SHATTUCK LABS INC STTK
COM · Common Stock · CUSIP 82024L103
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersAustin, TX
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 63.3m as of 2025-10-23, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.65. Options: 1 managers hold calls ($365 notional), 0 hold puts (—).
Trends to Q4 2025
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 63 |
| Q4 2022 | 49 |
| Q1 2023 | 50 |
| Q2 2023 | 43 |
| Q3 2023 | 42 |
| Q4 2023 | 58 |
| Q1 2024 | 71 |
| Q2 2024 | 75 |
| Q3 2024 | 79 |
| Q4 2024 | 76 |
| Q1 2025 | 76 |
| Q2 2025 | 62 |
| Q3 2025 | 56 |
| Q4 2025 | 65 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2024 | 51 | 23 |
| Q2 2024 | 50 | 35 |
| Q3 2024 | 42 | 27 |
| Q4 2024 | 37 | 35 |
| Q1 2025 | 24 | 30 |
| Q2 2025 | 31 | 45 |
| Q3 2025 | 25 | 41 |
| Q4 2025 | 32 | 18 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q1 2025 | $95 | $0 | 0.00 |
| Q2 2025 | $28.5k | $0 | 0.00 |
| Q3 2025 | $223.6k | $0 | 0.00 |
| Q4 2025 | $365 | $0 | 0.00 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | New | +1.9m |
| T. Rowe Price Investment Management, Inc. | New | +1.9m |
| Point72 Asset Management, L.P. | New | +1.1m |
| Aberdeen Group plc | Added | +436.7k |
| FMR LLC | Added | +389.2k |
| TD Asset Management Inc | New | +251.1k |
| VANGUARD GROUP INC | Added | +249.3k |
| SPHERA FUNDS MANAGEMENT LTD. | New | +195.2k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +150.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | New | +135.1k |
Biggest sellers
| Prosight Management, LP | Reduced | -3.1m |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | -249.9k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -213.5k |
| MARSHALL WACE, LLP | Reduced | -166.7k |
| 683 Capital Management, LLC | Reduced | -142.2k |
| JANE STREET GROUP, LLC | Reduced | -45.0k |
| PINNACLE ASSOCIATES LTD | Reduced | -38.1k |
| Keel Point, LLC | Reduced | -31.9k |
| BANK OF AMERICA CORP /DE/ | Reduced | -25.3k |
| Virtu Financial LLC | Sold out | -16.1k |
Biggest calls
| SIMPLEX TRADING, LLC | Reduced | $365100 shares |
Biggest puts
| None |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| T. Rowe Price Investment Management, Inc. 13G · institution +1.5 pts · filed 2026-08-14 | 15.3% |
ORBIMED ADVISORS LLC
13D · may seek influence
no change · filed 2026-06-15
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
10.0% |
| Redmile Group, LLC 13D · may seek influence no change · filed 2026-07-17 | 9.9% |
| Prosight Management, LP 13G · passive investor filed 2025-11-13 | 9.9% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 | 9.8% |
| BlackRock, Inc. 13G · institution +3.5 pts · filed 2026-10-27 | 5.3% |
| Deep Track Capital, LP 13G · passive investor new · filed 2026-06-17 | 5.2% |
Insider purchases and sales in Q4 2025
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q1 2024 | 0 | — | 2 | $418.5k | $418.5k |
| Q2 2024 | 2 | $82.7k | 0 | — | — |
| Q3 2024 | 0 | — | 0 | — | — |
| Q4 2024 | 2 | $210.9k | 1 | $166.7k | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 2 | $5.5m | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
None reported in Q4 2025.
