ALNYLAM PHARMACEUTICALS INC ALNY
COM · Common Stock · CUSIP 02043Q107 · ISIN US02043Q1076
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, MA
- Founded2002
- Websitealnylam.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($19.4m this quarter). Holder counts are more reliable. Shares outstanding: 125.0m as of 2023-07-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $189.99. Options: 18 managers hold calls ($119.5m notional), 19 hold puts ($161.7m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 497 |
| Q4 2022 | 488 |
| Q1 2023 | 478 |
| Q2 2023 | 478 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 244 | 232 |
| Q1 2023 | 227 | 219 |
| Q2 2023 | 215 | 208 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $298.4m | $269.6m | 0.90 |
| Q4 2022 | $400.3m | $317.8m | 0.79 |
| Q1 2023 | $193.7m | $158.9m | 0.82 |
| Q2 2023 | $119.5m | $161.7m | 1.35 |
Biggest buyers
| Capital International Investors | Added | +651.1k |
| MORGAN STANLEY | Added | +650.0k |
| AMERIPRISE FINANCIAL INC | Added | +422.2k |
| Bank of New York Mellon Corp | Added | +221.3k |
| T. Rowe Price Investment Management, Inc. | Added | +206.8k |
| CIBC Private Wealth Group LLC | Added | +107.1k |
| BARCLAYS PLC | Added | +68.5k |
| Legal & General Group Plc | Added | +67.4k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +63.9k |
| TWO SIGMA INVESTMENTS, LP | Added | +57.3k |
Biggest sellers
| FMR LLC | Reduced | -13.8m |
| NORGES BANK | Reduced | -818.1k |
| BANK OF AMERICA CORP /DE/ | Reduced | -418.9k |
| Balyasny Asset Management L.P. | Sold out | -251.8k |
| BAILLIE GIFFORD & CO | Reduced | -246.9k |
| BlackRock Inc. | Reduced | -162.8k |
| FIRST TRUST ADVISORS LP | Reduced | -153.7k |
| Man Group plc | Sold out | -131.2k |
| Assenagon Asset Management S.A. | Reduced | -124.3k |
| Dodge & Cox | Reduced | -105.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $32.2m169.4k shares |
| Caption Management, LLC | Added | $21.6m113.6k shares |
| CITADEL ADVISORS LLC | Reduced | $17.6m92.9k shares |
| MILLENNIUM MANAGEMENT LLC | New | $8.6m45.2k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $8.2m43.4k shares |
| GROUP ONE TRADING LLC | Reduced | $7.6m39.9k shares |
| Jefferies Financial Group Inc. | Reduced | $5.6m29.6k shares |
| JANE STREET GROUP, LLC | Reduced | $4.4m23.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.3m22.9k shares |
| Cubist Systematic Strategies, LLC | Unchanged | $3.2m16.6k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $39.8m209.8k shares |
| Caption Management, LLC | Added | $20.5m108.0k shares |
| CITADEL ADVISORS LLC | Reduced | $20.4m107.2k shares |
| LMR Partners LLP | New | $17.5m91.9k shares |
| MILLENNIUM MANAGEMENT LLC | New | $12.4m65.2k shares |
| JPMORGAN CHASE & CO | Unchanged | $9.5m50.0k shares |
| PEAK6 Investments LLC | Added | $7.2m38.1k shares |
| JANE STREET GROUP, LLC | Reduced | $7.0m37.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $7.0m36.8k shares |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | $5.9m311 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution -1.8 pts · filed 2026-05-06 | 11.0% |
| Capital World Investors 13G · institution filed 2026-05-14 | 8.2% |
