Sio Capital Management, LLC

NEW YORK, NY · CIK 1482416 · 13F filing filed 2026-08-14

No investment adviser registration (Form ADV) found for this filer. It may be a parent company whose subsidiaries are the registered advisers, a bank or insurer, or a manager based outside the US.

Legal entitySIO CAPITAL MANAGEMENT, LLC (US)

$583.5m reported value -15.9% vs Q1 2026

57positions

50.1%in top 10

15 new 10 added 21 reduced 31 sold out vs Q1 2026

Options: 1 call positions ($2.6m notional), 1 put positions ($18.2m notional) – listed below, not included above.

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	ANTERIS TECHNOLOGIES GLOBAL COM AVR	AVR	5,545,984	$54.6m9.36%	9.36%	Added +163.0k	+163,019 3.0%
2	CENCORA INC COM COR	COR	173,588	$49.1m8.42%	8.42%	Added +72.7k	+72,694 72.0%
3	MAXIMUS INC COM MMS	MMS	715,267	$38.5m6.59%	6.59%	Reduced -53.6k	-53,558 -7.0%
4	ALLOGENE THERAPEUTICS INC COM ALLO	ALLO	13,323,431	$27.7m4.75%	4.75%	New
5	GLOBUS MED INC CL A GMED	GMED	301,816	$23.8m4.09%	4.09%	New
6	GSK PLC SPONSORED ADR GSK	GSK	436,700	$22.9m3.92%	3.92%	Added +50.8k	+50,821 13.2%
7	TYRA BIOSCIENCES INC COM TYRA	TYRA	695,315	$22.2m3.81%	3.81%	Added +89.9k	+89,876 14.8%
8	WAYSTAR HLDG CORP COM WAY	WAY	925,834	$19.0m3.26%	3.26%	Reduced -716.4k	-716,402 -43.6%
9	IDEAYA BIOSCIENCES INC COM IDYA	IDYA	480,383	$17.9m3.07%	3.07%	New
10	ORUKA THERAPEUTICS INC COM ORKA	ORKA	177,118	$16.9m2.89%	2.89%	Added +44.6k	+44,622 33.7%
11	THE CIGNA GROUP COM CI	CI	57,750	$15.9m2.73%	2.73%	New
12	SANOFI SPONSORED ADR SNY	SNY	364,200	$15.5m2.66%	2.66%	Added +124.5k	+124,529 52.0%
13	ICON PLC SHS ICLR	ICLR	88,186	$15.3m2.63%	2.63%	Reduced -218.2k	-218,172 -71.2%
14	VIATRIS INC COM VTRS	VTRS	954,299	$15.2m2.60%	2.60%	New
15	CROSS CTRY HEALTHCARE INC COM CCRN	CCRN	1,098,393	$14.5m2.49%	2.49%	Unchanged
16	RAPPORT THERAPEUTICS INC COM RAPP	RAPP	307,657	$12.8m2.20%	2.20%	Reduced -59.2k	-59,152 -16.1%
17	ABBOTT LABS COM ABT	ABT	128,656	$11.7m2.00%	2.00%	Reduced -57.9k	-57,918 -31.0%
18	CELCUITY INC COM CELC	CELC	110,022	$11.5m1.97%	1.97%	Reduced -83.8k	-83,821 -43.2%
19	ZIMMER BIOMET HOLDINGS INC COM ZBH	ZBH	131,445	$11.3m1.94%	1.94%	Added +68.8k	+68,832 109.9%
20	REGENERON PHARMACEUTICALS COM REGN	REGN	18,000	$11.2m1.92%	1.92%	New
21	BRISTOL-MYERS SQUIBB CO COM BMY	BMY	193,500	$11.1m1.91%	1.91%	New
22	MEDTRONIC PLC SHS MDT	MDT	142,500	$11.1m1.91%	1.91%	New
23	VIR BIOTECHNOLOGY INC COM VIR	VIR	1,075,274	$11.0m1.88%	1.88%	Reduced -423.3k	-423,346 -28.2%
24	SENSEONICS HLDGS INC COM SENS	SENS	1,592,692	$9.0m1.55%	1.55%	Added +1.5m	+1,476,908 1275.6%
25	EYEPOINT PHARMACEUTICALS INC COM NEW EYPT	EYPT	623,130	$8.9m1.53%	1.53%	Reduced -98.7k	-98,655 -13.7%
