Vault-13

APELLIS PHARMACEUTICALS INC APLS

COM · Common Stock · CUSIP 03753U106 · ISIN US03753U1060

319 institutional holders +35 vs Q1 2023
107,414,357107.4m shares reported held*
$9.8bnreported value*
66 new 100 added 120 reduced 32 sold out net sold ≈ $544.3m (-6.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($27.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $91.07. Options: 33 managers hold calls ($229.1m notional), 25 hold puts ($165.6m).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0200400Q3 22: 251Q4 22: 245Q1 23: 284Q2 23: 319319Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022251
Q4 2022245
Q1 2023284
Q2 2023319

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 126 bought or addedQ4 22: 123 cut or sold outQ4 22Q1 23: 172 bought or addedQ1 23: 105 cut or sold outQ1 23Q2 23: 166 bought or addedQ2 23: 152 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 2022126123
Q1 2023172105
Q2 2023166152

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100m$200m$300mQ3 22 calls: $92.0mQ3 22 puts: $115.0mQ3 22P/C 1.25Q4 22 calls: $81.6mQ4 22 puts: $55.8mQ4 22P/C 0.68Q1 23 calls: $181.8mQ1 23 puts: $106.3mQ1 23P/C 0.58Q2 23 calls: $229.1mQ2 23 puts: $165.6mQ2 23P/C 0.72
Numbers
QuarterCallsPutsP/C
Q3 2022$92.0m$115.0m1.25
Q4 2022$81.6m$55.8m0.68
Q1 2023$181.8m$106.3m0.58
Q2 2023$229.1m$165.6m0.72

Biggest buyers

PRICE T ROWE ASSOCIATES INC /MD/ Added +2,482,186+2.5m
1832 Asset Management L.P. Added +530,800+530.8k
PICTET ASSET MANAGEMENT SA Added +478,585+478.6k
Avidity Partners Management LP New +468,700+468.7k
JANE STREET GROUP, LLC Added +417,698+417.7k
MILLENNIUM MANAGEMENT LLC Added +370,610+370.6k
CITADEL ADVISORS LLC Added +354,512+354.5k
LORD, ABBETT & CO. LLC Added +327,830+327.8k
DEERFIELD MANAGEMENT COMPANY, L.P. New +313,289+313.3k
HRT FINANCIAL LP New +309,024+309.0k

Biggest sellers

JANUS HENDERSON GROUP PLC Reduced -2,904,577-2.9m
BlackRock Inc. Reduced -1,907,824-1.9m
WELLINGTON MANAGEMENT GROUP LLP Reduced -1,614,164-1.6m
STATE STREET CORP Reduced -696,777-696.8k
JENNISON ASSOCIATES LLC Reduced -642,164-642.2k
Point72 Asset Management, L.P. Reduced -640,363-640.4k
MACQUARIE GROUP LTD Reduced -635,999-636.0k
Octagon Capital Advisors LP Reduced -631,700-631.7k
Bellevue Group AG Reduced -590,887-590.9k
FEDERATED HERMES, INC. Reduced -363,837-363.8k

Biggest calls

683 Capital Management, LLC New $45.6m501.0k shares
Balyasny Asset Management L.P. New $31.6m347.0k shares
Twin Tree Management, LP Reduced $22.0m241.8k shares
JANE STREET GROUP, LLC Reduced $16.6m182.7k shares
SIMPLEX TRADING, LLC Reduced $15.9m174.2k shares
Caption Management, LLC Reduced $15.1m165.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $14.1m155.0k shares
CITADEL ADVISORS LLC Reduced $11.9m130.6k shares
NOMURA HOLDINGS INC New $8.9m97.2k shares
MILLENNIUM MANAGEMENT LLC Added $8.4m92.2k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $20.8m228.8k shares
CITADEL ADVISORS LLC Added $19.6m215.6k shares
SIMPLEX TRADING, LLC Added $18.3m200.5k shares
BOOTHBAY FUND MANAGEMENT, LLC New $16.3m178.6k shares
JANE STREET GROUP, LLC Added $14.6m160.6k shares
Ikarian Capital, LLC New $12.1m133.0k shares
Jefferies Financial Group Inc. Added $12.0m132.0k shares
Caption Management, LLC Reduced $11.8m130.0k shares
GROUP ONE TRADING LLC Added $11.2m123.3k shares
GREAT POINT PARTNERS LLC New $8.6m94.7k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +6.0 pts · filed 2026-02-06 10.5% +6.0 pts 13.2m 2026-02-06
STATE STREET CORP 13G · institution new · filed 2026-05-12 5.4% new 6.8m 2026-05-12

