ULTRAGENYX PHARMACEUTICAL IN RARE
COM · Common Stock · CUSIP 90400D108 · ISIN US90400D1081
Biopharmaceutical company based in Novato, California, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNovato, CA
- Websiteultragenyx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($17.2m this quarter). Holder counts are more reliable. Shares outstanding: 98.6m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $33.28. Options: 14 managers hold calls ($57.5m notional), 10 hold puts ($69.3m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 233 |
| Q4 2022 | 228 |
| Q1 2023 | 230 |
| Q2 2023 | 243 |
| Q3 2023 | 222 |
| Q4 2023 | 238 |
| Q1 2024 | 271 |
| Q2 2024 | 275 |
| Q3 2024 | 303 |
| Q4 2024 | 316 |
| Q1 2025 | 304 |
| Q2 2025 | 313 |
| Q3 2025 | 304 |
| Q4 2025 | 289 |
| Q1 2026 | 298 |
| Q2 2026 | 310 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 163 | 120 |
| Q4 2024 | 149 | 151 |
| Q1 2025 | 155 | 148 |
| Q2 2025 | 167 | 151 |
| Q3 2025 | 181 | 145 |
| Q4 2025 | 153 | 155 |
| Q1 2026 | 180 | 132 |
| Q2 2026 | 171 | 142 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $88.8m | $34.0m | 0.38 |
| Q4 2025 | $75.9m | $47.6m | 0.63 |
| Q1 2026 | $27.9m | $25.8m | 0.93 |
| Q2 2026 | $57.5m | $69.3m | 1.21 |
Biggest buyers
| RTW INVESTMENTS, LP | Added | +4.1m |
| BlackRock, Inc. | Added | +3.4m |
| AQR CAPITAL MANAGEMENT LLC | Added | +2.0m |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Added | +1.5m |
| MPM BIOIMPACT LLC | New | +1.4m |
| TWO SIGMA INVESTMENTS, LP | Added | +1.4m |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +1.4m |
| STATE STREET CORP | Added | +1.1m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +1.1m |
| Jefferies Financial Group Inc. | Added | +914.1k |
Biggest sellers
| Assenagon Asset Management S.A. | Reduced | -2.0m |
| CITADEL ADVISORS LLC | Reduced | -1.9m |
| Sofinnova Investments, Inc. | Reduced | -1.4m |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -1.4m |
| Jones Hill Capital LP | Sold out | -1.2m |
| MILLENNIUM MANAGEMENT LLC | Reduced | -1.0m |
| Point72 Asset Management, L.P. | Sold out | -893.3k |
| HRT FINANCIAL LP | Sold out | -613.2k |
| Catalio Capital Management, LP | Reduced | -534.5k |
| Schonfeld Strategic Advisors LLC | Reduced | -441.9k |
Biggest calls
| Sofinnova Investments, Inc. | Added | $16.7m500.0k shares |
| Caption Management, LLC | Added | $13.8m411.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $9.2m276.0k shares |
| Stonepine Capital Management, LLC | New | $5.5m200.0k shares |
| Tetragon Partners GP Ltd | New | $3.3m100.0k shares |
| GOLDMAN SACHS GROUP INC | New | $2.0m60.0k shares |
| Squadron Capital Management LLC | New | $1.8m55.0k shares |
| GROUP ONE TRADING LLC | Added | $1.4m43.1k shares |
| CITADEL ADVISORS LLC | Reduced | $1.3m38.0k shares |
| JANE STREET GROUP, LLC | Reduced | $707.9k21.2k shares |
Biggest puts
| Caption Management, LLC | Added | $24.0m718.8k shares |
| GREAT POINT PARTNERS LLC | New | $20.0m600.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $17.0m509.0k shares |
| CITADEL ADVISORS LLC | Reduced | $3.3m99.1k shares |
| 683 Capital Management, LLC | New | $1.7m50.0k shares |
| SIMPLEX TRADING, LLC | Added | $1.1m33.0k shares |
| GROUP ONE TRADING LLC | Reduced | $834.8k25.0k shares |
| JANE STREET GROUP, LLC | Reduced | $621.1k18.6k shares |
| Walleye Capital LLC | Reduced | $380.6k11.4k shares |
| IMC-Chicago, LLC | Reduced | $320.5k9.6k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +3.2 pts · filed 2026-07-30 | 8.3% |
