Vault-13

AMICUS THERAPEUTICS INC FOLD

COM · Common Stock · CUSIP 03152W109 · ISIN US03152W1099

231 institutional holders +13 vs Q2 2023
298,655,628298.7m shares reported held*
$3.6bnreported value*
30 new 96 added 66 reduced 20 sold out net sold ≈ $86.9m (-7.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.8m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $12.17. Options: 15 managers hold calls ($14.3m notional), 13 hold puts ($9.8m).

Trends to Q3 2023

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 223Q4 22: 231Q1 23: 228Q2 23: 218Q3 23: 231231Q3 22Q4 22Q1 23Q2 23Q3 23
Numbers
QuarterHolders
Q3 2022223
Q4 2022231
Q1 2023228
Q2 2023218
Q3 2023231

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 123 bought or addedQ4 22: 96 cut or sold outQ4 22Q1 23: 127 bought or addedQ1 23: 85 cut or sold outQ1 23Q2 23: 102 bought or addedQ2 23: 107 cut or sold outQ2 23Q3 23: 126 bought or addedQ3 23: 86 cut or sold outQ3 23
Numbers
QuarterBought or addedCut or sold out
Q4 202212396
Q1 202312785
Q2 2023102107
Q3 202312686

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ4 22 calls: $8.9mQ4 22 puts: $7.2mQ4 22P/C 0.82Q1 23 calls: $4.4mQ1 23 puts: $6.4mQ1 23P/C 1.44Q2 23 calls: $11.5mQ2 23 puts: $5.0mQ2 23P/C 0.43Q3 23 calls: $14.3mQ3 23 puts: $9.8mQ3 23P/C 0.69
Numbers
QuarterCallsPutsP/C
Q4 2022$8.9m$7.2m0.82
Q1 2023$4.4m$6.4m1.44
Q2 2023$11.5m$5.0m0.43
Q3 2023$14.3m$9.8m0.69

Biggest buyers

WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC Added +8,070,098+8.1m
VICTORY CAPITAL MANAGEMENT INC Added +2,350,262+2.4m
FMR LLC Added +468,611+468.6k
AMERICAN CENTURY COMPANIES INC Added +429,257+429.3k
Nuveen Asset Management, LLC Added +426,144+426.1k
MASSACHUSETTS FINANCIAL SERVICES CO /MA/ Added +340,673+340.7k
ExodusPoint Capital Management, LP Added +317,580+317.6k
FIRST TRUST ADVISORS LP Added +312,508+312.5k
MACQUARIE GROUP LTD Added +290,671+290.7k
ENVESTNET ASSET MANAGEMENT INC Added +248,220+248.2k

Biggest sellers

DEUTSCHE BANK AG\ Reduced -6,112,106-6.1m
Point72 Asset Management, L.P. Reduced -6,054,203-6.1m
Redmile Group, LLC Reduced -2,622,340-2.6m
MORGAN STANLEY Reduced -2,312,116-2.3m
ORBIMED ADVISORS LLC Sold out -1,856,400-1.9m
NORGES BANK Reduced -870,000-870.0k
D. E. Shaw & Co., Inc. Reduced -771,735-771.7k
Artal Group S.A. Reduced -500,000-500.0k
JPMORGAN CHASE & CO Reduced -432,962-433.0k
Integral Health Asset Management, LLC Sold out -387,000-387.0k

Biggest calls

Artal Group S.A. Unchanged $6.1m500.0k shares
Jefferies Financial Group Inc. Added $2.1m174.6k shares
CITIGROUP INC Reduced $1.1m91.5k shares
Caption Management, LLC Added $1.1m90.0k shares
SIMPLEX TRADING, LLC Added $818.0k67.3k shares
JANE STREET GROUP, LLC Added $601.9k49.5k shares
CITADEL ADVISORS LLC Added $583.7k48.0k shares
J. Goldman & Co LP New $492.5k40.5k shares
GROUP ONE TRADING LLC Added $423.2k34.8k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $394.0k32.4k shares