26	CYBIN INC COM NEW COM NEW		1,300,000	$8.6m1.47%	1.47%	New
27	ANI PHARMACEUTICALS INC COM ANIP	ANIP	97,305	$8.1m1.38%	1.38%	Reduced -168.2k	-168,238 -63.4%
28	PROTARA THERAPEUTICS INC COM STK TARA	TARA	1,921,872	$7.3m1.26%	1.26%	Reduced -48.0k	-47,967 -2.4%
29	RELMADA THERAPEUTICS INC COM RLMD	RLMD	1,003,562	$6.9m1.19%	1.19%	Added +38.6k	+38,562 4.0%
30	TANGO THERAPEUTICS INC COM TNGX	TNGX	208,500	$6.5m1.12%	1.12%	New
31	AQUESTIVE THERAPEUTICS INC COM AQST	AQST	1,486,175	$6.2m1.06%	1.06%	Reduced -436.7k	-436,712 -22.7%
32	DIANTHUS THERAPEUTICS INC COM DNTH	DNTH	59,254	$5.8m0.99%	0.99%	Reduced -310.8k	-310,791 -84.0%
33	SIONNA THERAPEUTICS INC COM SION	SION	127,808	$5.6m0.96%	0.96%	Reduced -166.5k	-166,532 -56.6%
34	OCULAR THERAPEUTIX INC COM OCUL	OCUL	539,493	$5.3m0.91%	0.91%	Reduced -429.1k	-429,104 -44.3%
35	ZENAS BIOPHARMA INC COM ZBIO	ZBIO	208,557	$5.3m0.91%	0.91%	Reduced -123.2k	-123,173 -37.1%
36	BRIGHT MINDS BIOSCIENCES INC COM NEW DRUG	DRUG	73,952	$5.2m0.89%	0.89%	Reduced -12.1k	-12,131 -14.1%
37	ONKURE THERAPEUTICS INC COM CL A OKUR	OKUR	1,078,965	$4.9m0.84%	0.84%	Unchanged
38	SAVARA INC COM SVRA	SVRA	617,675	$3.8m0.65%	0.65%	Added +3.8k	+3,787 0.6%
39	PMV PHARMACEUTICALS INC COM PMVP	PMVP	2,634,137	$3.5m0.60%	0.60%	Reduced -442.4k	-442,443 -14.4%
40	AVEANNA HEALTHCARE HLDGS INC COM AVAH	AVAH	369,036	$3.2m0.54%	0.54%	New
41	OVID THERAPEUTICS INC COM OVID	OVID	1,005,334	$2.7m0.46%	0.46%	Reduced -247.0k	-247,047 -19.7%
42	IMMUNOME INC COM IMNM	IMNM	124,168	$2.6m0.45%	0.45%	Reduced -40.9k	-40,942 -24.8%
43	AN2 THERAPEUTICS INC COM ANTX	ANTX	529,933	$2.6m0.44%	0.44%	Reduced -127.3k	-127,267 -19.4%
44	SERINA THERAPEUTICS INC COM SHS SER	SER	1,000,000	$1.9m0.33%	0.33%	Unchanged
45	ALIGOS THERAPEUTICS INC COM NEW ALGS	ALGS	327,237	$1.9m0.32%	0.32%	Unchanged
46	IBIO INC COM NEW IBIO	IBIO	904,268	$1.6m0.27%	0.27%	Unchanged
47	XILIO THERAPEUTICS INC COM XLO	XLO	152,464	$1.5m0.25%	0.25%	Unchanged
48	ARTIVION INC COM AORT	AORT	48,481	$1.1m0.19%	0.19%	New
49	BRIDGEBIO ONCOLOGY THERAPEUT COM NEW BBOT	BBOT	130,628	$995.4k0.17%	0.17%	Unchanged
50	TELA BIO INC COM TELA	TELA	636,300	$477.2k0.08%	0.08%	Unchanged
51	ADAGIO MED HLDGS INC COM ADGM	ADGM	698,989	$455.5k0.08%	0.08%	Reduced -589.5k	-589,472 -45.8%
52	NEUROONE MED TECHNOLOGIES CO COM NMTC	NMTC	82,767	$251.6k0.04%	0.04%	New
53	ENVERIC BIOSCIENCES INC COM SHS ENVB	ENVB	180,000	$248.4k0.04%	0.04%	New
54	MODULAR MED INC COM NEW MODD	MODD	26,190	$117.9k0.02%	0.02%	Unchanged
55	QT IMAGING HLDGS INC COM QTI	QTI	15,236	$62.0k0.01%	0.01%	New
56	ROCKET PHARMACEUTICALS INC W EXP 09/02/202 W EXP 09/02/202		400,000	$1.5k0.00%	0.00%	Unchanged
57	HUMACYTE INC *W EXP 08/27/202 HUMAW	HUMAW	49,998	$4770.00%	0.00%	Unchanged

