Vault-13

STRUCTURE THERAPEUTICS INC GPCR

SPONSORED ADS · ADR · CUSIP 86366E106

173 institutional holders +22 vs Q1 2025
54,481,82854.5m shares reported held*
$1.1bnreported value*
37 new 63 added 44 reduced 16 sold out net sold ≈ $31.3m (-1.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.9m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $20.74. Options: 11 managers hold calls ($12.5m notional), 10 hold puts ($10.8m).

Trends to Q2 2025

Institutional holders

Managers reporting a position, each quarter

0100200Q1 23: 38Q2 23: 49Q3 23: 85Q4 23: 123Q1 24: 121Q2 24: 167Q3 24: 161Q4 24: 165Q1 25: 151Q2 25: 173173Q1 23Q3 23Q1 24Q3 24Q1 25Q2 25
Numbers
QuarterHolders
Q1 202338
Q2 202349
Q3 202385
Q4 2023123
Q1 2024121
Q2 2024167
Q3 2024161
Q4 2024165
Q1 2025151
Q2 2025173

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 23: 71 bought or addedQ3 23: 12 cut or sold outQ4 23: 84 bought or addedQ4 23: 41 cut or sold outQ4 23Q1 24: 71 bought or addedQ1 24: 61 cut or sold outQ2 24: 123 bought or addedQ2 24: 46 cut or sold outQ2 24Q3 24: 94 bought or addedQ3 24: 68 cut or sold outQ4 24: 82 bought or addedQ4 24: 73 cut or sold outQ4 24Q1 25: 70 bought or addedQ1 25: 83 cut or sold outQ2 25: 100 bought or addedQ2 25: 60 cut or sold outQ2 25
Numbers
QuarterBought or addedCut or sold out
Q3 20237112
Q4 20238441
Q1 20247161
Q2 202412346
Q3 20249468
Q4 20248273
Q1 20257083
Q2 202510060

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30mQ3 24 calls: $21.7mQ3 24 puts: $18.6mQ3 24P/C 0.86Q4 24 calls: $28.7mQ4 24 puts: $17.3mQ4 24P/C 0.60Q1 25 calls: $12.4mQ1 25 puts: $11.7mQ1 25P/C 0.94Q2 25 calls: $12.5mQ2 25 puts: $10.8mQ2 25P/C 0.86
Numbers
QuarterCallsPutsP/C
Q3 2024$21.7m$18.6m0.86
Q4 2024$28.7m$17.3m0.60
Q1 2025$12.4m$11.7m0.94
Q2 2025$12.5m$10.8m0.86

Biggest buyers

BAKER BROS. ADVISORS LP Added +2,147,202+2.1m
Deep Track Capital, LP Added +1,033,917+1.0m
ORBIMED ADVISORS LLC Added +547,272+547.3k
Casdin Capital, LLC Added +525,000+525.0k
Pacific Heights Asset Management LLC New +460,000+460.0k
MILLENNIUM MANAGEMENT LLC Added +429,896+429.9k
Logos Global Management LP Added +425,000+425.0k
CITADEL ADVISORS LLC Added +336,139+336.1k
Schonfeld Strategic Advisors LLC New +321,591+321.6k
MORGAN STANLEY Added +224,907+224.9k

Biggest sellers

Capital Research Global Investors Sold out -2,164,145-2.2m
FIL Ltd Sold out -1,150,440-1.2m
FMR LLC Reduced -968,742-968.7k
WELLINGTON MANAGEMENT GROUP LLP Reduced -915,414-915.4k
FEDERATED HERMES, INC. Reduced -702,648-702.6k
Driehaus Capital Management LLC Reduced -599,951-600.0k
Vestal Point Capital, LP Reduced -588,990-589.0k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -424,305-424.3k
BlackRock, Inc. Reduced -323,171-323.2k
READYSTATE ASSET MANAGEMENT LP Reduced -302,629-302.6k

