ANAVEX LIFE SCIENCES CORP AVXL
COM NEW · Common Stock · CUSIP 032797300 · ISIN US0327973006
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersNew York, NY
- Websiteanavex.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($31.4k this quarter). Holder counts are more reliable. Shares outstanding: 92.7m as of 2026-08-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.59. Options: 11 managers hold calls ($2.7m notional), 7 hold puts ($839.6k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 148 |
| Q4 2022 | 139 |
| Q1 2023 | 142 |
| Q2 2023 | 145 |
| Q3 2023 | 145 |
| Q4 2023 | 154 |
| Q1 2024 | 148 |
| Q2 2024 | 142 |
| Q3 2024 | 146 |
| Q4 2024 | 169 |
| Q1 2025 | 182 |
| Q2 2025 | 179 |
| Q3 2025 | 186 |
| Q4 2025 | 185 |
| Q1 2026 | 190 |
| Q2 2026 | 179 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 69 | 48 |
| Q4 2024 | 86 | 61 |
| Q1 2025 | 95 | 67 |
| Q2 2025 | 91 | 59 |
| Q3 2025 | 83 | 66 |
| Q4 2025 | 87 | 82 |
| Q1 2026 | 106 | 75 |
| Q2 2026 | 87 | 88 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $21.1m | $17.3m | 0.82 |
| Q4 2025 | $9.4m | $7.1m | 0.75 |
| Q1 2026 | $7.2m | $2.3m | 0.32 |
| Q2 2026 | $2.7m | $839.6k | 0.31 |
Biggest buyers
| FEDERATED HERMES, INC. | Added | +539.6k |
| MARSHALL WACE, LLP | Added | +470.0k |
| BlackRock, Inc. | Added | +446.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +219.2k |
| BARCLAYS PLC | Added | +215.9k |
| AQR CAPITAL MANAGEMENT LLC | Added | +206.2k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +190.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +165.5k |
| Point72 Asset Management, L.P. | New | +157.5k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | New | +123.0k |
Biggest sellers
| STATE STREET CORP | Reduced | -2.6m |
| JANE STREET GROUP, LLC | Sold out | -725.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -676.1k |
| HRT FINANCIAL LP | Sold out | -657.9k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -276.8k |
| CITADEL ADVISORS LLC | Reduced | -230.3k |
| XTX Topco Ltd | Reduced | -225.4k |
| WELLINGTON MANAGEMENT GROUP LLP | Sold out | -219.1k |
| BANK OF AMERICA CORP /DE/ | Reduced | -208.9k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -201.3k |
Biggest calls
| GREAT POINT PARTNERS LLC | Unchanged | $1.4m521.3k shares |
| CITADEL ADVISORS LLC | Reduced | $560.2k216.3k shares |
| IMC-Chicago, LLC | Reduced | $231.5k89.4k shares |
| GROUP ONE TRADING LLC | Reduced | $208.8k80.6k shares |
| Walleye Capital LLC | Added | $125.1k48.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $95.1k36.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $33.4k12.9k shares |
| JANE STREET GROUP, LLC | New | $26.7k10.3k shares |
| SUMMIT SECURITIES GROUP LLC | New | $20.9k1.0k shares |
| Strategic Family Wealth Counselors, L.L.C. | Reduced | $15.5k6.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $355.3k137.2k shares |
| CITADEL ADVISORS LLC | Added | $263.4k101.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $135.2k52.2k shares |
| HRT FINANCIAL LP | Reduced | $38.0k15.0k shares |
| IMC-Chicago, LLC | Reduced | $31.6k12.2k shares |
| GROUP ONE TRADING LLC | Reduced | $14.5k5.6k shares |
| Walleye Capital LLC | Reduced | $1.6k600 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.00% of their portfolio | 8.1m $20.9m | Added +446.0k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 4.1m $10.5m | Added +190.6k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 3.0m $7.9m | Reduced -201.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.4m $6.2m | Added +219.2k |
| STATE STREET CORP 0.00% of their portfolio | 1.9m $5.0m | Reduced -2.6m |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 1.1m $2.8m | Added +539.6k |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 963.0k $2.5m | Added +206.2k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 948.6k $2.5m | Added +165.5k |
| Summit Financial, LLC 0.03% of their portfolio | 909.4k $2.4m | Reduced -31.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 890.6k $2.3m | Added +86.2k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 889.5k $2.3m | Added +470.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 784.5k $2.0m | Added +59.3k |
| BARCLAYS PLC 0.00% of their portfolio | 754.2k $2.0m | Added +215.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 734.8k $1.9m | Reduced -21.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 654.3k $1.7m | Reduced -208.9k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 621.5k $1.6m | Reduced -25.7k |
| UBS Group AG 0.00% of their portfolio | 620.4k $1.6m | Added +50.4k |
| Private Advisor Group, LLC 0.01% of their portfolio | 504.0k $1.3m | Added +4.3k |
| LPL Financial LLC 0.00% of their portfolio | 406.1k $1.1m | Reduced -12.5k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 332.6k $861.4k | Added +95.8k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 329.1k $852.4k | Reduced -230.3k |
| PVG ASSET MANAGEMENT CORP 0.49% of their portfolio | 327.3k $847.8k | Reduced -200 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 319.5k $827.6k | Reduced -676.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 288.2k $746.4k | Added +40.4k |
| Apella Capital, LLC 0.01% of their portfolio | 228.0k $617.9k | Added +75.0k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 201.8k $522.7k | Added +63.5k |
| MORGAN STANLEY 0.00% of their portfolio | 195.0k $505.0k | Reduced -162.8k |
