Vault-13

SOLENO THERAPEUTICS INC SLNO

COM · Common Stock · CUSIP 834203309

168 institutional holders +24 vs Q3 2024
51,032,27351.0m shares reported held*
$2.3bnreported value*
37 new 77 added 26 reduced 24 sold out net bought ≈ $172.0m (+3.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($331.7k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $44.94. Options: 18 managers hold calls ($120.4m notional), 18 hold puts ($123.4m).

Trends to Q4 2024

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 20Q4 22: 26Q1 23: 21Q2 23: 23Q3 23: 55Q4 23: 77Q1 24: 99Q2 24: 115Q3 24: 144Q4 24: 168168Q3 22Q1 23Q3 23Q1 24Q3 24Q4 24
Numbers
QuarterHolders
Q3 202220
Q4 202226
Q1 202321
Q2 202323
Q3 202355
Q4 202377
Q1 202499
Q2 2024115
Q3 2024144
Q4 2024168

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q1 23: 8 bought or addedQ1 23: 9 cut or sold outQ2 23: 6 bought or addedQ2 23: 9 cut or sold outQ2 23Q3 23: 41 bought or addedQ3 23: 12 cut or sold outQ4 23: 55 bought or addedQ4 23: 22 cut or sold outQ4 23Q1 24: 72 bought or addedQ1 24: 26 cut or sold outQ2 24: 76 bought or addedQ2 24: 41 cut or sold outQ2 24Q3 24: 96 bought or addedQ3 24: 42 cut or sold outQ4 24: 114 bought or addedQ4 24: 50 cut or sold outQ4 24
Numbers
QuarterBought or addedCut or sold out
Q1 202389
Q2 202369
Q3 20234112
Q4 20235522
Q1 20247226
Q2 20247641
Q3 20249642
Q4 202411450

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$50m$100m$150mQ1 24 calls: $17.1mQ1 24 puts: $4.1mQ1 24P/C 0.24Q2 24 calls: $2.1mQ2 24 puts: $15.7mQ2 24P/C 7.49Q3 24 calls: $44.5mQ3 24 puts: $24.0mQ3 24P/C 0.54Q4 24 calls: $120.4mQ4 24 puts: $123.4mQ4 24P/C 1.02
Numbers
QuarterCallsPutsP/C
Q1 2024$17.1m$4.1m0.24
Q2 2024$2.1m$15.7m7.49
Q3 2024$44.5m$24.0m0.54
Q4 2024$120.4m$123.4m1.02

Biggest buyers

JANUS HENDERSON GROUP PLC Added +1,107,166+1.1m
CITADEL ADVISORS LLC Added +950,670+950.7k
Nantahala Capital Management, LLC Added +658,518+658.5k
WESTFIELD CAPITAL MANAGEMENT CO LP Added +385,752+385.8k
Holocene Advisors, LP Added +361,103+361.1k
Siren, L.L.C. New +351,818+351.8k
Logos Global Management LP New +350,000+350.0k
Avoro Capital Advisors LLC Added +344,000+344.0k
Vestal Point Capital, LP Added +340,000+340.0k
TimesSquare Capital Management, LLC New +339,774+339.8k