Fell to 5% or below in the last year: MORGAN STANLEY (0.0%, 2026-06-05), RTW INVESTMENTS, LP (2.9%, 2026-05-15), Deep Track Capital, LP (3.5%, 2026-05-15), BIOGEN INC. (0.0%, 2026-05-14), WELLINGTON MANAGEMENT GROUP LLP (0.2%, 2026-04-07), VANGUARD GROUP INC (0.0%, 2026-03-26), EcoR1 Capital, LLC (2.7%, 2025-11-14)

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Avoro Capital Advisors LLC 13.73% of their portfolio NEW YORK, NY 11,111,11111.1m $1.0bn $1.0bn 13.73% Unchanged
2 VANGUARD GROUP INC 0.02% of their portfolio Valley Forge, PA 9,401,2909.4m $856.5m $856.5m 0.02% Reduced -127.7k -127,654
3 PRICE T ROWE ASSOCIATES INC /MD/ 0.09% of their portfolio BALTIMORE, MD 7,072,2267.1m $644.3m $644.3m 0.09% Added +2.5m +2,482,186
4 WELLINGTON MANAGEMENT GROUP LLP 0.12% of their portfolio Boston, MA 6,664,2756.7m $607.1m $607.1m 0.12% Reduced -1.6m -1,614,164
5 BlackRock Inc. 0.01% of their portfolio New York, NY 5,747,6275.7m $523.6m $523.6m 0.01% Reduced -1.9m -1,907,824
6 T. Rowe Price Investment Management, Inc. 0.35% of their portfolio BALTIMORE, MD 5,638,8755.6m $513.7m $513.7m 0.35% Reduced -121.8k -121,789
7 EcoR1 Capital, LLC 13.09% of their portfolio San Francisco, CA 5,451,6475.5m $496.6m $496.6m 13.09% Unchanged
8 FMR LLC 0.03% of their portfolio BOSTON, MA 4,225,5954.2m $385.0m $385.0m 0.03% Reduced -25.3k -25,279
9 Octagon Capital Advisors LP 33.28% of their portfolio NEW YORK, NY 2,618,3002.6m $238.5m $238.5m 33.28% Reduced -631.7k -631,700
10 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,283,0852.3m $208.0m $208.0m 0.01% Reduced -696.8k -696,777
11 LORD, ABBETT & CO. LLC 0.34% of their portfolio JERSEY CITY, NJ 2,136,2862.1m $194.6m $194.6m 0.34% Added +327.8k +327,830
12 JENNISON ASSOCIATES LLC 0.15% of their portfolio NEW YORK, NY 1,970,6032.0m $179.5m $179.5m 0.15% Reduced -642.2k -642,164
13 JPMORGAN CHASE & CO 0.02% of their portfolio NEW YORK, NY 1,786,9821.8m $162.8m $162.8m 0.02% Added +138.5k +138,530
14 JANUS HENDERSON GROUP PLC 0.10% of their portfolio LONDON, X0 1,776,9051.8m $161.9m $161.9m 0.10% Reduced -2.9m -2,904,577
15 Boxer Capital, LLC 6.66% of their portfolio San Diego, CA 1,576,0001.6m $143.6m $143.6m 6.66% Unchanged
16 GEODE CAPITAL MANAGEMENT, LLC 0.02% of their portfolio BOSTON, MA 1,498,3891.5m $136.5m $136.5m 0.02% Reduced -339.9k -339,890
17 Cormorant Asset Management, LP 6.80% of their portfolio BOSTON, MA 1,310,0001.3m $119.3m $119.3m 6.80% Reduced -50.0k -50,000
18 Point72 Asset Management, L.P. 0.39% of their portfolio STAMFORD, CT 1,239,3611.2m $112.9m $112.9m 0.39% Reduced -640.4k -640,363
19 Invesco Ltd. 0.03% of their portfolio ATLANTA, GA 1,152,3961.2m $105.0m $105.0m 0.03% Added +111.4k +111,415
20 Artal Group S.A. 3.06% of their portfolio LUXEMBOURG, N4 1,050,0671.1m $95.7m $95.7m 3.06% Reduced -166.2k -166,245
21 NORGES BANK 0.02% of their portfolio OSLO, Q8 1,023,0261.0m $93.2m $93.2m 0.02% Added +91.5k +91,516
22 PICTET ASSET MANAGEMENT SA 0.10% of their portfolio GENEVA 73, V8 928,624928.6k $84.6m $84.6m 0.10% Added +478.6k +478,585
23 MILLENNIUM MANAGEMENT LLC 0.09% of their portfolio NEW YORK, NY 918,811918.8k $83.7m $83.7m 0.09% Added +370.6k +370,610
