PROTAGONIST THERAPEUTICS INC PTGX
COM · Common Stock · CUSIP 74366E102 · ISIN US74366E1029
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNewark, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($80.8k this quarter). Holder counts are more reliable. Shares outstanding: 57.7m as of 2023-10-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $16.68. Options: 6 managers hold calls ($12.2m notional), 5 hold puts ($1.1m).
Trends to Q3 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 132 |
| Q4 2022 | 138 |
| Q1 2023 | 138 |
| Q2 2023 | 168 |
| Q3 2023 | 145 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 69 | 59 |
| Q1 2023 | 78 | 74 |
| Q2 2023 | 103 | 62 |
| Q3 2023 | 83 | 80 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2022 | $10.4m | $2.6m | 0.25 |
| Q1 2023 | $42.3m | $13.2m | 0.31 |
| Q2 2023 | $49.7m | $22.8m | 0.46 |
| Q3 2023 | $12.2m | $1.1m | 0.09 |
Biggest buyers
| BVF INC/IL | Added | +2.0m |
| BRAIDWELL LP | New | +1.1m |
| Point72 Asset Management, L.P. | New | +1.1m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Added | +935.0k |
| Kynam Capital Management, LP | Added | +843.4k |
| MANGROVE PARTNERS IM, LLC | New | +439.3k |
| STATE STREET CORP | Added | +390.2k |
| Sio Capital Management, LLC | New | +248.1k |
| BlackRock Inc. | Added | +220.2k |
| Ghost Tree Capital, LLC | Added | +175.0k |
Biggest sellers
| Cormorant Asset Management, LP | Sold out | -1.5m |
| Holocene Advisors, LP | Sold out | -802.5k |
| DEUTSCHE BANK AG\ | Reduced | -789.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -592.7k |
| Artal Group S.A. | Sold out | -500.0k |
| CITADEL ADVISORS LLC | Reduced | -498.2k |
| Woodline Partners LP | Sold out | -427.3k |
| PERCEPTIVE ADVISORS LLC | Reduced | -415.5k |
| Nuveen Asset Management, LLC | Reduced | -399.9k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -351.8k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $5.5m331.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.3m196.6k shares |
| JPMORGAN CHASE & CO | Reduced | $1.7m100.0k shares |
| GROUP ONE TRADING LLC | Reduced | $1.7m99.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $105.0k6.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $530.4k31.8k shares |
| CITADEL ADVISORS LLC | Reduced | $408.7k24.5k shares |
| GROUP ONE TRADING LLC | Added | $200.2k12.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.0k300 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-10-27 | 15.2% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-13 | 10.0% |
| Farallon Capital Partners, L.P. 13G · passive investor no change · filed 2026-02-06 | 10.0% |
| RTW INVESTMENTS, LP 13G · institution filed 2026-02-17 | 8.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.5% |
| STATE STREET CORP 13G · institution +0.3 pts · filed 2026-08-07 | 5.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution new · filed 2026-02-10 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q3 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2021 | 0 | — | 1 | $482.1k | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 0 | — | — |
None reported in Q3 2023.
Holders, Q3 2023
| Manager | Shares | Change |
|---|---|---|
| BVF INC/IL 2.58% of their portfolio | 5.7m $95.8m | Added +2.0m |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.51% of their portfolio | 5.4m $90.8m | Added +935.0k |
| RTW INVESTMENTS, LP 1.91% of their portfolio | 5.4m $90.3m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 5.2m $87.2m | Added +220.2k |
| STATE STREET CORP 0.00% of their portfolio | 3.9m $65.8m | Added +390.2k |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.2m $53.8m | Added +80.6k |
| JOHNSON & JOHNSON 15.05% of their portfolio | 2.4m $40.9m | Unchanged |
| Kynam Capital Management, LP 5.04% of their portfolio | 1.8m $30.3m | Added +843.4k |
| COWEN AND COMPANY, LLC 1.94% of their portfolio | 1.7m $27.6m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.2m $19.7m | Added +104.1k |
| BRAIDWELL LP 0.58% of their portfolio | 1.1m $18.5m | New |
| Point72 Asset Management, L.P. 0.06% of their portfolio | 1.1m $18.5m | New |
| PERCEPTIVE ADVISORS LLC 0.59% of their portfolio | 1.1m $17.6m | Reduced -415.5k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 941.3k $15.7m | Reduced -97.8k |
| Jefferies Financial Group Inc. 0.35% of their portfolio | 835.6k $13.9m | Added +75.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 832.0k $13.9m | Added +300 |
| 683 Capital Management, LLC 1.24% of their portfolio | 732.8k $12.2m | Reduced -81.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 700.0k $11.7m | Reduced -592.7k |
| Candriam S.C.A. 0.07% of their portfolio | 630.0k $10.5m | Reduced -95.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 562.7k $9.4m | Added +24.6k |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 554.3k $9.2m | Reduced -6.2k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 536.0k $8.9m | Reduced -399.9k |
| FMR LLC 0.00% of their portfolio | 509.2k $8.5m | Added +1.8k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 467.2k $7.8m | Reduced -92.0k |
| MANGROVE PARTNERS IM, LLC 0.56% of their portfolio | 439.3k $7.3m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 439.1k $7.3m | Added +19.5k |
| MORGAN STANLEY 0.00% of their portfolio | 429.0k $7.2m | Reduced -149.0k |
| Ghost Tree Capital, LLC 3.23% of their portfolio | 400.0k $6.7m | Added +175.0k |
| Rafferty Asset Management, LLC 0.03% of their portfolio | 350.3k $5.8m | Added +64.8k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 336.3k $5.6m | Reduced -40.2k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.10% of their portfolio | 320.0k $5.3m | Unchanged |