Biggest calls

Nantahala Capital Management, LLC Unchanged $3.1m150.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $2.2m106.7k shares
Walleye Trading LLC Reduced $1.8m86.5k shares
CITADEL ADVISORS LLC Added $1.7m81.2k shares
GROUP ONE TRADING LLC Reduced $1.2m59.2k shares
JANE STREET GROUP, LLC Added $916.7k44.2k shares
Caption Management, LLC Added $725.9k35.0k shares
UBS Group AG Added $647.1k31.2k shares
SIMPLEX TRADING, LLC Reduced $130.0k6.3k shares
Walleye Capital LLC New $31.1k1.5k shares

Biggest puts

JANE STREET GROUP, LLC Added $2.8m134.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $2.2m106.1k shares
CITADEL ADVISORS LLC Reduced $1.8m89.1k shares
GROUP ONE TRADING LLC Reduced $1.3m63.7k shares
Caption Management, LLC Added $1.3m61.9k shares
SIMPLEX TRADING, LLC Reduced $759.0k36.6k shares
PEAK6 LLC Added $456.3k22.0k shares
Walleye Trading LLC Unchanged $76.7k3.7k shares
Walleye Capital LLC New $29.0k1.4k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 13.2% -1.8 pts 28.2m 2026-08-06
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 10.1% -1.8 pts 21.4m 2026-02-10
Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 9.4% new 16.2m 2025-11-14
JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 7.7% -0.3 pts 4.4m 2025-11-14
Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 6.0% -1.4 pts 12.3m 2026-02-13

Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)

Insider purchases and sales in Q2 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

None reported in Q2 2025.