| Nuveen, LLC 0.00% of their portfolio | 182.7k $473.2k | Added +13.6k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 157.5k $407.9k | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 146.3k $379.0k | Added +17.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 146.3k $449.1k | Added +31.1k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 123.0k $318.6k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 116.7k $302.2k | Added +37.2k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 115.5k $299.0k | Added +70.6k |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 114.2k $295.9k | Added +45.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 112.0k $290.2k | Added +5.9k |
| Invesco Ltd. 0.00% of their portfolio | 109.9k $284.8k | Added +37.5k |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 102.9k $270.2k | Reduced -4.9k |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 96.9k $251.0k | Added +96.3k |
| ALPS ADVISORS INC 0.00% of their portfolio | 94.1k $243.6k | Added +18.6k |
| Cerity Partners LLC 0.00% of their portfolio | 88.4k $228.8k | Added +74.2k |
| Hikari Power Ltd 0.03% of their portfolio | 85.6k $222.0k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 79.3k $205.5k | Added +4.4k |
| Cetera Investment Advisers 0.00% of their portfolio | 75.1k $194.6k | Added +21.0k |
| SHEETS SMITH WEALTH MANAGEMENT 0.02% of their portfolio | 71.3k $184.6k | Reduced -46.5k |
| 180 WEALTH ADVISORS, LLC 0.02% of their portfolio | 71.0k $184.0k | Reduced -48.4k |
| Mariner, LLC 0.00% of their portfolio | 67.1k $173.9k | Added +14.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 66.7k $173.0k | Added +3.5k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 66.6k $172.6k | Added +4.5k |
| LexAurum Advisors, LLC 0.02% of their portfolio | 65.0k $168.5k | Reduced -2.4k |
| Voleon Capital Management LP 0.00% of their portfolio | 63.5k $164.5k | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 60.5k $156.7k | New |
| FMR LLC 0.00% of their portfolio | 60.0k $155.5k | Added +51.5k |
| Creative Planning 0.00% of their portfolio | 59.8k $154.8k | Reduced -48.6k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 59.1k $153.1k | Reduced -15.3k |
| Abel Hall, LLC 0.03% of their portfolio | 56.8k $147.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 53.7k $139.2k | Added +24.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 51.6k $133.7k | Added +16.2k |
| Geneos Wealth Management Inc. 0.00% of their portfolio | 48.1k $124.6k | Reduced -500 |
| Hayek Kallen Investment Management 0.04% of their portfolio | 47.1k $122.0k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 46.8k $121.6k | Reduced -3.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 42.5k $110.0k | Reduced -7.3k |
| AXQ CAPITAL, LP 0.01% of their portfolio | 40.7k $105.5k | Added +29.3k |
| Snowden Capital Advisors LLC 0.00% of their portfolio | 40.5k $104.9k | Reduced -630 |
| Foster Victor Wealth Advisors, LLC 0.01% of their portfolio | 39.9k $97.0k | Unchanged |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 39.5k $102.3k | Reduced -1.2k |
| Squarepoint Ops LLC 0.00% of their portfolio | 38.4k $99.5k | New |
| Carnegie Investment Counsel 0.00% of their portfolio | 38.2k $99.0k | Reduced -29.4k |
| Opus Capital Group, LLC 0.01% of their portfolio | 37.7k $98.0k | Unchanged |
| NewEdge Advisors, LLC 0.00% of their portfolio | 36.9k $95.5k | Added +157 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 34.5k $89.3k | Reduced -4.2k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 34.1k $88.3k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 32.9k $85.2k | Reduced -15.0k |
| XTX Topco Ltd 0.00% of their portfolio | 32.7k $84.7k | Reduced -225.4k |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 31.1k $77.8k | Added +1.6k |
| Independent Advisor Alliance 0.00% of their portfolio | 30.6k $79.2k | Reduced -8 |
| Forum Financial Management, LP 0.00% of their portfolio | 30.1k $78.0k | Unchanged |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 29.9k $77.4k | Added +14.4k |
| CHOREO, LLC 0.00% of their portfolio | 29.7k $76.9k | Reduced -1.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 29.3k $75.9k | Added +903 |
| MERCER GLOBAL ADVISORS INC /ADV 0.00% of their portfolio | 28.7k $74.4k | Added +13.7k |
| Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio | 27.9k $72.0k | Added +13.0k |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 27.6k $71.4k | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 27.2k $70.5k | Unchanged |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 25.9k $67.0k | Added +1.5k |
| Atria Investments, Inc 0.00% of their portfolio | 25.5k $66.1k | Reduced -7.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 23.5k $60.8k | Added +17.1k |
| Beacon Pointe Advisors, LLC 0.00% of their portfolio | 23.2k $60.0k | Added +185 |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 23.1k $59.8k | Unchanged |
| Jain Global LLC 0.00% of their portfolio | 22.0k $57.0k | New |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 21.5k $55.8k | Reduced -2.1k |
| Dana Investment Advisors, Inc. 0.00% of their portfolio | 20.4k $52.9k | Unchanged |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 20.4k $52.8k | Reduced -22.3k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 20.3k $52.7k | Unchanged |
| Hamilton Point Investment Advisors, LLC 0.01% of their portfolio | 20.3k $52.6k | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 19.4k $50.3k | Added +4.5k |
| Advisory Alpha, LLC 0.00% of their portfolio | 18.8k $48.8k | Added +6.5k |
| StoneX Group Inc. 0.00% of their portfolio | 18.7k $51.4k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 18.2k $47.2k | Unchanged |
| Gladstone Institutional Advisory LLC 0.00% of their portfolio | 17.7k $45.8k | Reduced -54.7k |