UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($489.9k this quarter). Holder counts are more reliable. Shares outstanding: 47.7m as of 2023-07-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $11.47. Options: 22 managers hold calls ($31.3m notional), 16 hold puts ($31.1m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
| Q2 2023 | 178 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 87 | 83 |
| Q1 2023 | 81 | 90 |
| Q2 2023 | 92 | 91 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $37.4m | $7.5m | 0.20 |
| Q4 2022 | $57.7m | $13.8m | 0.24 |
| Q1 2023 | $31.3m | $16.9m | 0.54 |
| Q2 2023 | $31.3m | $31.1m | 1.00 |
Biggest buyers
| JANE STREET GROUP, LLC | Added | +545.2k |
| MILLENNIUM MANAGEMENT LLC | Added | +440.7k |
| CITADEL ADVISORS LLC | Added | +313.8k |
| PICTET ASSET MANAGEMENT SA | Added | +280.3k |
| Balyasny Asset Management L.P. | Added | +269.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ | New | +206.7k |
| 683 Capital Management, LLC | Added | +202.0k |
| Schonfeld Strategic Advisors LLC | Added | +199.5k |
| GROUP ONE TRADING LLC | Added | +181.7k |
| Parallax Volatility Advisers, L.P. | Added | +136.8k |
Biggest sellers
| FMR LLC | Reduced | -2.9m |
| PFM Health Sciences, LP | Reduced | -2.0m |
| Deep Track Capital, LP | Sold out | -865.8k |
| Point72 Asset Management, L.P. | Reduced | -830.9k |
| Aquilo Capital Management, LLC | Sold out | -637.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -630.0k |
| LORD, ABBETT & CO. LLC | Sold out | -517.1k |
| Integral Health Asset Management, LLC | Sold out | -500.0k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | Reduced | -463.0k |
| MPM BIOIMPACT LLC | Sold out | -348.2k |
Biggest calls
| BOOTHBAY FUND MANAGEMENT, LLC | New | $7.0m609.4k shares |
| Nantahala Capital Management, LLC | Unchanged | $4.4m387.7k shares |
| Caption Management, LLC | Reduced | $3.4m294.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.1m267.2k shares |
| MILLENNIUM MANAGEMENT LLC | New | $2.6m226.2k shares |
| Integral Health Asset Management, LLC | New | $2.3m200.0k shares |
| Ikarian Capital, LLC | New | $1.8m154.4k shares |
| ExodusPoint Capital Management, LP | New | $1.7m150.0k shares |
| Parallax Volatility Advisers, L.P. | Reduced | $978.7k85.4k shares |
| SIMPLEX TRADING, LLC | Added | $974.0k85.0k shares |
Biggest puts
| JANE STREET GROUP, LLC | Added | $7.2m632.4k shares |
| Caption Management, LLC | Added | $5.4m469.6k shares |
| GROUP ONE TRADING LLC | Added | $5.3m465.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.3m463.2k shares |
| Parallax Volatility Advisers, L.P. | Added | $2.4m209.0k shares |
| CITADEL ADVISORS LLC | Added | $2.3m201.6k shares |
| SIMPLEX TRADING, LLC | Added | $1.3m112.9k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $649.8k56.7k shares |
| CITIGROUP INC | Reduced | $341.5k29.8k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Not comparable | $338.2k55.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17), Vestal Point Capital, LP (0.4%, 2025-11-14)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 1 | $542.2k | — |
| Q1 2022 | 0 | — | 11 | $754.9k | — |
| Q2 2022 | 0 | — | 2 | $122.3k | — |
| Q3 2022 | 0 | — | 1 | $1.1m | — |
| Q4 2022 | 0 | — | 6 | $691.3k | — |
| Q1 2023 | 0 | — | 13 | $1.4m | — |
| Q2 2023 | 0 | — | 10 | $448.1k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-16 | Gut Robert Director | Sold | $60.9k3.2k shares |
| 2023-06-16 | CALOZ PIERRE Chief Operating Officer | Sold | $54.9k2.9k shares |
| 2023-06-16 | Soteropoulos Paula Director | Sold | $43.2k2.3k shares |
| 2023-06-16 | Balachandran Madhavan Director | Sold | $43.2k2.3k shares |
| 2023-06-16 | Jacques Rachelle Suzanne Director | Sold | $43.2k2.3k shares |
| 2023-06-16 | Meek David D. Director | Sold | $43.2k2.3k shares |
| 2023-06-16 | Kaye Jack Director | Sold | $43.2k2.3k shares |
| 2023-06-16 | Springhorn Jeremy P. Director | Sold | $43.2k2.3k shares |
| 2023-06-16 | POST LEONARD E Director | Sold | $43.1k2.3k shares |
