KRYSTAL BIOTECH INC KRYS
COM · Common Stock · CUSIP 501147102
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPittsburgh, PA
- Websitekrystalbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.1m this quarter). Holder counts are more reliable. Shares outstanding: 25.8m as of 2023-05-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $80.03. Options: 9 managers hold calls ($10.6m notional), 10 hold puts ($11.7m).
Trends to Q1 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 149 |
| Q4 2022 | 156 |
| Q1 2023 | 162 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 76 | 61 |
| Q1 2023 | 76 | 66 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $5.1m | $10.9m | 2.14 |
| Q4 2022 | $5.7m | $21.4m | 3.77 |
| Q1 2023 | $10.6m | $11.7m | 1.10 |
Biggest buyers
| FMR LLC | Added | +2.3m |
| Avoro Capital Advisors LLC | Added | +340.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +136.9k |
| GOLDMAN SACHS GROUP INC | Added | +110.3k |
| Nicholas Investment Partners, LP | Added | +107.6k |
| Candriam S.C.A. | New | +92.0k |
| DIMENSIONAL FUND ADVISORS LP | Added | +72.8k |
| MORGAN STANLEY | Added | +60.8k |
| CITADEL ADVISORS LLC | Added | +54.6k |
| Driehaus Capital Management LLC | New | +53.9k |
Biggest sellers
| LORD, ABBETT & CO. LLC | Reduced | -633.6k |
| First Light Asset Management, LLC | Reduced | -277.7k |
| VICTORY CAPITAL MANAGEMENT INC | Reduced | -127.2k |
| Soleus Capital Management, L.P. | Reduced | -103.0k |
| Rubric Capital Management LP | Sold out | -92.6k |
| Frazier Life Sciences Management, L.P. | Reduced | -54.3k |
| Point72 Asset Management, L.P. | Reduced | -53.9k |
| CREDIT SUISSE AG/ | Reduced | -50.1k |
| SG Americas Securities, LLC | Reduced | -33.1k |
| Integral Health Asset Management, LLC | Reduced | -30.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.4m42.2k shares |
| GROUP ONE TRADING LLC | Reduced | $2.0m25.6k shares |
| JANE STREET GROUP, LLC | New | $1.7m20.9k shares |
| SIMPLEX TRADING, LLC | Added | $1.4m17.0k shares |
| CITADEL ADVISORS LLC | Reduced | $896.7k11.2k shares |
| CITIGROUP INC | New | $664.5k8.3k shares |
| Walleye Trading LLC | New | $320.2k4.0k shares |
| Walleye Capital LLC | New | $264.2k3.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $5.7m71.2k shares |
| CITADEL ADVISORS LLC | Reduced | $1.4m17.9k shares |
| SIMPLEX TRADING, LLC | Added | $1.2m15.3k shares |
| Ikarian Capital, LLC | Reduced | $824.6k10.3k shares |
| Walleye Trading LLC | New | $744.6k9.3k shares |
| CITIGROUP INC | New | $664.5k8.3k shares |
| Walleye Capital LLC | New | $552.4k6.9k shares |
| GROUP ONE TRADING LLC | Reduced | $536.4k6.7k shares |
| Cutler Group LLC / CA | Unchanged | $14.0k400 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-10-27 | 11.6% |
| Krishnan Krish S 13G · exempt (held before listing) filed 2026-05-04 | 11.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q1 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2021 | 0 | — | 0 | — | — |
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 3 | $7.0m | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 2 | $4.1m | — |
| Q4 2022 | 0 | — | 2 | $3.1m | — |
| Q1 2023 | 0 | — | 3 | $8.3m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-03-01 | ROSSI DINO A Director | Sold | $3.3m40.0k shares |
| 2023-01-18 | Krishnan Krish S President and CEO, director | Sold | $231.0k2.9k shares |
| 2023-01-18 | Krishnan Suma President, R&D, director | Sold | $231.0k2.9k shares |
| 2023-01-18 | Krishnan Suma President, R&D, director | Sold | $230.9k2.9k shares |
| 2023-01-18 | Krishnan Krish S President and CEO, director | Sold | $230.9k2.9k shares |
| 2023-01-17 | Krishnan Krish S President and CEO, director | Sold | $1.8m22.1k shares |
| 2023-01-17 | Krishnan Suma President, R&D, director | Sold | $1.8m22.1k shares |
| 2023-01-17 | Krishnan Suma President, R&D, director · By Spouse | Sold | $1.8m21.8k shares |
| 2023-01-17 | Krishnan Krish S President and CEO, director · By Spouse | Sold | $1.8m21.8k shares |
