UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 47.6m as of 2023-05-04, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $20.16. Options: 17 managers hold calls ($31.3m notional), 14 hold puts ($16.9m).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 87 | 83 |
| Q1 2023 | 81 | 90 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $37.4m | $7.5m | 0.20 |
| Q4 2022 | $57.7m | $13.8m | 0.24 |
| Q1 2023 | $31.3m | $16.9m | 0.54 |
Biggest buyers
| FMR LLC | Added | +2.7m |
| Deep Track Capital, LP | New | +865.8k |
| Ghost Tree Capital, LLC | New | +375.0k |
| Nantahala Capital Management, LLC | Added | +370.1k |
| PICTET ASSET MANAGEMENT SA | Added | +353.0k |
| Balyasny Asset Management L.P. | New | +336.1k |
| ORBIMED ADVISORS LLC | Added | +316.9k |
| Schonfeld Strategic Advisors LLC | New | +229.0k |
| Tri Locum Partners LP | New | +227.3k |
| LORD, ABBETT & CO. LLC | Added | +208.3k |
Biggest sellers
| MPM BIOIMPACT LLC | Reduced | -591.7k |
| Point72 Asset Management, L.P. | Reduced | -528.9k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -399.2k |
| NORGES BANK | Reduced | -235.1k |
| PFM Health Sciences, LP | Reduced | -192.2k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC | Reduced | -153.0k |
| HRT FINANCIAL LP | Sold out | -127.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -126.7k |
| China Universal Asset Management Co., Ltd. | Reduced | -113.9k |
| Granite Point Capital Management, L.P. | Sold out | -84.0k |
Biggest calls
| Nantahala Capital Management, LLC | Reduced | $7.8m387.7k shares |
| Caption Management, LLC | Added | $7.4m366.6k shares |
| SPHERA FUNDS MANAGEMENT LTD. | New | $3.5m175.4k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.0m101.0k shares |
| Parallax Volatility Advisers, L.P. | Added | $1.9m94.2k shares |
| CITADEL ADVISORS LLC | Reduced | $1.7m84.1k shares |
| JANE STREET GROUP, LLC | Reduced | $1.3m66.2k shares |
| CITIGROUP INC | Reduced | $1.1m57.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.1m56.3k shares |
| CAPSTONE INVESTMENT ADVISORS, LLC | Unchanged | $1.0m50.0k shares |
Biggest puts
| Caption Management, LLC | Added | $6.3m314.1k shares |
| UBS Group AG | New | $2.0m100.0k shares |
| JANE STREET GROUP, LLC | New | $1.7m84.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.3m62.4k shares |
| CITADEL ADVISORS LLC | Added | $1.2m61.1k shares |
| CITIGROUP INC | Reduced | $1.1m57.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $710.9k35.3k shares |
| Parallax Volatility Advisers, L.P. | Reduced | $706.9k35.1k shares |
| NOMURA HOLDINGS INC | New | $704.9k35.0k shares |
| GROUP ONE TRADING LLC | Added | $638.4k31.7k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 1 | $542.2k | — |
| Q1 2022 | 0 | — | 11 | $754.9k | — |
| Q2 2022 | 0 | — | 2 | $122.3k | — |
| Q3 2022 | 0 | — | 1 | $1.1m | — |
| Q4 2022 | 0 | — | 6 | $691.3k | — |
| Q1 2023 | 0 | — | 13 | $1.4m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-03-07 | Kapusta Matthew C CEO, Managing Director, director | Sold | $53.9k2.5k shares |
| 2023-03-07 | CALOZ PIERRE Chief Operating Officer | Sold | $21.1k990 shares |
| 2023-03-07 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $21.1k986 shares |
| 2023-03-07 | Dolmetsch Ricardo President, R&D | Sold | $17.6k837 shares |
| 2023-03-07 | Kuta Alexander Edward III Executive VP, Operations | Sold | $12.5k585 shares |
| 2023-02-28 | Kapusta Matthew C CEO, Managing Director, director | Sold | $104.9k5.0k shares |
| 2023-02-28 | Gut Robert Director | Sold | $30.3k1.4k shares |
| 2023-02-28 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $28.6k1.4k shares |
| 2023-02-28 | Kuta Alexander Edward III Executive VP, Operations | Sold | $25.5k1.2k shares |
| 2023-02-27 | Kapusta Matthew C CEO, Managing Director, director | Sold | $388.3k19.5k shares |
| 2023-02-27 | KLEMT CHRISTIAN Chief Financial Officer | Sold | $197.5k9.8k shares |
| 2023-02-27 | Dolmetsch Ricardo President, R&D | Sold | $136.0k6.9k shares |
| 2023-02-27 | Kuta Alexander Edward III Executive VP, Operations | Sold | $110.2k5.5k shares |
| 2023-02-27 | CALOZ PIERRE Chief Operating Officer | Sold | $85.6k4.4k shares |
| 2023-02-27 | Gut Robert Director | Sold | $10.6k537 shares |
| 2023-02-27 | Springhorn Jeremy P. Director | Sold | $7.8k384 shares |
| 2023-02-27 | Jacques Rachelle Suzanne Director | Sold | $7.7k384 shares |