| 2023-06-16 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $30.1k1.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| BlackRock Inc. 0.00% of their portfolio | 4.9m $56.7m | Added +24.8k |
| Nantahala Capital Management, LLC 3.96% of their portfolio | 2.8m $32.6m | Reduced -221.4k |
| STATE STREET CORP 0.00% of their portfolio | 2.5m $29.1m | Reduced -296.4k |
| FMR LLC 0.00% of their portfolio | 2.5m $28.2m | Reduced -2.9m |
| ORBIMED ADVISORS LLC 0.43% of their portfolio | 2.1m $23.7m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $16.0m | Reduced -14.4k |
| 683 Capital Management, LLC 1.44% of their portfolio | 1.3m $14.8m | Added +202.0k |
| MORGAN STANLEY 0.00% of their portfolio | 1.3m $14.5m | Added +82.3k |
| PICTET ASSET MANAGEMENT SA 0.01% of their portfolio | 914.9k $10.5m | Added +280.3k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 789.5k $9.0m | Added +440.7k |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 706.2k $8.1m | Unchanged |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 656.1k $7.5m | Added +313.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 619.4k $7.1m | Reduced -119.4k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 605.5k $6.9m | Added +269.4k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 576.2k $6.6m | Added +545.2k |
| NORGES BANK 0.00% of their portfolio | 538.4k $6.2m | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 433.4k $5.0m | Added +4.1k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 428.5k $4.9m | Added +199.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 427.3k $4.9m | Added +13.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 403.2k $4.6m | Reduced -36.1k |
| Tekla Capital Management LLC 0.16% of their portfolio | 356.3k $4.1m | Reduced -296.2k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 331.4k $3.8m | Added +71.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 320.6k $3.7m | Added +72.7k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 313.0k $3.6m | Reduced -830.9k |
| NORDEA INVESTMENT MANAGEMENT AB 0.00% of their portfolio | 296.8k $3.3m | Added +14.2k |
| Privium Fund Management B.V. 0.85% of their portfolio | 264.3k $2.9m | Reduced -37.0k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.02% of their portfolio | 254.3k $2.9m | Added +121.7k |
| Verition Fund Management LLC 0.04% of their portfolio | 251.3k $2.9m | Added +107.8k |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 238.1k $2.7m | Reduced -226.2k |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 235.1k $2.7m | Reduced -167.4k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 233.6k $2.7m | Reduced -10.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 224.6k $2.6m | Reduced -92.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 222.0k $2.5m | Added +3.0k |
| Ghost Tree Capital, LLC 0.89% of their portfolio | 215.0k $2.5m | Reduced -160.0k |
| Invesco Ltd. 0.00% of their portfolio | 210.8k $2.4m | Reduced -9.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 206.7k $2.4m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 205.6k $2.4m | Added +91.6k |
| Caption Management, LLC 0.40% of their portfolio | 198.2k $2.3m | Added +92.9k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 198.1k $2.3m | Reduced -17.7k |
| Swedbank AB 0.00% of their portfolio | 197.8k $2.3m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 194.6k $2.2m | Reduced -282.5k |
| GROUP ONE TRADING LLC 0.09% of their portfolio | 191.2k $2.2m | Added +181.7k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 190.7k $2.2m | Added +24.1k |
| Allianz Asset Management GmbH 0.00% of their portfolio | 182.4k $2.1m | Added +9.5k |
| BANQUE PICTET & CIE SA 0.02% of their portfolio | 168.1k $1.9m | Reduced -64.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 161.8k $1.9m | Reduced -3.8k |
| BARCLAYS PLC 0.00% of their portfolio | 157.6k $1.8m | Added +90.1k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 149.4k $1.7m | Reduced -50 |
| SPHERA FUNDS MANAGEMENT LTD. 0.37% of their portfolio | 148.7k $1.7m | Added +86.7k |