Holders, Q2 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 6,875,7696.9m $142.6m $142.6m 0.03% Reduced -915.4k -915,414
2 Deep Track Capital, LP 3.42% of their portfolio GREENWICH, CT 5,133,9175.1m $106.5m $106.5m 3.42% Added +1.0m +1,033,917
3 FMR LLC 0.01% of their portfolio BOSTON, MA 4,914,9654.9m $101.9m $101.9m 0.01% Reduced -968.7k -968,742
4 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 4,573,0064.6m $94.9m $94.9m 0.05% Added +217.8k +217,812
5 BAKER BROS. ADVISORS LP 0.50% of their portfolio NEW YORK, NY 2,508,7672.5m $52.0m $52.0m 0.50% Added +2.1m +2,147,202
6 BVF INC/IL 1.31% of their portfolio San Francisco, CA 1,771,4171.8m $36.7m $36.7m 1.31% Unchanged
7 Capital International Investors 0.01% of their portfolio Los Angeles, CA 1,618,8761.6m $33.6m $33.6m 0.01% Reduced -150 -150
8 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 1,588,1981.6m $32.9m $32.9m 0.01% Added +106.4k +106,389
9 RA CAPITAL MANAGEMENT, L.P. 0.53% of their portfolio BOSTON, MA 1,517,4181.5m $31.5m $31.5m 0.53% Unchanged
10 CITADEL ADVISORS LLC 0.02% of their portfolio MIAMI, FL 1,328,4791.3m $27.6m $27.6m 0.02% Added +336.1k +336,139
11 Casdin Capital, LLC 2.31% of their portfolio New York, NY 1,225,0001.2m $25.4m $25.4m 2.31% Added +525.0k +525,000
12 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 1,220,0551.2m $25.3m $25.3m 0.02% Added +429.9k +429,896
13 Vestal Point Capital, LP 1.31% of their portfolio NEW YORK, NY 1,200,0001.2m $24.9m $24.9m 1.31% Reduced -589.0k -588,990
14 ORBIMED ADVISORS LLC 0.63% of their portfolio New York, NY 1,199,3001.2m $24.9m $24.9m 0.63% Added +547.3k +547,272
15 Rock Springs Capital Management LP 1.47% of their portfolio Baltimore, MD 1,135,8791.1m $23.6m $23.6m 1.47% Added +2.9k +2,900
16 TCG Crossover Management, LLC 2.52% of their portfolio PALO ALTO, CA 1,063,0001.1m $22.0m $22.0m 2.52% Unchanged
17 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 917,346917.3k $19.0m $19.0m 0.00% Added +224.9k +224,907
18 PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio DES MOINES, IA 853,202853.2k $17.7m $17.7m 0.01% Added +96.5k +96,495
19 Logos Global Management LP 2.35% of their portfolio San Francisco, CA 850,000850.0k $17.6m $17.6m 2.35% Added +425.0k +425,000
20 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 741,783741.8k $15.4m $15.4m 0.00% Added +1.6k +1,631
21 Driehaus Capital Management LLC 0.11% of their portfolio Chicago, IL 672,792672.8k $14.0m $14.0m 0.11% Reduced -600.0k -599,951
22 Catalio Capital Management, LP 2.92% of their portfolio NEW YORK, NY 670,575670.6k $13.9m $13.9m 2.92% Reduced -34.3k -34,289
23 AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio KANSAS CITY, MO 491,193491.2k $10.2m $10.2m 0.01% Reduced -19.0k -19,008
24 FEDERATED HERMES, INC. 0.02% of their portfolio PITTSBURGH, PA 468,300468.3k $9.7m $9.7m 0.02% Reduced -702.6k -702,648
25 Pacific Heights Asset Management LLC 0.51% of their portfolio San Francisco, CA 460,000460.0k $9.5m $9.5m 0.51% New
26 Monashee Investment Management LLC 4.71% of their portfolio Boston, MA 430,000430.0k $8.9m $8.9m 4.71% Added +137.1k +137,138
27 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 424,548424.5k $8.8m $8.8m 0.00% Added +30.2k +30,162
28 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 401,624401.6k $8.3m $8.3m 0.01% Added +152.7k +152,725
29 Handelsbanken Fonder AB 0.03% of their portfolio STOCKHOLM, V7 380,000380.0k $7.9m $7.9m 0.03% Unchanged
30 DEERFIELD MANAGEMENT COMPANY, L.P. 0.14% of their portfolio New York, NY 373,407373.4k $7.7m $7.7m 0.14% Unchanged
31 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 352,868352.9k $7.3m $7.3m 0.00% Reduced -424.3k -424,305
32 Bellevue Group AG 0.16% of their portfolio ZURICH, V8 348,527348.5k $7.2m $7.2m 0.16% Added +126.8k +126,812
33 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 330,000330.0k $6.8m $6.8m 0.02% Added +100.6k +100,569