| RTW INVESTMENTS, LP 13G · institution new · filed 2026-08-14 | 7.9% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution +1.5 pts · filed 2026-07-31 | 7.0% |
| AQR CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-08-13 | 6.7% |
| Madison Avenue Partners, LP 13G · passive investor new · filed 2026-10-20 | 6.4% |
| STATE STREET CORP 13G · institution +1.2 pts · filed 2026-08-07 | 6.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.1% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC), FMR LLC (3.5%, 2026-02-05)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 2 | $1.3m | $908.9k |
| Q1 2025 | 0 | — | 8 | $6.8m | $4.2m |
| Q2 2025 | 0 | — | 2 | $118.8k | $89.9k |
| Q3 2025 | 0 | — | 2 | $80.9k | — |
| Q4 2025 | 0 | — | 2 | $365.3k | $112.1k |
| Q1 2026 | 0 | — | 7 | $2.7m | $371.6k |
| Q2 2026 | 0 | — | 5 | $575.0k | $516.4k |
| Q3 2026 | 0 | — | 3 | $339.7k | $337.4k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-15 | Huizenga Theodore Alan SVP, Chief Accounting Officer | Sold plan | $17.4k1.3k shares |
| 2026-09-03 | Huizenga Theodore Alan SVP, Chief Accounting Officer | Sold | $2.3k161 shares |
| 2026-08-03 | Horn Howard Chief Financial Officer | Sold plan | $117.0k4.7k shares |
| 2026-08-03 | Parschauer Karah Herdman EVP and Chief Legal Officer | Sold plan | $47.3k1.9k shares |
| 2026-07-01 | Horn Howard Chief Financial Officer | Sold plan | $155.6k4.7k shares |
| 2026-06-15 | Sanders Corazon (Corsee) D. Director | Sold | $50.1k2.0k shares |
| 2026-06-15 | Parschauer Karah Herdman EVP and Chief Legal Officer | Sold plan | $46.8k1.9k shares |
| 2026-06-01 | Horn Howard Chief Financial Officer | Sold plan | $110.6k4.7k shares |
| 2026-05-18 | SULIMAN SHEHNAAZ Director | Sold plan | $144.2k5.7k shares |
| 2026-05-05 | Crombez Eric EVP and Chief Medical Officer | Sold | $8.6k344 shares |
| 2026-05-01 | Horn Howard Chief Financial Officer | Sold plan | $116.6k4.7k shares |
| 2026-04-01 | Horn Howard Chief Financial Officer | Sold plan | $98.2k4.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 10.7m $355.7m | Added +3.4m |
| RTW INVESTMENTS, LP 2.22% of their portfolio | 7.8m $260.3m | Added +4.1m |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 6.8m $226.7m | Added +1.4m |
| AQR CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 6.6m $214.1m | Added +2.0m |
| STATE STREET CORP 0.01% of their portfolio | 6.2m $205.6m | Added +1.1m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 4.3m $143.5m | Added +106.7k |
| TWO SIGMA INVESTMENTS, LP 0.09% of their portfolio | 3.6m $120.9m | Added +1.4m |
| SANDS CAPITAL MANAGEMENT, LLC 0.39% of their portfolio | 3.2m $105.5m | Reduced -56.2k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.35% of their portfolio | 2.9m $98.2m | Added +1.5m |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.89% of their portfolio | 2.8m $95.1m | Added +656.8k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.6m $86.1m | Added +729.4k |
| Bellevue Group AG 1.39% of their portfolio | 2.0m $66.2m | Reduced -397.2k |
| D. E. Shaw & Co., Inc. 0.04% of their portfolio | 1.7m $57.8m | Added +469.2k |
| Sofinnova Investments, Inc. 3.06% of their portfolio | 1.7m $57.3m | Reduced -1.4m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 1.6m $52.8m | Added +1.1m |
| GW&K Investment Management, LLC 0.39% of their portfolio | 1.5m $49.5m | Reduced -134.2k |
