC COM CRL	CRL	111,183	$23.4m0.91%	0.91%	Reduced -6.9k	-6,900 -5.8%
34	SEAGEN INC COM SGEN	SGEN	112,331	$21.6m0.85%	0.85%	Reduced -112.3k	-112,332 -50.0%
35	SAREPTA THERAPEUTICS INC COM SRPT	SRPT	179,437	$20.5m0.80%	0.80%	Reduced -106.2k	-106,216 -37.2%
36	NOVO-NORDISK A S ADR NVO	NVO	122,777	$19.9m0.78%	0.78%	Added +11.5k	+11,454 10.3%
37	Oculis Holding AG COMMON COMMON		1,690,741	$18.8m0.74%	0.74%	Unchanged
38	MOLINA HEALTHCARE INC COM MOH	MOH	61,856	$18.6m0.73%	0.73%	Unchanged
39	JAZZ PHARMACEUTICALS PLC SHS USD JAZZ	JAZZ	147,779	$18.3m0.72%	0.72%	Unchanged
40	BIOMARIN PHARMACEUTICAL INC COM BMRN	BMRN	210,789	$18.3m0.72%	0.72%	Reduced -89.3k	-89,300 -29.8%
41	EDWARDS LIFESCIENCES CORP COM EW	EW	189,597	$17.9m0.70%	0.70%	Added +18.5k	+18,451 10.8%
42	HUMANA INC COM HUM	HUM	36,794	$16.5m0.64%	0.64%	Unchanged
43	APELLIS PHARMACEUTICALS INC COM APLS	APLS	173,248	$15.8m0.62%	0.62%	Added +38.1k	+38,124 28.2%
44	BAXTER INTL INC COM BAX	BAX	324,370	$14.8m0.58%	0.58%	Added +257.1k	+257,058 381.9%
45	EXELIXIS INC COM EXEL	EXEL	726,639	$13.9m0.54%	0.54%	Unchanged
46	NOVARTIS AG SPONSORED ADR NVS	NVS	136,225	$13.7m0.54%	0.54%	Unchanged
47	KARUNA THERAPEUTICS INC COM COM		58,577	$12.7m0.50%	0.50%	Added +5.1k	+5,125 9.6%
48	INSULET CORP COM PODD	PODD	43,847	$12.6m0.49%	0.49%	New
49	GUARDANT HEALTH INC COM GH	GH	346,084	$12.4m0.48%	0.48%	Reduced -126.1k	-126,100 -26.7%
50	ASCENDIS PHARMA A/S SPONSORED ADR SPONSORED ADR		138,791	$12.4m0.48%	0.48%	Added +15.0k	+15,000 12.1%
51	SPDR SER TR S&P BIOTECH XBI	XBI	147,677	$12.3m0.48%	0.48%	Unchanged
52	PHYSICIANS RLTY TR COM DOC	DOC	873,655	$12.2m0.48%	0.48%	Unchanged
53	TENET HEALTHCARE CORP COM NEW THC	THC	149,070	$12.1m0.47%	0.47%	New
54	BIONTECH SE SPONSORED ADS BNTX	BNTX	103,858	$11.2m0.44%	0.44%	Unchanged
55	NEUROCRINE BIOSCIENCES INC COM NBIX	NBIX	112,908	$10.6m0.42%	0.42%	Unchanged
56	ZIMMER BIOMET HOLDINGS INC COM ZBH	ZBH	67,356	$9.8m0.38%	0.38%	Unchanged
57	RALLYBIO CORP COM COM		1,727,067	$9.8m0.38%	0.38%	Unchanged
58	VAXCYTE INC COM PCVX	PCVX	194,232	$9.7m0.38%	0.38%	Added +189.2k	+189,232 3784.6%
59	ALKERMES PLC SHS ALKS	ALKS	309,613	$9.7m0.38%	0.38%	Unchanged