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
CORCEPT THERAPEUTICS INC CORT	CORT	674,759	$27.2m674.8k shares
LIVANOVA PLC LIVN	LIVN	421,615	$26.8m421.6k shares
EMBECTA CORP EMBC	EMBC	1,847,850	$16.3m1.8m shares
ABIVAX SA ABVX	ABVX	135,800	$15.1m135.8k shares
HAEMONETICS CORP MASS HAE	HAE	220,672	$12.4m220.7k shares
TELEFLEX INCORPORATED TFX	TFX	94,800	$11.3m94.8k shares
BIOMARIN PHARMACEUTICAL INC BMRN	BMRN	194,226	$11.0m194.2k shares
STRUCTURE THERAPEUTICS INC GPCR	GPCR	209,093	$10.1m209.1k shares
BIOHAVEN LTD BHVN	BHVN	1,163,926	$9.8m1.2m shares
MONOPAR THERAPEUTICS INC MNPR	MNPR	173,506	$9.5m173.5k shares
CRINETICS PHARMACEUTICALS IN CRNX	CRNX	249,887	$9.1m249.9k shares
EDGEWISE THERAPEUTICS INC EWTX	EWTX	268,986	$8.5m269.0k shares
COMPASS PATHWAYS PLC CMPS	CMPS	1,506,525	$8.3m1.5m shares
QUIDELORTHO CORP QDEL	QDEL	359,011	$5.9m359.0k shares
REPLIMUNE GROUP INC REPL	REPL	720,036	$5.5m720.0k shares
ORGANON & CO OGN	OGN	865,908	$5.2m865.9k shares
DISC MEDICINE INC IRON	IRON	65,203	$4.2m65.2k shares
INTEGRA LIFESCIENCES HLDGS C IART	IART	383,140	$3.6m383.1k shares
PROQR THRAPEUTICS N V PRQR	PRQR	1,954,715	$3.2m2.0m shares
SHOULDER INNOVATIONS INC SI	SI	210,641	$3.1m210.6k shares
KYMERA THERAPEUTICS INC KYMR	KYMR	32,235	$2.7m32.2k shares
CONTEXT THERAPEUTICS INC CNTX	CNTX	917,922	$2.4m917.9k shares
HYPERFINE INC HYPR	HYPR	1,000,000	$1.1m1.0m shares
FOGHORN THERAPEUTICS INC FHTX	FHTX	122,889	$587.4k122.9k shares
TERNS PHARMACEUTICALS INC		10,100	$532.5k10.1k shares

Options (notional value)

Underlying	Ticker	Type	Shares controlled	Notional	Change
SELLAS LIFE SCIENCES GROUP I SLS · Put	SLS	Put	1,230,700	$18.2m1.2m shares	New
HIMS & HERS HEALTH INC HIMS · Call	HIMS	Call	75,000	$2.6m75.0k shares	New

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
SERINA THERAPEUTICS INC SER · 13G · filed 2026-05-04	SER	6.7%≈ $1.9m	new	13G	2026-05-04
ANTERIS TECHNOLOGIES GLOBAL AVR · 13G · filed 2026-05-04	AVR	5.5%≈ $53.0m	+0.6 pts	13G	2026-05-04
ALIGOS THERAPEUTICS INC ALGS · 13G · filed 2026-02-11	ALGS	5.5%≈ $1.9m	no change	13G	2026-02-11
APREA THERAPEUTICS INC 13G · filed 2025-02-10		5.1%		13G	2025-02-10