AXSOME THERAPEUTICS INC AXSM
COM · Common Stock · CUSIP 05464T104 · ISIN US05464T1043
American biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Founded2012
- Websiteaxsome.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($575.7k this quarter). Holder counts are more reliable. Shares outstanding: 47.3m as of 2023-10-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $69.89. Options: 19 managers hold calls ($56.4m notional), 14 hold puts ($36.8m).
Trends to Q3 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 189 |
| Q4 2022 | 219 |
| Q1 2023 | 198 |
| Q2 2023 | 233 |
| Q3 2023 | 229 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 110 | 101 |
| Q1 2023 | 90 | 106 |
| Q2 2023 | 135 | 72 |
| Q3 2023 | 111 | 98 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q4 2022 | $179.1m | $132.8m | 0.74 |
| Q1 2023 | $79.2m | $56.9m | 0.72 |
| Q2 2023 | $105.6m | $60.5m | 0.57 |
| Q3 2023 | $56.4m | $36.8m | 0.65 |
Biggest buyers
| CITADEL ADVISORS LLC | Added | +841.3k |
| Deep Track Capital, LP | Added | +756.5k |
| Jefferies Financial Group Inc. | New | +553.2k |
| EVENTIDE ASSET MANAGEMENT, LLC | New | +346.7k |
| Soleus Capital Management, L.P. | Added | +212.6k |
| BlackRock Inc. | Added | +210.9k |
| PERCEPTIVE ADVISORS LLC | Added | +210.2k |
| RTW INVESTMENTS, LP | Added | +205.3k |
| HSBC HOLDINGS PLC | New | +148.8k |
| Nuveen Asset Management, LLC | Added | +115.3k |
Biggest sellers
| Cormorant Asset Management, LP | Sold out | -340.0k |
| FMR LLC | Reduced | -270.4k |
| Avidity Partners Management LP | Reduced | -248.2k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -232.1k |
| IRIDIAN ASSET MANAGEMENT LLC/CT | Reduced | -167.4k |
| JANE STREET GROUP, LLC | Reduced | -150.3k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | Reduced | -147.1k |
| MARSHALL WACE, LLP | Reduced | -132.3k |
| CLEAR STREET LLC | Sold out | -131.5k |
| Alyeska Investment Group, L.P. | Sold out | -125.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $21.3m304.9k shares |
| JANE STREET GROUP, LLC | Reduced | $8.1m116.5k shares |
| GROUP ONE TRADING LLC | Reduced | $6.6m94.3k shares |
| CITADEL ADVISORS LLC | Reduced | $5.7m81.7k shares |
| GTS SECURITIES LLC | New | $3.6m51.9k shares |
| D. E. Shaw & Co., Inc. | Unchanged | $2.4m34.6k shares |
| SIMPLEX TRADING, LLC | Reduced | $2.3m32.8k shares |
| CITIGROUP INC | New | $1.9m27.4k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.1m16.1k shares |
| PEAK6 Investments LLC | Reduced | $1.1m16.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $10.5m150.6k shares |
| CITADEL ADVISORS LLC | Reduced | $6.6m93.9k shares |
| GROUP ONE TRADING LLC | Reduced | $5.9m84.9k shares |
| JANE STREET GROUP, LLC | Reduced | $4.9m69.5k shares |
| GOLDMAN SACHS GROUP INC | New | $2.5m35.4k shares |
| CITIGROUP INC | New | $1.9m27.4k shares |
| WOLVERINE TRADING, LLC | Reduced | $1.4m20.2k shares |
| GTS SECURITIES LLC | New | $1.2m17.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $887.0k12.7k shares |
| Walleye Trading LLC | Added | $433.3k6.2k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-07-27 | 5.3% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26)
Insider purchases and sales in Q3 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2021 | 4 | $345.1k | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 1 | $2.2m | $2.2m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-09-15 | Coleman Mark Director | Sold plan | $1.4m18.6k shares |
| 2023-09-15 | Coleman Mark Director | Sold plan | $828.3k11.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q3 2023
| Manager | Shares | Change |
|---|---|---|
| RTW INVESTMENTS, LP 6.62% of their portfolio | 4.5m $313.8m | Added +205.3k |
| VANGUARD GROUP INC 0.01% of their portfolio | 3.7m $260.6m | Reduced -13.6k |
| BlackRock Inc. 0.01% of their portfolio | 2.9m $205.1m | Added +210.9k |
| Fairmount Funds Management LLC 19.69% of their portfolio | 2.3m $163.6m | Reduced -3.7k |
