STRUCTURE THERAPEUTICS INC GPCR
SPONSORED ADS · ADR · CUSIP 86366E106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.9m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $20.74. Options: 11 managers hold calls ($12.5m notional), 10 hold puts ($10.8m).
Trends to Q2 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 38 |
| Q2 2023 | 49 |
| Q3 2023 | 85 |
| Q4 2023 | 123 |
| Q1 2024 | 121 |
| Q2 2024 | 167 |
| Q3 2024 | 161 |
| Q4 2024 | 165 |
| Q1 2025 | 151 |
| Q2 2025 | 173 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2023 | 71 | 12 |
| Q4 2023 | 84 | 41 |
| Q1 2024 | 71 | 61 |
| Q2 2024 | 123 | 46 |
| Q3 2024 | 94 | 68 |
| Q4 2024 | 82 | 73 |
| Q1 2025 | 70 | 83 |
| Q2 2025 | 100 | 60 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2024 | $21.7m | $18.6m | 0.86 |
| Q4 2024 | $28.7m | $17.3m | 0.60 |
| Q1 2025 | $12.4m | $11.7m | 0.94 |
| Q2 2025 | $12.5m | $10.8m | 0.86 |
Biggest buyers
| BAKER BROS. ADVISORS LP | Added | +2.1m |
| Deep Track Capital, LP | Added | +1.0m |
| ORBIMED ADVISORS LLC | Added | +547.3k |
| Casdin Capital, LLC | Added | +525.0k |
| Pacific Heights Asset Management LLC | New | +460.0k |
| MILLENNIUM MANAGEMENT LLC | Added | +429.9k |
| Logos Global Management LP | Added | +425.0k |
| CITADEL ADVISORS LLC | Added | +336.1k |
| Schonfeld Strategic Advisors LLC | New | +321.6k |
| MORGAN STANLEY | Added | +224.9k |
Biggest sellers
| Capital Research Global Investors | Sold out | -2.2m |
| FIL Ltd | Sold out | -1.2m |
| FMR LLC | Reduced | -968.7k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -915.4k |
| FEDERATED HERMES, INC. | Reduced | -702.6k |
| Driehaus Capital Management LLC | Reduced | -600.0k |
| Vestal Point Capital, LP | Reduced | -589.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -424.3k |
| BlackRock, Inc. | Reduced | -323.2k |
| READYSTATE ASSET MANAGEMENT LP | Reduced | -302.6k |
Biggest calls
| Nantahala Capital Management, LLC | Unchanged | $3.1m150.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.2m106.7k shares |
| Walleye Trading LLC | Reduced | $1.8m86.5k shares |
| CITADEL ADVISORS LLC | Added | $1.7m81.2k shares |
| GROUP ONE TRADING LLC | Reduced | $1.2m59.2k shares |
| JANE STREET GROUP, LLC | Added | $916.7k44.2k shares |
| Caption Management, LLC | Added | $725.9k35.0k shares |
| UBS Group AG | Added | $647.1k31.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $130.0k6.3k shares |
| Walleye Capital LLC | New | $31.1k1.5k shares |
Biggest puts
| JANE STREET GROUP, LLC | Added | $2.8m134.5k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $2.2m106.1k shares |
| CITADEL ADVISORS LLC | Reduced | $1.8m89.1k shares |
| GROUP ONE TRADING LLC | Reduced | $1.3m63.7k shares |
| Caption Management, LLC | Added | $1.3m61.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $759.0k36.6k shares |
| PEAK6 LLC | Added | $456.3k22.0k shares |
| Walleye Trading LLC | Unchanged | $76.7k3.7k shares |
| Walleye Capital LLC | New | $29.0k1.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 | 13.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 | 9.4% |
| JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 | 7.7% |
| Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 | 6.0% |
Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)
Insider purchases and sales in Q2 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q2 2025.
