Vault-13

Q32 BIO INC QTTB

COM · Common Stock · CUSIP 746964105

71 institutional holders +18 vs Q1 2026
22,197,15822.2m shares reported held*
74.6% of all shares outstanding*
$282.8mreported value*
27 new 18 added 13 reduced 8 sold out net bought ≈ $162.7m (+12.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 29.8m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $12.74. Options: 0 managers hold calls (— notional), 3 hold puts ($3.3m).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

050100Q1 24: 39Q2 24: 55Q3 24: 74Q4 24: 93Q1 25: 74Q2 25: 62Q3 25: 53Q4 25: 52Q1 26: 53Q2 26: 7171Q1 24Q3 24Q1 25Q3 25Q1 26Q2 26
Numbers
QuarterHolders
Q1 202439
Q2 202455
Q3 202474
Q4 202493
Q1 202574
Q2 202562
Q3 202553
Q4 202552
Q1 202653
Q2 202671

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q3 24: 44 bought or addedQ3 24: 16 cut or sold outQ4 24: 50 bought or addedQ4 24: 30 cut or sold outQ4 24Q1 25: 24 bought or addedQ1 25: 44 cut or sold outQ2 25: 21 bought or addedQ2 25: 41 cut or sold outQ2 25Q3 25: 18 bought or addedQ3 25: 34 cut or sold outQ4 25: 16 bought or addedQ4 25: 28 cut or sold outQ4 25Q1 26: 22 bought or addedQ1 26: 17 cut or sold outQ2 26: 45 bought or addedQ2 26: 21 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20244416
Q4 20245030
Q1 20252444
Q2 20252141
Q3 20251834
Q4 20251628
Q1 20262217
Q2 20264521

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3m$4mQ3 25 calls: $0Q3 25 puts: $0Q3 25P/C —Q4 25 calls: $0Q4 25 puts: $0Q4 25P/C —Q1 26 calls: $0Q1 26 puts: $0Q1 26P/C —Q2 26 calls: $0Q2 26 puts: $3.3mQ2 26P/C —
Numbers
QuarterCallsPutsP/C
Q3 2025$0$0—
Q4 2025$0$0—
Q1 2026$0$0—
Q2 2026$0$3.3m—

Biggest buyers

Boxer Capital Management, LLC New +3,149,310+3.1m
BVF INC/IL New +2,350,000+2.4m
RA CAPITAL MANAGEMENT, L.P. New +2,332,457+2.3m
ORBIMED ADVISORS LLC Added +1,875,000+1.9m
Point72 Asset Management, L.P. New +1,173,396+1.2m
Logos Global Management LP New +800,000+800.0k
SummitTX Capital, L.P. New +733,774+733.8k
Atlas Venture Life Science Advisors, LLC Added +625,000+625.0k
Ikarian Capital, LLC New +430,000+430.0k
Woodline Partners LP New +286,212+286.2k

Biggest sellers

Carlyle Group Inc. Reduced -1,042,378-1.0m
Opaleye Management Inc. Reduced -325,228-325.2k
ARCH Venture Management, LLC Sold out -320,482-320.5k
MACKENZIE FINANCIAL CORP Sold out -246,304-246.3k
Pfizer Inc Sold out -101,618-101.6k
ACORN CAPITAL ADVISORS, LLC Reduced -98,881-98.9k
ADAR1 Capital Management, LLC Sold out -35,000-35.0k
RENAISSANCE TECHNOLOGIES LLC Reduced -27,315-27.3k
Cetera Investment Advisers Sold out -20,695-20.7k
EverSource Wealth Advisors, LLC Reduced -4,400-4.4k

Biggest calls

None

Biggest puts

Ikarian Capital, LLC New $2.5m200.0k shares
BOOTHBAY FUND MANAGEMENT, LLC New $781.0k61.3k shares
SIMPLEX TRADING, LLC New $2.5k200 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
ORBIMED ADVISORS LLC 13D · may seek influence -3.5 pts · filed 2026-07-20
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing
 13.9% -3.5 pts 4.1m≈ $52.6m 2026-07-20
Boxer Capital Management, LLC 13G · institution new · filed 2026-07-10 13.3% new 3.1m≈ $40.1m 2026-07-10
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor new · filed 2026-06-04 10.0% new 2.4m≈ $30.2m 2026-06-04
RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-06-04 9.8% new 2.3m≈ $29.7m 2026-06-04
BANK OF AMERICA CORP /DE/ 13G · institution new · filed 2026-10-28 7.4% new 2.2m≈ $28.1m 2026-10-28
Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-10-09 5.9% new 1.8m≈ $22.4m 2026-10-09
Opaleye Management Inc. 13G · passive investor -3.1 pts · filed 2026-07-31 5.5% -3.1 pts 931.0k≈ $11.9m 2026-07-31