34 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 321,591321.6k $6.7m $6.7m 0.05% New
35 ArrowMark Colorado Holdings LLC 0.11% of their portfolio Denver, CO 298,937298.9k $6.2m $6.2m 0.11% Added +53.8k +53,751
36 HSG Holding Ltd 0.28% of their portfolio NA, K3 266,062266.1k $5.5m $5.5m 0.28% Unchanged
37 BlackRock, Inc. 0.00% of their portfolio New York, NY 243,334243.3k $5.0m $5.0m 0.00% Reduced -323.2k -323,171
38 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 220,174220.2k $4.6m $4.6m 0.00% Reduced -104.3k -104,261
39 Foresite Capital Management VI LLC 2.45% of their portfolio WEST HOLLYWOOD, CA 210,000210.0k $4.4m $4.4m 2.45% Reduced -210.0k -210,000
40 Pier Capital, LLC 0.63% of their portfolio STAMFORD, CT 198,478198.5k $4.1m $4.1m 0.63% Reduced -14.0k -14,042
41 Ikarian Capital, LLC 1.26% of their portfolio DALLAS, TX 183,085183.1k $3.8m $3.8m 1.26% Reduced -81.0k -81,000
42 READYSTATE ASSET MANAGEMENT LP 0.15% of their portfolio CHICAGO, IL 178,612178.6k $3.7m $3.7m 0.15% Reduced -302.6k -302,629
43 Woodline Partners LP 0.02% of their portfolio San Francisco, CA 176,453176.5k $3.7m $3.7m 0.02% Added +1.0k +1,029
44 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 176,060176.1k $3.7m $3.7m 0.00% Added +145.4k +145,434
45 SILVERARC CAPITAL MANAGEMENT, LLC 0.75% of their portfolio BOSTON, MA 175,636175.6k $3.6m $3.6m 0.75% Reduced -12.4k -12,433
46 Nantahala Capital Management, LLC 0.25% of their portfolio NEW CANAAN, CT 168,553168.6k $3.5m $3.5m 0.25% Unchanged
47 CANADA PENSION PLAN INVESTMENT BOARD 0.00% of their portfolio TORONTO ONTARIO, A6 167,800167.8k $3.5m $3.5m 0.00% New
48 UBS Group AG 0.00% of their portfolio ZURICH, V8 152,981153.0k $3.2m $3.2m 0.00% Reduced -85.2k -85,216
49 CCG WEALTH MANAGEMENT, LLC 1.64% of their portfolio SAN DIEGO, CA 150,000150.0k $3.1m $3.1m 1.64% Unchanged
50 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.08% of their portfolio BALA CYNWYD, PA 139,717139.7k $2.9m $2.9m 0.08% Reduced -18.2k -18,244
51 Rhenman & Partners Asset Management AB 0.35% of their portfolio Stockholm, V7 135,100135.1k $2.8m $2.8m 0.35% Added +65.1k +65,100
52 First Light Asset Management, LLC 0.33% of their portfolio Edina, MN 122,226122.2k $2.5m $2.5m 0.33% Reduced -10.2k -10,154
53 Point72 Europe (London) LLP 0.12% of their portfolio LONDON, X0 116,697116.7k $2.4m $2.4m 0.12% Added +26.0k +26,000
54 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 111,900111.9k $2.3m $2.3m 0.00% Added +96.1k +96,100
55 Eversept Partners, LP 0.21% of their portfolio NEW YORK, NY 99,33899.3k $2.1m $2.1m 0.21% New
56 SPHERA FUNDS MANAGEMENT LTD. 0.52% of their portfolio TEL AVIV, L3 95,93195.9k $2.0m $2.0m 0.52% Added +11.9k +11,931
57 HighVista Strategies LLC 0.66% of their portfolio BOSTON, MA 86,62186.6k $1.8m $1.8m 0.66% Added +69.1k +69,060
58 Trexquant Investment LP 0.02% of their portfolio STAMFORD, CT 81,58881.6k $1.7m $1.7m 0.02% Reduced -38.8k -38,752
59 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 75,80275.8k $1.6m $1.6m 0.00% Added +7.6k +7,635
60 PLATINUM INVESTMENT MANAGEMENT LTD 0.10% of their portfolio SYDNEY AUSTRALIA 2000, C3 74,90074.9k $1.6m $1.6m 0.10% Unchanged
61 Verition Fund Management LLC 0.01% of their portfolio GREENWICH, CT 72,98473.0k $1.5m $1.5m 0.01% Added +53.4k +53,402
62 Cubist Systematic Strategies, LLC 0.02% of their portfolio STAMFORD, CT 71,69071.7k $1.5m $1.5m 0.02% Added +16.9k +16,874
63 BANQUE PICTET & CIE SA 0.02% of their portfolio GENEVA 73, V8 70,40170.4k $1.5m $1.5m 0.02% Reduced -11.4k -11,365
64 Jain Global LLC 0.02% of their portfolio NEW YORK, NY 69,36969.4k $1.4m $1.4m 0.02% Added +45.7k +45,730
65 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 65,83665.8k $1.4m $1.4m 0.00% Added +61.3k +61,318
66 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 63,36263.4k $1.3m $1.3m 0.00% Added +32.0k +31,972