Biggest sellers

Carlyle Group Inc. Reduced -2,695,916-2.7m
PERCEPTIVE ADVISORS LLC Reduced -1,703,936-1.7m
Alyeska Investment Group, L.P. Reduced -552,024-552.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -546,170-546.2k
Invesco Ltd. Reduced -322,157-322.2k
Ikarian Capital, LLC Sold out -221,437-221.4k
Frazier Life Sciences Management, L.P. Reduced -176,508-176.5k
SAMLYN CAPITAL, LLC Reduced -133,709-133.7k
STEMPOINT CAPITAL LP Sold out -123,177-123.2k
Woodline Partners LP Reduced -100,521-100.5k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $50.7m1.1m shares
Caption Management, LLC Added $34.9m776.3k shares
JANE STREET GROUP, LLC Added $6.5m144.2k shares
CITADEL ADVISORS LLC Added $6.3m139.6k shares
GROUP ONE TRADING LLC Added $5.4m120.8k shares
J. Goldman & Co LP Added $4.9m108.0k shares
DIADEMA PARTNERS LP First filing $4.3m94.6k shares
SIMPLEX TRADING, LLC Added $2.8m62.2k shares
SIG BROKERAGE, LP First filing $2.2m50.0k shares
TORONTO DOMINION BANK New $710.2k15.8k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $67.9m1.5m shares
Caption Management, LLC Added $19.7m438.5k shares
CITADEL ADVISORS LLC Added $8.6m190.8k shares
DIADEMA PARTNERS LP First filing $7.9m175.4k shares
GROUP ONE TRADING LLC New $4.6m102.3k shares
Ikarian Capital, LLC New $3.4m75.0k shares
Jefferies Financial Group Inc. New $3.3m74.2k shares
Balyasny Asset Management L.P. New $2.2m50.0k shares
SIMPLEX TRADING, LLC Added $2.0m45.1k shares
JANE STREET GROUP, LLC Reduced $1.1m23.4k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution +1.4 pts · filed 2026-04-24 6.9% +1.4 pts 3.5m 2026-04-24
ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 6.4% 2.8m 2025-02-12
STATE STREET CORP 13G · institution new · filed 2026-05-12 5.2% new 2.7m 2026-05-12

Fell to 5% or below in the last year: WELLINGTON MANAGEMENT GROUP LLP (0.0%, 2026-08-13), PRICE T ROWE ASSOCIATES INC /MD/ (2.0%, 2026-05-15), Avoro Capital Advisors LLC (4.5%, 2026-05-15), FMR LLC (0.4%, 2026-05-07), JANUS HENDERSON GROUP PLC (2.3%, 2026-05-07), VANGUARD GROUP INC (0.0%, 2026-03-27), Vivo Opportunity Fund Holdings, L.P. (4.2%, 2025-11-14)

