REPLIGEN CORP RGEN
COM · Common Stock · CUSIP 759916109 · ISIN US7599161095
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersWaltham, MA
- Founded1981
- Websiterepligen.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.4m this quarter). Holder counts are more reliable. Shares outstanding: 56.4m as of 2026-07-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $136.24. Options: 9 managers hold calls ($36.9m notional), 9 hold puts ($67.3m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 434 |
| Q4 2022 | 443 |
| Q1 2023 | 448 |
| Q2 2023 | 448 |
| Q3 2023 | 440 |
| Q4 2023 | 467 |
| Q1 2024 | 487 |
| Q2 2024 | 455 |
| Q3 2024 | 445 |
| Q4 2024 | 432 |
| Q1 2025 | 443 |
| Q2 2025 | 449 |
| Q3 2025 | 454 |
| Q4 2025 | 475 |
| Q1 2026 | 445 |
| Q2 2026 | 480 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 226 | 238 |
| Q4 2024 | 179 | 226 |
| Q1 2025 | 226 | 174 |
| Q2 2025 | 199 | 243 |
| Q3 2025 | 237 | 216 |
| Q4 2025 | 225 | 206 |
| Q1 2026 | 228 | 222 |
| Q2 2026 | 264 | 199 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $45.8m | $90.6m | 1.98 |
| Q4 2025 | $33.6m | $66.7m | 1.98 |
| Q1 2026 | $24.5m | $45.7m | 1.87 |
| Q2 2026 | $36.9m | $67.3m | 1.82 |
Biggest buyers
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | New | +788.6k |
| AMERIPRISE FINANCIAL INC | Added | +650.9k |
| Holocene Advisors, LP | Added | +583.3k |
| MAVERICK CAPITAL LTD | Added | +465.7k |
| FMR LLC | Added | +439.9k |
| WASATCH ADVISORS LP | Added | +346.7k |
| GOLDMAN SACHS GROUP INC | Added | +314.1k |
| JPMORGAN CHASE & CO | Added | +299.5k |
| FRED ALGER MANAGEMENT, LLC | Added | +299.0k |
| MARSHALL WACE, LLP | New | +282.1k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -3.1m |
| CITADEL ADVISORS LLC | Reduced | -722.9k |
| BlackRock, Inc. | Reduced | -608.1k |
| Vestal Point Capital, LP | Reduced | -525.0k |
| Point72 Asset Management, L.P. | Reduced | -403.3k |
| Champlain Investment Partners, LLC | Reduced | -374.9k |
| FRANKLIN RESOURCES INC | Reduced | -302.9k |
| Artemis Investment Management LLP | Reduced | -300.1k |
| Blue Whale Capital LLP | Reduced | -225.8k |
| Artisan Partners Limited Partnership | Sold out | -190.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $26.5m194.1k shares |
| CITADEL ADVISORS LLC | Added | $5.4m39.8k shares |
| JANE STREET GROUP, LLC | New | $1.7m12.8k shares |
| IMC-Chicago, LLC | Added | $1.6m11.8k shares |
| NOMURA HOLDINGS INC | New | $777.7k5.7k shares |
| HARVEST MANAGEMENT LLC | New | $723.1k5.3k shares |
| Walleye Trading LLC | New | $136.4k1.0k shares |
| Raiffeisen Bank International AG | Unchanged | $27.3k200 shares |
| Walleye Capital LLC | New | $13.6k100 shares |
Biggest puts
| JANE STREET GROUP, LLC | Added | $35.4m259.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $20.5m150.3k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $3.7m27.0k shares |
| Caption Management, LLC | New | $3.2m23.4k shares |
| IMC-Chicago, LLC | Reduced | $2.3m16.5k shares |
| CITADEL ADVISORS LLC | Reduced | $1.5m11.0k shares |
| SIMPLEX TRADING, LLC | Added | $627.6k4.6k shares |
| Walleye Capital LLC | New | $81.9k600 shares |
| Walleye Trading LLC | New | $40.9k300 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution +7.9 pts · filed 2026-10-07 | 13.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-24 | 9.3% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-07-31 | 5.0% |
