Avidity Partners Management LP

DALLAS, TX · CIK 1791827 · 13F filing filed 2026-08-14

SEC-registered investment adviser since 2020 · limited partnership

Assets managed$1.1bn
Staff9 · 7 in investment roles
Main clients (by assets)Private funds 100%
Private funds3 (3 hedge) · $1.1bn gross assets
Form ADV · 2026-03-31SEC adviser record

Legal entityAVIDITY PARTNERS MANAGEMENT LP (US)

$624.4m reported value -33.3% vs Q1 2026

45positions

81.9%in top 10

9 new 4 added 27 reduced 16 sold out vs Q1 2026

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	DIANTHUS THERAPEUTICS INC COM DNTH	DNTH	2,104,184	$205.1m32.85%	32.85%	Reduced -2.1m	-2,104,184 -50.0%
2	CG ONCOLOGY INC COM CGON	CGON	1,398,948	$99.4m15.92%	15.92%	Added +110.0k	+110,000 8.5%
3	ORUKA THERAPEUTICS INC COM ORKA	ORKA	760,424	$72.4m11.59%	11.59%	Reduced -760.4k	-760,424 -50.0%
4	JADE BIOSCIENCES INC COM NEW JBIO	JBIO	1,700,708	$37.8m6.05%	6.05%	Reduced -1.1m	-1,100,708 -39.3%
5	ENLIVEN THERAPEUTICS INC COM ELVN	ELVN	550,000	$27.9m4.47%	4.47%	Reduced -250.0k	-250,000 -31.2%
6	PERSPECTIVE THERAPEUTICS INC COM NEW CATX	CATX	6,299,999	$21.5m3.44%	3.44%	Reduced -5.8m	-5,799,999 -47.9%
7	AKTIS ONCOLOGY INC COM AKTS	AKTS	484,200	$15.6m2.50%	2.50%	Reduced -452.9k	-452,932 -48.3%
8	PALVELLA THERAPEUTICS INC NE COM PVLA	PVLA	70,000	$10.7m1.71%	1.71%	Reduced -70.0k	-70,000 -50.0%
9	MOBIA MED INC COMMON STOCK MOBI	MOBI	798,282	$10.7m1.71%	1.71%	New
10	REPLIGEN CORP COM RGEN	RGEN	77,800	$10.6m1.70%	1.70%	Reduced -77.8k	-77,800 -50.0%
11	IMMUNIC INC COM NEW IMUX	IMUX	669,941	$10.3m1.65%	1.65%	New
12	SENSEONICS HLDGS INC COM SENS	SENS	1,600,000	$9.1m1.46%	1.46%	New
13	KARYOPHARM THERAPEUTICS INC COM NEW KPTI	KPTI	924,487	$9.0m1.45%	1.45%	Reduced -3.0k	-2,995 -0.3%
14	TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS SPONSORED ADS		200,000	$6.8m1.09%	1.09%	Reduced -450.1k	-450,100 -69.2%
15	DEXCOM INC COM DXCM	DXCM	100,000	$6.7m1.08%	1.08%	Reduced -90.0k	-90,000 -47.4%
16	TEMPUS AI INC CL A TEM	TEM	105,000	$6.1m0.97%	0.97%	Added +15.0k	+15,000 16.7%
17	MEDTRONIC PLC SHS MDT	MDT	70,000	$5.5m0.88%	0.88%	Reduced -130.0k	-130,000 -65.0%
18	VIR BIOTECHNOLOGY INC COM VIR	VIR	519,300	$5.3m0.85%	0.85%	Reduced -1.1m	-1,050,000 -66.9%
19	STRUCTURE THERAPEUTICS INC SPONSORED ADS GPCR	GPCR	98,000	$5.3m0.84%	0.84%	Added +20.0k	+20,000 25.6%
20	ENCOMPASS HEALTH CORP COM EHC	EHC	42,000	$4.2m0.68%	0.68%	Reduced -42.0k	-42,000 -50.0%
21	TENAX THERAPEUTICS INC COM NEW TENX	TENX	265,934	$3.9m0.62%	0.62%	Reduced -215.9k	-215,934 -44.8%
22	NUVECTIS PHARMA INC COM NVCT	NVCT	200,000	$3.7m0.59%	0.59%	New
23	INSULET CORP COM PODD	PODD	24,000	$3.7m0.59%	0.59%	Added +14.0k	+14,000 140.0%
24	BOSTON SCIENTIFIC CORP COM BSX	BSX	80,000	$3.4m0.55%	0.55%	Reduced -40.0k	-40,000 -33.3%
25	SATELLOS BIOSCIENCE INC COM MSLE	MSLE	387,769	$3.0m0.48%	0.48%	Reduced -387.8k	-387,769 -50.0%
26	ALAMAR BIOSCIENCES INC COMMON STOCK ALMR	ALMR	110,000	$3.0m0.48%	0.48%	New
27	CONTEXT THERAPEUTICS INC COM CNTX	CNTX	4,998,267	$2.8m0.44%	0.44%	Reduced -5.0m	-4,998,267 -50.0%
28	GILEAD SCIENCES INC COM GILD	GILD	20,000	$2.5m0.40%	0.40%	Reduced -20.0k	-20,000 -50.0%
29	CHARLES RIV LABS INTL INC COM CRL	CRL	10,000	$2.3m0.36%	0.36%	Unchanged
30	PHATHOM PHARMACEUTICALS INC COM PHAT	PHAT	200,000	$2.2m0.35%	0.35%	Reduced -298.8k	-298,780 -59.9%
31	AVALYN PHARMACEUTICALS INC COM SHS AVLN	AVLN	60,000	$2.0m0.32%	0.32%	New
32	KAILERA THERAPEUTICS INC COMMON STOCK KLRA	KLRA	80,000	$1.8m0.28%	0.28%	New
33	GENMAB A/S SPONSORED ADS GMAB	GMAB	50,000	$1.4m0.22%	0.22%	Reduced -50.0k	-50,000 -50.0%
34	INTELLIA THERAPEUTICS INC COM NTLA	NTLA	75,000	$1.3m0.20%	0.20%	Reduced -75.0k	-75,000 -50.0%
35	CORVUS PHARMACEUTICALS INC COM CRVS	CRVS	80,000	$1.2m0.19%	0.19%	Reduced -150.0k	-150,000 -65.2%
36	ODDITY TECH LTD SHS CL A ODD	ODD	70,000	$1.1m0.17%	0.17%	Reduced -70.0k	-70,000 -50.0%
37	SCYNEXIS INC COM SCYX	SCYX	260,206	$1.1m0.17%	0.17%	New
38	EVOMMUNE INC COM SHS EVMN	EVMN	75,000	$996.8k0.16%	0.16%	New
39	ABBOTT LABS COM ABT	ABT	10,000	$907.4k0.15%	0.15%	Unchanged
40	BRIDGEBIO PHARMA INC COM BBIO	BBIO	10,000	$744.8k0.12%	0.12%	Unchanged
41	PELOTON INTERACTIVE INC CL A COM PTON	PTON	100,000	$591.0k0.09%	0.09%	Reduced -300.0k	-300,000 -75.0%
42	LEGEND BIOTECH CORP SPONSORED ADS LEGN	LEGN	15,000	$433.2k0.07%	0.07%	Unchanged
43	BRIDGEBIO ONCOLOGY THERAPEUT COM NEW BBOT	BBOT	43,853	$334.2k0.05%	0.05%	Reduced -43.9k	-43,853 -50.0%
44	SAVARA INC COM SVRA	SVRA	50,000	$308.0k0.05%	0.05%	Unchanged
45	TREVI THERAPEUTICS INC COM TRVI	TRVI	6,660	$124.2k0.02%	0.02%	Reduced -6.7k	-6,660 -50.0%