Holders, Q4 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Vivo Capital, LLC 31.68% of their portfolio Palo Alto, CA 6,291,8516.3m $282.8m $282.8m 31.68% Unchanged
2 JANUS HENDERSON GROUP PLC 0.12% of their portfolio LONDON, X0 5,188,2655.2m $233.1m $233.1m 0.12% Added +1.1m +1,107,166
3 Nantahala Capital Management, LLC 12.35% of their portfolio NEW CANAAN, CT 3,928,9663.9m $176.6m $176.6m 12.35% Added +658.5k +658,518
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.22% of their portfolio Boston, MA 2,775,9762.8m $124.8m $124.8m 0.22% Reduced -546.2k -546,170
5 Avoro Capital Advisors LLC 1.61% of their portfolio NEW YORK, NY 2,525,0002.5m $113.5m $113.5m 1.61% Added +344.0k +344,000
6 BlackRock, Inc. 0.00% of their portfolio New York, NY 2,009,7902.0m $90.3m $90.3m 0.00% Reduced -2.0k -2,027
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,884,5331.9m $84.7m $84.7m 0.00% Added +303.8k +303,806
8 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,630,7181.6m $73.3m $73.3m 0.01% Added +321.2k +321,223
9 Commodore Capital LP 5.02% of their portfolio NEW YORK, NY 1,525,0001.5m $68.5m $68.5m 5.02% Added +265.0k +265,000
10 PERCEPTIVE ADVISORS LLC 1.88% of their portfolio NEW YORK, NY 1,501,0401.5m $67.5m $67.5m 1.88% Reduced -1.7m -1,703,936
11 Carlyle Group Inc. 1.49% of their portfolio WASHINGTON, DC 1,375,6461.4m $61.8m $61.8m 1.49% Reduced -2.7m -2,695,916
12 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,347,0191.3m $60.5m $60.5m 0.00% Added +204.8k +204,850
13 Vestal Point Capital, LP 2.82% of their portfolio NEW YORK, NY 1,060,0001.1m $47.6m $47.6m 2.82% Added +340.0k +340,000
14 CITADEL ADVISORS LLC 0.04% of their portfolio MIAMI, FL 972,410972.4k $43.7m $43.7m 0.04% Added +950.7k +950,670
15 Holocene Advisors, LP 0.14% of their portfolio New York, NY 955,467955.5k $42.9m $42.9m 0.14% Added +361.1k +361,103
16 WESTFIELD CAPITAL MANAGEMENT CO LP 0.17% of their portfolio BOSTON, MA 881,460881.5k $39.6m $39.6m 0.17% Added +385.8k +385,752
17 Pictet Asset Management Holding SA 0.04% of their portfolio CAROUGE, V8 851,838851.8k $38.3m $38.3m 0.04% Added +276.2k +276,225
18 FMR LLC 0.00% of their portfolio BOSTON, MA 813,027813.0k $36.5m $36.5m 0.00% Added +147.7k +147,653
19 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 782,265782.3k $35.2m $35.2m 0.01% Added +99.1k +99,095
20 Sofinnova Investments, Inc. 2.49% of their portfolio Menlo Park, CA 757,248757.2k $34.0m $34.0m 2.49% Added +170.9k +170,904
21 Frazier Life Sciences Management, L.P. 1.30% of their portfolio PALO ALTO, CA 699,159699.2k $31.4m $31.4m 1.30% Reduced -176.5k -176,508
22 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 599,119599.1k $26.9m $26.9m 0.00% Added +58.8k +58,823
23 EMERALD ADVISERS, LLC 1.01% of their portfolio LEOLA, PA 580,919580.9k $26.1m $26.1m 1.01% Added +267.6k +267,585
24 TCG Crossover Management, LLC 2.42% of their portfolio PALO ALTO, CA 550,000550.0k $24.7m $24.7m 2.42% Unchanged
25 Artia Global Partners LP 8.96% of their portfolio MIAMI, FL 494,424494.4k $22.2m $22.2m 8.96% Added +220.0k +220,000
26 MILLENNIUM MANAGEMENT LLC 0.02% of their portfolio NEW YORK, NY 476,801476.8k $21.4m $21.4m 0.02% Added +221.9k +221,912
27 Alyeska Investment Group, L.P. 0.07% of their portfolio CHICAGO, IL 424,081424.1k $19.1m $19.1m 0.07% Reduced -552.0k -552,024
28 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 419,443419.4k $18.9m $18.9m 0.00% Added +56.3k +56,293
29 MARSHALL WACE, LLP 0.02% of their portfolio LONDON, X0 399,849399.8k $18.0m $18.0m 0.02% Added +152.0k +152,010
30 SAMLYN CAPITAL, LLC 0.27% of their portfolio New York, NY 378,103378.1k $17.0m $17.0m 0.27% Reduced -133.7k -133,709
31 EMERALD MUTUAL FUND ADVISERS TRUST 1.01% of their portfolio LEOLA, PA 368,574368.6k $16.6m $16.6m 1.01% Added +135.6k +135,566