| BVF INC/IL 4.02% of their portfolio | 2.1m $148.9m | Unchanged |
| FMR LLC 0.01% of their portfolio | 1.9m $129.9m | Reduced -270.4k |
| CITADEL ADVISORS LLC 0.10% of their portfolio | 1.3m $90.6m | Added +841.3k |
| Deep Track Capital, LP 3.09% of their portfolio | 1.1m $79.7m | Added +756.5k |
| RA CAPITAL MANAGEMENT, L.P. 1.38% of their portfolio | 1.0m $69.9m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 867.6k $60.6m | Added +42.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 778.5k $54.4m | Added +68.7k |
| ALETHEA CAPITAL MANAGEMENT, LLC 65.14% of their portfolio | 758.8k $53.0m | Reduced -1.1k |
| Pictet Asset Management Holding SA 0.06% of their portfolio | 646.4k $45.2m | First filing |
| Bellevue Group AG 0.71% of their portfolio | 631.5k $44.1m | Added +57.1k |
| Jefferies Financial Group Inc. 0.96% of their portfolio | 553.2k $38.7m | New |
| Point72 Asset Management, L.P. 0.13% of their portfolio | 531.9k $37.2m | Added +63.9k |
| PFM Health Sciences, LP 1.75% of their portfolio | 523.2k $36.6m | Added +27.6k |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 503.0k $35.2m | Reduced -232.1k |
| PERCEPTIVE ADVISORS LLC 1.13% of their portfolio | 481.6k $33.7m | Added +210.2k |
| Woodline Partners LP 0.37% of their portfolio | 452.1k $31.6m | Added +12.2k |
| Boxer Capital, LLC 1.49% of their portfolio | 400.0k $28.0m | Unchanged |
| Nicholas Investment Partners, LP 2.06% of their portfolio | 395.0k $27.6m | Added +96 |
| Hood River Capital Management LLC 0.86% of their portfolio | 383.3k $26.8m | Reduced -1.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 349.1k $24.4m | Added +22.9k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.44% of their portfolio | 346.7k $24.2m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 325.0k $22.7m | Reduced -119.4k |
| TANG CAPITAL MANAGEMENT LLC 3.16% of their portfolio | 320.0k $22.4m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 298.4k $20.9m | Reduced -24.9k |
| Avidity Partners Management LP 0.84% of their portfolio | 296.8k $20.7m | Reduced -248.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 289.9k $20.3m | Added +21.5k |
| Driehaus Capital Management LLC 0.23% of their portfolio | 248.9k $17.4m | Added +117 |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 237.6k $16.6m | Added +37.8k |
| Soleus Capital Management, L.P. 1.67% of their portfolio | 237.5k $16.6m | Added +212.6k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 216.6k $15.1m | Added +115.3k |
| NORGES BANK 0.00% of their portfolio | 210.2k $14.7m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 172.5k $12.1m | Reduced -776 |
| Bank of New York Mellon Corp 0.00% of their portfolio | 168.0k $11.7m | Added +6.9k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.12% of their portfolio | 160.7k $11.2m | Reduced -61.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 159.2k $11.1m | Added +19.3k |
| HSBC HOLDINGS PLC 0.01% of their portfolio | 148.8k $10.4m | New |
| IRIDIAN ASSET MANAGEMENT LLC/CT 2.05% of their portfolio | 145.0k $10.1m | Reduced -167.4k |
| Tri Locum Partners LP 3.20% of their portfolio | 142.5k $10.0m | Reduced -57.6k |
| US BANCORP \DE\ 0.02% of their portfolio | 138.8k $9.7m | Reduced -961 |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.05% of their portfolio | 125.7k $8.8m | Reduced -147.1k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 125.6k $8.8m | Reduced -150.3k |
| PUTNAM INVESTMENTS LLC 0.01% of their portfolio | 120.3k $8.4m | Added +3.0k |
| Ally Bridge Group (NY) LLC 9.07% of their portfolio | 110.6k $7.7m | New |
| Ghost Tree Capital, LLC 3.72% of their portfolio | 110.0k $7.7m | Unchanged |
| Cannell & Co. 0.25% of their portfolio | 104.2k $7.3m | Reduced -15.0k |
| Allspring Global Investments Holdings, LLC 0.01% of their portfolio | 103.7k $7.2m | Added +1.1k |
| CITIGROUP INC 0.01% of their portfolio | 102.7k $7.2m | Added +39.9k |
