GREAT POINT PARTNERS LLC

Greenwich, CT · CIK 1281446 · 13F filing filed 2026-08-14

SEC-registered investment adviser since 2012 · limited liability company

Assets managed$1.8bn
Staff28 · 23 in investment roles
Main clients (by assets)Private funds 100%
Private funds17 (2 hedge) · $1.8bn gross assets
Websitegppfunds.com
Form ADV · 2026-03-31SEC adviser record

Legal entityGREAT POINT PARTNERS, LLC (US)

$424.4m reported value +4.0% vs Q1 2026

37positions

53.6%in top 10

11 new 7 added 9 reduced 13 sold out vs Q1 2026

Options: 3 call positions ($58.4m notional), 2 put positions ($46.3m notional) – listed below, not included above.

This report includes the holdings of 2 other managers that share the investment decisions:

JAY JEFFREY R – reports through this filing
Nordahl Lillian – reports through this filing

Shares in two reports are counted once in each security's totals.

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	VOR BIOPHARMA INC COM NEW VOR	VOR	1,700,000	$31.3m7.37%	7.37%	Reduced -50.0k	-50,000 -2.9%
2	ABIVAX SA SPONSORED ADS ABVX	ABVX	204,314	$27.2m6.41%	6.41%	New
3	VERA THERAPEUTICS INC CL A VERA	VERA	600,836	$25.8m6.07%	6.07%	Added +401.5k	+401,488 201.4%
4	ZURA BIO LTD CLASS A ORD SHS ZURA	ZURA	4,215,930	$24.9m5.86%	5.86%	Unchanged
5	ALUMIS INC COM ALMS	ALMS	856,061	$24.1m5.68%	5.68%	Unchanged
6	SOL-GEL TECHNOLOGIES LTD SHS NEW SLGL	SLGL	274,363	$20.3m4.79%	4.79%	Unchanged
7	DEFINIUM THERAPEUTICS INC COM SHS DFTX	DFTX	425,000	$20.0m4.71%	4.71%	New
8	ANNEXON INC COM ANNX	ANNX	3,500,000	$20.0m4.71%	4.71%	Added +1.0m	+1,000,000 40.0%
9	ORUKA THERAPEUTICS INC COM ORKA	ORKA	183,330	$17.4m4.11%	4.11%	Unchanged
10	MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD MLTX	MLTX	855,813	$16.7m3.93%	3.93%	Added +355.8k	+355,813 71.2%
11	SAGIMET BIOSCIENCES INC COM SER A SGMT	SGMT	2,029,933	$15.7m3.70%	3.70%	New
12	CONTINEUM THERAPEUTICS INC CL A CTNM	CTNM	921,481	$15.1m3.56%	3.56%	Added +121.3k	+121,283 15.2%
13	IMMIX BIOPHARMA INC COM IMMX	IMMX	1,277,642	$13.2m3.10%	3.10%	Added +927.6k	+927,642 265.0%
14	CLIMB BIO INC COM CLYM	CLYM	1,000,000	$13.0m3.07%	3.07%	Reduced -334.1k	-334,130 -25.0%
15	AMYLYX PHARMACEUTICALS INC COM AMLX	AMLX	700,000	$12.6m2.96%	2.96%	Reduced -1.1m	-1,050,000 -60.0%
16	NEKTAR THERAPEUTICS COM NEW NKTR	NKTR	175,000	$12.2m2.88%	2.88%	Reduced -141.5k	-141,453 -44.7%
17	NEUROGENE INC COM NGNE	NGNE	352,180	$11.1m2.61%	2.61%	Reduced -147.8k	-147,820 -29.6%
18	LB PHARMACEUTICALS INC COM SHS LBRX	LBRX	317,221	$10.3m2.43%	2.43%	Added +17.2k	+17,221 5.7%
19	OPUS GENETICS INC COM IRD	IRD	1,970,187	$8.1m1.91%	1.91%	Added +1.6m	+1,645,847 507.4%
20	EUPRAXIA PHARMACEUTICALS INC COM EPRX	EPRX	1,200,000	$7.9m1.87%	1.87%	Unchanged
21	BRIGHT MINDS BIOSCIENCES INC COM NEW DRUG	DRUG	109,603	$7.7m1.81%	1.81%	Reduced -110.4k	-110,397 -50.2%
22	INFLARX NV COM IFRX	IFRX	3,046,557	$6.8m1.61%	1.61%	New
23	RELMADA THERAPEUTICS INC COM RLMD	RLMD	842,106	$5.8m1.37%	1.37%	Unchanged
24	JATT II ACQUISITION CORP ORD SHS JATT	JATT	500,000	$5.7m1.34%	1.34%	New
25	CULLINAN THERAPEUTICS INC COM CGEM	CGEM	300,000	$5.5m1.29%	1.29%	Unchanged
26	ALTIMMUNE INC COM NEW ALT	ALT	1,741,232	$5.3m1.25%	1.25%	New
27	AMANAT ACQUISITION CORP CL A ORD AMAN	AMAN	500,000	$5.1m1.20%	1.20%	New
28	REZOLUTE INC COM NEW RZLT	RZLT	951,809	$4.9m1.17%	1.17%	Unchanged
29	SILENCE THERAPEUTICS PLC ADS SLN	SLN	450,000	$4.9m1.16%	1.16%	Reduced -570.5k	-570,489 -55.9%
30	PALISADE BIO INC COM PALI	PALI	2,284,819	$4.8m1.13%	1.13%	Reduced -1.1m	-1,120,938 -32.9%
31	EVOMMUNE INC COM SHS EVMN	EVMN	325,000	$4.3m1.02%	1.02%	Unchanged
32	SCYNEXIS INC COM SCYX	SCYX	944,292	$3.8m0.91%	0.91%	New
33	ENLIVEN THERAPEUTICS INC COM ELVN	ELVN	70,000	$3.6m0.84%	0.84%	New
34	HUMACYTE INC COM HUMA	HUMA	3,750,000	$2.9m0.69%	0.69%	Unchanged
35	REIN THERAPEUTICS INC COM NEW RNTX	RNTX	2,575,000	$2.7m0.63%	0.63%	New
36	DBV TECHNOLOGIES S A SPONSORED ADS DBVT	DBVT	156,906	$2.6m0.61%	0.61%	New
37	PROMIS NEUROSCIENCES INC COM SHS PMN	PMN	86,150	$1.1m0.27%	0.27%	Reduced -285.3k	-285,252 -76.8%