32 Siren, L.L.C. 0.70% of their portfolio New York, NY 351,818351.8k $15.8m $15.8m 0.70% New
33 Logos Global Management LP 1.84% of their portfolio San Francisco, CA 350,000350.0k $15.7m $15.7m 1.84% New
34 TimesSquare Capital Management, LLC 0.22% of their portfolio NEW YORK, NY 339,774339.8k $15.3m $15.3m 0.22% New
35 PFM Health Sciences, LP 1.05% of their portfolio SAN FRANCISCO, CA 307,503307.5k $13.8m $13.8m 1.05% New
36 Woodline Partners LP 0.09% of their portfolio San Francisco, CA 301,562301.6k $13.6m $13.6m 0.09% Reduced -100.5k -100,521
37 Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 1.63% of their portfolio WARSZAWA, R9 299,244299.2k $13.5m $13.5m 1.63% New
38 Balyasny Asset Management L.P. 0.03% of their portfolio Chicago, IL 261,325261.3k $11.7m $11.7m 0.03% New
39 Altium Capital Management LLC 3.50% of their portfolio NEW YORK, NY 250,000250.0k $11.2m $11.2m 3.50% Added +37.1k +37,091
40 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 226,889226.9k $10.2m $10.2m 0.00% Added +34.3k +34,309
41 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 217,550217.6k $9.8m $9.8m 0.00% Added +25.0k +24,953
42 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 210,237210.2k $9.5m $9.5m 0.00% Added +136.3k +136,256
43 Affinity Asset Advisors, LLC 0.91% of their portfolio NEW YORK, NY 130,000130.0k $5.8m $5.8m 0.91% Added +105.0k +105,000
44 Allspring Global Investments Holdings, LLC 0.01% of their portfolio CHARLOTTE, NC 128,028128.0k $5.8m $5.8m 0.01% Reduced -13.4k -13,396
45 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 126,675126.7k $5.7m $5.7m 0.00% Added +74.1k +74,130
46 Polar Asset Management Partners Inc. 0.08% of their portfolio TORONTO, A6 125,400125.4k $5.6m $5.6m 0.08% Added +93.8k +93,800
47 Rock Springs Capital Management LP 0.21% of their portfolio Baltimore, MD 124,095124.1k $5.6m $5.6m 0.21% New
48 COMERICA BANK 0.02% of their portfolio DALLAS, TX 121,213121.2k $5.4m $5.4m 0.02% Added +85.8k +85,823
49 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 119,455119.5k $5.4m $5.4m 0.00% Added +37.0k +36,971
50 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 118,614118.6k $5.3m $5.3m 0.01% Added +95.5k +95,494
51 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.02% of their portfolio SAN FRANCISCO, CA 90,00090.0k $4.0m $4.0m 0.02% Not comparable
52 Ally Bridge Group (NY) LLC 3.38% of their portfolio NEW YORK, NY 87,62987.6k $3.9m $3.9m 3.38% New
53 Nan Fung Group Holdings Ltd 3.06% of their portfolio KAI TAK, K3 79,65079.7k $3.6m $3.6m 3.06% Added +15.7k +15,700
54 Exome Asset Management LLC 2.61% of their portfolio NEW YORK, NY 77,28577.3k $3.5m $3.5m 2.61% New
55 Walleye Capital LLC 0.03% of their portfolio NEW YORK, NY 76,93476.9k $3.5m $3.5m 0.03% New
56 DIADEMA PARTNERS LP 3.65% of their portfolio MORRISTOWN, NJ 71,98872.0k $3.2m $3.2m 3.65% First filing
57 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 71,32071.3k $3.2m $3.2m 0.00% New
58 Atika Capital Management LLC 0.41% of their portfolio NEW YORK, NY 70,70070.7k $3.2m $3.2m 0.41% New
59 Checkpoint Capital L.P. 1.60% of their portfolio SAN FRANCISCO, CA 70,02770.0k $3.1m $3.1m 1.60% Added +12.0k +12,044
60 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 68,01568.0k $3.1m $3.1m 0.00% Added +4.3k +4,260
61 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 66,48066.5k $3.0m $3.0m 0.01% Added +9.8k +9,847
62 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 63,10563.1k $2.8m $2.8m 0.00% Added +3.6k +3,627
63 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 59,73459.7k $2.7m $2.7m 0.00% Reduced -5.2k -5,200
64 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 53,83353.8k $2.4m $2.4m 0.00% Added +36.8k +36,785
65 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 51,15751.2k $2.3m $2.3m 0.00% Reduced -1.5k -1,477