Biggest puts

Caption Management, LLC Added $2.1m175.0k shares
Walleye Trading LLC New $1.6m130.7k shares
CITIGROUP INC Reduced $1.1m91.5k shares
SIMPLEX TRADING, LLC Added $953.0k78.4k shares
CITADEL ADVISORS LLC Added $781.9k64.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $726.0k59.7k shares
GROUP ONE TRADING LLC Added $696.8k57.3k shares
Jefferies Financial Group Inc. Added $598.3k49.2k shares
GTS SECURITIES LLC New $531.4k43.7k shares
JANE STREET GROUP, LLC Added $403.7k33.2k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution -1.9 pts · filed 2025-04-23 7.4% -1.9 pts 22.8m 2025-04-23
BARCLAYS PLC 13G · institution new · filed 2026-05-14 5.7% new 17.8m 2026-05-14
UBS Group AG 13G · institution new · filed 2026-05-07 5.5% new 17.1m 2026-05-07
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 16.4m 2026-04-29

Fell to 5% or below in the last year: GOLDMAN SACHS GROUP INC (0.0%, 2026-08-12), GLAZER CAPITAL, LLC (0.0%, 2026-05-01), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC), WELLINGTON MANAGEMENT GROUP LLP (0.4%, 2026-02-10), WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC (3.4%, 2026-02-09)