24 ORBIMED ADVISORS LLC 1.51% of their portfolio New York, NY 910,200910.2k $82.9m $82.9m 1.51% Unchanged
25 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 852,272852.3k $77.6m $77.6m 0.01% Reduced -16.9k -16,916
26 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio SAN FRANCISCO, CA 828,522828.5k $75.5m $75.5m 0.02% Reduced -155.0k -154,987
27 PERCEPTIVE ADVISORS LLC 2.15% of their portfolio NEW YORK, NY 812,037812.0k $74.0m $74.0m 2.15% Added +256.7k +256,693
28 MACQUARIE GROUP LTD 0.08% of their portfolio Sydney, NSW 2000, C3 775,480775.5k $70.6m $70.6m 0.08% Reduced -636.0k -635,999
29 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 756,665756.7k $68.9m $68.9m 0.01% Added +3.8k +3,803
30 1832 Asset Management L.P. 0.12% of their portfolio TORONTO, A6 661,700661.7k $60.3m $60.3m 0.12% Added +530.8k +530,800
31 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 634,897634.9k $57.8m $57.8m 0.01% Reduced -28.3k -28,298
32 Logos Global Management LP 7.86% of their portfolio San Francisco, CA 625,000625.0k $56.9m $56.9m 7.86% Reduced -175.0k -175,000
33 WESTFIELD CAPITAL MANAGEMENT CO LP 0.35% of their portfolio BOSTON, MA 596,232596.2k $54.3m $54.3m 0.35% Reduced -196.0k -196,014
34 CITADEL ADVISORS LLC 0.05% of their portfolio MIAMI, FL 528,572528.6k $48.2m $48.2m 0.05% Added +354.5k +354,512
35 Fiera Capital Corp 0.14% of their portfolio MONTREAL, A8 527,920527.9k $48.1m $48.1m 0.14% Reduced -12.5k -12,462
36 D. E. Shaw & Co., Inc. 0.07% of their portfolio New York, NY 527,811527.8k $48.1m $48.1m 0.07% Added +115.0k +114,958
37 Laurion Capital Management LP 2.04% of their portfolio NEW YORK, NY 522,929522.9k $47.6m $47.6m 2.04% Added +148.6k +148,590
38 Bellevue Group AG 0.67% of their portfolio ZURICH, V8 518,495518.5k $47.2m $47.2m 0.67% Reduced -590.9k -590,887
39 Assenagon Asset Management S.A. 0.18% of their portfolio SENNINGERBERG, N4 498,710498.7k $45.4m $45.4m 0.18% Reduced -244.5k -244,536
40 JANE STREET GROUP, LLC 0.06% of their portfolio NEW YORK, NY 481,082481.1k $43.8m $43.8m 0.06% Added +417.7k +417,698
41 TD Asset Management Inc 0.05% of their portfolio Toronto, A6 478,726478.7k $43.6m $43.6m 0.05% Added +100.8k +100,758
42 DEUTSCHE BANK AG\ 0.02% of their portfolio FRANKFURT AM MAIN, 2M 478,366478.4k $43.6m $43.6m 0.02% Reduced -121.1k -121,062
43 Avidity Partners Management LP 1.49% of their portfolio DALLAS, TX 468,700468.7k $42.7m $42.7m 1.49% New
44 Polar Capital Holdings Plc 0.29% of their portfolio London, X0 465,000465.0k $42.4m $42.4m 0.29% Unchanged
45 EAGLE ASSET MANAGEMENT INC 0.23% of their portfolio ST PETERSBURG, FL 450,932450.9k $41.1m $41.1m 0.23% Added +221.6k +221,550
46 Nicholas Investment Partners, LP 2.58% of their portfolio RANCHO SANTA FE, CA 414,419414.4k $37.8m $37.8m 2.58% Added +77.5k +77,468
47 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 409,842409.8k $37.3m $37.3m 0.00% Reduced -197.9k -197,893
48 VICTORY CAPITAL MANAGEMENT INC 0.04% of their portfolio San Antonio, TX 400,957401.0k $36.5m $36.5m 0.04% Reduced -161.2k -161,212