| Capital Research Global Investors 13G · institution +1.7 pts · filed 2026-05-14 | 7.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 2 | $6.4m | — |
| Q1 2022 | 0 | — | 1 | $4.5m | — |
| Q2 2022 | 0 | — | 1 | $2.6m | — |
| Q3 2022 | 0 | — | 2 | $8.8m | — |
| Q4 2022 | 0 | — | 1 | $5.0m | — |
| Q1 2023 | 0 | — | 4 | $13.4m | — |
| Q2 2023 | 0 | — | 6 | $4.0m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-04-28 | Garg Pushkal CMO & EVP Dev & Med Affairs | Sold | $488.6k2.5k shares |
| 2023-04-27 | Greenstreet Yvonne Chief Executive Officer, director | Sold | $1.5m7.6k shares |
| 2023-04-27 | Vaishnaw Akshay President | Sold | $465.5k2.4k shares |
| 2023-04-27 | Garg Pushkal CMO & EVP Dev & Med Affairs | Sold | $357.9k1.8k shares |
| 2023-04-27 | Tanguler Tolga EVP, Chief Commercial Officer | Sold | $287.2k1.5k shares |
| 2023-04-27 | Poulton Jeffrey V. EVP, Chief Financial Officer | Sold | $190.1k977 shares |
| 2023-04-06 | Franchini Indrani Lall EVP, CLO & Secretary | Sold | $735.0k3.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| Capital World Investors 0.60% of their portfolio | 16.5m $3.1bn | Added +21.4k |
| FMR LLC 0.20% of their portfolio | 12.5m $2.4bn | Reduced -13.8m |
| VANGUARD GROUP INC 0.05% of their portfolio | 11.6m $2.2bn | Added +18.1k |
| BAILLIE GIFFORD & CO 1.35% of their portfolio | 8.4m $1.6bn | Reduced -246.9k |
| BlackRock Inc. 0.04% of their portfolio | 8.4m $1.6bn | Reduced -162.8k |
| WELLINGTON MANAGEMENT GROUP LLP 0.22% of their portfolio | 6.1m $1.2bn | Reduced -86.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.10% of their portfolio | 3.9m $738.0m | Reduced -87.3k |
| Dodge & Cox 0.48% of their portfolio | 3.8m $719.8m | Reduced -105.0k |
| T. Rowe Price Investment Management, Inc. 0.42% of their portfolio | 3.2m $615.0m | Added +206.8k |
| JPMORGAN CHASE & CO 0.07% of their portfolio | 3.1m $595.1m | Added +38.2k |
| STATE STREET CORP 0.03% of their portfolio | 2.9m $549.4m | Added +37.4k |
| Capital International Investors 0.13% of their portfolio | 2.9m $547.2m | Added +651.1k |
| Capital Research Global Investors 0.12% of their portfolio | 2.4m $447.3m | Reduced -84.8k |
| MORGAN STANLEY 0.04% of their portfolio | 1.9m $357.2m | Added +650.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.04% of their portfolio | 1.8m $341.7m | Added +63.9k |
| RTW INVESTMENTS, LP 6.09% of their portfolio | 1.7m $319.7m | Unchanged |
| Avoro Capital Advisors LLC 2.85% of their portfolio | 1.1m $209.9m | Unchanged |
| Bellevue Group AG 2.44% of their portfolio | 899.6k $170.9m | Added +16.4k |
| Legal & General Group Plc 0.05% of their portfolio | 798.4k $151.6m | Added +67.4k |
| Bank of New York Mellon Corp 0.03% of their portfolio | 775.6k $147.3m | Added +221.3k |
| NORTHERN TRUST CORP 0.03% of their portfolio | 772.5k $146.7m | Added +10.9k |
| NORGES BANK 0.03% of their portfolio | 703.4k $133.6m | Reduced -818.1k |
| Amundi 0.06% of their portfolio | 674.8k $128.0m | Added +21.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.07% of their portfolio | 673.9k $135.0m | Unchanged |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.04% of their portfolio | 672.4k $127.7m | Reduced -93.4k |
| PICTET ASSET MANAGEMENT SA 0.15% of their portfolio | 648.5k $123.2m | Added +44.5k |