67 Jump Financial, LLC 0.02% of their portfolio Chicago, IL 63,23463.2k $1.3m $1.3m 0.02% Added +32.5k +32,524
68 EXCHANGE TRADED CONCEPTS, LLC 0.02% of their portfolio Oklahoma City, OK 61,73261.7k $1.3m $1.3m 0.02% Added +22.8k +22,809
69 DAFNA Capital Management LLC 0.34% of their portfolio LOS ANGELES, CA 59,00059.0k $1.2m $1.2m 0.34% Unchanged
70 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 58,07358.1k $1.2m $1.2m 0.00% Added +4.8k +4,838
71 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 58,00058.0k $1.2m $1.2m 0.00% Unchanged
72 BOOTHBAY FUND MANAGEMENT, LLC 0.04% of their portfolio NEW YORK, NY 57,62257.6k $1.2m $1.2m 0.04% Reduced -19.7k -19,672
73 PFM Health Sciences, LP 0.10% of their portfolio SAN FRANCISCO, CA 56,59456.6k $1.2m $1.2m 0.10% Added +16.2k +16,194
74 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 54,18154.2k $1.1m $1.1m 0.00% Added +8.4k +8,444
75 Exome Asset Management LLC 0.95% of their portfolio NEW YORK, NY 53,74453.7k $1.1m $1.1m 0.95% Reduced -49.2k -49,200
76 SECTORAL ASSET MANAGEMENT INC 0.70% of their portfolio MONTREAL, A8 51,36951.4k $1.1m $1.1m 0.70% Added +17.7k +17,674
77 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 43,68643.7k $906.0k $906.0k 0.00% Unchanged
78 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 42,44242.4k $880.2k $880.2k 0.00% Reduced -91.8k -91,797
79 Quinn Opportunity Partners LLC 0.07% of their portfolio CHARLOTTESVILLE, VA 42,00042.0k $871.1k $871.1k 0.07% Added +20.0k +20,000
80 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 40,78940.8k $846.0k $846.0k 0.00% Added +52 +52
81 Susquehanna Portfolio Strategies, LLC 0.02% of their portfolio Bala Cynwyd, PA 39,96040.0k $828.8k $828.8k 0.02% New
82 Mariner, LLC 0.00% of their portfolio Overland Park, KS 39,50139.5k $819.3k $819.3k 0.00% Added +21.4k +21,450
83 Walleye Capital LLC 0.01% of their portfolio NEW YORK, NY 38,67338.7k $802.1k $802.1k 0.01% New
84 TrueMark Investments, LLC 0.17% of their portfolio CHICAGO, IL 37,76537.8k $783.2k $783.2k 0.17% Reduced -1.5k -1,452
85 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 36,10036.1k $748.7k $748.7k 0.00% New
86 Birchview Capital, LP 0.74% of their portfolio BURLINGTON, VT 36,00036.0k $746.6k $746.6k 0.74% New
87 Sofinnova Investments, Inc. 0.05% of their portfolio Menlo Park, CA 34,35334.4k $712.5k $712.5k 0.05% Reduced -599 -599
88 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 33,45933.5k $693.9k $693.9k 0.00% Added +22.7k +22,719
89 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 31,07331.1k $644.5k $644.5k 0.00% Reduced -12.0k -12,007
90 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 30,65530.7k $635.8k $635.8k 0.00% Reduced -21.2k -21,225
91 Caption Management, LLC 0.05% of their portfolio OKLAHOMA CITY, OK 28,17428.2k $584.3k $584.3k 0.05% Added +18.9k +18,918
92 NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio TOKYO, M0 24,87424.9k $515.9k $515.9k 0.00% Reduced -4.1k -4,100
93 DCF Advisers, LLC 0.25% of their portfolio MOUNT PLEASANT, SC 24,75024.8k $513.3k $513.3k 0.25% New
94 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 24,60024.6k $510.2k $510.2k 0.00% New
95 SIMPLEX TRADING, LLC 0.01% of their portfolio CHICAGO, IL 23,09423.1k $478.0k $478.0k 0.01% Added +2.5k +2,490
96 NEOS Investment Management LLC 0.01% of their portfolio Westport, CT 22,88022.9k $474.5k $474.5k 0.01% Added +290 +290
97 Tema ETFs LLC 0.13% of their portfolio New York, NY 22,88022.9k $474.5k $474.5k 0.13% Added +290 +290
98 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 22,49922.5k $466.6k $466.6k 0.00% New
99 Tejara Capital Ltd 0.22% of their portfolio London, X0 22,40022.4k $464.6k $464.6k 0.22% New
100 Headlands Technologies LLC 0.06% of their portfolio CHICAGO, IL 22,33822.3k $463.3k $463.3k 0.06% Added +18.9k +18,930