Vault-13

BLUEPRINT MEDICINES CORP BPMC

COM · Common Stock · CUSIP 09627Y109 · ISIN US09627Y1091

222 institutional holders +7 vs Q1 2023
63,827,93563.8m shares reported held*
$4.0bnreported value*
29 new 74 added 78 reduced 25 sold out net sold ≈ $543.2m (-8.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.4m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $63.13. Options: 12 managers hold calls ($17.7m notional), 14 hold puts ($37.4m).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 240Q4 22: 223Q1 23: 215Q2 23: 222222Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022240
Q4 2022223
Q1 2023215
Q2 2023222

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 117 bought or addedQ4 22: 112 cut or sold outQ4 22Q1 23: 120 bought or addedQ1 23: 93 cut or sold outQ1 23Q2 23: 103 bought or addedQ2 23: 103 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 2022117112
Q1 202312093
Q2 2023103103

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ3 22 calls: $24.4mQ3 22 puts: $14.2mQ3 22P/C 0.58Q4 22 calls: $10.8mQ4 22 puts: $15.9mQ4 22P/C 1.47Q1 23 calls: $15.8mQ1 23 puts: $21.8mQ1 23P/C 1.38Q2 23 calls: $17.7mQ2 23 puts: $37.4mQ2 23P/C 2.11
Numbers
QuarterCallsPutsP/C
Q3 2022$24.4m$14.2m0.58
Q4 2022$10.8m$15.9m1.47
Q1 2023$15.8m$21.8m1.38
Q2 2023$17.7m$37.4m2.11

Biggest buyers

EcoR1 Capital, LLC New +1,798,300+1.8m
PRICE T ROWE ASSOCIATES INC /MD/ Added +674,942+674.9k
ALKEON CAPITAL MANAGEMENT LLC Added +591,745+591.7k
Polar Capital Holdings Plc New +500,000+500.0k
Avidity Partners Management LP New +415,000+415.0k
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC Added +392,041+392.0k
Hood River Capital Management LLC New +273,449+273.4k
Woodline Partners LP Added +185,985+186.0k
MILLENNIUM MANAGEMENT LLC Added +174,563+174.6k
Rock Springs Capital Management LP Added +153,624+153.6k

Biggest sellers

FMR LLC Reduced -10,936,107-10.9m
Hudson Bay Capital Management LP Reduced -479,418-479.4k
BAKER BROS. ADVISORS LP Sold out -333,665-333.7k
ExodusPoint Capital Management, LP Reduced -317,430-317.4k
Candriam S.C.A. Reduced -302,790-302.8k
STATE STREET CORP Reduced -252,286-252.3k
WELLINGTON MANAGEMENT GROUP LLP Reduced -213,989-214.0k
CITADEL ADVISORS LLC Reduced -178,076-178.1k
Aquilo Capital Management, LLC Reduced -173,842-173.8k
MORGAN STANLEY Reduced -142,831-142.8k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $4.2m66.6k shares
ORACLE INVESTMENT MANAGEMENT INC New $4.1m64.5k shares
JANE STREET GROUP, LLC Reduced $3.8m60.2k shares
PEAK6 Investments LLC New $1.7m26.4k shares
CITIGROUP INC Unchanged $1.6m25.0k shares
Parallax Volatility Advisers, L.P. New $1.4m22.5k shares
CITADEL ADVISORS LLC Reduced $410.8k6.5k shares
SIMPLEX TRADING, LLC Reduced $189.0k3.0k shares
GROUP ONE TRADING LLC Reduced $183.3k2.9k shares
Walleye Capital LLC Reduced $145.4k2.3k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $15.5m245.6k shares
GROUP ONE TRADING LLC Added $6.1m97.2k shares
JANE STREET GROUP, LLC Reduced $4.6m73.5k shares
CITADEL ADVISORS LLC Added $2.6m41.7k shares
SIMPLEX TRADING, LLC Added $2.1m33.5k shares
CITIGROUP INC Unchanged $1.6m25.0k shares
Parallax Volatility Advisers, L.P. New $1.4m22.5k shares
Jefferies Financial Group Inc. Added $1.4m22.4k shares
UBS Group AG Unchanged $948.0k15.0k shares
GOLDMAN SACHS GROUP INC Added $682.6k10.8k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-04-23 8.0% 5.1m 2025-04-23
Pentwater Capital Management LP 13G · institution new · filed 2025-08-14 6.0% new 3.9m 2025-08-14

