Vault-13

AKERO THERAPEUTICS INC AKRO

COM · Common Stock · CUSIP 00973Y108

183 institutional holders +24 vs Q2 2023
57,866,91357.9m shares reported held*
$2.9bnreported value*
36 new 79 added 39 reduced 11 sold out net bought ≈ $108.9m (+2.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $50.81. Options: 23 managers hold calls ($139.6m notional), 24 hold puts ($150.8m).

Trends to Q3 2023

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 146Q4 22: 162Q1 23: 157Q2 23: 159Q3 23: 183183Q3 22Q4 22Q1 23Q2 23Q3 23
Numbers
QuarterHolders
Q3 2022146
Q4 2022162
Q1 2023157
Q2 2023159
Q3 2023183

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 103 bought or addedQ4 22: 60 cut or sold outQ4 22Q1 23: 75 bought or addedQ1 23: 77 cut or sold outQ1 23Q2 23: 96 bought or addedQ2 23: 64 cut or sold outQ2 23Q3 23: 115 bought or addedQ3 23: 50 cut or sold outQ3 23
Numbers
QuarterBought or addedCut or sold out
Q4 202210360
Q1 20237577
Q2 20239664
Q3 202311550

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150m$200mQ4 22 calls: $54.4mQ4 22 puts: $55.7mQ4 22P/C 1.02Q1 23 calls: $25.3mQ1 23 puts: $16.9mQ1 23P/C 0.67Q2 23 calls: $40.8mQ2 23 puts: $60.2mQ2 23P/C 1.47Q3 23 calls: $139.6mQ3 23 puts: $150.8mQ3 23P/C 1.08
Numbers
QuarterCallsPutsP/C
Q4 2022$54.4m$55.7m1.02
Q1 2023$25.3m$16.9m0.67
Q2 2023$40.8m$60.2m1.47
Q3 2023$139.6m$150.8m1.08

Biggest buyers

ALLIANCEBERNSTEIN L.P. Added +1,161,305+1.2m
LORD, ABBETT & CO. LLC Added +945,796+945.8k
BlackRock Inc. Added +656,167+656.2k
Avoro Capital Advisors LLC New +555,555+555.6k
PRICE T ROWE ASSOCIATES INC /MD/ Added +520,551+520.6k
FRED ALGER MANAGEMENT, LLC Added +427,303+427.3k
JPMORGAN CHASE & CO Added +377,258+377.3k
Bank of New York Mellon Corp Added +346,317+346.3k
VANGUARD GROUP INC Added +326,308+326.3k
ALKEON CAPITAL MANAGEMENT LLC Added +300,000+300.0k

Biggest sellers

Skorpios Trust Sold out -1,621,829-1.6m
Commodore Capital LP Reduced -1,110,000-1.1m
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -1,105,868-1.1m
MARSHALL WACE, LLP Reduced -662,523-662.5k
PERCEPTIVE ADVISORS LLC Reduced -321,250-321.2k
Avidity Partners Management LP Reduced -285,900-285.9k
D. E. Shaw & Co., Inc. Reduced -274,221-274.2k
Ghost Tree Capital, LLC Reduced -245,000-245.0k
Atlas Venture Life Science Advisors, LLC Reduced -235,000-235.0k
SILVERARC CAPITAL MANAGEMENT, LLC Reduced -210,021-210.0k

Biggest calls

Holocene Advisors, LP New $29.7m586.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $15.3m301.7k shares
JPMORGAN CHASE & CO Added $12.7m251.9k shares
Ghost Tree Capital, LLC New $12.6m250.0k shares
JANE STREET GROUP, LLC Added $11.0m217.6k shares
Caption Management, LLC Added $10.4m205.3k shares
SILVERARC CAPITAL MANAGEMENT, LLC Reduced $10.1m200.0k shares
Ikarian Capital, LLC New $10.1m2.0k shares
GROUP ONE TRADING LLC Added $6.1m121.1k shares
PERCEPTIVE ADVISORS LLC New $5.5m800.0k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $57.7m1.1m shares
Ikarian Capital, LLC New $15.4m3.0k shares
BARCLAYS PLC New $10.5m208.4k shares
GROUP ONE TRADING LLC Reduced $7.9m156.5k shares
Caption Management, LLC Added $7.2m143.0k shares
JANE STREET GROUP, LLC Reduced $7.0m138.0k shares
Schonfeld Strategic Advisors LLC New $5.6m110.0k shares
SILVERARC CAPITAL MANAGEMENT, LLC New $5.4m106.6k shares
MOORE CAPITAL MANAGEMENT, LP New $5.2m102.4k shares
BOOTHBAY FUND MANAGEMENT, LLC New $4.1m80.5k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
GENERAL ATLANTIC, L.P. 13G · passive investor filed 2025-05-15 8.4% 6.8m 2025-05-15