| LOOMIS SAYLES & CO L P 0.20% of their portfolio | 645.1k $122.5m | Reduced -13.1k |
| AMERIPRISE FINANCIAL INC 0.04% of their portfolio | 625.3k $118.8m | Added +422.2k |
| GILDER GAGNON HOWE & CO LLC 1.56% of their portfolio | 598.7k $113.7m | Reduced -22.5k |
| Nuveen Asset Management, LLC 0.04% of their portfolio | 552.7k $105.0m | Reduced -56.4k |
| ALLIANCEBERNSTEIN L.P. 0.04% of their portfolio | 550.3k $104.5m | Added +14.3k |
| DEUTSCHE BANK AG\ 0.05% of their portfolio | 486.9k $92.5m | Added +27.3k |
| Swiss National Bank 0.06% of their portfolio | 447.6k $85.0m | Reduced -40.7k |
| AMERICAN CENTURY COMPANIES INC 0.06% of their portfolio | 438.9k $83.4m | Reduced -5.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.02% of their portfolio | 416.1k $79.0m | Added +10.8k |
| Mitsubishi UFJ Trust & Banking Corp 0.17% of their portfolio | 393.4k $74.7m | Reduced -14.5k |
| Invesco Ltd. 0.02% of their portfolio | 390.1k $74.1m | Added +22.8k |
| TD Asset Management Inc 0.08% of their portfolio | 359.1k $68.2m | Reduced -783 |
| BANK OF AMERICA CORP /DE/ 0.01% of their portfolio | 352.3k $66.9m | Reduced -418.9k |
| CIBC Private Wealth Group LLC 0.07% of their portfolio | 349.0k $66.3m | Added +107.1k |
| Rock Springs Capital Management LP 1.56% of their portfolio | 345.0k $65.5m | Unchanged |
| Swedbank AB 0.11% of their portfolio | 333.9k $63.4m | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.03% of their portfolio | 326.7k $62.0m | Reduced -10.9k |
| Candriam S.C.A. 0.44% of their portfolio | 318.9k $60.6m | Reduced -9.4k |
| Sumitomo Mitsui Trust Group, Inc. 0.04% of their portfolio | 298.6k $56.7m | Reduced -42.3k |
| JANUS HENDERSON GROUP PLC 0.03% of their portfolio | 291.8k $55.4m | Reduced -7.0k |
| Casdin Capital, LLC 4.65% of their portfolio | 280.0k $53.2m | Added +10.0k |
| FIRST TRUST ADVISORS LP 0.06% of their portfolio | 276.4k $52.5m | Reduced -153.7k |
| Corient Private Wealth LP 0.12% of their portfolio | 272.5k $51.8m | Reduced -353 |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 259.0k $49.2m | Added +14.6k |
| EAGLE ASSET MANAGEMENT INC 0.27% of their portfolio | 259.0k $49.2m | Reduced -4.5k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 255.9k $48.6m | Added +25.7k |
| D. E. Shaw & Co., Inc. 0.07% of their portfolio | 248.3k $47.2m | Added +16.9k |
| ROYAL BANK OF CANADA 0.01% of their portfolio | 246.2k $46.8m | Added +30.1k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 241.0k $45.8m | Added +22.5k |
| Polar Capital Holdings Plc 0.31% of their portfolio | 235.0k $44.6m | Reduced -76.9k |
| California Public Employees Retirement System 0.04% of their portfolio | 226.3k $43.0m | Reduced -10.8k |
| TWO SIGMA INVESTMENTS, LP 0.11% of their portfolio | 224.7k $42.7m | Added +57.3k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.12% of their portfolio | 221.2k $42.0m | Added +38.4k |
| BARCLAYS PLC 0.03% of their portfolio | 210.1k $39.9m | Added +68.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.05% of their portfolio | 198.6k $37.7m | Reduced -4.7k |
| TWO SIGMA ADVISERS, LP 0.09% of their portfolio | 193.6k $36.8m | Added +38.5k |
| AXA S.A. 0.11% of their portfolio | 178.8k $34.0m | Added +5.0k |