Fell to 5% or below in the last year: Point72 Asset Management, L.P. (5.0%, 2026-08-14), Sirenia Capital Management LP (0.0%, 2026-08-14), Carlyle Group Inc. (4.1%, 2026-07-06), Atlas Venture Fund X, L.P. (3.6%, 2026-05-28), PFIZER INC (2.3%, 2026-02-13)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q4 24: 0 buyingQ4 24: 0 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 3 sellingQ3 25Q4 25: 0 buyingQ4 25: 2 sellingQ1 26: 0 buyingQ1 26: 3 sellingQ1 26Q2 26: 2 buyingQ2 26: 0 sellingQ3 26: 0 buyingQ3 26: 3 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—0——
Q1 20250—0——
Q2 20250—0——
Q3 20250—3$31.9k—
Q4 20250—2$109.3k—
Q1 20260—3$75.3k—
Q2 20262$15.0m0——
Q3 20260—3$275.1k—
DateInsiderTradeSharesPrice ValueTheir holding
2026-08-25 Morrison Jodie Pope CEO, director Sold 9,845 $16.56 $163.0k9.8k shares -3%
2026-08-25 Kalowski Lee CFO and President Sold 3,972 $16.56 $65.8k4.0k shares -3%
2026-08-25 Violette Shelia M. Chief Scientific Officer Sold 2,798 $16.56 $46.3k2.8k shares -2%
2026-05-28 ORBIMED ADVISORS LLC +2 Director · See footnotes Bought 1,875,000 $8.00 $15.0m1.9m shares new
2026-05-28 Xu Diyong Director · See footnotes Bought 1,875,000 $8.00 $15.0m1.9m shares new