Fell to 5% or below in the last year: JANUS HENDERSON GROUP PLC (4.1%, 2026-02-17), RTW INVESTMENTS, LP (0.0%, 2026-02-17), Deep Track Capital, LP (0.0%, 2026-02-13), WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-02-10)

Holders, Q3 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 JANUS HENDERSON GROUP PLC 0.15% of their portfolio LONDON, X0 4,486,7264.5m $227.0m $227.0m 0.15% Added +61.6k +61,607
2 BlackRock Inc. 0.01% of their portfolio New York, NY 3,977,3204.0m $201.2m $201.2m 0.01% Added +656.2k +656,167
3 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 3,810,1943.8m $192.7m $192.7m 0.03% Added +520.6k +520,551
4 ALKEON CAPITAL MANAGEMENT LLC 1.21% of their portfolio New York, NY 3,767,3803.8m $190.6m $190.6m 1.21% Added +300.0k +300,000
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,012,1823.0m $152.4m $152.4m 0.00% Added +326.3k +326,308
6 FMR LLC 0.01% of their portfolio BOSTON, MA 2,750,3482.8m $139.1m $139.1m 0.01% Added +162.8k +162,820
7 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,505,8482.5m $126.7m $126.7m 0.01% Added +265.6k +265,617
8 BAKER BROS. ADVISORS LP 0.69% of their portfolio NEW YORK, NY 2,368,3782.4m $119.8m $119.8m 0.69% Unchanged
9 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.22% of their portfolio Boston, MA 1,943,0091.9m $98.3m $98.3m 0.22% Reduced -1.1m -1,105,868
10 GENERAL ATLANTIC, L.P. 1.39% of their portfolio New York, NY 1,785,7141.8m $90.3m $90.3m 1.39% Unchanged
11 Redmile Group, LLC 4.26% of their portfolio LARKSPUR, CA 1,769,6841.8m $89.5m $89.5m 4.26% Reduced -42.0k -41,988
12 Boxer Capital, LLC 4.51% of their portfolio San Diego, CA 1,676,7331.7m $84.8m $84.8m 4.51% Unchanged
13 PERCEPTIVE ADVISORS LLC 2.75% of their portfolio NEW YORK, NY 1,619,4251.6m $81.9m $81.9m 2.75% Reduced -321.2k -321,250
14 LORD, ABBETT & CO. LLC 0.15% of their portfolio JERSEY CITY, NJ 1,558,2521.6m $78.8m $78.8m 0.15% Added +945.8k +945,796
15 Rock Springs Capital Management LP 1.92% of their portfolio Baltimore, MD 1,419,1501.4m $71.8m $71.8m 1.92% Reduced -131.6k -131,604
16 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 1,281,7101.3m $64.8m $64.8m 0.03% Added +1.2m +1,161,305
17 Yiheng Capital Management, L.P. 5.58% of their portfolio SAN FRANCISCO, CA 1,221,6741.2m $61.8m $61.8m 5.58% Added +20.1k +20,083
18 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,103,3061.1m $55.8m $55.8m 0.01% Added +278.6k +278,599
19 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 828,961829.0k $41.9m $41.9m 0.01% Reduced -72.2k -72,244
20 Avidity Partners Management LP 1.51% of their portfolio DALLAS, TX 739,100739.1k $37.4m $37.4m 1.51% Reduced -285.9k -285,900
21 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 714,578714.6k $36.1m $36.1m 0.00% Added +377.3k +377,258
22 Logos Global Management LP 4.33% of their portfolio San Francisco, CA 600,000600.0k $30.3m $30.3m 4.33% Added +80.0k +80,000
23 Commodore Capital LP 3.34% of their portfolio NEW YORK, NY 565,000565.0k $28.6m $28.6m 3.34% Reduced -1.1m -1,110,000
24 Avoro Capital Advisors LLC 0.44% of their portfolio NEW YORK, NY 555,555555.6k $28.1m $28.1m 0.44% New
25 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 538,023538.0k $27.2m $27.2m 0.01% Added +77.6k +77,594
26 EVENTIDE ASSET MANAGEMENT, LLC 0.47% of their portfolio Boston, MA 513,876513.9k $26.0m $26.0m 0.47% Added +134.8k +134,756
27 Bank of New York Mellon Corp 0.01% of their portfolio NEW YORK, NY 500,245500.2k $25.3m $25.3m 0.01% Added +346.3k +346,317
28 FRED ALGER MANAGEMENT, LLC 0.13% of their portfolio NEW YORK, NY 441,086441.1k $22.3m $22.3m 0.13% Added +427.3k +427,303
29 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 439,736439.7k $22.2m $22.2m 0.00% Added +54.1k +54,078
30 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 419,430419.4k $21.2m $21.2m 0.01% Added +124.8k +124,768
