INTERNATIONAL BIOTECHNOLOGY TRUST PLC

London, X0 · CIK 942257 · 13F filing filed 2023-11-14

No investment adviser registration (Form ADV) found for this filer. It may be a parent company whose subsidiaries are the registered advisers, a bank or insurer, or a manager based outside the US.

Legal entityINTERNATIONAL BIOTECHNOLOGY TRUST PLC (GB)

Others nearbyLondon

As an employer

In the UK

1 UK companies in the group; those with staff figures, a pay gap report, FCA authorisation or fund management as their business are listed.

Sources: Companies House (accounts filed electronically; the largest groups often file on paper, so their staff numbers can be missing), the UK gender pay gap service (employers with 250+ staff) and the FCA's Financial Services Register. Contains public sector information licensed under the Open Government Licence v3.0.

$296.8m reported value -9.6% vs Q2 2023

65positions

47.8%in top 10

9 new 18 added 13 reduced 5 sold out vs Q2 2023

Holdings, Q3 2023

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	AMGEN INC COM AMGN	AMGN	79,246	$21.3m7.17%	7.17%	Reduced -38.0k	-38,000 -32.4%
2	INCYTE CORP COM INCY	INCY	358,454	$20.7m6.97%	6.97%	Unchanged
3	GILEAD SCIENCES INC COM GILD	GILD	233,584	$17.5m5.90%	5.90%	Added +89.0k	+89,000 61.6%
4	INTRA-CELLULAR THERAPIES INC COM ITCI	ITCI	317,856	$16.5m5.57%	5.57%	Added +141.0k	+141,000 79.7%
5	BIOMARIN PHARMACEUTICAL INC COM BMRN	BMRN	153,656	$13.6m4.58%	4.58%	Added +95.0k	+95,000 162.0%
6	SUPERNUS PHARMACEUTICALS INC COM SUPN	SUPN	426,500	$11.8m3.96%	3.96%	Reduced -97.0k	-97,000 -18.5%
7	VERA THERAPEUTICS INC CL A VERA	VERA	758,355	$10.4m3.50%	3.50%	Reduced -216.9k	-216,872 -22.2%
8	BIOGEN INC COM BIIB	BIIB	40,200	$10.3m3.48%	3.48%	Added +29.2k	+29,200 265.4%
9	HARMONY BIOSCIENCES HLDGS IN COM HRMY	HRMY	314,500	$10.3m3.47%	3.47%	Reduced -256.0k	-256,000 -44.9%
10	MIRATI THERAPEUTICS INC COM MRTX	MRTX	216,000	$9.4m3.17%	3.17%	Reduced -44.0k	-44,000 -16.9%
11	ULTRAGENYX PHARMACEUTICAL IN COM RARE	RARE	250,052	$8.9m3.00%	3.00%	Added +170.0k	+170,000 212.4%
12	UNIQURE NV SHS QURE	QURE	1,241,500	$8.3m2.81%	2.81%	Added +1.2m	+1,226,000 7909.7%
13	AURINIA PHARMACEUTICALS INC COM AUPH	AUPH	1,040,530	$8.1m2.72%	2.72%	Added +467.0k	+467,000 81.4%
14	UNITED THERAPEUTICS CORP DEL COM UTHR	UTHR	33,959	$7.7m2.58%	2.58%	Reduced -18.8k	-18,800 -35.6%
15	VERTEX PHARMACEUTICALS INC COM VRTX	VRTX	21,000	$7.3m2.46%	2.46%	Unchanged
16	REGENERON PHARMACEUTICALS COM REGN	REGN	8,847	$7.3m2.45%	2.45%	Reduced -18.2k	-18,153 -67.2%
17	ILLUMINA INC COM ILMN	ILMN	50,500	$6.9m2.34%	2.34%	Unchanged
18	ALNYLAM PHARMACEUTICALS INC COM ALNY	ALNY	36,800	$6.5m2.20%	2.20%	Reduced -44.8k	-44,800 -54.9%
19	AMYLYX PHARMACEUTICALS INC COM AMLX	AMLX	295,000	$5.4m1.82%	1.82%	Added +270.0k	+270,000 1080.0%
20	KRYSTAL BIOTECH INC COM KRYS	KRYS	46,092	$5.3m1.80%	1.80%	Added +147	+147 0.3%
21	KARUNA THERAPEUTICS INC COM COM		30,500	$5.2m1.74%	1.74%	Added +4.8k	+4,800 18.7%
22	AXSOME THERAPEUTICS INC COM AXSM	AXSM	58,300	$4.1m1.37%	1.37%	Unchanged
23	ERASCA INC COM ERAS	ERAS	1,926,000	$3.8m1.28%	1.28%	Added +500.0k	+500,000 35.1%
24	ACADIA PHARMACEUTICALS INC COM ACAD	ACAD	179,702	$3.7m1.26%	1.26%	Added +28.7k	+28,702 19.0%
25	REVANCE THERAPEUTICS INC COM RVNC	RVNC	288,726	$3.3m1.11%	1.11%	Unchanged
26	NEUROCRINE BIOSCIENCES INC COM NBIX	NBIX	28,877	$3.2m1.09%	1.09%	Reduced -40.0k	-40,000 -58.1%
