ARROWHEAD PHARMACEUTICALS IN ARWR
COM · Common Stock · CUSIP 04280A100 · ISIN US04280A1007
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersPasadena, CA
- Founded1989
- Websitearrowheadpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.8m this quarter). Holder counts are more reliable. Shares outstanding: 107.2m as of 2023-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $35.57. Options: 11 managers hold calls ($15.2m notional), 12 hold puts ($12.5m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 278 |
| Q4 2022 | 283 |
| Q1 2023 | 257 |
| Q2 2023 | 274 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 128 | 130 |
| Q1 2023 | 117 | 143 |
| Q2 2023 | 117 | 137 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $19.4m | $15.2m | 0.78 |
| Q4 2022 | $23.3m | $20.0m | 0.86 |
| Q1 2023 | $10.1m | $7.2m | 0.71 |
| Q2 2023 | $15.2m | $12.5m | 0.82 |
Biggest buyers
| Driehaus Capital Management LLC | New | +507.7k |
| Avoro Capital Advisors LLC | New | +357.4k |
| DIMENSIONAL FUND ADVISORS LP | New | +354.4k |
| MARSHALL WACE, LLP | New | +301.0k |
| VANGUARD GROUP INC | Added | +283.9k |
| TWO SIGMA INVESTMENTS, LP | Added | +220.7k |
| FRED ALGER MANAGEMENT, LLC | New | +167.1k |
| SECTORAL ASSET MANAGEMENT INC | New | +143.9k |
| Ikarian Capital, LLC | New | +130.0k |
| ORBIMED ADVISORS LLC | New | +117.0k |
Biggest sellers
| Avidity Partners Management LP | Reduced | -816.3k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -641.0k |
| JANUS HENDERSON GROUP PLC | Reduced | -594.6k |
| Woodline Partners LP | Reduced | -496.3k |
| STATE STREET CORP | Reduced | -395.2k |
| Balyasny Asset Management L.P. | Sold out | -275.8k |
| NOMURA HOLDINGS INC | Reduced | -257.8k |
| CITADEL ADVISORS LLC | Reduced | -254.3k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -251.5k |
| Hudson Bay Capital Management LP | Reduced | -182.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.0m168.8k shares |
| GROUP ONE TRADING LLC | Added | $2.2m61.0k shares |
| CITIGROUP INC | Reduced | $2.0m54.9k shares |
| CITADEL ADVISORS LLC | Reduced | $1.7m46.6k shares |
| JANE STREET GROUP, LLC | Reduced | $1.1m30.5k shares |
| Caption Management, LLC | Unchanged | $1.1m30.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $524.0k14.7k shares |
| WOLVERINE TRADING, LLC | Reduced | $388.0k10.8k shares |
| Walleye Trading LLC | Reduced | $278.1k7.8k shares |
| Walleye Capital LLC | Reduced | $57.1k1.6k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $4.5m127.0k shares |
| CITIGROUP INC | Reduced | $2.0m54.9k shares |
| CITADEL ADVISORS LLC | Added | $1.6m45.4k shares |
| Caption Management, LLC | Unchanged | $1.1m30.0k shares |
| JANE STREET GROUP, LLC | Added | $1.0m28.2k shares |
| SIMPLEX TRADING, LLC | Added | $895.0k25.1k shares |
| GROUP ONE TRADING LLC | Added | $784.5k22.0k shares |
| WOLVERINE TRADING, LLC | New | $348.5k9.7k shares |
| Walleye Capital LLC | Reduced | $164.0k4.6k shares |
| Walleye Trading LLC | Reduced | $153.3k4.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution -2.1 pts · filed 2026-07-27 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution +1.3 pts · filed 2026-08-14 | 9.6% |
| FMR LLC 13G · institution new · filed 2026-05-06 | 5.2% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD PORTFOLIO MANAGEMENT LLC (4.5%, 2026-07-31; now reported by VANGUARD CAPITAL MANAGEMENT LLC), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 1 | $43.5k | 3 | $9.9m | — |
| Q1 2022 | 0 | — | 7 | $13.2m | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 2 | $1.8m | — |
| Q1 2023 | 0 | — | 4 | $1.7m | — |
| Q2 2023 | 0 | — | 3 | $4.9m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-30 | Hamilton James C Chief Discovery/Trans Medicine | Sold | $106.6k3.0k shares |
| 2023-06-27 | Myszkowski Kenneth Allen Chief Financial Officer | Sold | $543.0k15.0k shares |
| 2023-05-05 | GIVEN DOUGLAS B Director | Sold | $265.9k6.5k shares |
| 2023-05-04 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $2.0m50.0k shares |
| 2023-05-03 | Anzalone Christopher Richard Chief Executive Officer, director | Sold | $2.1m54.9k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| BlackRock Inc. 0.01% of their portfolio | 12.8m $456.8m | Added +100.4k |