Holders, Q3 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 PERCEPTIVE ADVISORS LLC 11.32% of their portfolio NEW YORK, NY 27,692,91727.7m $336.7m $336.7m 11.32% Added +30.0k +30,000
2 Avoro Capital Advisors LLC 5.20% of their portfolio NEW YORK, NY 27,400,00027.4m $333.2m $333.2m 5.20% Unchanged
3 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 27,131,87327.1m $329.9m $329.9m 0.01% Added +107.5k +107,456
4 BlackRock Inc. 0.01% of their portfolio New York, NY 20,941,77720.9m $254.7m $254.7m 0.01% Added +43.2k +43,184
5 Redmile Group, LLC 9.80% of their portfolio LARKSPUR, CA 16,944,62116.9m $206.0m $206.0m 9.80% Reduced -2.6m -2,622,340
6 JANUS HENDERSON GROUP PLC 0.12% of their portfolio LONDON, X0 14,934,02114.9m $181.6m $181.6m 0.12% Added +10.4k +10,433
7 JPMORGAN CHASE & CO 0.02% of their portfolio NEW YORK, NY 13,009,42913.0m $158.2m $158.2m 0.02% Reduced -433.0k -432,962
8 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 11,372,43611.4m $138.3m $138.3m 0.01% Added +193.2k +193,194
9 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 10,748,69210.7m $130.7m $130.7m 0.01% Reduced -2.3m -2,312,116
10 Palo Alto Investors LP 12.11% of their portfolio PALO ALTO, CA 10,524,02210.5m $128.0m $128.0m 12.11% Unchanged
11 WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.42% of their portfolio CHICAGO, IL 10,376,76310.4m $126.2m $126.2m 0.42% Added +8.1m +8,070,098
12 Pictet Asset Management Holding SA 0.13% of their portfolio CAROUGE, V8 8,397,5118.4m $102.1m $102.1m 0.13% First filing
13 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 7,523,6897.5m $91.5m $91.5m 0.02% Reduced -296.6k -296,607
14 MACQUARIE GROUP LTD 0.11% of their portfolio Sydney, NSW 2000, C3 7,212,6527.2m $87.7m $87.7m 0.11% Added +290.7k +290,671
15 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 5,606,1665.6m $68.2m $68.2m 0.01% Added +210.6k +210,560
16 Fiera Capital Corp 0.20% of their portfolio MONTREAL, A8 5,085,8715.1m $61.8m $61.8m 0.20% Added +106.1k +106,086
17 AMERICAN CENTURY COMPANIES INC 0.04% of their portfolio KANSAS CITY, MO 4,343,8704.3m $52.8m $52.8m 0.04% Added +429.3k +429,257
18 Artal Group S.A. 2.15% of their portfolio LUXEMBOURG, N4 4,062,5674.1m $49.4m $49.4m 2.15% Reduced -500.0k -500,000
19 Balyasny Asset Management L.P. 0.12% of their portfolio Chicago, IL 3,385,4323.4m $41.2m $41.2m 0.12% Added +160.4k +160,399
20 VICTORY CAPITAL MANAGEMENT INC 0.04% of their portfolio San Antonio, TX 2,949,2062.9m $35.9m $35.9m 0.04% Added +2.4m +2,350,262
21 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 2,831,9302.8m $34.4m $34.4m 0.01% Added +15.6k +15,608
22 FMR LLC 0.00% of their portfolio BOSTON, MA 2,778,2322.8m $33.8m $33.8m 0.00% Added +468.6k +468,611
23 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 2,518,0842.5m $30.6m $30.6m 0.01% Reduced -278.0k -278,037
24 NORGES BANK 0.01% of their portfolio OSLO, Q8 2,416,3172.4m $29.4m $29.4m 0.01% Reduced -870.0k -870,000
25 Boxer Capital, LLC 1.51% of their portfolio San Diego, CA 2,325,0002.3m $28.3m $28.3m 1.51% Unchanged
26 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 2,244,6332.2m $27.3m $27.3m 0.00% Reduced -134.3k -134,269
27 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 2,178,6912.2m $26.5m $26.5m 0.01% Added +72.7k +72,674
28 NOVO HOLDINGS A/S 1.88% of their portfolio HELLERUP, G7 2,095,9002.1m $25.5m $25.5m 1.88% Unchanged
29 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.01% of their portfolio Boston, MA 1,821,9591.8m $22.2m $22.2m 0.01% Added +340.7k +340,673
30 Finepoint Capital LP 9.02% of their portfolio BOSTON, MA 1,489,0251.5m $18.1m $18.1m 9.02% Added +163.2k +163,250
31 NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio ALBANY, NY 1,474,1731.5m $17.9m $17.9m 0.03% Added +8.3k +8,309
32 PANAGORA ASSET MANAGEMENT INC 0.11% of their portfolio BOSTON, MA 1,430,4241.4m $17.4m $17.4m 0.11% Added +97.0k +96,980
