Vault-13

SHATTUCK LABS INC STTK

COM · Common Stock · CUSIP 82024L103

65 institutional holders +9 vs Q3 2025
42,533,43542.5m shares reported held*
67.2% of all shares outstanding*
$155.2mreported value*
15 new 17 added 14 reduced 4 sold out net bought ≈ $12.8m (+3.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 63.3m as of 2025-10-23, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.65. Options: 1 managers hold calls ($365 notional), 0 hold puts (—).

Trends to Q4 2025

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 63Q4 22: 49Q1 23: 50Q2 23: 43Q3 23: 42Q4 23: 58Q1 24: 71Q2 24: 75Q3 24: 79Q4 24: 76Q1 25: 76Q2 25: 62Q3 25: 56Q4 25: 6565Q3 22Q2 23Q1 24Q4 24Q4 25
Numbers
QuarterHolders
Q3 202263
Q4 202249
Q1 202350
Q2 202343
Q3 202342
Q4 202358
Q1 202471
Q2 202475
Q3 202479
Q4 202476
Q1 202576
Q2 202562
Q3 202556
Q4 202565

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 24: 51 bought or addedQ1 24: 23 cut or sold outQ2 24: 50 bought or addedQ2 24: 35 cut or sold outQ2 24Q3 24: 42 bought or addedQ3 24: 27 cut or sold outQ4 24: 37 bought or addedQ4 24: 35 cut or sold outQ4 24Q1 25: 24 bought or addedQ1 25: 30 cut or sold outQ2 25: 31 bought or addedQ2 25: 45 cut or sold outQ2 25Q3 25: 25 bought or addedQ3 25: 41 cut or sold outQ4 25: 32 bought or addedQ4 25: 18 cut or sold outQ4 25
Numbers
QuarterBought or addedCut or sold out
Q1 20245123
Q2 20245035
Q3 20244227
Q4 20243735
Q1 20252430
Q2 20253145
Q3 20252541
Q4 20253218

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100k$200k$300kQ1 25 calls: $95Q1 25 puts: $0Q1 25P/C 0.00Q2 25 calls: $28.5kQ2 25 puts: $0Q2 25P/C 0.00Q3 25 calls: $223.6kQ3 25 puts: $0Q3 25P/C 0.00Q4 25 calls: $365Q4 25 puts: $0Q4 25P/C 0.00
Numbers
QuarterCallsPutsP/C
Q1 2025$95$00.00
Q2 2025$28.5k$00.00
Q3 2025$223.6k$00.00
Q4 2025$365$00.00

Biggest buyers

PRICE T ROWE ASSOCIATES INC /MD/ New +1,926,140+1.9m
T. Rowe Price Investment Management, Inc. New +1,861,138+1.9m
Point72 Asset Management, L.P. New +1,068,231+1.1m
Aberdeen Group plc Added +436,673+436.7k
FMR LLC Added +389,233+389.2k
TD Asset Management Inc New +251,050+251.1k
VANGUARD GROUP INC Added +249,345+249.3k
SPHERA FUNDS MANAGEMENT LTD. New +195,212+195.2k
GEODE CAPITAL MANAGEMENT, LLC Added +150,318+150.3k
MANUFACTURERS LIFE INSURANCE COMPANY, THE New +135,056+135.1k

Biggest sellers

Prosight Management, LP Reduced -3,069,693-3.1m
ACADIAN ASSET MANAGEMENT LLC Reduced -249,921-249.9k
MILLENNIUM MANAGEMENT LLC Reduced -213,493-213.5k
MARSHALL WACE, LLP Reduced -166,741-166.7k
683 Capital Management, LLC Reduced -142,216-142.2k
JANE STREET GROUP, LLC Reduced -45,001-45.0k
PINNACLE ASSOCIATES LTD Reduced -38,085-38.1k
Keel Point, LLC Reduced -31,903-31.9k
BANK OF AMERICA CORP /DE/ Reduced -25,271-25.3k
Virtu Financial LLC Sold out -16,054-16.1k

Biggest calls

SIMPLEX TRADING, LLC Reduced $365100 shares

Biggest puts

None

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.5 pts · filed 2026-08-14 15.3% +1.5 pts 13.4m≈ $93.2m 2026-08-14
ORBIMED ADVISORS LLC 13D · may seek influence no change · filed 2026-06-15
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing
10.0% no change 9.0m≈ $62.6m 2026-06-15
Redmile Group, LLC 13D · may seek influence no change · filed 2026-07-17 9.9% no change 10.0m≈ $69.5m 2026-07-17
Prosight Management, LP 13G · passive investor filed 2025-11-13 9.9% 6.5m≈ $45.4m 2025-11-13
ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 9.8% 4.7m≈ $32.4m 2025-02-12
BlackRock, Inc. 13G · institution +3.5 pts · filed 2026-10-27 5.3% +3.5 pts 5.3m≈ $37.1m 2026-10-27
Deep Track Capital, LP 13G · passive investor new · filed 2026-06-17 5.2% new 5.0m≈ $34.7m 2026-06-17