60	DENALI THERAPEUTICS INC COM DNLI	DNLI	324,829	$9.6m0.38%	0.38%	Unchanged
61	AVANTOR INC COM AVTR	AVTR	459,488	$9.4m0.37%	0.37%	Unchanged
62	OMEGA HEALTHCARE INVS INC COM OHI	OHI	306,433	$9.4m0.37%	0.37%	Unchanged
63	UNITED THERAPEUTICS CORP DEL COM UTHR	UTHR	41,465	$9.2m0.36%	0.36%	Reduced -19.7k	-19,735 -32.2%
64	INTRA-CELLULAR THERAPIES INC COM ITCI	ITCI	131,435	$8.3m0.33%	0.33%	Reduced -40.9k	-40,936 -23.8%
65	ACADIA HEALTHCARE COMPANY IN COM ACHC	ACHC	100,912	$8.0m0.31%	0.31%	Reduced -85.6k	-85,575 -45.9%
66	MADRIGAL PHARMACEUTICALS INC COM MDGL	MDGL	34,434	$8.0m0.31%	0.31%	Added +22.0k	+21,953 175.9%
67	RESMED INC COM RMD	RMD	34,704	$7.6m0.30%	0.30%	Reduced -38.5k	-38,485 -52.6%
68	HORIZON THERAPEUTICS PUB L SHS HZNP	HZNP	72,425	$7.4m0.29%	0.29%	New
69	INSPIRE MED SYS INC COM INSP	INSP	22,018	$7.1m0.28%	0.28%	New
70	CYTOKINETICS INC COM NEW CYTK	CYTK	219,025	$7.1m0.28%	0.28%	Unchanged
71	STERIS PLC SHS USD STE	STE	31,072	$7.0m0.27%	0.27%	Unchanged
72	SANOFI SPONSORED ADR SNY	SNY	123,454	$6.7m0.26%	0.26%	Unchanged
73	R1 RCM INC COM COM		356,851	$6.6m0.26%	0.26%	Unchanged
74	CVS HEALTH CORP COM CVS	CVS	93,621	$6.5m0.25%	0.25%	Unchanged
75	MEDPACE HLDGS INC COM MEDP	MEDP	26,918	$6.5m0.25%	0.25%	Added +17.5k	+17,483 185.3%
76	IMMUNOVANT INC COM IMVT	IMVT	336,200	$6.4m0.25%	0.25%	Added +220.8k	+220,800 191.3%
77	INTELLIA THERAPEUTICS INC COM NTLA	NTLA	154,269	$6.3m0.25%	0.25%	Unchanged
78	LTC PPTYS INC COM LTC	LTC	182,293	$6.0m0.24%	0.24%	Unchanged
79	SABRA HEALTH CARE REIT INC COM SBRA	SBRA	510,660	$6.0m0.24%	0.24%	Unchanged
80	SMITH & NEPHEW PLC SPDN ADR NEW SNN	SNN	181,710	$5.9m0.23%	0.23%	Unchanged
81	CHINOOK THERAPEUTICS INC COM ADRO	ADRO	150,863	$5.8m0.23%	0.23%	Added +67.4k	+67,363 80.7%
82	WEST PHARMACEUTICAL SVSC INC COM WST	WST	15,036	$5.8m0.23%	0.23%	Unchanged
83	CEREVEL THERAPEUTICS HLDNG I COM CERE	CERE	176,483	$5.6m0.22%	0.22%	Unchanged
84	LIVANOVA PLC SHS LIVN	LIVN	108,480	$5.6m0.22%	0.22%	Added +44.6k	+44,600 69.8%
85	VERADIGM INC COM MDRX	MDRX	428,580	$5.4m0.21%	0.21%	Unchanged
86	AGILENT TECHNOLOGIES INC COM A	A	43,191	$5.2m0.20%	0.20%	Unchanged
87	MARINUS PHARMACEUTICALS INC COM NEW MRNS	MRNS	411,101	$4.5m0.17%	0.17%	Reduced -45.7k	-45,679 -10.0%