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.04% of their portfolio BOSTON, MA 6,708,1376.7m $424.0m $424.0m 0.04% Reduced -10.9m -10,936,107
2 BlackRock Inc. 0.01% of their portfolio New York, NY 6,535,7356.5m $413.1m $413.1m 0.01% Reduced -86.6k -86,568
3 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 5,929,4275.9m $374.7m $374.7m 0.01% Added +50.5k +50,483
4 PRICE T ROWE ASSOCIATES INC /MD/ 0.05% of their portfolio BALTIMORE, MD 5,623,3765.6m $355.4m $355.4m 0.05% Added +674.9k +674,942
5 WELLINGTON MANAGEMENT GROUP LLP 0.06% of their portfolio Boston, MA 4,923,7144.9m $311.2m $311.2m 0.06% Reduced -214.0k -213,989
6 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,502,9932.5m $158.2m $158.2m 0.01% Reduced -252.3k -252,286
7 T. Rowe Price Investment Management, Inc. 0.11% of their portfolio BALTIMORE, MD 2,451,0352.5m $154.9m $154.9m 0.11% Reduced -35.9k -35,915
8 Rock Springs Capital Management LP 3.29% of their portfolio Baltimore, MD 2,186,6722.2m $138.2m $138.2m 3.29% Added +153.6k +153,624
9 EcoR1 Capital, LLC 2.99% of their portfolio San Francisco, CA 1,798,3001.8m $113.7m $113.7m 2.99% New
10 ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio NASHVILLE, TN 1,611,1811.6m $101.8m $101.8m 0.04% Reduced -130.6k -130,623
11 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,608,5691.6m $101.7m $101.7m 0.01% Added +56.8k +56,813
12 MACQUARIE GROUP LTD 0.11% of their portfolio Sydney, NSW 2000, C3 1,518,0861.5m $95.9m $95.9m 0.11% Added +20.7k +20,700
13 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.30% of their portfolio CHICAGO, IL 1,474,4901.5m $93.2m $93.2m 0.30% Added +392.0k +392,041
14 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,221,1931.2m $77.2m $77.2m 0.01% Added +58.6k +58,553
15 ALKEON CAPITAL MANAGEMENT LLC 0.36% of their portfolio New York, NY 943,928943.9k $59.7m $59.7m 0.36% Added +591.7k +591,745
16 Fisher Asset Management, LLC 0.03% of their portfolio PLANO, TX 799,381799.4k $50.5m $50.5m 0.03% Added +5.3k +5,310
17 PICTET ASSET MANAGEMENT SA 0.05% of their portfolio GENEVA 73, V8 723,766723.8k $45.7m $45.7m 0.05% Added +150.1k +150,122
18 AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio KANSAS CITY, MO 637,729637.7k $40.3m $40.3m 0.03% Added +23.0k +23,008
19 BROWN ADVISORY INC 0.06% of their portfolio BALTIMORE, MD 635,196635.2k $40.1m $40.1m 0.06% Added +1.8k +1,788
20 Casdin Capital, LLC 3.42% of their portfolio New York, NY 620,000620.0k $39.2m $39.2m 3.42% Reduced -50.0k -50,000
21 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 585,697585.7k $37.0m $37.0m 0.01% Added +8.1k +8,071
22 NORGES BANK 0.01% of their portfolio OSLO, Q8 573,186573.2k $36.2m $36.2m 0.01% Added +12.4k +12,394
23 Polar Capital Holdings Plc 0.22% of their portfolio London, X0 500,000500.0k $31.6m $31.6m 0.22% New
24 EMERALD ADVISERS, LLC 1.37% of their portfolio LEOLA, PA 496,053496.1k $31.4m $31.4m 1.37% Added +57.8k +57,804
25 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 482,483482.5k $30.5m $30.5m 0.01% Added +9.6k +9,593
26 Aquilo Capital Management, LLC 18.62% of their portfolio SAN FRANCISCO, CA 448,987449.0k $28.4m $28.4m 18.62% Reduced -173.8k -173,842
27 NOVO HOLDINGS A/S 2.19% of their portfolio HELLERUP, G7 448,804448.8k $28.4m $28.4m 2.19% Unchanged
28 EVENTIDE ASSET MANAGEMENT, LLC 0.47% of their portfolio Boston, MA 438,500438.5k $27.7m $27.7m 0.47% Unchanged
29 Avidity Partners Management LP 0.92% of their portfolio DALLAS, TX 415,000415.0k $26.2m $26.2m 0.92% New
30 EMERALD MUTUAL FUND ADVISERS TRUST 1.42% of their portfolio LEOLA, PA 413,327413.3k $26.1m $26.1m 1.42% Added +54.5k +54,507
31 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 389,496389.5k $24.6m $24.6m 0.00% Reduced -142.8k -142,831
32 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 389,356389.4k $24.6m $24.6m 0.01% Added +54.8k +54,765