Holders, Q2 2025
| Manager | Shares | Change |
|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 6.9m $142.6m | Reduced -915.4k |
| Deep Track Capital, LP 3.42% of their portfolio | 5.1m $106.5m | Added +1.0m |
| FMR LLC 0.01% of their portfolio | 4.9m $101.9m | Reduced -968.7k |
| JANUS HENDERSON GROUP PLC 0.05% of their portfolio | 4.6m $94.9m | Added +217.8k |
| BAKER BROS. ADVISORS LP 0.50% of their portfolio | 2.5m $52.0m | Added +2.1m |
| BVF INC/IL 1.31% of their portfolio | 1.8m $36.7m | Unchanged |
| Capital International Investors 0.01% of their portfolio | 1.6m $33.6m | Reduced -150 |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 1.6m $32.9m | Added +106.4k |
| RA CAPITAL MANAGEMENT, L.P. 0.53% of their portfolio | 1.5m $31.5m | Unchanged |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 1.3m $27.6m | Added +336.1k |
| Casdin Capital, LLC 2.31% of their portfolio | 1.2m $25.4m | Added +525.0k |
| MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio | 1.2m $25.3m | Added +429.9k |
| Vestal Point Capital, LP 1.31% of their portfolio | 1.2m $24.9m | Reduced -589.0k |
| ORBIMED ADVISORS LLC 0.63% of their portfolio | 1.2m $24.9m | Added +547.3k |
| Rock Springs Capital Management LP 1.47% of their portfolio | 1.1m $23.6m | Added +2.9k |
| TCG Crossover Management, LLC 2.52% of their portfolio | 1.1m $22.0m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 917.3k $19.0m | Added +224.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 853.2k $17.7m | Added +96.5k |
| Logos Global Management LP 2.35% of their portfolio | 850.0k $17.6m | Added +425.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 741.8k $15.4m | Added +1.6k |
| Driehaus Capital Management LLC 0.11% of their portfolio | 672.8k $14.0m | Reduced -600.0k |
| Catalio Capital Management, LP 2.92% of their portfolio | 670.6k $13.9m | Reduced -34.3k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 491.2k $10.2m | Reduced -19.0k |
| FEDERATED HERMES, INC. 0.02% of their portfolio | 468.3k $9.7m | Reduced -702.6k |
| Pacific Heights Asset Management LLC 0.51% of their portfolio | 460.0k $9.5m | New |
| Monashee Investment Management LLC 4.71% of their portfolio | 430.0k $8.9m | Added +137.1k |
| Invesco Ltd. 0.00% of their portfolio | 424.5k $8.8m | Added +30.2k |
| Aberdeen Group plc 0.01% of their portfolio | 401.6k $8.3m | Added +152.7k |
| Handelsbanken Fonder AB 0.03% of their portfolio | 380.0k $7.9m | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.14% of their portfolio | 373.4k $7.7m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 352.9k $7.3m | Reduced -424.3k |
| Bellevue Group AG 0.16% of their portfolio | 348.5k $7.2m | Added +126.8k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 330.0k $6.8m | Added +100.6k |
| Schonfeld Strategic Advisors LLC 0.05% of their portfolio | 321.6k $6.7m | New |
| ArrowMark Colorado Holdings LLC 0.11% of their portfolio | 298.9k $6.2m | Added +53.8k |
| HSG Holding Ltd 0.28% of their portfolio | 266.1k $5.5m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 243.3k $5.0m | Reduced -323.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 220.2k $4.6m | Reduced -104.3k |
| Foresite Capital Management VI LLC 2.45% of their portfolio | 210.0k $4.4m | Reduced -210.0k |
| Pier Capital, LLC 0.63% of their portfolio | 198.5k $4.1m | Reduced -14.0k |
| Ikarian Capital, LLC 1.26% of their portfolio | 183.1k $3.8m | Reduced -81.0k |
| READYSTATE ASSET MANAGEMENT LP 0.15% of their portfolio | 178.6k $3.7m | Reduced -302.6k |
| Woodline Partners LP 0.02% of their portfolio | 176.5k $3.7m | Added +1.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 176.1k $3.7m | Added +145.4k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.75% of their portfolio | 175.6k $3.6m | Reduced -12.4k |
| Nantahala Capital Management, LLC 0.25% of their portfolio | 168.6k $3.5m | Unchanged |
| CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio | 167.8k $3.5m | New |
| UBS Group AG 0.00% of their portfolio | 153.0k $3.2m | Reduced -85.2k |
| CCG WEALTH MANAGEMENT, LLC 1.64% of their portfolio | 150.0k $3.1m | Unchanged |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.08% of their portfolio | 139.7k $2.9m | Reduced -18.2k |