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (3.1%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC), Roy T. Eddleman Living Trust (4.8%, 2026-02-13)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 1 | $3.4m | — |
| Q1 2025 | 1 | $37.7k | 1 | $4.1m | $4.1m |
| Q2 2025 | 0 | — | 1 | $3.3m | $3.3m |
| Q3 2025 | 1 | $201.8k | 1 | $3.5m | — |
| Q4 2025 | 0 | — | 4 | $8.6m | $5.1m |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 2 | $642.8k | $642.8k |
| Q3 2026 | 0 | — | 2 | $5.0m | $5.0m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-24 | Loeillot Olivier Chief Executive Officer, director | Sold plan | $2.5m12.9k shares |
| 2026-09-21 | Loeillot Olivier Chief Executive Officer, director | Sold plan | $976.7k5.4k shares |
| 2026-09-04 | Loeillot Olivier Chief Executive Officer, director | Sold plan | $503.5k3.0k shares |
| 2026-08-20 | Loeillot Olivier Chief Executive Officer, director | Sold plan | $976.7k5.4k shares |
| 2026-07-16 | Garland Jason K CFO | Sold plan | $79.5k530 shares |
| 2026-06-25 | Garland Jason K CFO | Sold plan | $106.3k733 shares |
| 2026-04-21 | Loeillot Olivier Chief Executive Officer, director | Sold plan | $536.5k3.8k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| BlackRock, Inc. 0.01% of their portfolio | 5.4m $734.7m | Reduced -608.1k |
| FMR LLC 0.02% of their portfolio | 3.3m $453.9m | Added +439.9k |
| UNITED CAPITAL FINANCIAL ADVISORS, LLC 2.10% of their portfolio | 2.8m $380.8m | Added +16.7k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 2.4m $329.0m | Added +14.7k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio | 2.3m $315.6m | Added +7.7k |
| MAVERICK CAPITAL LTD 2.44% of their portfolio | 2.0m $270.8m | Added +465.7k |
| STATE STREET CORP 0.01% of their portfolio | 1.8m $245.7m | Added +23.2k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio | 1.8m $239.1m | Reduced -3.1m |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.07% of their portfolio | 1.6m $220.6m | Added +219.5k |
| WASATCH ADVISORS LP 1.42% of their portfolio | 1.6m $217.0m | Added +346.7k |
| AMERIPRISE FINANCIAL INC 0.04% of their portfolio | 1.6m $215.0m | Added +650.9k |
| Bank of New York Mellon Corp 0.03% of their portfolio | 1.5m $207.8m | Reduced -8.5k |
| T. Rowe Price Investment Management, Inc. 0.13% of their portfolio | 1.4m $192.6m | Added +44.9k |
| Invesco Ltd. 0.01% of their portfolio | 1.4m $189.3m | Added +109.0k |
| Holocene Advisors, LP 0.40% of their portfolio | 1.3m $176.3m | Added +583.3k |
| RTW INVESTMENTS, LP 1.45% of their portfolio | 1.2m $169.3m | Added +34.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 1.1m $145.0m | Reduced -2.0k |
| CONGRESS ASSET MANAGEMENT CO 0.85% of their portfolio | 1.0m $138.1m | Added +214.4k |
| Conestoga Capital Advisors, LLC 2.91% of their portfolio | 981.0k $133.8m | Reduced -116.8k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 965.4k $131.7m | Added +314.1k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 949.9k $129.6m | Added +95.1k |
| Stephens Investment Management Group LLC 1.37% of their portfolio | 937.1k $127.9m | Added +181.5k |
| FRANKLIN RESOURCES INC 0.03% of their portfolio | 890.2k $121.5m | Reduced -302.9k |
| ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio | 795.3k $93.7m | Reduced -36.5k |