66 UBS Group AG 0.00% of their portfolio ZURICH, V8 50,15550.2k $2.3m $2.3m 0.00% Added +5.5k +5,490
67 TANG CAPITAL MANAGEMENT LLC 0.15% of their portfolio SAN DIEGO, CA 50,00050.0k $2.2m $2.2m 0.15% New
68 683 Capital Management, LLC 0.22% of their portfolio NEW YORK, NY 50,00050.0k $2.2m $2.2m 0.22% Reduced -1.3k -1,322
69 Union Square Park Capital Management, LLC 2.45% of their portfolio New York, NY 50,00050.0k $2.2m $2.2m 2.45% New
70 READYSTATE ASSET MANAGEMENT LP 0.09% of their portfolio CHICAGO, IL 50,00050.0k $2.2m $2.2m 0.09% New
71 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 49,94949.9k $2.2m $2.2m 0.00% Added +110 +110
72 F/m Investments LLC 0.08% of their portfolio WASHINGTON, DC 47,79447.8k $2.1m $2.1m 0.08% New
73 Swiss National Bank 0.00% of their portfolio ZURICH, V8 45,90045.9k $2.1m $2.1m 0.00% Added +9.9k +9,900
74 J. Goldman & Co LP 0.07% of their portfolio NEW YORK, NY 45,34245.3k $2.0m $2.0m 0.07% Added +23.6k +23,570
75 HARBOR CAPITAL ADVISORS, INC. 0.07% of their portfolio CHICAGO, IL 37,29637.3k $1.7m $1.7m 0.07% Added +1.2k +1,248
76 ADAR1 Capital Management, LLC 0.34% of their portfolio AUSTIN, TX 36,83036.8k $1.7m $1.7m 0.34% Added +26.8k +26,830
77 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 35,10635.1k $1.6m $1.6m 0.00% Added +7.2k +7,223
78 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 34,39534.4k $1.5m $1.5m 0.00% Added +3.6k +3,624
79 Atle Fund Management AB 0.47% of their portfolio STOCKHOLM, V7 30,94030.9k $984.8k $984.8k 0.47% Added +4.5k +4,550
80 CenterBook Partners LP 0.08% of their portfolio GREENWICH, CT 30,13630.1k $1.4m $1.4m 0.08% New
81 Moody Aldrich Partners LLC 0.25% of their portfolio MARBLEHEAD, MA 29,61429.6k $1.3m $1.3m 0.25% New
82 Aquatic Capital Management LLC 0.04% of their portfolio CHICAGO, IL 29,20829.2k $1.3m $1.3m 0.04% New
83 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 27,50427.5k $1.2m $1.2m 0.00% Added +5.5k +5,462
84 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 26,53226.5k $1.2m $1.2m 0.00% Added +14.8k +14,824
85 MARTINGALE ASSET MANAGEMENT L P 0.03% of their portfolio BOSTON, MA 25,17825.2k $1.1m $1.1m 0.03% Added +3.2k +3,203
86 Jefferies Financial Group Inc. 0.01% of their portfolio NEW YORK, NY 24,01424.0k $1.1m $1.1m 0.01% Reduced -11.3k -11,281
87 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 23,81023.8k $1.1m $1.1m 0.00% Added +800 +800
88 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 23,72423.7k $1.1m $1.1m 0.00% Reduced -4.1k -4,106
89 Legal & General Group Plc 0.00% of their portfolio London, X0 23,47123.5k $1.1m $1.1m 0.00% Added +3.4k +3,416
90 Caption Management, LLC 0.04% of their portfolio OKLAHOMA CITY, OK 23,14823.1k $1.0m $1.0m 0.04% Reduced -32.1k -32,052
91 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 21,97722.0k $987.9k $987.9k 0.00% Added +4.2k +4,201
92 Persistent Asset Partners Ltd 0.94% of their portfolio HONG KONG, K3 21,80921.8k $1.1m $1.1m 0.94% First filing
93 PRELUDE CAPITAL MANAGEMENT, LLC 0.08% of their portfolio NEW YORK, NY 20,31620.3k $913.2k $913.2k 0.08% New
94 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 17,17117.2k $772.8k $772.8k 0.00% Added +2.3k +2,278
95 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 16,87216.9k $758.4k $758.4k 0.00% Added +3.5k +3,457
96 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 16,44416.4k $739.2k $739.2k 0.00% Added +5.3k +5,258
97 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 15,53915.5k $698.5k $698.5k 0.00% Added +2.8k +2,767
98 MAPLELANE CAPITAL, LLC 0.07% of their portfolio New York, NY 15,15915.2k $681.4k $681.4k 0.07% Reduced -9.8k -9,841
99 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 15,00015.0k $674.2k $674.2k 0.00% New
100 FRED ALGER MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 14,80514.8k $665.5k $665.5k 0.00% Added +8.7k +8,660