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
APOGEE THERAPEUTICS INC		374,000	$31.5m374.0k shares
KALVISTA PHARMACEUTICALS INC KALV	KALV	675,000	$13.6m675.0k shares
IMMUNOVANT INC IMVT	IMVT	545,625	$13.6m545.6k shares
JADE BIOSCIENCES INC JBIO	JBIO	964,462	$13.6m964.5k shares
ZENAS BIOPHARMA INC ZBIO	ZBIO	524,066	$10.2m524.1k shares
COMPASS THERAPEUTICS INC CMPX	CMPX	1,350,000	$7.1m1.4m shares
SCYNEXIS INC		7,554,347	$6.9m7.6m shares
CONTEXT THERAPEUTICS INC CNTX	CNTX	2,238,496	$5.9m2.2m shares
UNICYCIVE THERAPEUTICS INC UNCY	UNCY	796,558	$5.2m796.6k shares
TENAX THERAPEUTICS INC TENX	TENX	327,307	$5.2m327.3k shares
PHARVARIS N V PHVS	PHVS	82,800	$2.3m82.8k shares
AVALO THERAPEUTICS INC AVTX	AVTX	124,666	$1.9m124.7k shares
ALKERMES PLC ALKS	ALKS	50,000	$1.8m50.0k shares

Options (notional value)

Underlying	Ticker	Type	Shares controlled	Notional	Change
ABIVAX SA ABVX · Call	ABVX	Call	400,000	$53.3m400.0k shares	New
IMMUNITYBIO INC IBRX · Put	IBRX	Put	3,000,800	$26.3m3.0m shares	Unchanged
ULTRAGENYX PHARMACEUTICAL IN RARE · Put	RARE	Put	600,000	$20.0m600.0k shares	New
GALECTIN THERAPEUTICS INC GALT · Call	GALT	Call	800,000	$3.7m800.0k shares	Unchanged
ANAVEX LIFE SCIENCES CORP AVXL · Call	AVXL	Call	521,300	$1.4m521.3k shares	Unchanged

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
SCYNEXIS INC SCYX · 13G · filed 2026-08-14	SCYX	10.0%≈ $4.4m		13G	2026-08-14
SCYNEXIS INC 13G · filed 2026-04-07		10.0%	new	13G	2026-04-07
PROMIS NEUROSCIENCES INC PMN · 13G · filed 2025-11-14	PMN	10.0%	no change	13G	2025-11-14
UNICYCIVE THERAPEUTICS INC 13G · filed 2025-02-14		10.0%		13G	2025-02-14
SOL-GEL TECHNOLOGIES LTD SLGL · 13G · filed 2026-03-31	SLGL	8.4%≈ $20.3m	new	13G	2026-03-31
PROMIS NEUROSCIENCES INC PMN · 13G · filed 2026-08-14	PMN	7.7%≈ $9.7m	-2.3 pts	13G	2026-08-14
AMANAT ACQUISITION CORP AMAN · 13G · filed 2026-08-14	AMAN	6.7%≈ $5.1m	+1.5 pts	13G	2026-08-14
RESEARCH ALLIANCE CORP III RACC · 13G · filed 2026-09-11	RACC	6.5%≈ $5.4m	new	13G	2026-09-11
JATT II ACQUISITION CORP JATT · 13G · filed 2026-08-14	JATT	6.2%≈ $5.7m	-0.2 pts	13G	2026-08-14