Holders, Q4 2025
| Manager | Shares | Change |
|---|---|---|
| ORBIMED ADVISORS LLC 0.47% of their portfolio | 6.3m $23.0m | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 6.3m $23.0m | Unchanged |
| Redmile Group, LLC 1.49% of their portfolio | 5.5m $20.2m | Unchanged |
| NEXTBio Capital Management LP 6.74% of their portfolio | 3.1m $11.5m | First filing |
| Prosight Management, LP 1.80% of their portfolio | 2.4m $8.7m | Reduced -3.1m |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.4m $8.7m | Added +249.3k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.9m $7.0m | New |
| T. Rowe Price Investment Management, Inc. 0.00% of their portfolio | 1.9m $6.8m | New |
| CLARK ESTATES INC/NY 1.31% of their portfolio | 1.5m $5.4m | Unchanged |
| 683 Capital Management, LLC 0.42% of their portfolio | 1.4m $5.1m | Reduced -142.2k |
| PINNACLE ASSOCIATES LTD 0.06% of their portfolio | 1.4m $4.9m | Reduced -38.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.1m $4.0m | Reduced -25.3k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 1.1m $3.9m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 618.3k $2.3m | Added +150.3k |
| Aberdeen Group plc 0.00% of their portfolio | 531.2k $1.9m | Added +436.7k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 489.9k $1.8m | Reduced -166.7k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 477.4k $1.7m | Reduced -213.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 437.7k $1.6m | Added +29.1k |
| BlackRock, Inc. 0.00% of their portfolio | 418.5k $1.5m | Added +7.2k |
| FMR LLC 0.00% of their portfolio | 392.6k $1.4m | Added +389.2k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 340.7k $1.2m | Added +123.8k |
| TD Asset Management Inc 0.00% of their portfolio | 251.1k $916.3k | New |
| STATE STREET CORP 0.00% of their portfolio | 215.4k $786.3k | Added +38.7k |
| SPHERA FUNDS MANAGEMENT LTD. 0.15% of their portfolio | 195.2k $712.5k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 170.6k $622.7k | Added +57.9k |
| Pathstone Holdings, LLC 0.00% of their portfolio | 157.1k $573.4k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 148.4k $541.8k | Added +80.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 145.4k $530.9k | Added +54.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 135.1k $486.2k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 128.2k $467.8k | Added +111.4k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 110.4k $402.9k | Unchanged |
| LBJ Family Wealth Advisors, Ltd. 0.16% of their portfolio | 82.2k $300.0k | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 79.4k $289.0k | Reduced -249.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 68.8k $251.3k | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 65.7k $239.9k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 64.8k $236.5k | Added +45.5k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 54.0k $197.3k | Reduced -45.0k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 42.3k $154.4k | Unchanged |
| EP Wealth Advisors, LLC 0.00% of their portfolio | 41.2k $150.3k | First filing |
| PIPER SANDLER & CO. 0.10% of their portfolio | 39.5k $144.1k | Unchanged |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 38.8k $141.5k | Added +22.8k |
| Invesco Ltd. 0.00% of their portfolio | 28.2k $103.0k | New |
| CHOREO, LLC 0.00% of their portfolio | 27.3k $76.5k | Unchanged |
| OMERS ADMINISTRATION Corp 0.00% of their portfolio | 26.5k $96.7k | New |
| RITHOLTZ WEALTH MANAGEMENT 0.00% of their portfolio | 26.0k $94.9k | Unchanged |
| XTX Topco Ltd 0.00% of their portfolio | 24.9k $90.8k | Reduced -1.4k |
| CITIGROUP INC 0.00% of their portfolio | 24.8k $90.6k | Added +9.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 23.2k $84.7k | New |
| Mallini Complete Financial Planning LLC 0.07% of their portfolio | 22.6k $82.6k | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 20.9k $76.2k | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 18.1k $66.1k | Added +1.5k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 17.7k $64.6k | Unchanged |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 17.3k $63.1k | New |
| Keel Point, LLC 0.00% of their portfolio | 14.3k $52.1k | Reduced -31.9k |
| Engineers Gate Manager LP 0.00% of their portfolio | 13.7k $49.9k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 13.2k $48.2k | Added +11.8k |
| Creative Planning 0.00% of their portfolio | 12.3k $45.0k | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 11.5k $42.0k | New |
| STONERIDGE INVESTMENT PARTNERS LLC 0.03% of their portfolio | 10.5k $38.0k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 540 $2.0k | Reduced -418 |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 343 $1.3k | Reduced -263 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 92 $336 | Unchanged |
| Optiver Holding B.V. 0.00% of their portfolio | 66 $241 | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 64 $0 | Reduced -14.5k |
| CWM, LLC 0.00% of their portfolio | 43 $0 | Reduced -84 |