| Rhenman & Partners Asset Management AB 0.35% of their portfolio | 135.1k $2.8m | Added +65.1k |
| First Light Asset Management, LLC 0.33% of their portfolio | 122.2k $2.5m | Reduced -10.2k |
| Point72 Europe (London) LLP 0.12% of their portfolio | 116.7k $2.4m | Added +26.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 111.9k $2.3m | Added +96.1k |
| Eversept Partners, LP 0.21% of their portfolio | 99.3k $2.1m | New |
| SPHERA FUNDS MANAGEMENT LTD. 0.52% of their portfolio | 95.9k $2.0m | Added +11.9k |
| HighVista Strategies LLC 0.66% of their portfolio | 86.6k $1.8m | Added +69.1k |
| Trexquant Investment LP 0.02% of their portfolio | 81.6k $1.7m | Reduced -38.8k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 75.8k $1.6m | Added +7.6k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.10% of their portfolio | 74.9k $1.6m | Unchanged |
| Verition Fund Management LLC 0.01% of their portfolio | 73.0k $1.5m | Added +53.4k |
| Cubist Systematic Strategies, LLC 0.02% of their portfolio | 71.7k $1.5m | Added +16.9k |
| BANQUE PICTET & CIE SA 0.02% of their portfolio | 70.4k $1.5m | Reduced -11.4k |
| Jain Global LLC 0.02% of their portfolio | 69.4k $1.4m | Added +45.7k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 65.8k $1.4m | Added +61.3k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 63.4k $1.3m | Added +32.0k |
| Jump Financial, LLC 0.02% of their portfolio | 63.2k $1.3m | Added +32.5k |
| EXCHANGE TRADED CONCEPTS, LLC 0.02% of their portfolio | 61.7k $1.3m | Added +22.8k |
| DAFNA Capital Management LLC 0.34% of their portfolio | 59.0k $1.2m | Unchanged |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 58.1k $1.2m | Added +4.8k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 58.0k $1.2m | Unchanged |
| BOOTHBAY FUND MANAGEMENT, LLC 0.04% of their portfolio | 57.6k $1.2m | Reduced -19.7k |
| PFM Health Sciences, LP 0.10% of their portfolio | 56.6k $1.2m | Added +16.2k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 54.2k $1.1m | Added +8.4k |
| Exome Asset Management LLC 0.95% of their portfolio | 53.7k $1.1m | Reduced -49.2k |
| SECTORAL ASSET MANAGEMENT INC 0.70% of their portfolio | 51.4k $1.1m | Added +17.7k |
| TD Asset Management Inc 0.00% of their portfolio | 43.7k $906.0k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 42.4k $880.2k | Reduced -91.8k |
| Quinn Opportunity Partners LLC 0.07% of their portfolio | 42.0k $871.1k | Added +20.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 40.8k $846.0k | Added +52 |
| Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio | 40.0k $828.8k | New |
| Mariner, LLC 0.00% of their portfolio | 39.5k $819.3k | Added +21.4k |
| Walleye Capital LLC 0.01% of their portfolio | 38.7k $802.1k | New |
| TrueMark Investments, LLC 0.17% of their portfolio | 37.8k $783.2k | Reduced -1.5k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 36.1k $748.7k | New |
| Birchview Capital, LP 0.74% of their portfolio | 36.0k $746.6k | New |
| Sofinnova Investments, Inc. 0.05% of their portfolio | 34.4k $712.5k | Reduced -599 |
| STATE STREET CORP 0.00% of their portfolio | 33.5k $693.9k | Added +22.7k |
| ALPS ADVISORS INC 0.00% of their portfolio | 31.1k $644.5k | Reduced -12.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 30.7k $635.8k | Reduced -21.2k |
| Caption Management, LLC 0.05% of their portfolio | 28.2k $584.3k | Added +18.9k |
| NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio | 24.9k $515.9k | Reduced -4.1k |
| DCF Advisers, LLC 0.25% of their portfolio | 24.8k $513.3k | New |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 24.6k $510.2k | New |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 23.1k $478.0k | Added +2.5k |
| NEOS Investment Management LLC 0.01% of their portfolio | 22.9k $474.5k | Added +290 |
| Tema ETFs LLC 0.13% of their portfolio | 22.9k $474.5k | Added +290 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 22.5k $466.6k | New |
| Tejara Capital Ltd 0.22% of their portfolio | 22.4k $464.6k | New |
| Headlands Technologies LLC 0.06% of their portfolio | 22.3k $463.3k | Added +18.9k |