| MPM BIOIMPACT LLC 2.89% of their portfolio | 1.4m $47.4m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.4m $45.3m | Added +552.4k |
| MORGAN STANLEY 0.00% of their portfolio | 1.3m $44.2m | Reduced -175.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 1.3m $41.8m | Reduced -1.4m |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.18% of their portfolio | 1.2m $41.5m | Reduced -185.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $38.3m | Added +101.9k |
| Candriam S.C.A. 0.15% of their portfolio | 1.0m $33.4m | Reduced -94.3k |
| Rock Springs Capital Management LP 1.58% of their portfolio | 967.9k $32.3m | Reduced -250.9k |
| Jefferies Financial Group Inc. 0.29% of their portfolio | 929.6k $31.0m | Added +914.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 920.3k $30.7m | Added +384.7k |
| Eagle Health Investments LP 4.89% of their portfolio | 884.1k $29.5m | Unchanged |
| Qube Research & Technologies Ltd 0.03% of their portfolio | 882.2k $29.5m | Reduced -32.5k |
| Russell Investments Group, Ltd. 0.02% of their portfolio | 784.1k $26.2m | Added +381.1k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 760.8k $25.4m | Reduced -1.0m |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 760.0k $25.4m | Added +201.6k |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 753.7k $23.2m | Added +150.1k |
| Nuveen, LLC 0.01% of their portfolio | 694.0k $23.2m | Added +31.9k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 671.4k $22.4m | Added +63.2k |
| UBS Group AG 0.00% of their portfolio | 657.7k $22.0m | Reduced -175.0k |
| Palo Alto Investors LP 2.75% of their portfolio | 596.5k $19.9m | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. 2.81% of their portfolio | 588.5k $19.6m | Reduced -220.8k |
| Legal & General Group Plc 0.00% of their portfolio | 586.5k $19.6m | Reduced -3.8k |
| PANAGORA ASSET MANAGEMENT INC 0.06% of their portfolio | 586.2k $19.6m | New |
| FMR LLC 0.00% of their portfolio | 576.8k $19.3m | Added +289.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 575.3k $19.2m | Added +222.2k |
| Trexquant Investment LP 0.11% of their portfolio | 556.4k $18.6m | Added +166.9k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 498.2k $16.6m | Added +7.4k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 493.1k $15.3m | Added +247.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 470.7k $15.7m | Added +129.6k |
| TORONTO DOMINION BANK 0.02% of their portfolio | 415.0k $13.9m | Added +414.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio | 413.7k $13.8m | Reduced -148.0k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.01% of their portfolio | 409.3k $13.7m | Reduced -8.9k |
| Krensavage Asset Management, LLC 4.96% of their portfolio | 390.9k $13.1m | Unchanged |
| ALGERT GLOBAL LLC 0.15% of their portfolio | 390.0k $13.0m | Reduced -38.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 381.4k $12.7m | Reduced -69.7k |
| SummitTX Capital, L.P. 0.33% of their portfolio | 374.3k $12.5m | Added +26.5k |
| Privium Fund Management B.V. 2.08% of their portfolio | 338.8k $11.3m | Reduced -26.0k |
| Squarepoint Ops LLC 0.02% of their portfolio | 338.4k $11.3m | Reduced -106.2k |
| Walleye Capital LLC 0.05% of their portfolio | 334.9k $11.2m | Added +215.1k |
| Catalio Capital Management, LP 1.98% of their portfolio | 316.3k $10.6m | Reduced -534.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 315.8k $10.5m | Added +3.1k |