| Parallax Volatility Advisers, L.P. 0.06% of their portfolio | 145.8k $1.7m | Added +136.8k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio | 144.0k $1.6m | Added +68.9k |
| ALGERT GLOBAL LLC 0.06% of their portfolio | 122.7k $1.4m | New |
| Legal & General Group Plc 0.00% of their portfolio | 111.8k $1.3m | Reduced -1.3k |
| BRIDGER MANAGEMENT, LLC 0.42% of their portfolio | 111.0k $1.3m | New |
| CITIGROUP INC 0.00% of their portfolio | 99.8k $1.1m | Reduced -206.0k |
| PDT Partners, LLC 0.15% of their portfolio | 96.0k $1.1m | Added +32.4k |
| Swiss National Bank 0.00% of their portfolio | 92.0k $1.1m | Added +1.0k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 83.8k $960.4k | Added +18.3k |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 83.4k $955.0k | Added +42.6k |
| Public Sector Pension Investment Board 0.01% of their portfolio | 74.3k $851.8k | Added +1.9k |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 70.8k $811.0k | Unchanged |
| Woodline Partners LP 0.01% of their portfolio | 69.7k $799.0k | Reduced -101.0k |
| SANDERS MORRIS HARRIS LLC 0.18% of their portfolio | 68.1k $805.3k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 63.0k $722.0k | Added +5.0k |
| Alpha DNA Investment Management LLC 0.41% of their portfolio | 62.8k $720.0k | New |
| Ergoteles LLC 0.03% of their portfolio | 61.6k $705.8k | Added +26.0k |
| PFM Health Sciences, LP 0.03% of their portfolio | 60.6k $694.7k | Reduced -2.0m |
| Pale Fire Capital SE 0.07% of their portfolio | 60.1k $688.7k | New |
| MOORE CAPITAL MANAGEMENT, LP 0.02% of their portfolio | 60.0k $687.6k | Added +45.0k |
| Trexquant Investment LP 0.02% of their portfolio | 60.0k $687.6k | New |
| Virtu Financial LLC 0.05% of their portfolio | 56.6k $648.0k | New |
| Weiss Multi-Strategy Advisers LLC 0.01% of their portfolio | 53.9k $617.0k | Reduced -4.0k |
| Vontobel Holding Ltd. 0.01% of their portfolio | 53.6k $614.0k | Reduced -11.1k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 53.0k $607.2k | Added +1.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 51.3k $587.5k | Added +547 |
| Sonic GP LLC 0.38% of their portfolio | 50.0k $573.0k | Unchanged |
| Sigma Planning Corp 0.02% of their portfolio | 49.9k $571.5k | Added +776 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 47.6k $958.8k | Unchanged |
| AlphaCentric Advisors LLC 0.30% of their portfolio | 47.5k $544.4k | New |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 0.00% of their portfolio | 47.3k $542.4k | Added +3.7k |
| AE Wealth Management LLC 0.00% of their portfolio | 44.4k $509.1k | New |
| Mach-1 Financial Group, LLC 0.20% of their portfolio | 42.8k $490.8k | New |
| Engineers Gate Manager LP 0.02% of their portfolio | 42.6k $488.3k | New |
| Henry James International Management Inc. 0.21% of their portfolio | 42.6k $488.2k | Reduced -46.4k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 37.2k $426.3k | Added +186 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 37.0k $423.9k | Reduced -580 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 36.9k $422.7k | Reduced -2.0k |
| TEXAS PERMANENT SCHOOL FUND CORP 0.00% of their portfolio | 36.9k $422.5k | Reduced -76 |
| PROFUND ADVISORS LLC 0.02% of their portfolio | 36.8k $421.9k | Reduced -4.0k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 31.7k $363.2k | Reduced -42.9k |
| State of Alaska, Department of Revenue 0.00% of their portfolio | 27.6k $315.0k | Reduced -659 |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 27.3k $312.5k | Added +9.3k |
| Squarepoint Ops LLC 0.00% of their portfolio | 26.9k $308.1k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 26.1k $299.7k | New |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 25.5k $292.0k | Added +1.1k |
| Jefferies Financial Group Inc. 0.01% of their portfolio | 25.0k $286.5k | New |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 24.3k $278.1k | Added +9.2k |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 24.2k $277.4k | Reduced -181 |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 23.1k $264.0k | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 22.1k $252.9k | Reduced -1.1k |