33 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 328,102328.1k $20.7m $20.7m 0.00% Reduced -84.9k -84,921
34 Woodline Partners LP 0.22% of their portfolio San Francisco, CA 291,362291.4k $18.4m $18.4m 0.22% Added +186.0k +185,985
35 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 283,970284.0k $18.0m $18.0m 0.01% Reduced -24.1k -24,131
36 Hood River Capital Management LLC 0.51% of their portfolio PALM BEACH GARDENS, FL 273,449273.4k $17.3m $17.3m 0.51% New
37 PANAGORA ASSET MANAGEMENT INC 0.10% of their portfolio BOSTON, MA 269,311269.3k $17.0m $17.0m 0.10% Reduced -5.0k -5,030
38 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 262,617262.6k $16.6m $16.6m 0.00% Reduced -940 -940
39 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 252,349252.3k $11.4m $11.4m 0.01% Unchanged
40 DAFNA Capital Management LLC 4.35% of their portfolio LOS ANGELES, CA 251,521251.5k $15.9m $15.9m 4.35% Reduced -9.7k -9,714
41 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 232,535232.5k $14.7m $14.7m 0.02% Added +174.6k +174,563
42 EAGLE ASSET MANAGEMENT INC 0.07% of their portfolio ST PETERSBURG, FL 204,385204.4k $12.9m $12.9m 0.07% Added +39.7k +39,749
43 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 191,512191.5k $12.1m $12.1m 0.01% Added +24.2k +24,160
44 Granahan Investment Management, LLC 0.36% of their portfolio WALTHAM, MA 184,503184.5k $11.7m $11.7m 0.36% Reduced -47.7k -47,716
45 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 174,327174.3k $11.0m $11.0m 0.00% Reduced -5.6k -5,623
46 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 160,110160.1k $10.1m $10.1m 0.01% Added +48.0k +47,971
47 Candriam S.C.A. 0.07% of their portfolio STRASSEN, N4 151,222151.2k $9.6m $9.6m 0.07% Reduced -302.8k -302,790
48 Hudson Bay Capital Management LP 0.09% of their portfolio STAMFORD, CT 146,600146.6k $9.3m $9.3m 0.09% Reduced -479.4k -479,418
49 PEREGRINE CAPITAL MANAGEMENT LLC 0.25% of their portfolio MINNEAPOLIS, MN 143,589143.6k $9.1m $9.1m 0.25% Reduced -16.0k -16,015
50 Rafferty Asset Management, LLC 0.05% of their portfolio New York, NY 141,997142.0k $9.0m $9.0m 0.05% Reduced -19.9k -19,893
51 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 137,989138.0k $8.7m $8.7m 0.01% Reduced -21.4k -21,443
52 SECTORAL ASSET MANAGEMENT INC 1.44% of their portfolio MONTREAL, A8 136,837136.8k $8.6m $8.6m 1.44% Added +14.9k +14,937
53 Swiss National Bank 0.01% of their portfolio ZURICH, V8 130,600130.6k $8.3m $8.3m 0.01% Added +1.5k +1,500
54 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 123,307123.3k $7.8m $7.8m 0.00% Added +12.1k +12,084
55 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 123,223123.2k $7.8m $7.8m 0.01% Added +118.2k +118,248
56 JACOBS LEVY EQUITY MANAGEMENT, INC 0.04% of their portfolio FLORHAM PARK, NJ 111,531111.5k $7.0m $7.0m 0.04% Reduced -15.3k -15,321
57 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 110,979111.0k $7.0m $7.0m 0.01% Reduced -178.1k -178,076
58 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 104,347104.3k $6.6m $6.6m 0.00% Added +2.9k +2,947
59 SEGALL BRYANT & HAMILL, LLC 0.06% of their portfolio CHICAGO, IL 95,71195.7k $6.0m $6.0m 0.06% Added +531 +531
60 California Public Employees Retirement System 0.00% of their portfolio Sacramento, CA 91,22691.2k $5.8m $5.8m 0.00% Reduced -4.6k -4,609
61 EFG Asset Management (North America) Corp. 1.22% of their portfolio Portland, OR 90,12490.1k $5.7m $5.7m 1.22% Reduced -20.0k -20,017
62 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 83,87083.9k $5.3m $5.3m 0.01% Added +2.6k +2,637
63 UBS Group AG 0.00% of their portfolio ZURICH, V8 81,76681.8k $5.2m $5.2m 0.00% Reduced -2.9k -2,907
64 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 78,76278.8k $5.0m $5.0m 0.00% Reduced -28.2k -28,246
65 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 75,47975.5k $4.8m $4.8m 0.00% Added +12.2k +12,203