| RHUMBLINE ADVISERS 0.04% of their portfolio | 175.3k $33.3m | Added +17.4k |
| National Pension Service 0.05% of their portfolio | 172.0k $32.9m | Added +15.8k |
| Handelsbanken Fonder AB 0.17% of their portfolio | 169.6k $32.2m | Reduced -1.6k |
| CREDIT SUISSE AG/ 0.03% of their portfolio | 168.1k $31.9m | Added +36.1k |
| Squarepoint Ops LLC 0.18% of their portfolio | 167.6k $31.8m | Added +34.4k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.05% of their portfolio | 167.5k $31.8m | Reduced -1.7k |
| ROYAL LONDON ASSET MANAGEMENT LTD 0.10% of their portfolio | 164.2k $31.2m | Added +39.5k |
| DekaBank Deutsche Girozentrale 0.07% of their portfolio | 160.4k $30.6m | Added +36.4k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 150.4k $28.6m | Reduced -10.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio | 147.6k $28.0m | Reduced -25.0k |
| Tekla Capital Management LLC 1.06% of their portfolio | 143.2k $27.2m | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 142.1k $27.0m | Reduced -6.0k |
| Eagle Health Investments LP 4.86% of their portfolio | 136.8k $26.0m | Unchanged |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.06% of their portfolio | 136.6k $25.9m | Reduced -462 |
| HighTower Advisors, LLC 0.05% of their portfolio | 125.8k $23.9m | Added +226 |
| NOVO HOLDINGS A/S 1.74% of their portfolio | 118.4k $22.5m | Unchanged |
| TOBAM 1.56% of their portfolio | 108.6k $20.6m | Reduced -18.1k |
| APG Asset Management N.V. 0.04% of their portfolio | 108.4k $18.9m | Reduced -7.0k |
| FIL Ltd 0.02% of their portfolio | 106.4k $20.2m | Reduced -22.4k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio | 101.5k $19.3m | Reduced -13.4k |
| CAPITAL INTERNATIONAL LTD /CA/ 1.00% of their portfolio | 93.6k $17.8m | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) 0.12% of their portfolio | 92.8k $17.6m | Reduced -33.7k |
| Assenagon Asset Management S.A. 0.07% of their portfolio | 90.9k $17.3m | Reduced -124.3k |
| Nicholas Investment Partners, LP 1.17% of their portfolio | 90.4k $17.2m | Unchanged |
| NEUBERGER BERMAN GROUP LLC 0.02% of their portfolio | 89.8k $17.1m | Added +397 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio | 89.5k $17.0m | Reduced -24.9k |
| Treasurer of the State of North Carolina 0.09% of their portfolio | 86.9k $16.5m | Reduced -1.6k |
| CAPITAL INTERNATIONAL SARL 0.72% of their portfolio | 84.4k $16.0m | Added +7.3k |
| Clearbridge Investments, LLC 0.01% of their portfolio | 83.2k $15.8m | Added +6.9k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 4.72% of their portfolio | 81.6k $15.5m | Added +35.0k |
| VAN ECK ASSOCIATES CORP 0.03% of their portfolio | 78.0k $14.8m | Reduced -3.3k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 75.0k $14.2m | Added +51.6k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio | 74.9k $14.2m | Reduced -66.5k |
| State of New Jersey Common Pension Fund D 0.05% of their portfolio | 73.8k $14.0m | Unchanged |
| UBS Group AG 0.01% of their portfolio | 73.5k $14.0m | Added +33.4k |
| NOMURA ASSET MANAGEMENT CO LTD 0.06% of their portfolio | 66.2k $12.6m | Reduced -1.1k |
| TORONTO DOMINION BANK 0.01% of their portfolio | 61.7k $11.7m | Added +27.5k |