27	SAREPTA THERAPEUTICS INC COM SRPT	SRPT	26,700	$3.2m1.09%	1.09%	Added +7.9k	+7,900 42.0%
28	ROCKET PHARMACEUTICALS INC COM RCKT	RCKT	156,000	$3.2m1.08%	1.08%	Unchanged
29	DENALI THERAPEUTICS INC COM DNLI	DNLI	154,000	$3.2m1.07%	1.07%	Reduced -34.0k	-34,000 -18.1%
30	ASTRAZENECA PLC SPONSORED ADR SPONSORED ADR		46,500	$3.1m1.06%	1.06%	New
31	XENON PHARMACEUTICALS INC COM XENE	XENE	91,500	$3.1m1.05%	1.05%	Added +66.0k	+66,000 258.8%
32	CRISPR THERAPEUTICS AG NAMEN AKT CRSP	CRSP	63,000	$2.9m0.96%	0.96%	New
33	MADRIGAL PHARMACEUTICALS INC COM MDGL	MDGL	18,300	$2.7m0.90%	0.90%	Unchanged
34	LEGEND BIOTECH CORP SPONSORED ADS LEGN	LEGN	38,000	$2.6m0.86%	0.86%	Unchanged
35	HALOZYME THERAPEUTICS INC COM HALO	HALO	62,200	$2.4m0.80%	0.80%	Reduced -33.3k	-33,300 -34.9%
36	MARINUS PHARMACEUTICALS INC COM NEW MRNS	MRNS	290,000	$2.3m0.79%	0.79%	Added +200.0k	+200,000 222.2%
37	BEIGENE LTD SPONSORED ADR ONC	ONC	12,700	$2.3m0.77%	0.77%	Added +4.0k	+4,000 46.0%
38	JAZZ PHARMACEUTICALS PLC SHS USD JAZZ	JAZZ	17,200	$2.2m0.75%	0.75%	Unchanged
39	MIRUM PHARMACEUTICALS INC COM MIRM	MIRM	67,500	$2.1m0.72%	0.72%	Unchanged
40	IOVANCE BIOTHERAPEUTICS INC COM IOVA	IOVA	445,000	$2.0m0.68%	0.68%	Added +380.0k	+380,000 584.6%
41	IONIS PHARMACEUTICALS INC COM IONS	IONS	43,000	$1.9m0.66%	0.66%	Unchanged
42	ZAI LAB LTD ADR ZLAB	ZLAB	78,958	$1.9m0.65%	0.65%	Unchanged
43	GENMAB A/S SPONSORED ADS GMAB	GMAB	44,300	$1.6m0.53%	0.53%	New
44	CELLDEX THERAPEUTICS INC NEW COM NEW CLDX	CLDX	48,099	$1.3m0.45%	0.45%	Unchanged
45	COGENT BIOSCIENCES INC COM COGT	COGT	135,000	$1.3m0.44%	0.44%	New
46	DYNE THERAPEUTICS INC COM DYN	DYN	137,751	$1.2m0.41%	0.41%	Reduced -163.0k	-163,000 -54.2%
47	NOVOCURE LTD ORD SHS NVCR	NVCR	74,000	$1.2m0.40%	0.40%	Added +42.0k	+42,000 131.2%
48	AMICUS THERAPEUTICS INC COM FOLD	FOLD	90,000	$1.1m0.37%	0.37%	New
49	CYTOKINETICS INC COM NEW CYTK	CYTK	37,000	$1.1m0.37%	0.37%	Unchanged
50	GUARDANT HEALTH INC COM GH	GH	36,500	$1.1m0.36%	0.36%	Unchanged
51	INSMED INC COM PAR $.01 INSM	INSM	40,100	$1.0m0.34%	0.34%	Unchanged
52	BLUEPRINT MEDICINES CORP COM BPMC	BPMC	20,000	$1.0m0.34%	0.34%	New
53	AKERO THERAPEUTICS INC COM AKRO	AKRO	18,489	$935.2k0.32%	0.32%	Reduced -60.0k	-60,000 -76.4%
54	KEZAR LIFE SCIENCES INC COM COM		703,825	$830.5k0.28%	0.28%	New
55	INTELLIA THERAPEUTICS INC COM NTLA	NTLA	24,000	$757.9k0.26%	0.26%	Unchanged
56	PROTHENA CORP PLC SHS PRTA	PRTA	15,000	$722.9k0.24%	0.24%	New
57	AGIOS PHARMACEUTICALS INC COM AGIO	AGIO	24,000	$593.5k0.20%	0.20%	Unchanged
58	BEAM THERAPEUTICS INC COM BEAM	BEAM	23,500	$564.7k0.19%	0.19%	Unchanged
59	VENTYX BIOSCIENCES INC COM VTYX	VTYX	15,000	$520.6k0.18%	0.18%	Unchanged
60	VIR BIOTECHNOLOGY INC COM VIR	VIR	47,000	$439.9k0.15%	0.15%	New
61	I MAB SPONSORED ADS NBP	NBP	310,499	$409.9k0.14%	0.14%	Unchanged
62	PTC THERAPEUTICS INC COM PTCT	PTCT	17,000	$380.6k0.13%	0.13%	Unchanged
63	ARVINAS INC COM ARVN	ARVN	17,000	$333.5k0.11%	0.11%	Unchanged
64	PROTAGONIST THERAPEUTICS INC COM PTGX	PTGX	19,900	$331.9k0.11%	0.11%	Unchanged
65	RELMADA THERAPEUTICS INC COM RLMD	RLMD	10,000	$30.0k0.01%	0.01%	Unchanged

Sold out since Q2 2023

Security	Ticker	Shares held before	Value then
APELLIS PHARMACEUTICALS INC APLS	APLS	129,700	$11.8m129.7k shares
HORIZON PHARMA PLC		67,000	$6.9m67.0k shares
TRAVERE THERAPEUTICS INC TVTX	TVTX	441,019	$6.8m441.0k shares
SAGE THERAPEUTICS INC SAGE	SAGE	20,000	$939.4k20.0k shares
HUTCHMED CHINA LTD HCM	HCM	68,000	$816.0k68.0k shares