| UBS Group AG 0.02% of their portfolio | 795.0k $108.5m | Added +124.7k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.32% of their portfolio | 788.6k $107.6m | New |
| BAMCO INC /NY/ 0.15% of their portfolio | 748.5k $102.1m | Added +200.1k |
| FRED ALGER MANAGEMENT, LLC 0.33% of their portfolio | 733.7k $100.1m | Added +299.0k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.07% of their portfolio | 696.2k $95.0m | Added +176.1k |
| GENEVA CAPITAL MANAGEMENT LLC 2.05% of their portfolio | 656.1k $89.5m | Reduced -37.6k |
| FIRST TRUST ADVISORS LP 0.05% of their portfolio | 634.2k $86.5m | Added +4.1k |
| NORGES BANK 0.01% of their portfolio | 575.2k $78.5m | Not comparable |
| VOYA INVESTMENT MANAGEMENT LLC 0.06% of their portfolio | 549.2k $74.9m | Reduced -73.7k |
| MORGAN STANLEY 0.00% of their portfolio | 543.2k $74.1m | Reduced -140.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 481.7k $65.7m | Added +28.7k |
| TimesSquare Capital Management, LLC 0.90% of their portfolio | 447.0k $61.0m | Reduced -9.1k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 444.1k $60.6m | Reduced -600 |
| Thrivent Financial for Lutherans 0.10% of their portfolio | 436.9k $59.6m | Added +11.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 427.8k $58.9m | Added +299.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 426.3k $58.2m | Added +48.1k |
| Jupiter Topco LLC 0.02% of their portfolio | 406.0k $55.4m | First filing |
| Vestal Point Capital, LP 1.28% of their portfolio | 400.0k $54.6m | Reduced -525.0k |
| Impax Asset Management Group plc 0.35% of their portfolio | 396.5k $54.1m | Reduced -42.0k |
| CITADEL ADVISORS LLC 0.03% of their portfolio | 376.3k $51.3m | Reduced -722.9k |
| SEI INVESTMENTS CO 0.04% of their portfolio | 373.3k $50.9m | Added +101.2k |
| AMERICAN CAPITAL MANAGEMENT INC 2.21% of their portfolio | 361.1k $49.3m | Added +3.3k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.05% of their portfolio | 356.9k $48.7m | Reduced -20.1k |
| DF DENT & CO INC 0.92% of their portfolio | 356.9k $48.7m | Reduced -8.3k |
| Balyasny Asset Management L.P. 0.09% of their portfolio | 355.5k $48.5m | Added +230.0k |
| VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio | 336.3k $45.9m | Added +5.5k |
| Granahan Investment Management, LLC 1.62% of their portfolio | 332.3k $45.3m | Added +245.3k |
| PRIMECAP MANAGEMENT CO/CA/ 0.03% of their portfolio | 323.3k $44.1m | Added +88.2k |
| Champlain Investment Partners, LLC 1.12% of their portfolio | 319.0k $43.5m | Reduced -374.9k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.26% of their portfolio | 290.6k $39.6m | Added +205.5k |
| MARSHALL WACE, LLP 0.03% of their portfolio | 282.1k $38.5m | New |
| 12 West Capital Management LP 7.15% of their portfolio | 280.2k $38.2m | Added +88.9k |
| Daiwa Securities Group Inc. 0.08% of their portfolio | 266.0k $36.3m | Added +26.1k |
| PERCEPTIVE ADVISORS LLC 0.53% of their portfolio | 248.2k $33.9m | Reduced -32.3k |
| LMR Partners LLP 0.23% of their portfolio | 228.6k $31.2m | Reduced -24.5k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 213.0k $29.1m | Reduced -22.4k |
| NZS Capital, LLC 0.73% of their portfolio | 205.3k $28.0m | Added +2.0k |
| BRADLEY FOSTER & SARGENT INC/CT 0.38% of their portfolio | 195.4k $26.7m | New |