| VANGUARD GROUP INC 0.01% of their portfolio | 11.0m $391.3m | Added +283.9k |
| STATE STREET CORP 0.01% of their portfolio | 5.5m $196.4m | Reduced -395.2k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 2.9m $102.7m | Reduced -29.1k |
| FMR LLC 0.01% of their portfolio | 2.7m $97.2m | Reduced -22.0k |
| Invesco Ltd. 0.02% of their portfolio | 2.2m $79.5m | Added +47.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 2.2m $76.8m | Added +74.5k |
| Rokos Capital Management LLP 1.18% of their portfolio | 1.7m $58.9m | Unchanged |
| CREDIT SUISSE AG/ 0.05% of their portfolio | 1.4m $51.0m | Added +43.5k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 1.3m $46.3m | Reduced -21.7k |
| NORGES BANK 0.01% of their portfolio | 1.1m $40.9m | Reduced -111.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 1.1m $40.8m | Reduced -12.5k |
| FIRST MANHATTAN CO. LLC. 0.14% of their portfolio | 1.1m $39.2m | Added +73.5k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 1.0m $36.9m | Reduced -4.9k |
| Avidity Partners Management LP 1.15% of their portfolio | 925.0k $33.0m | Reduced -816.3k |
| Aquilo Capital Management, LLC 20.09% of their portfolio | 858.5k $30.6m | Reduced -160.0k |
| Western Financial Corp/CA 19.93% of their portfolio | 820.3k $29.3m | Reduced -11 |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 641.1k $22.9m | Reduced -71.5k |
| Commodore Capital LP 2.44% of their portfolio | 610.0k $21.8m | Added +35.0k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 594.0k $21.2m | Reduced -254.3k |
| MORGAN STANLEY 0.00% of their portfolio | 541.6k $19.3m | Reduced -92.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 537.0k $13.6m | Unchanged |
| Driehaus Capital Management LLC 0.23% of their portfolio | 507.7k $18.1m | New |
| NOMURA HOLDINGS INC 0.18% of their portfolio | 503.3k $17.9m | Reduced -257.8k |
| Assenagon Asset Management S.A. 0.07% of their portfolio | 497.8k $17.8m | Added +74.5k |
| EAGLE ASSET MANAGEMENT INC 0.10% of their portfolio | 483.0k $17.2m | Added +67.0k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 451.3k $16.1m | Reduced -14.9k |
| E. Ohman J:or Asset Management AB 0.56% of their portfolio | 435.3k $15.5m | Added +43.2k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 419.1k $14.9m | Reduced -25.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 384.9k $13.7m | Added +92.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 381.7k $13.6m | Reduced -94.1k |
| Avoro Capital Advisors LLC 0.17% of their portfolio | 357.4k $12.7m | New |
| BARCLAYS PLC 0.01% of their portfolio | 356.9k $12.7m | Added +40.9k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 354.4k $12.6m | New |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 343.6k $12.3m | Reduced -1.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 340.6k $12.1m | Reduced -103.1k |
| UBS Group AG 0.01% of their portfolio | 331.0k $11.8m | Added +31.6k |
| Retirement Systems of Alabama 0.05% of their portfolio | 331.0k $11.8m | Reduced -3.8k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 328.4k $11.7m | Reduced -641.0k |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 311.0k $11.1m | Added +220.7k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 304.7k $10.9m | Added +27.5k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 301.0k $10.7m | New |
| Mirae Asset Global Investments Co., Ltd. 0.02% of their portfolio | 274.7k $9.8m | Reduced -56.0k |
| Privium Fund Management B.V. 2.68% of their portfolio | 259.0k $9.3m | Unchanged |
| PANAGORA ASSET MANAGEMENT INC 0.05% of their portfolio | 253.6k $9.0m | Added +3.0k |
| JOHNSON & JOHNSON 2.74% of their portfolio | 247.6k $8.8m | Unchanged |
| Rafferty Asset Management, LLC 0.05% of their portfolio | 235.2k $8.4m | Reduced -27.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 231.3k $8.2m | Reduced -71.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 230.0k $8.2m | Reduced -8.9k |