33 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,397,0951.4m $17.0m $17.0m 0.00% Added +4.5k +4,481
34 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 1,240,8261.2m $15.1m $15.1m 0.01% Added +426.1k +426,144
35 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 1,182,1071.2m $14.4m $14.4m 0.00% Added +5.8k +5,808
36 PRIMECAP MANAGEMENT CO/CA/ 0.01% of their portfolio PASADENA, CA 1,094,2001.1m $13.3m $13.3m 0.01% Unchanged
37 RICE HALL JAMES & ASSOCIATES, LLC 0.83% of their portfolio San Diego, CA 1,078,8651.1m $13.1m $13.1m 0.83% Added +30.2k +30,202
38 Rock Springs Capital Management LP 0.35% of their portfolio Baltimore, MD 1,063,8061.1m $12.9m $12.9m 0.35% Unchanged
39 Point72 Asset Management, L.P. 0.04% of their portfolio STAMFORD, CT 946,697946.7k $11.5m $11.5m 0.04% Reduced -6.1m -6,054,203
40 ExodusPoint Capital Management, LP 0.15% of their portfolio NEW YORK, NY 941,433941.4k $11.4m $11.4m 0.15% Added +317.6k +317,580
41 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 917,719917.7k $11.2m $11.2m 0.00% Added +150.6k +150,641
42 GREAT POINT PARTNERS LLC 1.96% of their portfolio Greenwich, CT 857,000857.0k $10.4m $10.4m 1.96% Added +155.6k +155,608
43 SECTORAL ASSET MANAGEMENT INC 1.90% of their portfolio MONTREAL, A8 803,464803.5k $9.8m $9.8m 1.90% Added +73.5k +73,540
44 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 751,573751.6k $9.1m $9.1m 0.01% Reduced -139.3k -139,308
45 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 735,194735.2k $8.9m $8.9m 0.01% Reduced -20.0k -20,000
46 PEREGRINE CAPITAL MANAGEMENT LLC 0.26% of their portfolio MINNEAPOLIS, MN 728,685728.7k $8.9m $8.9m 0.26% Added +19.0k +19,014
47 MPM BIOIMPACT LLC 2.32% of their portfolio BOSTON, MA 716,139716.1k $8.7m $8.7m 2.32% Added +200.0k +200,000
48 Rafferty Asset Management, LLC 0.05% of their portfolio New York, NY 708,239708.2k $8.6m $8.6m 0.05% Added +59.7k +59,727
49 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 697,201697.2k $8.5m $8.5m 0.00% Reduced -50.4k -50,351
50 Candriam S.C.A. 0.05% of their portfolio STRASSEN, N4 578,879578.9k $7.0m $7.0m 0.05% Reduced -115.0k -115,000
51 NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio NEW YORK, NY 546,685546.7k $6.6m $6.6m 0.01% Added +4.2k +4,200
52 UBS Group AG 0.00% of their portfolio ZURICH, V8 521,670521.7k $6.3m $6.3m 0.00% Added +121.1k +121,102
53 Swiss National Bank 0.00% of their portfolio ZURICH, V8 469,200469.2k $5.7m $5.7m 0.00% Added +7.6k +7,600
54 CM Management, LLC 5.81% of their portfolio GULF BREEZE, FL 450,000450.0k $5.5m $5.5m 5.81% Unchanged
55 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 419,254419.3k $5.1m $5.1m 0.00% Reduced -13.7k -13,652
56 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 416,120416.1k $5.1m $5.1m 0.01% Added +1.4k +1,372
57 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 412,436412.4k $5.0m $5.0m 0.00% Added +7.1k +7,096
58 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 393,728393.7k $4.8m $4.8m 0.00% Added +248.2k +248,220
59 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 386,565386.6k $4.7m $4.7m 0.01% Added +224.9k +224,870
60 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 374,667374.7k $4.6m $4.6m 0.01% Added +10.3k +10,303
61 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 360,191360.2k $4.4m $4.4m 0.01% Reduced -771.7k -771,735
62 SILVERCREST ASSET MANAGEMENT GROUP LLC 0.03% of their portfolio NEW YORK, NY 358,999359.0k $4.4m $4.4m 0.03% Added +78.6k +78,615
63 Hudson Bay Capital Management LP 0.02% of their portfolio STAMFORD, CT 350,000350.0k $4.3m $4.3m 0.02% Added +195.0k +195,000
64 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 337,349337.3k $4.1m $4.1m 0.00% Reduced -30 -30
65 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 326,312326.3k $4.0m $4.0m 0.00% Reduced -32.3k -32,340
66 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 322,686322.7k $3.9m $3.9m 0.00% Added +312.5k +312,508