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 ORBIMED ADVISORS LLC 1.00% of their portfolio New York, NY 4,127,9874.1m $52.6m $52.6m 1.00% Added +1.9m +1,875,000
2 Boxer Capital Management, LLC 3.02% of their portfolio San Diego, CA 3,149,3103.1m $40.1m $40.1m 3.02% New
3 Atlas Venture Life Science Advisors, LLC 3.93% of their portfolio CAMBRIDGE, MA 2,717,1062.7m $34.6m $34.6m 3.93% Added +625.0k +625,000
4 BVF INC/IL 0.77% of their portfolio San Francisco, CA 2,350,0002.4m $29.9m $29.9m 0.77% New
5 RA CAPITAL MANAGEMENT, L.P. 0.26% of their portfolio BOSTON, MA 2,332,4572.3m $29.7m $29.7m 0.26% New
6 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 1,173,3961.2m $14.9m $14.9m 0.02% New
7 Opaleye Management Inc. 1.07% of their portfolio BOSTON, MA 931,000931.0k $11.9m $11.9m 1.07% Reduced -325.2k -325,228
8 Logos Global Management LP 0.44% of their portfolio San Francisco, CA 800,000800.0k $10.2m $10.2m 0.44% New
9 SummitTX Capital, L.P. 0.25% of their portfolio FORT WORTH, TX 733,774733.8k $9.3m $9.3m 0.25% New
10 VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio MALVERN, PA 518,803518.8k $6.6m $6.6m 0.00% Added +212.4k +212,402
11 Ikarian Capital, LLC 0.90% of their portfolio DALLAS, TX 430,000430.0k $5.5m $5.5m 0.90% New
12 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 286,212286.2k $3.6m $3.6m 0.01% New
13 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 272,752272.8k $3.5m $3.5m 0.00% Added +254.0k +253,982
14 Sanofi 0.58% of their portfolio Paris, I0 244,083244.1k $3.1m $3.1m 0.58% Unchanged
15 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 218,234218.2k $2.8m $2.8m 0.00% Added +45.6k +45,648
16 ACORN CAPITAL ADVISORS, LLC 0.75% of their portfolio NEW YORK, NY 216,171216.2k $2.8m $2.8m 0.75% Reduced -98.9k -98,881
17 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 179,600179.6k $2.3m $2.3m 0.00% Reduced -27.3k -27,315
18 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 162,747162.7k $2.1m $2.1m 0.00% Added +97.1k +97,148
19 MONIMUS CAPITAL MANAGEMENT, LP 0.43% of their portfolio WOODBRIDGE, NJ 132,036132.0k $1.7m $1.7m 0.43% Reduced -2.3k -2,274
20 BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio NEW YORK, NY 130,427130.4k $1.7m $1.7m 0.03% New
21 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 122,690122.7k $1.6m $1.6m 0.00% Added +4.5k +4,538
22 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 120,663120.7k $1.5m $1.5m 0.00% Added +105.2k +105,182
23 BlackRock, Inc. 0.00% of their portfolio New York, NY 118,507118.5k $1.5m $1.5m 0.00% Added +32.4k +32,360
24 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 67,04567.0k $854.2k $854.2k 0.00% Added +14.6k +14,605
25 VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio MALVERN, PA 66,21766.2k $843.6k $843.6k 0.00% Added +16.2k +16,222
26 Carlyle Group Inc. 0.01% of their portfolio WASHINGTON, DC 60,36360.4k $769.0k $769.0k 0.01% Reduced -1.0m -1,042,378
27 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 52,21452.2k $665.2k $665.2k 0.00% Added +10.7k +10,700
28 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 49,58249.6k $631.7k $631.7k 0.00% Added +7.2k +7,236
29 Quadrature Capital Ltd 0.00% of their portfolio LONDON, X0 36,39636.4k $463.7k $463.7k 0.00% New
30 Cambridge Investment Research Advisors, Inc. 0.00% of their portfolio FAIRFIELD, IA 36,16236.2k $460.0k $460.0k 0.00% Added +1.1k +1,137
31 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 34,61334.6k $441.0k $441.0k 0.01% Added +22.0k +22,000
32 DAFNA Capital Management LLC 0.08% of their portfolio LOS ANGELES, CA 32,89632.9k $419.1k $419.1k 0.08% New
33 Knott David M Jr 0.20% of their portfolio SYOSSET, NY 30,41230.4k $387.4k $387.4k 0.20% New
34 Affinity Asset Advisors, LLC 0.02% of their portfolio NEW YORK, NY 27,77727.8k $353.9k $353.9k 0.02% Unchanged
35 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 23,79023.8k $303.1k $303.1k 0.00% New
36 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 23,63123.6k $301.1k $301.1k 0.00% Reduced -1.4k -1,402
37 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 23,58823.6k $300.5k $300.5k 0.00% New
38 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 23,34223.3k $297.4k $297.4k 0.00% New
39 MANGROVE PARTNERS IM, LLC 0.02% of their portfolio Greenwich, CT 22,15022.1k $282.2k $282.2k 0.02% New
40 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 18,17018.2k $231.5k $231.5k 0.00% New
41 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 15,94915.9k $203.0k $203.0k 0.00% New
42 UBS Group AG 0.00% of their portfolio ZURICH, V8 15,00815.0k $191.2k $191.2k 0.00% Added +14.7k +14,738
43 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 12,34212.3k $157.2k $157.2k 0.00% New
44 ExodusPoint Capital Management, LP 0.00% of their portfolio NEW YORK, NY 11,33611.3k $144.4k $144.4k 0.00% New
45 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 10,92810.9k $139.2k $139.2k 0.00% New
46 XTX Topco Ltd 0.00% of their portfolio LONDON, X0 10,87410.9k $138.5k $138.5k 0.00% New
47 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 6,4566.5k $82.3k $82.3k 0.00% Reduced -3.1k -3,104
48 Vanguard Global Advisers, LLC 0.00% of their portfolio MALVERN, PA 4,8244.8k $61.5k $61.5k 0.00% Added +2.9k +2,909
49 FMR LLC 0.00% of their portfolio BOSTON, MA 3,3883.4k $43.2k $43.2k 0.00% Reduced -12 -12
50 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 2,8882.9k $36.8k $36.8k 0.00% New
51 Private Wealth Asset Management, LLC 0.00% of their portfolio OMAHA, NE 1,7001.7k $21.7k $21.7k 0.00% New
52 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 1,1111.1k $14.2k $14.2k 0.00% Reduced -37 -37
53 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 1,0501.1k $13.4k $13.4k 0.00% Reduced -1.2k -1,223
54 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 577577 $7.4k $7.4k 0.00% Unchanged
55 JONES FINANCIAL COMPANIES LLLP 0.00% of their portfolio DES PERES, MO 500500 $6.6k $6.6k 0.00% Unchanged
56 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 454454 $5.8k $5.8k 0.00% Unchanged
57 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 303303 $3.9k $3.9k 0.00% Unchanged
58 EverSource Wealth Advisors, LLC 0.00% of their portfolio BIRMINGHAM, AL 240240 $3.1k $3.1k 0.00% Reduced -4.4k -4,400
59 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 166166 $2.1k $2.1k 0.00% Unchanged
60 Truvestments Capital LLC 0.00% of their portfolio SARASOTA, FL 162162 $2.1k $2.1k 0.00% New
61 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 124124 $1.6k $1.6k 0.00% Unchanged
62 Allworth Financial LP 0.00% of their portfolio FOLSOM, CA 108108 $1.4k $1.4k 0.00% Added +10 +10
63 SBI Securities Co., Ltd. 0.00% of their portfolio TOKYO, M0 9494 $1.2k $1.2k 0.00% Reduced -10 -10
64 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 7070 $888 $888 0.00% Unchanged
65 Clearstead Advisors, LLC 0.00% of their portfolio CLEVELAND, OH 6767 $854 $854 0.00% New
66 Caitong International Asset Management Co., Ltd 0.00% of their portfolio HONG KONG, K3 4545 $573 $573 0.00% New
67 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 4343 $0 $0 0.00% Reduced -2.7k -2,701
68 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 3434 $433 $433 0.00% Unchanged
69 HARBOUR INVESTMENTS, INC. 0.00% of their portfolio MADISON, WI 1111 $140 $140 0.00% Unchanged
70 AdvisorNet Financial, Inc 0.00% of their portfolio MINNETONKA, MN 22 $25 $25 0.00% Unchanged
71 DANSKE BANK A/S 0.00% of their portfolio COPENHAGEN V, G7 11 $13 $13 0.00% Unchanged