| Swiss National Bank 0.01% of their portfolio | 224.0k $8.0m | Added +6.7k |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 223.9k $8.0m | Reduced -22.3k |
| Legal & General Group Plc 0.00% of their portfolio | 223.0k $8.0m | Reduced -8.9k |
| Candriam S.C.A. 0.06% of their portfolio | 220.1k $7.8m | Reduced -68.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 217.4k $7.8m | Reduced -27.0k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 216.3k $7.7m | Reduced -11.6k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.05% of their portfolio | 209.6k $7.5m | Reduced -6.1k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 182.0k $6.5m | Unchanged |
| FRED ALGER MANAGEMENT, LLC 0.03% of their portfolio | 167.1k $6.0m | New |
| WEALTH EFFECTS LLC 2.57% of their portfolio | 164.1k $5.9m | Added +7.2k |
| NORDEA INVESTMENT MANAGEMENT AB 0.01% of their portfolio | 160.1k $5.8m | Added +35.7k |
| BAMCO INC /NY/ 0.02% of their portfolio | 156.4k $5.6m | Added +25.1k |
| California Public Employees Retirement System 0.00% of their portfolio | 154.1k $5.5m | Unchanged |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 151.6k $5.4m | Added +10.2k |
| SECTORAL ASSET MANAGEMENT INC 0.86% of their portfolio | 143.9k $5.1m | New |
| BANQUE PICTET & CIE SA 0.04% of their portfolio | 137.9k $4.9m | Reduced -32.0k |
| Vivo Capital, LLC 0.34% of their portfolio | 137.4k $4.9m | Unchanged |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 136.2k $4.9m | Reduced -900 |
| Ikarian Capital, LLC 1.56% of their portfolio | 130.0k $4.6m | New |
| KORNITZER CAPITAL MANAGEMENT INC /KS 0.09% of their portfolio | 126.5k $4.5m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 124.6k $4.4m | Reduced -2.1k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.05% of their portfolio | 124.2k $4.4m | Reduced -12.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 118.0k $4.2m | Added +30.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 117.8k $4.2m | Reduced -4.2k |
| ALGERT GLOBAL LLC 0.18% of their portfolio | 117.3k $4.2m | Added +96.7k |
| ORBIMED ADVISORS LLC 0.08% of their portfolio | 117.0k $4.2m | New |
| MetLife Investment Management, LLC 0.03% of their portfolio | 116.4k $4.2m | Reduced -1.9k |
| CWM, LLC 0.02% of their portfolio | 113.0k $4.0m | Added +26.6k |
| Hudson Bay Capital Management LP 0.04% of their portfolio | 112.5k $4.0m | Reduced -182.5k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 110.0k $3.9m | Added +4.4k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 109.9k $3.9m | Reduced -47.0k |
| CITIGROUP INC 0.00% of their portfolio | 102.5k $3.7m | Reduced -130.4k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 101.2k $3.6m | Reduced -251.5k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.03% of their portfolio | 100.4k $3.6m | Added +14.9k |
| CAPITAL FUND MANAGEMENT S.A. 0.06% of their portfolio | 99.8k $3.6m | Reduced -5.9k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 97.5k $3.5m | Added +22.0k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.12% of their portfolio | 97.2k $3.5m | Added +21.0k |
| Woodline Partners LP 0.04% of their portfolio | 96.0k $3.4m | Reduced -496.3k |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 95.7k $3.4m | Added +67.1k |
| TEXAS PERMANENT SCHOOL FUND CORP 0.03% of their portfolio | 94.1k $3.4m | Reduced -3.0k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 88.3k $3.1m | Reduced -4.8k |
| CASTLEARK MANAGEMENT LLC 0.14% of their portfolio | 85.7k $3.1m | New |
| HRT FINANCIAL LP 0.03% of their portfolio | 80.5k $2.9m | Added +64.7k |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 77.4k $2.8m | Reduced -6.0k |
| Trexquant Investment LP 0.07% of their portfolio | 71.9k $2.6m | Added +55.9k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 70.7k $2.5m | Unchanged |
| AMALGAMATED BANK 0.02% of their portfolio | 69.3k $2.5m | Reduced -2.4k |
| M28 Capital Management LP 3.18% of their portfolio | 67.4k $2.4m | Unchanged |
| Fiera Capital Corp 0.01% of their portfolio | 59.1k $2.1m | Added +30 |
| ASSETMARK, INC 0.01% of their portfolio | 58.7k $2.1m | Added +2.1k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 58.0k $2.1m | New |