Insider purchases and sales in Q4 2025

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q1 24: 0 buyingQ1 24: 2 sellingQ2 24: 2 buyingQ2 24: 0 sellingQ2 24Q3 24: 0 buyingQ3 24: 0 sellingQ4 24: 2 buyingQ4 24: 1 sellingQ4 24Q1 25: 0 buyingQ1 25: 0 sellingQ2 25: 0 buyingQ2 25: 0 sellingQ2 25Q3 25: 2 buyingQ3 25: 0 sellingQ4 25: 0 buyingQ4 25: 0 sellingQ4 25
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q1 20240—2$418.5k$418.5k
Q2 20242$82.7k0——
Q3 20240—0——
Q4 20242$210.9k1$166.7k—
Q1 20250—0——
Q2 20250—0——
Q3 20252$5.5m0——
Q4 20250—0——

None reported in Q4 2025.

Holders, Q4 2025

#ManagerLocationShares Value% of their portfolioChangeShares change
1 ORBIMED ADVISORS LLC 0.47% of their portfolio New York, NY 6,306,1276.3m $23.0m $23.0m 0.47% Unchanged
2 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 6,306,1276.3m $23.0m $23.0m 0.03% Unchanged
3 Redmile Group, LLC 1.49% of their portfolio LARKSPUR, CA 5,539,7245.5m $20.2m $20.2m 1.49% Unchanged
4 NEXTBio Capital Management LP 6.74% of their portfolio AUSTIN, TX 3,149,9073.1m $11.5m $11.5m 6.74% First filing
5 Prosight Management, LP 1.80% of their portfolio DALLAS, TX 2,381,5022.4m $8.7m $8.7m 1.80% Reduced -3.1m -3,069,693
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,377,7462.4m $8.7m $8.7m 0.00% Added +249.3k +249,345
7 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,926,1401.9m $7.0m $7.0m 0.00% New
8 T. Rowe Price Investment Management, Inc. 0.00% of their portfolio BALTIMORE, MD 1,861,1381.9m $6.8m $6.8m 0.00% New
9 CLARK ESTATES INC/NY 1.31% of their portfolio NEW YORK, NY 1,475,6481.5m $5.4m $5.4m 1.31% Unchanged
10 683 Capital Management, LLC 0.42% of their portfolio NEW YORK, NY 1,390,0001.4m $5.1m $5.1m 0.42% Reduced -142.2k -142,216
11 PINNACLE ASSOCIATES LTD 0.06% of their portfolio NEW YORK, NY 1,350,6381.4m $4.9m $4.9m 0.06% Reduced -38.1k -38,085
12 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 1,106,6171.1m $4.0m $4.0m 0.00% Reduced -25.3k -25,271
13 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 1,068,2311.1m $3.9m $3.9m 0.01% New
14 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 618,277618.3k $2.3m $2.3m 0.00% Added +150.3k +150,318
15 Aberdeen Group plc 0.00% of their portfolio EDINBURGH, X0 531,177531.2k $1.9m $1.9m 0.00% Added +436.7k +436,673
16 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 489,912489.9k $1.8m $1.8m 0.00% Reduced -166.7k -166,741
17 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 477,408477.4k $1.7m $1.7m 0.00% Reduced -213.5k -213,493
18 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 437,729437.7k $1.6m $1.6m 0.00% Added +29.1k +29,131
19 BlackRock, Inc. 0.00% of their portfolio New York, NY 418,529418.5k $1.5m $1.5m 0.00% Added +7.2k +7,237
20 FMR LLC 0.00% of their portfolio BOSTON, MA 392,600392.6k $1.4m $1.4m 0.00% Added +389.2k +389,233
21 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 340,700340.7k $1.2m $1.2m 0.00% Added +123.8k +123,833
22 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 251,050251.1k $916.3k $916.3k 0.00% New
23 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 215,418215.4k $786.3k $786.3k 0.00% Added +38.7k +38,700
24 SPHERA FUNDS MANAGEMENT LTD. 0.15% of their portfolio TEL AVIV, L3 195,212195.2k $712.5k $712.5k 0.15% New
25 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 170,600170.6k $622.7k $622.7k 0.00% Added +57.9k +57,923
26 Pathstone Holdings, LLC 0.00% of their portfolio ENGLEWOOD, NJ 157,083157.1k $573.4k $573.4k 0.00% Unchanged
27 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 148,427148.4k $541.8k $541.8k 0.00% Added +80.3k +80,311
28 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 145,445145.4k $530.9k $530.9k 0.00% Added +54.2k +54,173
29 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 135,056135.1k $486.2k $486.2k 0.00% New