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
IMMUNIC INC		7,369,352	$13.9m7.4m shares
HUMANA INC HUM	HUM	25,000	$5.9m25.0k shares
SCYNEXIS INC		4,163,320	$3.8m4.2m shares
ICON PLC ICLR	ICLR	32,000	$3.7m32.0k shares
NATERA INC NTRA	NTRA	18,000	$3.7m18.0k shares
HIMS & HERS HEALTH INC HIMS	HIMS	125,000	$2.9m125.0k shares
CORCEPT THERAPEUTICS INC CORT	CORT	60,000	$2.6m60.0k shares
CENTENE CORP DEL CNC	CNC	70,000	$2.3m70.0k shares
ANTERIS TECHNOLOGIES GLOBAL AVR	AVR	300,000	$1.8m300.0k shares
MOONLAKE IMMUNOTHERAPEUTICS MLTX	MLTX	100,000	$1.8m100.0k shares
KENVUE INC KVUE	KVUE	100,000	$1.7m100.0k shares
REVOLUTION MEDICINES INC RVMD	RVMD	15,000	$1.5m15.0k shares
ABIVAX SA ABVX	ABVX	10,000	$1.1m10.0k shares
ARBUTUS BIOPHARMA CORP ABUS	ABUS	250,000	$1.1m250.0k shares
UNITEDHEALTH GROUP INC UNH	UNH	3,800	$1.0m3.8k shares
ACADIA PHARMACEUTICALS INC ACAD	ACAD	25,934	$579.8k25.9k shares

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
IMMUNIC INC 13G · filed 2026-04-17		9.9%	+5.1 pts	13G	2026-04-17
CONTEXT THERAPEUTICS INC CNTX · 13G · filed 2026-05-12	CNTX	8.7%≈ $4.6m	-1.2 pts	13G	2026-05-12
PERSPECTIVE THERAPEUTICS INC CATX · 13G · filed 2026-03-10	CATX	5.3%≈ $20.6m	+1.1 pts	13G	2026-03-10