66 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 74,34274.3k $4.7m $4.7m 0.01% Added +9.7k +9,702
67 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 73,01273.0k $4.6m $4.6m 0.01% Reduced -1.8k -1,781
68 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 71,48071.5k $4.5m $4.5m 0.01% Reduced -19.0k -19,046
69 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 67,52967.5k $4.3m $4.3m 0.00% Reduced -5.2k -5,227
70 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 63,09463.1k $4.0m $4.0m 0.01% Reduced -4.7k -4,698
71 Raymond James Financial Services Advisors, Inc. 0.01% of their portfolio ST. PETERSBURG, FL 61,64761.6k $3.9m $3.9m 0.01% Added +26.3k +26,292
72 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 60,46760.5k $3.8m $3.8m 0.00% Reduced -87.8k -87,840
73 Legal & General Group Plc 0.00% of their portfolio London, X0 57,86457.9k $3.7m $3.7m 0.00% Reduced -399 -399
74 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 56,40156.4k $3.6m $3.6m 0.00% Added +13.2k +13,225
75 PLATINUM INVESTMENT MANAGEMENT LTD 0.12% of their portfolio SYDNEY AUSTRALIA 2000, C3 56,17156.2k $3.6m $3.6m 0.12% Unchanged
76 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 55,97956.0k $3.5m $3.5m 0.00% Added +10.8k +10,821
77 NBW CAPITAL LLC 0.77% of their portfolio BOSTON, MA 52,54052.5k $3.3m $3.3m 0.77% Reduced -1.1k -1,057
78 CAPTRUST FINANCIAL ADVISORS 0.01% of their portfolio RALEIGH, NC 49,80549.8k $3.1m $3.1m 0.01% Added +22.2k +22,227
79 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 48,14548.1k $3.0m $3.0m 0.00% Reduced -8.8k -8,846
80 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.06% of their portfolio CHICAGO, IL 47,78447.8k $3.0m $3.0m 0.06% Reduced -1.4k -1,449
81 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 43,56143.6k $2.8m $2.8m 0.01% Reduced -8.4k -8,398
82 ORACLE INVESTMENT MANAGEMENT INC 2.47% of their portfolio GREENWICH, CT 41,37741.4k $2.6m $2.6m 2.47% New
83 SYNOVUS FINANCIAL CORP 0.03% of their portfolio Columbus, GA 40,48140.5k $2.6m $2.6m 0.03% Reduced -2.6k -2,632
84 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 35,85235.9k $2.3m $2.3m 0.00% Reduced -1.5k -1,476
85 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 35,51235.5k $2.2m $2.2m 0.00% Reduced -32.8k -32,756
86 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 34,99635.0k $2.2m $2.2m 0.00% Reduced -6.9k -6,929
87 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.02% of their portfolio New York, NY 33,26933.3k $2.1m $2.1m 0.02% Reduced -2.5k -2,542
88 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio Boston, MA 32,90332.9k $2.1m $2.1m 0.00% New
89 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 32,31632.3k $2.0m $2.0m 0.01% Added +534 +534
90 RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio ST PETERSBURG, FL 29,73529.7k $1.9m $1.9m 0.00% Added +14.6k +14,639
91 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 29,27129.3k $1.8m $1.8m 0.01% Added +431 +431
92 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 29,09829.1k $1.8m $1.8m 0.00% Added +5.7k +5,667
93 Zimmer Partners, LP 0.04% of their portfolio NEW YORK, NY 28,40028.4k $1.8m $1.8m 0.04% New
94 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 28,14028.1k $1.8m $1.8m 0.00% Unchanged
95 CAPITAL FUND MANAGEMENT S.A. 0.03% of their portfolio PARIS, I0 26,86026.9k $1.7m $1.7m 0.03% Reduced -98.8k -98,775
96 PROFUND ADVISORS LLC 0.09% of their portfolio BETHESDA, MD 26,43826.4k $1.7m $1.7m 0.09% Reduced -4.2k -4,162
97 GROUP ONE TRADING LLC 0.07% of their portfolio CHICAGO, IL 26,27526.3k $1.7m $1.7m 0.07% Added +14.7k +14,671
98 VIRGINIA RETIREMENT SYSTEMS ET Al 0.02% of their portfolio RICHMOND, VA 25,90025.9k $1.6m $1.6m 0.02% Added +2.4k +2,400
99 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 25,15025.1k $1.7m $1.7m 0.00% Unchanged
100 Erste Asset Management GmbH 0.03% of their portfolio VIENNA, C4 25,10025.1k $1.7m $1.7m 0.03% Unchanged