MEREO BIOPHARMA GROUP PLC MREO
SPON ADS · ADR · CUSIP 589492107 · ISIN US5894921072
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $0.32. Options: 5 managers hold calls ($286.6k notional), 4 hold puts ($31.0k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 63 |
| Q4 2022 | 61 |
| Q1 2023 | 59 |
| Q2 2023 | 54 |
| Q3 2023 | 57 |
| Q4 2023 | 65 |
| Q1 2024 | 81 |
| Q2 2024 | 80 |
| Q3 2024 | 78 |
| Q4 2024 | 92 |
| Q1 2025 | 91 |
| Q2 2025 | 87 |
| Q3 2025 | 84 |
| Q4 2025 | 70 |
| Q1 2026 | 63 |
| Q2 2026 | 61 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 30 | 34 |
| Q4 2024 | 35 | 34 |
| Q1 2025 | 40 | 35 |
| Q2 2025 | 42 | 35 |
| Q3 2025 | 36 | 38 |
| Q4 2025 | 35 | 55 |
| Q1 2026 | 29 | 38 |
| Q2 2026 | 27 | 29 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $5.8m | $410.4k | 0.07 |
| Q4 2025 | $1.7m | $902.2k | 0.54 |
| Q1 2026 | $314.9k | $212.2k | 0.67 |
| Q2 2026 | $286.6k | $31.0k | 0.11 |
Biggest buyers
| TWO SIGMA INVESTMENTS, LP | Added | +1.1m |
| Ishara Investments LP | New | +768.8k |
| JANE STREET GROUP, LLC | Added | +635.0k |
| CITADEL ADVISORS LLC | New | +444.2k |
| NOMURA HOLDINGS INC | New | +104.4k |
| James J. Burns & Company, LLC | New | +95.4k |
| Quarry LP | New | +93.8k |
| XTX Topco Ltd | Added | +90.0k |
| GOLDMAN SACHS GROUP INC | New | +85.2k |
| JMN Financial LLC | New | +76.7k |
Biggest sellers
| EcoR1 Capital, LLC | Reduced | -12.4m |
| Newtyn Management, LLC | Reduced | -4.1m |
| MILLENNIUM MANAGEMENT LLC | Sold out | -3.6m |
| MARSHALL WACE, LLP | Reduced | -507.1k |
| Knott David M Jr | Sold out | -300.3k |
| BlackRock, Inc. | Reduced | -233.3k |
| 683 Capital Management, LLC | Reduced | -222.1k |
| ACADIAN ASSET MANAGEMENT LLC | Sold out | -209.1k |
| GROUP ONE TRADING LLC | Reduced | -168.3k |
| ADAR1 Capital Management, LLC | Sold out | -150.0k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $160.4k504.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $55.5k173.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $46.5k146.2k shares |
| GROUP ONE TRADING LLC | Reduced | $20.4k64.3k shares |
| JANE STREET GROUP, LLC | Reduced | $3.7k11.8k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $16.2k51.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $14.7k46.0k shares |
| GROUP ONE TRADING LLC | Reduced | $32100 shares |
| SIMPLEX TRADING, LLC | Reduced | $31100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| 683 Capital Management, LLC 13G · passive investor new · filed 2026-01-06 | 8.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 13G · institution filed 2025-02-12 | 5.6% |
Fell to 5% or below in the last year: BANK OF AMERICA CORP /DE/ (3.4%, 2026-10-28), EcoR1 Capital, LLC (6.0%, 2026-08-14), JANUS HENDERSON GROUP PLC (0.0%, 2026-02-17), Northpond Ventures, LP (0.0%, 2026-02-17), Frazier Life Sciences Public Fund, L.P. (0.0%, 2026-02-13), MANGROVE PARTNERS IM, LLC (4.9%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Rubric Capital Management LP 0.04% of their portfolio | 15.3m $4.9m | Unchanged |
| 683 Capital Management, LLC 0.34% of their portfolio | 11.8m $3.7m | Reduced -222.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 8.2m $2.6m | Reduced -6 |
| Defilade Capital Management, L.P. 0.32% of their portfolio | 7.6m $2.4m | Unchanged |
| Newtyn Management, LLC 0.12% of their portfolio | 3.0m $953.1k | Reduced -4.1m |
| Tejara Capital Ltd 0.27% of their portfolio | 2.0m $647.3k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 1.4m $460.3k | Reduced -42.5k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 1.3m $419.1k | Added +1.1m |
| EcoR1 Capital, LLC 0.02% of their portfolio | 1.0m $317.7k | Reduced -12.4m |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 774.9k $246.2k | Added +635.0k |
| Ishara Investments LP 0.18% of their portfolio | 768.8k $244.2k | New |