| CITIGROUP INC 0.00% of their portfolio | 298.8k $10.0m | Reduced -16.7k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.01% of their portfolio | 297.8k $9.9m | Added +116.0k |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 290.8k $9.7m | Added +284.1k |
| GordonMD Global Investments LP 4.67% of their portfolio | 289.1k $9.7m | Unchanged |
| Jump Financial, LLC 0.09% of their portfolio | 287.0k $9.6m | Reduced -217.2k |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.00% of their portfolio | 272.9k $9.1m | Added +12.5k |
| Invesco Ltd. 0.00% of their portfolio | 250.5k $8.4m | Reduced -39.0k |
| Quantinno Capital Management LP 0.01% of their portfolio | 250.5k $8.4m | Added +63.0k |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 241.7k $8.1m | Reduced -2.0m |
| KENNEDY CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 216.0k $7.2m | Reduced -3.3k |
| WORLDQUANT MILLENNIUM ADVISORS LLC 0.02% of their portfolio | 214.4k $7.2m | Added +63.8k |
| SEI INVESTMENTS CO 0.01% of their portfolio | 211.8k $7.1m | Added +119.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 210.5k $7.0m | Reduced -1.9m |
| Ishara Investments LP 5.03% of their portfolio | 205.0k $6.8m | Added +30.8k |
| Man Group plc 0.01% of their portfolio | 195.1k $6.5m | Reduced -18.2k |
| FIFTH THIRD BANCORP 0.01% of their portfolio | 193.2k $6.5m | Added +83.0k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 191.6k $6.4m | Reduced -309.3k |
| Blue Owl Capital Holdings LP 0.93% of their portfolio | 182.6k $6.1m | Reduced -120.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 180.9k $6.0m | Reduced -343.9k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 172.1k $5.3m | Reduced -7.0k |
| Woodline Partners LP 0.02% of their portfolio | 171.8k $5.7m | Unchanged |
| Atom Investors LP 0.51% of their portfolio | 171.8k $5.7m | Added +78.1k |
| Swiss National Bank 0.00% of their portfolio | 167.7k $5.6m | Reduced -3.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 167.2k $5.6m | Reduced -55.8k |
| Ikarian Capital, LLC 0.91% of their portfolio | 165.6k $5.5m | Reduced -317.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 164.8k $5.5m | Added +92.9k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 159.9k $5.3m | Added +2.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 157.6k $5.3m | Added +88.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 156.8k $5.2m | Added +85.3k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.10% of their portfolio | 156.6k $5.2m | Added +14.6k |
| BARCLAYS PLC 0.00% of their portfolio | 154.9k $5.2m | Reduced -94.9k |
| Eversept Partners, LP 0.28% of their portfolio | 154.1k $5.1m | Added +91.6k |
| Ghisallo Capital Management LLC 0.10% of their portfolio | 150.0k $5.0m | New |
| Corient Private Wealth LP 0.01% of their portfolio | 146.5k $4.9m | Added +9.9k |
| Mariner, LLC 0.01% of their portfolio | 146.4k $4.9m | Added +85.1k |
| FRED ALGER MANAGEMENT, LLC 0.02% of their portfolio | 143.2k $4.8m | Reduced -154.9k |
| SR One Capital Management, LP 0.44% of their portfolio | 137.8k $4.6m | Unchanged |
| B Group, Inc. 2.56% of their portfolio | 135.0k $4.5m | Unchanged |
| PINNACLE ASSOCIATES LTD 0.05% of their portfolio | 131.1k $4.4m | Added +28.4k |
| Caption Management, LLC 0.15% of their portfolio | 130.0k $4.3m | Added +20.0k |
| MOORE CAPITAL MANAGEMENT, LP 0.10% of their portfolio | 128.0k $4.3m | Reduced -29.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 124.4k $2.6m | Added +96.4k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 124.1k $4.1m | Added +20.7k |