67 TRANSCEND CAPITAL ADVISORS, LLC 0.34% of their portfolio MADISON, NJ 286,504286.5k $3.5m $3.5m 0.34% Added +359 +359
68 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 283,400283.4k $3.4m $3.4m 0.00% Added +31.2k +31,226
69 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.02% of their portfolio TORONTO, A6 275,500275.5k $3.4m $3.4m 0.02% Reduced -123.4k -123,423
70 Faithward Advisors, LLC 0.68% of their portfolio LANCASTER, PA 272,173272.2k $2.8m $2.8m 0.68% Reduced -6.5k -6,488
71 Hillsdale Investment Management Inc. 0.30% of their portfolio Toronto, A6 270,660270.7k $3.3m $3.3m 0.30% Added +180 +180
72 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 260,768260.8k $3.2m $3.2m 0.00% Reduced -104.0k -104,043
73 Allianz Asset Management GmbH 0.01% of their portfolio MUNICH, 2M 254,854254.9k $3.1m $3.1m 0.01% Reduced -9.0k -8,976
74 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 250,551250.6k $3.0m $3.0m 0.00% Reduced -29.3k -29,310
75 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 246,039246.0k $3.0m $3.0m 0.00% Reduced -25.4k -25,363
76 Jump Financial, LLC 0.11% of their portfolio Chicago, IL 237,389237.4k $2.9m $2.9m 0.11% Added +153.3k +153,282
77 WEDGE CAPITAL MANAGEMENT L L P/NC 0.05% of their portfolio CHARLOTTE, NC 224,885224.9k $2.7m $2.7m 0.05% Added +31.0k +30,990
78 Man Group plc 0.01% of their portfolio LONDON, X0 219,130219.1k $2.7m $2.7m 0.01% New
79 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 217,700217.7k $2.6m $2.6m 0.01% Unchanged
80 Legal & General Group Plc 0.00% of their portfolio London, X0 214,241214.2k $2.6m $2.6m 0.00% Added +4.2k +4,169
81 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 211,895211.9k $2.6m $2.6m 0.02% Added +2.7k +2,716
82 Mirae Asset Global Investments Co., Ltd. 0.01% of their portfolio SEOUL, M5 210,400210.4k $2.6m $2.6m 0.01% Reduced -8.7k -8,737
83 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 189,991190.0k $2.3m $2.3m 0.01% Reduced -22.8k -22,782
84 GREAT LAKES ADVISORS, LLC 0.02% of their portfolio CHICAGO, IL 184,384184.4k $2.2m $2.2m 0.02% Reduced -173.2k -173,202
85 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 178,113178.1k $2.2m $2.2m 0.01% Reduced -6.5k -6,466
86 Ghost Tree Capital, LLC 1.03% of their portfolio NEW YORK, NY 175,000175.0k $2.1m $2.1m 1.03% Reduced -25.0k -25,000
87 Cubist Systematic Strategies, LLC 0.03% of their portfolio STAMFORD, CT 172,308172.3k $2.1m $2.1m 0.03% Added +144.4k +144,352
88 Walleye Capital LLC 0.03% of their portfolio NEW YORK, NY 172,169172.2k $2.1m $2.1m 0.03% New
89 MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio New York, NY 171,097171.1k $2.1m $2.1m 0.03% Reduced -10.2k -10,189
90 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 162,485162.5k $2.0m $2.0m 0.00% Reduced -76.6k -76,606
91 Orion Porfolio Solutions, LLC 0.02% of their portfolio OMAHA, NE 154,359154.4k $1.9m $1.9m 0.02% Reduced -5.2k -5,157
92 Orion Portfolio Solutions, LLC 0.02% of their portfolio Omaha, NE 154,359154.4k $1.9m $1.9m 0.02% Reduced -5.2k -5,157
93 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 150,049150.0k $1.8m $1.8m 0.00% Added +36.7k +36,669
94 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 148,666148.7k $1.8m $1.8m 0.01% Unchanged
95 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 148,400148.4k $1.8m $1.8m 0.00% New
96 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 146,628146.6k $1.8m $1.8m 0.00% Reduced -6.1m -6,112,106
97 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 139,951140.0k $1.7m $1.7m 0.01% Added +5.0k +4,976
98 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 137,686137.7k $1.7m $1.7m 0.00% Added +23.0k +23,049
99 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 132,603132.6k $1.6m $1.6m 0.00% Added +8.6k +8,600
100 AlphaCentric Advisors LLC 0.91% of their portfolio SAN JUAN, PR 132,500132.5k $1.6m $1.6m 0.91% Unchanged