| HHLR ADVISORS, LTD. 0.16% of their portfolio | 100.0k $7.0m | Unchanged |
| Squarepoint Ops LLC 0.03% of their portfolio | 96.8k $6.8m | New |
| WCM INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 96.0k $6.7m | Added +1.7k |
| MPM BIOIMPACT LLC 1.75% of their portfolio | 93.6k $6.5m | Unchanged |
| Altium Capital Management LLC 3.72% of their portfolio | 92.0k $6.4m | Added +52.0k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.19% of their portfolio | 91.1k $6.4m | Reduced -16.4k |
| Artia Global Partners LP 2.55% of their portfolio | 87.8k $6.1m | Unchanged |
| Lindbrook Capital, LLC 0.66% of their portfolio | 84.3k $5.9m | Reduced -150 |
| WMS Partners, LLC 0.45% of their portfolio | 80.7k $5.6m | Added +711 |
| Sofinnova Investments, Inc. 0.40% of their portfolio | 80.4k $5.6m | Reduced -98.9k |
| Moody Aldrich Partners LLC 0.98% of their portfolio | 73.6k $5.1m | Added +8.9k |
| Privium Fund Management B.V. 1.50% of their portfolio | 72.0k $5.0m | Unchanged |
| Swiss National Bank 0.00% of their portfolio | 71.7k $5.0m | Reduced -4.1k |
| Atika Capital Management LLC 0.71% of their portfolio | 71.0k $5.0m | Reduced -41.0k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 67.7k $4.7m | Reduced -7.6k |
| Hennion & Walsh Asset Management, Inc. 0.30% of their portfolio | 67.0k $4.7m | Reduced -10.4k |
| Invesco Ltd. 0.00% of their portfolio | 62.4k $4.4m | Reduced -109.1k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 61.1k $4.3m | Reduced -123.1k |
| NATIONAL BANK OF CANADA /FI/ 0.01% of their portfolio | 60.2k $4.0m | Reduced -9.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 60.0k $4.2m | Added +2.4k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 59.2k $4.1m | Reduced -132.3k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 1.37% of their portfolio | 58.3k $4.1m | Unchanged |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 57.3k $4.0m | Reduced -3.3k |
| HighVista Strategies LLC 1.84% of their portfolio | 57.0k $4.0m | Added +7.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 56.6k $4.0m | Added +1.2k |
| J. Goldman & Co LP 0.19% of their portfolio | 53.8k $3.8m | Added +37.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 50.8k $3.6m | Added +4.1k |
| Candriam S.C.A. 0.02% of their portfolio | 50.1k $3.5m | Unchanged |
| BALDWIN WEALTH PARTNERS LLC/MA 0.29% of their portfolio | 48.0k $3.4m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 41.3k $2.9m | Added +590 |
| CWM, LLC 0.02% of their portfolio | 40.1k $2.8m | Added +12.1k |
| Rhenman & Partners Asset Management AB 0.30% of their portfolio | 40.1k $2.8m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 37.1k $2.6m | Added +8.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 36.6k $2.6m | Reduced -5.0k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.03% of their portfolio | 36.2k $2.5m | Reduced -2.2k |
| ALPS ADVISORS INC 0.02% of their portfolio | 34.8k $2.4m | Added +2.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 34.4k $2.4m | Added +9.6k |
| Legal & General Group Plc 0.00% of their portfolio | 33.9k $2.4m | Added +576 |
| SVB FINANCIAL GROUP 4.45% of their portfolio | 33.8k $2.4m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 32.8k $2.3m | Added +18.2k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 32.5k $2.3m | Unchanged |
| DekaBank Deutsche Girozentrale 0.01% of their portfolio | 30.0k $2.2m | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 29.2k $2.0m | Reduced -9.1k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 29.1k $2.0m | Reduced -514 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 26.7k $1.9m | Added +13.1k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio | 25.7k $1.8m | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 25.0k $1.7m | Added +1.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 22.6k $1.6m | Added +2.1k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 21.5k $1.5m | Reduced -24.6k |