49 EVENTIDE ASSET MANAGEMENT, LLC 0.61% of their portfolio Boston, MA 397,141397.1k $36.2m $36.2m 0.61% Reduced -97.9k -97,859
50 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 357,289357.3k $32.5m $32.5m 0.01% Reduced -35.1k -35,107
51 Driehaus Capital Management LLC 0.40% of their portfolio Chicago, IL 347,376347.4k $31.6m $31.6m 0.40% Added +76.7k +76,683
52 MARSHALL WACE, LLP 0.07% of their portfolio LONDON, X0 342,352342.4k $31.2m $31.2m 0.07% Added +249.9k +249,906
53 Candriam S.C.A. 0.21% of their portfolio STRASSEN, N4 326,507326.5k $29.7m $29.7m 0.21% Reduced -117.0k -117,000
54 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.05% of their portfolio BALA CYNWYD, PA 315,910315.9k $28.8m $28.8m 0.05% Added +234.1k +234,114
55 DEERFIELD MANAGEMENT COMPANY, L.P. 0.61% of their portfolio New York, NY 313,289313.3k $28.5m $28.5m 0.61% New
56 BARCLAYS PLC 0.02% of their portfolio LONDON, X0 312,230312.2k $28.4m $28.4m 0.02% Added +70.0k +70,049
57 HRT FINANCIAL LP 0.27% of their portfolio NEW YORK, NY 309,024309.0k $28.2m $28.2m 0.27% New
58 Balyasny Asset Management L.P. 0.08% of their portfolio Chicago, IL 304,169304.2k $27.7m $27.7m 0.08% Reduced -313.7k -313,728
59 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 300,995301.0k $27.4m $27.4m 0.04% Added +57.9k +57,875
60 ACUTA CAPITAL PARTNERS, LLC 18.37% of their portfolio REDWOOD CITY, CA 297,596297.6k $27.1m $27.1m 18.37% Added +7.1k +7,096
61 PFM Health Sciences, LP 1.01% of their portfolio SAN FRANCISCO, CA 274,498274.5k $25.0m $25.0m 1.01% Reduced -9.8k -9,771
62 Fiduciary Trust Co 0.44% of their portfolio Boston, MA 273,916273.9k $25.0m $25.0m 0.44% Reduced -268.4k -268,375
63 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 262,398262.4k $23.9m $23.9m 0.01% Reduced -87.2k -87,156
64 Finepoint Capital LP 7.62% of their portfolio BOSTON, MA 241,690241.7k $22.0m $22.0m 7.62% Reduced -42.0k -42,000
65 VOYA INVESTMENT MANAGEMENT LLC 0.02% of their portfolio ATLANTA, GA 221,414221.4k $20.2m $20.2m 0.02% Reduced -57.8k -57,772
66 Rhenman & Partners Asset Management AB 1.82% of their portfolio Stockholm, V7 190,000190.0k $17.3m $17.3m 1.82% Added +5.0k +5,000
67 California Public Employees Retirement System 0.01% of their portfolio Sacramento, CA 182,188182.2k $16.6m $16.6m 0.01% Added +40.2k +40,182
68 FRED ALGER MANAGEMENT, LLC 0.08% of their portfolio NEW YORK, NY 181,995182.0k $16.6m $16.6m 0.08% Reduced -249 -249
69 Ghost Tree Capital, LLC 5.92% of their portfolio NEW YORK, NY 180,000180.0k $16.4m $16.4m 5.92% Added +15.4k +15,380
70 PRUDENTIAL FINANCIAL INC 0.02% of their portfolio NEWARK, NJ 177,080177.1k $16.1m $16.1m 0.02% Reduced -259 -259
71 Swiss National Bank 0.01% of their portfolio ZURICH, V8 175,700175.7k $16.0m $16.0m 0.01% Reduced -15.3k -15,300
72 AXA S.A. 0.05% of their portfolio PARIS, I0 173,495173.5k $15.8m $15.8m 0.05% Added +2.4k +2,386
73 Tekla Capital Management LLC 0.62% of their portfolio Boston, MA 173,248173.2k $15.8m $15.8m 0.62% Added +38.1k +38,124
74 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 169,673169.7k $15.5m $15.5m 0.01% Added +33.1k +33,077