88	UNIQURE NV SHS QURE	QURE	356,280	$4.1m0.16%	0.16%	Reduced -296.2k	-296,166 -45.4%
89	CENCORA INC COM COR	COR	20,417	$3.9m0.15%	0.15%	Unchanged
90	MEDICAL PPTYS TRUST INC COM MPT	MPT	411,743	$3.8m0.15%	0.15%	Unchanged
91	BEIGENE LTD SPONSORED ADR ONC	ONC	20,952	$3.7m0.15%	0.15%	Unchanged
92	IONIS PHARMACEUTICALS INC COM IONS	IONS	87,840	$3.6m0.14%	0.14%	Unchanged
93	BIOCRYST PHARMACEUTICALS INC COM BCRX	BCRX	504,528	$3.6m0.14%	0.14%	Unchanged
94	REATA PHARMACEUTICALS INC CL A RETA	RETA	34,250	$3.5m0.14%	0.14%	Added +16.4k	+16,400 91.9%
95	TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS SPONSORED ADS		459,651	$3.5m0.14%	0.14%	Unchanged
96	WELLTOWER INC COM WELL	WELL	41,484	$3.4m0.13%	0.13%	Unchanged
97	HEALTHCARE RLTY TR CL A COM HR	HR	174,686	$3.3m0.13%	0.13%	Unchanged
98	VENTAS INC COM VTR	VTR	66,681	$3.2m0.12%	0.12%	Unchanged
99	ISHARES TR ISHARES BIOTECH IBB	IBB	24,569	$3.1m0.12%	0.12%	Unchanged
100	HEALTHPEAK PROPERTIES INC COM DOC	DOC	150,392	$3.0m0.12%	0.12%	Unchanged

Sold out since Q1 2023

Security	Ticker	Shares held before	Value then
TRAVERE THERAPEUTICS INC TVTX	TVTX	418,520	$9.4m418.5k shares
LABORATORY CORP AMER HLDGS		40,042	$9.2m40.0k shares
LANTHEUS HLDGS INC LNTH	LNTH	79,495	$6.6m79.5k shares
VECTIVBIO HLDG AG		682,834	$5.9m682.8k shares
PROMETHEUS BIOSCIENCES INC		50,538	$5.4m50.5k shares
AMEDISYS INC AMED	AMED	68,949	$5.1m68.9k shares
ADDUS HOMECARE CORP ADUS	ADUS	42,380	$4.5m42.4k shares
CARDIOVASCULAR SYS INC DEL CSII	CSII	174,859	$3.5m174.9k shares
KURA ONCOLOGY INC KURA	KURA	283,281	$3.5m283.3k shares
CATALENT INC CTLT	CTLT	49,406	$3.2m49.4k shares
BLUEPRINT MEDICINES CORP BPMC	BPMC	67,710	$3.0m67.7k shares
ULTRAGENYX PHARMACEUTICAL IN RARE	RARE	67,065	$2.7m67.1k shares
ARROWHEAD PHARMACEUTICALS IN ARWR	ARWR	100,422	$2.6m100.4k shares
SYNDAX PHARMACEUTICALS INC SNDX	SNDX	117,717	$2.5m117.7k shares
ALIGN TECHNOLOGY INC ALGN	ALGN	6,925	$2.3m6.9k shares
OPTION CARE HEALTH INC OPCH	OPCH	64,975	$2.1m65.0k shares
MERUS N V MRUS	MRUS	69,025	$1.3m69.0k shares
ZAI LAB LTD ZLAB	ZLAB	34,640	$1.2m34.6k shares
MERSANA THERAPEUTICS INC		162,383	$667.4k162.4k shares
BIOHAVEN LTD BHVN	BHVN	35,087	$479.3k35.1k shares