5AM Venture Management, LLC

SAN FRANCISCO, CA · CIK 1799883 · 13F filing filed 2026-08-14

SEC-registered investment adviser since 2021 · limited liability company

Assets managed$1.1bn
Staff32 · 18 in investment roles
Main clients (by assets)Private funds 100%
Private funds12 (1 hedge) · $947.0m gross assets
Website5amventures.com
Form ADV · 2026-03-30SEC adviser record

Kindhedge funds, private equity, venture, futures
Others nearbySan Francisco, CA, Boston, MA, New York, NY

As an employer

Offices in1 country
Private fundsventure capital 9, private equity 2, hedge 1

Where they work

people there (dot area)number not reportedmain officeHover or tap a dot. Australian and UK companies are placed at their business or registered address, with their staff across the whole country.

Offices

From Form ADV: the main office and the other offices where it does advisory work (at most the 25 largest), with the people doing investment work at each. “About” is worked out: the firm's investment staff less its other offices. Each city links to the other managers there.

City	Country	People
San Francisco, CA (main office)United States	United States	about 8
Boston, MAUnited States	United States	7
New York, NYUnited States	United States	3

US visa salary filings

Filings FY20251
Median salary offered$350,000
Middle half$350,000 – $350,000
Job titles1

Job title	Filings	Median	Range
Senior Research AnalystNew York, NY	1	$350,000

Source: US Department of Labor, Labor Condition Application disclosure data (certified, full-time, yearly equivalent). These are the salaries the employer committed to pay the visa roles it filed for, at least the prevailing wage for the job and place; they are not the pay of all its staff. Filed by: 5AM Venture Management, LLC.

Map: places from GeoNames (CC BY 4.0), outlines from Natural Earth.

$287.9m reported value -20.1% vs Q1 2026

16positions

85.6%in top 10

0 new 0 added 1 reduced 4 sold out vs Q1 2026

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	MAPLIGHT THERAPEUTICS INC COM MPLT	MPLT	950,011	$34.0m11.83%	11.83%	Unchanged
2	TYRA BIOSCIENCES INC COM TYRA	TYRA	1,029,298	$32.9m11.42%	11.42%	Unchanged
3	ENTRADA THERAPEUTICS INC COM TRDA	TRDA	4,056,379	$29.9m10.37%	10.37%	Unchanged
4	PHARVARIS N V COM PHVS	PHVS	797,600	$27.6m9.58%	9.58%	Unchanged
5	CAMP4 THERAPEUTICS CORP COM CAMP	CAMP	5,869,091	$25.6m8.91%	8.91%	Unchanged
6	ARTIVA BIOTHERAPEUTICS INC COM ARTV	ARTV	2,353,304	$22.8m7.93%	7.93%	Unchanged
7	TECTONIC THERAPEUTIC INC COM TECX	TECX	606,660	$20.9m7.24%	7.24%	Unchanged
8	ZENTALIS PHARMACEUTICALS INC COM ZNTL	ZNTL	3,947,913	$19.1m6.65%	6.65%	Unchanged
9	CELLDEX THERAPEUTICS INC NEW COM NEW CLDX	CLDX	497,270	$18.5m6.43%	6.43%	Unchanged
10	EYEPOINT PHARMACEUTICALS INC COM NEW EYPT	EYPT	1,050,000	$15.0m5.22%	5.22%	Unchanged
11	BIOHAVEN LTD COM BHVN	BHVN	738,972	$11.0m3.82%	3.82%	Unchanged
12	SURROZEN INC COM NEW SRZN	SRZN	271,250	$7.0m2.44%	2.44%	Reduced -116.2k	-116,250 -30.0%
13	SKYE BIOSCIENCE INC COM NEW COM NEW		9,681,763	$6.7m2.33%	2.33%	Unchanged
14	ALX ONCOLOGY HLDGS INC COM ALXO	ALXO	3,057,325	$6.3m2.20%	2.20%	Unchanged
15	PROTARA THERAPEUTICS INC COM STK TARA	TARA	1,369,782	$5.2m1.82%	1.82%	Unchanged
16	SILENCE THERAPEUTICS PLC ADS SLN	SLN	476,200	$5.2m1.82%	1.82%	Unchanged

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
ERASCA INC ERAS	ERAS	3,485,971	$56.4m3.5m shares
CENTESSA PHARMACEUTICALS PLC		580,945	$23.1m580.9k shares
GH RESEARCH PLC GHRS	GHRS	572,665	$8.1m572.7k shares
RALLYBIO CORP RLYB	RLYB	291,788	$2.6m291.8k shares