| KENNEDY CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 319.5k $5.3m | Reduced -84.1k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 316.9k $5.3m | Reduced -95.2k |
| Gratus Capital, LLC 0.33% of their portfolio | 292.9k $4.9m | Added +73.3k |
| Eversept Partners, LP 0.53% of their portfolio | 286.7k $4.8m | Added +172.1k |
| Sio Capital Management, LLC 1.28% of their portfolio | 248.1k $4.1m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 239.0k $4.0m | Reduced -57.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 232.3k $3.9m | Reduced -32.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 226.3k $3.8m | Reduced -164.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 201.4k $3.4m | Added +1.9k |
| READYSTATE ASSET MANAGEMENT LP 0.26% of their portfolio | 184.3k $3.1m | Reduced -20.5k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.02% of their portfolio | 180.5k $3.0m | Added +52.3k |
| ExodusPoint Capital Management, LP 0.04% of their portfolio | 177.1k $3.0m | Added +162.5k |
| BARCLAYS PLC 0.00% of their portfolio | 176.8k $2.9m | Reduced -16.6k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 154.1k $2.6m | New |
| CITIGROUP INC 0.00% of their portfolio | 147.8k $2.5m | Added +40.3k |
| TWINBEECH CAPITAL LP 0.05% of their portfolio | 147.3k $2.5m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 144.0k $2.4m | Reduced -58.3k |
| GREAT LAKES ADVISORS, LLC 0.02% of their portfolio | 141.6k $2.4m | Reduced -5.5k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 139.5k $2.3m | Reduced -23.9k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.04% of their portfolio | 136.3k $2.3m | Added +69.2k |
| Walleye Capital LLC 0.03% of their portfolio | 133.8k $2.2m | Added +81.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 129.0k $2.2m | Reduced -17.5k |
| Artia Global Partners LP 0.78% of their portfolio | 112.3k $1.9m | Unchanged |
| TD Asset Management Inc 0.00% of their portfolio | 110.8k $1.8m | Added +55.4k |
| MONTANOVA CAPITAL, LLC 0.10% of their portfolio | 108.3k $1.8m | Added +27.2k |
| Swiss National Bank 0.00% of their portfolio | 100.6k $1.7m | Added +2.6k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 91.7k $1.5m | New |
| UBS Group AG 0.00% of their portfolio | 90.7k $1.5m | Added +25.2k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.01% of their portfolio | 88.0k $1.5m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 87.3k $1.5m | Added +7.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 82.8k $1.4m | Added +4.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 76.6k $1.3m | Added +5.5k |
| Birchview Capital, LP 0.54% of their portfolio | 76.0k $1.3m | Added +38.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 74.1k $1.2m | Added +8.2k |
| ALGERT GLOBAL LLC 0.06% of their portfolio | 72.8k $1.2m | Added +45.6k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 71.9k $1.2m | Reduced -789.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 71.1k $1.2m | Added +6.3k |
| Moody Aldrich Partners LLC 0.22% of their portfolio | 69.0k $1.2m | Added +27.1k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 61.5k $1.0m | Added +11.8k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 60.2k $1.0m | Added +30.5k |
| PROFUND ADVISORS LLC 0.05% of their portfolio | 58.7k $979.4k | Added +6.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 57.2k $954.8k | Added +41.3k |
| Campbell & CO Investment Adviser LLC 0.11% of their portfolio | 56.6k $943.7k | Added +36.0k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 53.1k $885.4k | Reduced -4.6k |
| Knott David M Jr 0.35% of their portfolio | 52.4k $873.0k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 50.8k $847.3k | Reduced -498.2k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 50.1k $835.9k | Reduced -12.7k |
| Ghisallo Capital Management LLC 0.09% of their portfolio | 50.0k $834.0k | Unchanged |
| Public Sector Pension Investment Board 0.01% of their portfolio | 49.0k $817.3k | Reduced -97.0k |
| Legal & General Group Plc 0.00% of their portfolio | 44.8k $746.7k | Added +265 |
| AlphaCentric Advisors LLC 0.41% of their portfolio | 43.5k $725.6k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 43.0k $716.6k | Added +1.4k |
| ALPS ADVISORS INC 0.01% of their portfolio | 42.4k $708.0k | Added +368 |
| Invesco Ltd. 0.00% of their portfolio | 40.9k $682.2k | Reduced -223.5k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 40.2k $670.8k | Reduced -31.8k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 38.5k $642.3k | Added +16.7k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 37.2k $620.9k | Added +1.6k |
| Jump Financial, LLC 0.02% of their portfolio | 35.4k $591.1k | Added +21.1k |
| Hennion & Walsh Asset Management, Inc. 0.03% of their portfolio | 31.7k $528.2k | Added +15.0k |
| Bellevue Group AG 0.01% of their portfolio | 30.0k $500.4k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 28.6k $477.0k | Unchanged |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 28.5k $475.5k | Added +2.4k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 28.4k $473.7k | Added +12.1k |
| Engineers Gate Manager LP 0.02% of their portfolio | 25.9k $431.2k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 23.2k $387.0k | Added +237 |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 21.8k $363.5k | Added +20 |
| MARSHALL WACE, LLP 0.00% of their portfolio | 21.7k $362.7k | Reduced -142.8k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 0.11% of their portfolio | 19.9k $331.9k | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 18.9k $315.0k | Unchanged |