| 2023-02-27 | Kaye Jack Director | Sold | $7.7k384 shares |
| 2023-02-27 | Balachandran Madhavan Director | Sold | $7.7k384 shares |
| 2023-02-27 | POST LEONARD E Director | Sold | $7.7k389 shares |
| 2023-02-27 | Soteropoulos Paula Director | Sold | $7.7k384 shares |
| 2023-02-27 | Meek David D. Director | Sold | $7.7k389 shares |
| 2023-01-18 | Soteropoulos Paula Director | Sold | $135.5k6.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.00% of their portfolio | 5.4m $108.6m | Added +2.7m |
| BlackRock Inc. 0.00% of their portfolio | 4.9m $99.1m | Reduced -58.0k |
| Nantahala Capital Management, LLC 5.93% of their portfolio | 3.1m $61.8m | Added +370.1k |
| STATE STREET CORP 0.00% of their portfolio | 2.8m $57.2m | Added +120.1k |
| PFM Health Sciences, LP 1.96% of their portfolio | 2.1m $42.5m | Reduced -192.2k |
| ORBIMED ADVISORS LLC 0.82% of their portfolio | 2.1m $41.6m | Added +316.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $28.4m | Reduced -1.8k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $23.9m | Added +124.0k |
| Point72 Asset Management, L.P. 0.08% of their portfolio | 1.1m $23.0m | Reduced -528.9k |
| 683 Capital Management, LLC 1.97% of their portfolio | 1.1m $22.0m | Reduced -52.0k |
| Deep Track Capital, LP 0.74% of their portfolio | 865.8k $17.4m | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 738.7k $14.9m | Added +67.4k |
| MACQUARIE GROUP LTD 0.02% of their portfolio | 706.2k $14.2m | Unchanged |
| Tekla Capital Management LLC 0.50% of their portfolio | 652.4k $13.1m | Unchanged |
| Aquilo Capital Management, LLC 7.52% of their portfolio | 637.5k $12.8m | Added +12.7k |
| PICTET ASSET MANAGEMENT SA 0.02% of their portfolio | 634.6k $12.8m | Added +353.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 630.0k $12.7m | Unchanged |
| NORGES BANK 0.00% of their portfolio | 538.4k $10.8m | Reduced -235.1k |
| LORD, ABBETT & CO. LLC 0.02% of their portfolio | 517.1k $10.4m | Added +208.3k |
| Integral Health Asset Management, LLC 2.09% of their portfolio | 500.0k $10.1m | Reduced -50.0k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 2.69% of their portfolio | 478.5k $9.6m | Reduced -153.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 477.1k $9.6m | Reduced -30.9k |
| ExodusPoint Capital Management, LP 0.11% of their portfolio | 464.2k $9.3m | Added +172.3k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 439.3k $8.8m | Reduced -16.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 429.3k $8.6m | Reduced -6.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 413.9k $8.3m | Added +3.3k |
| Hudson Bay Capital Management LP 0.05% of their portfolio | 402.5k $8.1m | Added +183.5k |
| Ghost Tree Capital, LLC 2.86% of their portfolio | 375.0k $7.6m | New |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 348.8k $7.0m | Reduced -399.2k |
| MPM BIOIMPACT LLC 1.82% of their portfolio | 348.2k $7.0m | Reduced -591.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 342.4k $6.9m | Added +138.3k |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 336.1k $6.8m | New |
| Assenagon Asset Management S.A. 0.03% of their portfolio | 330.6k $6.7m | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 317.5k $6.4m | Reduced -15.6k |
| CITIGROUP INC 0.01% of their portfolio | 305.9k $6.2m | Added +97.6k |
| Privium Fund Management B.V. 2.04% of their portfolio | 301.3k $6.1m | Unchanged |
| NORDEA INVESTMENT MANAGEMENT AB 0.01% of their portfolio | 282.6k $5.6m | Reduced -2.1k |
| TWO SIGMA INVESTMENTS, LP 0.02% of their portfolio | 260.3k $5.2m | Reduced -6.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 247.8k $5.0m | Added +52.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 244.2k $4.9m | Reduced -4.6k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.02% of their portfolio | 234.2k $4.7m | Added +3.3k |
| BANQUE PICTET & CIE SA 0.05% of their portfolio | 232.3k $4.7m | Reduced -39.2k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 229.0k $4.6m | New |
| Tri Locum Partners LP 1.39% of their portfolio | 227.3k $4.6m | New |
| Invesco Ltd. 0.00% of their portfolio | 220.1k $4.4m | Added +616 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 219.0k $4.4m | Reduced -539 |
| Rafferty Asset Management, LLC 0.03% of their portfolio | 215.7k $4.3m | Added +18.1k |
| Swedbank AB 0.01% of their portfolio | 197.8k $4.0m | Unchanged |