75 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 165,710165.7k $15.1m $15.1m 0.01% Added +65.4k +65,449
76 Schonfeld Strategic Advisors LLC 0.13% of their portfolio NEW YORK, NY 164,203164.2k $15.0m $15.0m 0.13% Added +88.2k +88,176
77 Connor, Clark & Lunn Investment Management Ltd. 0.07% of their portfolio VANCOUVER, A1 149,976150.0k $13.7m $13.7m 0.07% Reduced -2.0k -2,019
78 FEDERATED HERMES, INC. 0.03% of their portfolio PITTSBURGH, PA 147,465147.5k $13.4m $13.4m 0.03% Reduced -363.8k -363,837
79 SECTORAL ASSET MANAGEMENT INC 2.19% of their portfolio MONTREAL, A8 143,859143.9k $13.1m $13.1m 2.19% Reduced -28.6k -28,631
80 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.06% of their portfolio JUPITER, FL 143,402143.4k $13.1m $13.1m 0.06% Added +77.2k +77,167
81 CIBC Private Wealth Group LLC 0.01% of their portfolio ATLANTA, GA 141,560141.6k $12.9m $12.9m 0.01% Added +27.6k +27,590
82 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 141,078141.1k $12.9m $12.9m 0.00% Added +61.4k +61,405
83 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 140,485140.5k $12.8m $12.8m 0.00% Added +3.2k +3,242
84 RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio NEW YORK, NY 138,513138.5k $12.6m $12.6m 0.02% New
85 Russell Investments Group, Ltd. 0.02% of their portfolio Seattle, WA 137,527137.5k $12.5m $12.5m 0.02% Reduced -673 -673
86 Ikarian Capital, LLC 4.11% of their portfolio DALLAS, TX 133,800133.8k $12.2m $12.2m 4.11% Added +33.8k +33,800
87 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 132,873132.9k $12.1m $12.1m 0.01% Added +1.9k +1,912
88 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 131,787131.8k $12.0m $12.0m 0.00% Added +37.8k +37,801
89 Senator Investment Group LP 0.53% of their portfolio New York, NY 130,000130.0k $11.8m $11.8m 0.53% Not comparable
90 INTERNATIONAL BIOTECHNOLOGY TRUST PLC 3.60% of their portfolio London, X0 129,700129.7k $11.8m $11.8m 3.60% Added +98.0k +98,000
91 Allspring Global Investments Holdings, LLC 0.02% of their portfolio CHARLOTTE, NC 128,655128.7k $11.7m $11.7m 0.02% Reduced -2.3k -2,256
92 PNC Financial Services Group, Inc. 0.01% of their portfolio Pittsburgh, PA 122,351122.4k $11.1m $11.1m 0.01% Added +60.9k +60,886
93 Ergoteles LLC 0.50% of their portfolio NEW YORK, NY 114,713114.7k $10.5m $10.5m 0.50% New
94 Granahan Investment Management, LLC 0.32% of their portfolio WALTHAM, MA 113,775113.8k $10.4m $10.4m 0.32% Reduced -49.7k -49,676
95 Saturn V Capital Management LP 5.43% of their portfolio AUSTIN, TX 107,406107.4k $9.8m $9.8m 5.43% Reduced -15.8k -15,759
96 BANQUE PICTET & CIE SA 0.09% of their portfolio GENEVA 73, V8 107,135107.1k $9.8m $9.8m 0.09% Reduced -31.5k -31,467
97 Polar Asset Management Partners Inc. 0.19% of their portfolio TORONTO, A6 105,810105.8k $9.6m $9.6m 0.19% Added +6.6k +6,600
98 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 104,487104.5k $9.5m $9.5m 0.01% Reduced -8.1k -8,116
99 Artia Global Partners LP 3.23% of their portfolio MIAMI, FL 102,940102.9k $9.4m $9.4m 3.23% New
100 SG Americas Securities, LLC 0.08% of their portfolio NEW YORK, NY 101,111101.1k $9.2m $9.2m 0.08% Added +90.0k +90,048