| Wealthspire Advisors, LLC 0.00% of their portfolio | 765.0k $243.0k | Reduced -31.0k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 444.2k $141.1k | New |
| Rangeley Capital, LLC 0.10% of their portfolio | 329.2k $104.6k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 213.3k $67.8k | Added +17.4k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 179.9k $57.6k | Reduced -507.1k |
| XTX Topco Ltd 0.00% of their portfolio | 174.5k $55.4k | Added +90.0k |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 167.5k $53.2k | Reduced -168.3k |
| STATE STREET CORP 0.00% of their portfolio | 134.8k $42.8k | Added +1.4k |
| NOMURA HOLDINGS INC 0.00% of their portfolio | 104.4k $33.2k | New |
| James J. Burns & Company, LLC 0.00% of their portfolio | 95.4k $30.3k | New |
| Quarry LP 0.00% of their portfolio | 93.8k $29.8k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 85.2k $27.1k | New |
| JMN Financial LLC 0.02% of their portfolio | 76.7k $24.4k | New |
| BlackRock, Inc. 0.00% of their portfolio | 69.7k $22.1k | Reduced -233.3k |
| Virtu Financial LLC 0.00% of their portfolio | 61.3k $19.0k | Added +24.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 58.5k $19.4k | Added +36.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 52.1k $16.6k | Added +3.7k |
| Significant Wealth Partners LLC 0.01% of their portfolio | 32.7k $10.4k | Added +7.0k |
| Clear Harbor Asset Management, LLC 0.00% of their portfolio | 32.0k $10.1k | Reduced -3.0k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 26.8k $8.5k | Added +7.2k |
| Centiva Capital, LP 0.00% of their portfolio | 25.0k $7.9k | Unchanged |
| Engineers Gate Manager LP 0.00% of their portfolio | 24.0k $7.6k | Reduced -1 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 18.8k $6.0k | New |
| NFSG Corp 0.00% of their portfolio | 18.8k $6.0k | Unchanged |
| OneDigital Investment Advisors LLC 0.00% of their portfolio | 18.3k $5.8k | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 16.7k $5.3k | Added +306 |
| IHT Wealth Management, LLC 0.00% of their portfolio | 15.0k $4.8k | Unchanged |
| TWO SIGMA SECURITIES, LLC 0.00% of their portfolio | 12.9k $4.1k | New |
| J. Safra Sarasin Holding AG 0.00% of their portfolio | 12.8k $4.1k | New |
| SG Americas Securities, LLC 0.00% of their portfolio | 12.8k $4.0k | New |
| MML INVESTORS SERVICES, LLC 0.00% of their portfolio | 12.2k $3.9k | Unchanged |
| World Investment Advisors 0.00% of their portfolio | 10.0k $3.3k | Unchanged |
| Astoria Portfolio Advisors LLC. 0.00% of their portfolio | 10.0k $3.2k | Unchanged |
| GAMMA Investing LLC 0.00% of their portfolio | 9.3k $3.0k | Reduced -10.0k |
| Arax Advisory Partners 0.00% of their portfolio | 5.8k $1.8k | Added +1.8k |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 2.0k $635 | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 1.5k $477 | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.5k $479 | Unchanged |
| Markowski Investments 0.00% of their portfolio | 1.5k $477 | First filing |
| SIT INVESTMENT ASSOCIATES INC 0.00% of their portfolio | 970 $0 | Unchanged |
| New England Capital Financial Advisors LLC 0.00% of their portfolio | 300 $96 | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 231 $73 | Added +1 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 114 $36 | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 100 $32 | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 52 $17 | New |
| US BANCORP \DE\ 0.00% of their portfolio | 13 $4 | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 3 $1 | Unchanged |
| Axiom Investment Management LLC 0.00% of their portfolio | 1 $0 | Unchanged |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 1 $0 | New |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 1 $0 | New |