| Allianz Asset Management GmbH 0.01% of their portfolio | 172.9k $3.5m | Added +71.8k |
| Woodline Partners LP 0.05% of their portfolio | 170.7k $3.4m | New |
| Mirae Asset Global Investments Co., Ltd. 0.01% of their portfolio | 166.6k $3.4m | Added +9.6k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 165.6k $3.3m | Added +2.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 149.5k $3.0m | Reduced -3.5k |
| Verition Fund Management LLC 0.05% of their portfolio | 143.4k $2.9m | New |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.02% of their portfolio | 132.7k $2.7m | Added +32.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 114.0k $2.3m | Reduced -126.7k |
| Legal & General Group Plc 0.00% of their portfolio | 113.1k $2.3m | Reduced -1.2k |
| Caption Management, LLC 0.45% of their portfolio | 105.3k $2.1m | Added +34.0k |
| Walleye Capital LLC 0.04% of their portfolio | 104.6k $2.1m | New |
| Swiss National Bank 0.00% of their portfolio | 91.0k $1.8m | Reduced -10.5k |
| Henry James International Management Inc. 0.76% of their portfolio | 89.0k $1.8m | Added +178 |
| JUPITER ASSET MANAGEMENT LTD 0.02% of their portfolio | 85.0k $1.7m | Unchanged |
| UBS Group AG 0.00% of their portfolio | 84.6k $1.7m | Reduced -39.8k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 82.6k $1.7m | Added +67.2k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.04% of their portfolio | 75.1k $1.5m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 74.6k $1.5m | Added +40.4k |
| Public Sector Pension Investment Board 0.01% of their portfolio | 72.5k $1.5m | Reduced -2.9k |
| Endurant Capital Management LP 0.73% of their portfolio | 71.0k $1.4m | New |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 70.8k $1.4m | Added +300 |
| BARCLAYS PLC 0.00% of their portfolio | 67.5k $1.4m | Reduced -39.6k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 65.5k $1.3m | Added +5.0k |
| Vontobel Holding Ltd. 0.01% of their portfolio | 64.6k $1.3m | Reduced -7.2k |
| PDT Partners, LLC 0.17% of their portfolio | 63.6k $1.3m | Added +42.2k |
| SPHERA FUNDS MANAGEMENT LTD. 0.27% of their portfolio | 62.0k $1.2m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 58.0k $1.2m | Reduced -3.6k |
| Weiss Multi-Strategy Advisers LLC 0.03% of their portfolio | 57.9k $1.2m | Added +19.5k |
| MIRABELLA FINANCIAL SERVICES LLP 0.22% of their portfolio | 53.2k $1.3m | Reduced -15.0k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 51.4k $1.0m | Added +3.5k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 50.7k $1.0m | Added +38.0k |
| Sonic GP LLC 0.77% of their portfolio | 50.0k $1.0m | Unchanged |
| Sigma Planning Corp 0.03% of their portfolio | 49.1k $988.8k | Added +395 |
| Jump Financial, LLC 0.04% of their portfolio | 47.7k $960.5k | Added +14.8k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 47.6k $958.8k | Added +12.8k |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS 0.01% of their portfolio | 43.6k $878.5k | Reduced -469 |
| PROFUND ADVISORS LLC 0.05% of their portfolio | 40.8k $822.5k | New |
| Thrivent Financial for Lutherans 0.00% of their portfolio | 40.8k $822.0k | Reduced -1.4k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 39.4k $767.0k | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 38.9k $782.6k | Reduced -1.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 37.6k $757.0k | Added +5.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 37.0k $745.5k | Added +418 |
| TEXAS PERMANENT SCHOOL FUND CORP 0.01% of their portfolio | 36.9k $744.1k | Added +9.2k |
| Ergoteles LLC 0.03% of their portfolio | 35.6k $717.1k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 31.0k $623.5k | Reduced -18.4k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 30.2k $608.7k | Added +15.1k |
| State of Alaska, Department of Revenue 0.01% of their portfolio | 28.2k $568.0k | Reduced -475 |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 24.4k $491.2k | Reduced -4.8k |
| State of Tennessee, Department of Treasury 0.00% of their portfolio | 24.4k $490.5k | Reduced -3.2k |
| BLUEFIN CAPITAL MANAGEMENT, LLC 0.07% of their portfolio | 24.2k $486.9k | New |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 23.1k $465.7k | Reduced -432 |
| YOUSIF CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 22.4k $451.5k | Reduced -4.6k |