| Blue Whale Capital LLP 0.77% of their portfolio | 178.4k $24.3m | Reduced -225.8k |
| BRAIDWELL LP 0.89% of their portfolio | 177.1k $24.2m | Added +129.6k |
| BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio | 176.8k $24.1m | Reduced -679 |
| ROYCE & ASSOCIATES LP 0.19% of their portfolio | 174.8k $23.8m | Added +58.9k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 172.8k $23.6m | Added +4.0k |
| RIVERBRIDGE PARTNERS LLC 0.66% of their portfolio | 172.5k $23.5m | Reduced -86.0k |
| SEGALL BRYANT & HAMILL, LLC 0.27% of their portfolio | 169.8k $23.2m | Added +14.8k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.03% of their portfolio | 168.3k $23.0m | Reduced -13.1k |
| Point72 Asset Management, L.P. 0.03% of their portfolio | 166.2k $22.7m | Reduced -403.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 161.7k $22.1m | Reduced -2.0k |
| FIFTH THIRD BANCORP 0.03% of their portfolio | 157.4k $21.5m | Reduced -3.6k |
| BARCLAYS PLC 0.01% of their portfolio | 155.7k $21.2m | Reduced -38.3k |
| Allspring Global Investments Holdings, LLC 0.03% of their portfolio | 153.1k $21.3m | Reduced -127.4k |
| LOOMIS SAYLES & CO L P 0.03% of their portfolio | 148.7k $20.3m | Reduced -3.9k |
| Baird Financial Group, Inc. 0.03% of their portfolio | 144.6k $19.7m | Reduced -27.1k |
| Gotham Asset Management, LLC 0.05% of their portfolio | 142.6k $19.5m | Added +113.9k |
| Assenagon Asset Management S.A. 0.01% of their portfolio | 142.0k $19.4m | New |
| BROWN CAPITAL MANAGEMENT LLC 3.84% of their portfolio | 140.9k $19.2m | Reduced -29.1k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 140.4k $19.2m | Added +12.5k |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.06% of their portfolio | 134.6k $18.4m | Unchanged |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 134.4k $18.3m | Reduced -2.0k |
| Curi Capital, LLC 0.27% of their portfolio | 125.7k $17.1m | Added +7.0k |
| Artemis Investment Management LLP 0.15% of their portfolio | 121.7k $16.6m | Reduced -300.1k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 120.4k $16.4m | Reduced -39.4k |
| Nuveen, LLC 0.00% of their portfolio | 117.5k $16.0m | Added +12.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.02% of their portfolio | 117.1k $16.0m | Reduced -59.2k |
| OSAIC HOLDINGS, INC. 0.02% of their portfolio | 115.1k $15.7m | Added +28.9k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 111.8k $15.2m | Reduced -38.1k |
| OSTERWEIS CAPITAL MANAGEMENT INC 0.71% of their portfolio | 111.0k $15.1m | Added +18.8k |
| PALISADE CAPITAL MANAGEMENT, LP 0.65% of their portfolio | 109.8k $15.0m | Reduced -130.9k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 109.4k $14.9m | Added +9.7k |
| Swiss National Bank 0.01% of their portfolio | 104.7k $14.3m | Reduced -1.1k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.09% of their portfolio | 100.0k $13.7m | Unchanged |
| LORD, ABBETT & CO. LLC 0.04% of their portfolio | 98.0k $13.4m | Added +9.6k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.40% of their portfolio | 90.0k $12.3m | New |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 83.3k $11.4m | New |
| Freshford Capital Management, LLC 3.69% of their portfolio | 79.0k $10.8m | New |
| Avidity Partners Management LP 1.70% of their portfolio | 77.8k $10.6m | Reduced -77.8k |