30 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 128,165128.2k $467.8k $467.8k 0.00% Added +111.4k +111,365
31 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 110,394110.4k $402.9k $402.9k 0.00% Unchanged
32 LBJ Family Wealth Advisors, Ltd. 0.16% of their portfolio AUSTIN, TX 82,17782.2k $300.0k $300.0k 0.16% Unchanged
33 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 79,36779.4k $289.0k $289.0k 0.00% Reduced -249.9k -249,921
34 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 68,84668.8k $251.3k $251.3k 0.00% New
35 Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio VANCOUVER, A1 65,73465.7k $239.9k $239.9k 0.00% New
36 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 64,78564.8k $236.5k $236.5k 0.00% Added +45.5k +45,525
37 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 54,04654.0k $197.3k $197.3k 0.00% Reduced -45.0k -45,001
38 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.00% of their portfolio HOUSTON, TX 42,30042.3k $154.4k $154.4k 0.00% Unchanged
39 EP Wealth Advisors, LLC 0.00% of their portfolio TORRANCE, CA 41,16741.2k $150.3k $150.3k 0.00% First filing
40 PIPER SANDLER & CO. 0.10% of their portfolio MINNEAPOLIS, MN 39,46739.5k $144.1k $144.1k 0.10% Unchanged
41 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 38,75738.8k $141.5k $141.5k 0.00% Added +22.8k +22,806
42 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 28,23128.2k $103.0k $103.0k 0.00% New
43 CHOREO, LLC 0.00% of their portfolio ROCKFORD, IL 27,25127.3k $76.5k $76.5k 0.00% Unchanged
44 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 26,50026.5k $96.7k $96.7k 0.00% New
45 RITHOLTZ WEALTH MANAGEMENT 0.00% of their portfolio NEW YORK, NY 26,00026.0k $94.9k $94.9k 0.00% Unchanged
46 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 24,87324.9k $90.8k $90.8k 0.00% Reduced -1.4k -1,353
47 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 24,83224.8k $90.6k $90.6k 0.00% Added +9.7k +9,724
48 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 23,19223.2k $84.7k $84.7k 0.00% New
49 Mallini Complete Financial Planning LLC 0.07% of their portfolio GAINESVILLE, FL 22,63222.6k $82.6k $82.6k 0.07% New
50 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 20,88120.9k $76.2k $76.2k 0.00% Unchanged
51 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 18,10818.1k $66.1k $66.1k 0.00% Added +1.5k +1,457
52 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 17,70017.7k $64.6k $64.6k 0.00% Unchanged
53 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 17,28217.3k $63.1k $63.1k 0.00% New
54 Keel Point, LLC 0.00% of their portfolio HUNTSVILLE, AL 14,27014.3k $52.1k $52.1k 0.00% Reduced -31.9k -31,903
55 Engineers Gate Manager LP 0.00% of their portfolio NEW YORK, NY 13,67013.7k $49.9k $49.9k 0.00% Unchanged
56 UBS Group AG 0.00% of their portfolio ZURICH, V8 13,20413.2k $48.2k $48.2k 0.00% Added +11.8k +11,771
57 Creative Planning 0.00% of their portfolio OVERLAND PARK, KS 12,33512.3k $45.0k $45.0k 0.00% Unchanged
58 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 11,50011.5k $42.0k $42.0k 0.00% New
59 STONERIDGE INVESTMENT PARTNERS LLC 0.03% of their portfolio RADNOR, PA 10,45310.5k $38.0k $38.0k 0.03% New
60 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 540540 $2.0k $2.0k 0.00% Reduced -418 -418
61 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 343343 $1.3k $1.3k 0.00% Reduced -263 -263
62 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 9292 $336 $336 0.00% Unchanged
63 Optiver Holding B.V. 0.00% of their portfolio AMSTERDAM, P7 6666 $241 $241 0.00% Unchanged
64 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 6464 $0 $0 0.00% Reduced -14.5k -14,457
65 CWM, LLC 0.00% of their portfolio OMAHA, NE 4343 $0 $0 0.00% Reduced -84 -84