31 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 399,285399.3k $20.2m $20.2m 0.02% First filing
32 Atlas Venture Life Science Advisors, LLC 2.81% of their portfolio CAMBRIDGE, MA 359,251359.3k $18.2m $18.2m 2.81% Reduced -235.0k -235,000
33 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.03% of their portfolio BALA CYNWYD, PA 350,909350.9k $17.7m $17.7m 0.03% Added +256.4k +256,446
34 ORBIMED ADVISORS LLC 0.38% of their portfolio New York, NY 350,000350.0k $17.7m $17.7m 0.38% Added +150.5k +150,500
35 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 331,085331.1k $31.2m $31.2m 0.01% Added +122.0k +122,042
36 Artisan Partners Limited Partnership 0.03% of their portfolio Milwaukee, WI 311,036311.0k $15.7m $15.7m 0.03% Added +73.5k +73,452
37 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 302,587302.6k $15.3m $15.3m 0.02% Reduced -23.3k -23,305
38 HHLR ADVISORS, LTD. 0.31% of their portfolio GRAND CAYMAN, E9 273,002273.0k $13.8m $13.8m 0.31% Unchanged
39 MARSHALL WACE, LLP 0.03% of their portfolio LONDON, X0 260,535260.5k $13.2m $13.2m 0.03% Reduced -662.5k -662,523
40 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 252,553252.6k $12.8m $12.8m 0.00% Added +16.1k +16,104
41 Ensign Peak Advisors, Inc 0.03% of their portfolio SALT LAKE CITY, UT 232,614232.6k $11.8m $11.8m 0.03% Added +55.0k +55,000
42 PFM Health Sciences, LP 0.52% of their portfolio SAN FRANCISCO, CA 214,298214.3k $10.8m $10.8m 0.52% New
43 Schonfeld Strategic Advisors LLC 0.10% of their portfolio NEW YORK, NY 212,008212.0k $10.7m $10.7m 0.10% Added +36.8k +36,808
44 Ikarian Capital, LLC 3.76% of their portfolio DALLAS, TX 200,000200.0k $10.1m $10.1m 3.76% New
45 GREAT POINT PARTNERS LLC 1.89% of their portfolio Greenwich, CT 198,500198.5k $10.0m $10.0m 1.89% New
46 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 194,885194.9k $9.9m $9.9m 0.00% Added +46.0k +45,966
47 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 193,452193.5k $9.8m $9.8m 0.01% Reduced -104.1k -104,120
48 Rafferty Asset Management, LLC 0.05% of their portfolio New York, NY 183,497183.5k $9.3m $9.3m 0.05% Added +25.2k +25,225
49 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 176,036176.0k $8.9m $8.9m 0.01% Reduced -88.4k -88,390
50 Long Focus Capital Management, LLC 1.04% of their portfolio SAN JUAN, PR 144,000144.0k $7.3m $7.3m 1.04% Unchanged
51 D. E. Shaw & Co., Inc. 0.01% of their portfolio New York, NY 136,898136.9k $6.9m $6.9m 0.01% Reduced -274.2k -274,221
52 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 131,483131.5k $6.7m $6.7m 0.00% Added +7.6k +7,591
53 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 131,446131.4k $6.6m $6.6m 0.00% Reduced -11.6k -11,632
54 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 126,092126.1k $6.4m $6.4m 0.01% Added +63.3k +63,346
55 Parkman Healthcare Partners LLC 1.08% of their portfolio STAMFORD, CT 116,107116.1k $5.9m $5.9m 1.08% Added +81.1k +81,107
56 Walleye Trading LLC 0.14% of their portfolio NEW YORK, NY 115,563115.6k $5.8m $5.8m 0.14% Added +68.1k +68,112
57 Ghost Tree Capital, LLC 2.82% of their portfolio NEW YORK, NY 115,000115.0k $5.8m $5.8m 2.82% Reduced -245.0k -245,000
58 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 110,599110.6k $5.6m $5.6m 0.00% Reduced -64.0k -63,951
59 University of Wisconsin Foundation 6.02% of their portfolio MADISON, WI 103,816103.8k $5.3m $5.3m 6.02% New
60 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 102,420102.4k $5.2m $5.2m 0.00% Reduced -166.5k -166,497
61 BRIDGER MANAGEMENT, LLC 1.88% of their portfolio NEW YORK, NY 101,500101.5k $5.1m $5.1m 1.88% New
62 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 100,000100.0k $5.1m $5.1m 0.04% Reduced -15.0k -15,000
63 Integral Health Asset Management, LLC 0.72% of their portfolio New York, NY 100,000100.0k $5.1m $5.1m 0.72% Added +30.0k +30,000
64 Swiss National Bank 0.00% of their portfolio ZURICH, V8 97,30097.3k $4.9m $4.9m 0.00% Added +1.0k +1,000
65 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 96,49096.5k $4.9m $4.9m 0.01% Added +24.0k +23,955
66 PEREGRINE CAPITAL MANAGEMENT LLC 0.14% of their portfolio MINNEAPOLIS, MN 95,44795.4k $4.8m $4.8m 0.14% New
67 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 76,61376.6k $3.9m $3.9m 0.00% Added +12.2k +12,183
68 CLOUGH CAPITAL PARTNERS L P 0.39% of their portfolio Boston, MA 72,20072.2k $3.7m $3.7m 0.39% New
69 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 70,78470.8k $3.6m $3.6m 0.00% Added +9.6k +9,610
70 Simplify Asset Management Inc. 0.50% of their portfolio Las Vegas, NV 59,77759.8k $3.0m $3.0m 0.50% Unchanged
71 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 59,52159.5k $3.0m $3.0m 0.01% Added +24.0k +24,047
72 UBS Group AG 0.00% of their portfolio ZURICH, V8 58,40358.4k $3.0m $3.0m 0.00% Added +32.0k +31,968
73 TWINBEECH CAPITAL LP 0.05% of their portfolio PURCHASE, NY 54,78054.8k $2.8m $2.8m 0.05% New
74 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 51,58651.6k $2.6m $2.6m 0.01% Added +10.3k +10,300
75 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 50,50050.5k $2.6m $2.6m 0.00% Reduced -3.4k -3,391
76 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 50,25950.3k $2.5m $2.5m 0.01% Reduced -3.5k -3,483
77 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 46,53946.5k $2.4m $2.4m 0.00% Added +8.4k +8,449
78 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 45,60645.6k $2.3m $2.3m 0.00% Reduced -2.8k -2,845
79 Legal & General Group Plc 0.00% of their portfolio London, X0 43,24943.2k $2.2m $2.2m 0.00% Added +2.9k +2,885
80 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 43,19543.2k $2.2m $2.2m 0.00% Reduced -7.4k -7,424
81 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 42,62042.6k $2.2m $2.2m 0.05% Added +32.5k +32,547
82 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 41,00841.0k $2.1m $2.1m 0.02% Added +343 +343
83 BOOTHBAY FUND MANAGEMENT, LLC 0.07% of their portfolio NEW YORK, NY 40,28040.3k $2.0m $2.0m 0.07% New
84 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 39,28339.3k $2.0m $2.0m 0.01% Reduced -38.2k -38,250
85 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 38,60038.6k $2.0m $2.0m 0.01% New
86 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 35,59135.6k $1.8m $1.8m 0.01% New
87 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 33,80033.8k $1.7m $1.7m 0.00% Unchanged
88 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 33,61133.6k $1.7m $1.7m 0.00% Added +2.6k +2,553
89 SIMPLEX TRADING, LLC 0.06% of their portfolio CHICAGO, IL 33,58233.6k $1.7m $1.7m 0.06% Reduced -21.4k -21,419
90 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 33,33133.3k $1.7m $1.7m 0.00% Added +6.2k +6,159
91 TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio STAMFORD, CT 31,88131.9k $1.6m $1.6m 0.02% New
92 SILVERARC CAPITAL MANAGEMENT, LLC 0.59% of their portfolio BOSTON, MA 31,33631.3k $1.6m $1.6m 0.59% Reduced -210.0k -210,021
93 PROFUND ADVISORS LLC 0.09% of their portfolio BETHESDA, MD 31,22231.2k $1.6m $1.6m 0.09% Added +2.2k +2,228
94 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 30,31830.3k $1.5m $1.5m 0.00% Added +3.5k +3,499
95 Campbell & CO Investment Adviser LLC 0.18% of their portfolio BALTIMORE, MD 29,64929.6k $1.5m $1.5m 0.18% Added +11.7k +11,699
96 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 27,60027.6k $1.3m $1.3m 0.00% Added +6.0k +6,000
97 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 26,99527.0k $1.4m $1.4m 0.01% Added +3.3k +3,311
98 AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio New York, NY 25,61725.6k $1.3m $1.3m 0.01% Added +4.0k +3,993
99 Chicago Partners Investment Group LLC 0.02% of their portfolio CHICAGO, IL 25,20025.2k $304.4k $304.4k 0.02% Unchanged
100 GROUP ONE TRADING LLC 0.05% of their portfolio CHICAGO, IL 25,01825.0k $1.3m $1.3m 0.05% Reduced -55.5k -55,546