| 2023-01-17 | Krishnan Suma President, R&D, director | Sold | $28.6k346 shares |
| 2023-01-17 | Krishnan Krish S President and CEO, director | Sold | $28.5k345 shares |
| 2023-01-04 | Krishnan Suma President, R&D, director | Sold | $315.4k3.9k shares |
| 2023-01-04 | Krishnan Krish S President and CEO, director | Sold | $315.4k3.9k shares |
| 2023-01-04 | Krishnan Suma President, R&D, director | Sold | $300.1k3.7k shares |
| 2023-01-04 | Krishnan Krish S President and CEO, director | Sold | $300.1k3.7k shares |
| 2023-01-03 | Krishnan Krish S President and CEO, director | Sold | $136.6k1.7k shares |
| 2023-01-03 | Krishnan Krish S President and CEO, director | Sold | $136.6k1.7k shares |
| 2023-01-03 | Krishnan Suma President, R&D, director | Sold | $136.6k1.7k shares |
| 2023-01-03 | Krishnan Suma President, R&D, director | Sold | $136.6k1.7k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2023
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.02% of their portfolio | 4.4m $351.8m | Added +2.3m |
| LORD, ABBETT & CO. LLC 0.28% of their portfolio | 1.9m $153.9m | Reduced -633.6k |
| Redmile Group, LLC 6.65% of their portfolio | 1.9m $153.2m | Added +16.6k |
| Avoro Capital Advisors LLC 2.08% of their portfolio | 1.8m $140.1m | Added +340.0k |
| BlackRock Inc. 0.00% of their portfolio | 1.7m $137.4m | Added +16.5k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.2m $96.3m | Added +14.1k |
| STATE STREET CORP 0.00% of their portfolio | 1.0m $82.2m | Reduced -12.6k |
| Frazier Life Sciences Management, L.P. 5.48% of their portfolio | 945.4k $75.7m | Reduced -54.3k |
| CREDIT SUISSE AG/ 0.05% of their portfolio | 632.8k $50.7m | Reduced -50.1k |
| PICTET ASSET MANAGEMENT SA 0.06% of their portfolio | 632.4k $50.6m | Added +6.4k |
| Point72 Asset Management, L.P. 0.14% of their portfolio | 502.4k $40.2m | Reduced -53.9k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 462.1k $37.0m | Added +72.8k |
| Hood River Capital Management LLC 1.16% of their portfolio | 447.4k $35.8m | Added +20.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 430.6k $34.5m | Added +18.4k |
| Artal Group S.A. 1.96% of their portfolio | 412.1k $33.0m | Added +12.1k |
| Nicholas Investment Partners, LP 2.28% of their portfolio | 374.7k $30.0m | Added +107.6k |
| BRAIDWELL LP 0.92% of their portfolio | 348.0k $27.9m | Reduced -10.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.56% of their portfolio | 311.9k $25.0m | Added +136.9k |
| BAKER BROS. ADVISORS LP 0.13% of their portfolio | 302.7k $24.2m | Unchanged |
| Skandinaviska Enskilda Banken AB (publ) 0.16% of their portfolio | 286.0k $22.9m | Reduced -1.5k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 257.9k $20.6m | Added +110.3k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 238.4k $19.1m | Added +472 |
| C WorldWide Group Holding A/S 0.25% of their portfolio | 225.8k $18.1m | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 212.1k $17.0m | Reduced -127.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 201.5k $16.1m | Added +189 |
| First Light Asset Management, LLC 1.41% of their portfolio | 196.0k $15.7m | Reduced -277.7k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 159.9k $12.8m | Reduced -726 |
| ExodusPoint Capital Management, LP 0.12% of their portfolio | 136.1k $10.9m | Added +30.4k |
| MORGAN STANLEY 0.00% of their portfolio | 126.8k $10.2m | Added +60.8k |
| S SQUARED TECHNOLOGY, LLC 5.14% of their portfolio | 108.2k $8.7m | Unchanged |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 107.3k $8.6m | Added +54.6k |
| Handelsbanken Fonder AB 0.05% of their portfolio | 105.2k $8.4m | Unchanged |
| Verition Fund Management LLC 0.12% of their portfolio | 93.6k $7.5m | Added +13.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 92.9k $7.4m | Added +24.8k |
| Candriam S.C.A. 0.05% of their portfolio | 92.0k $6.8m | New |
| Soleus Capital Management, L.P. 0.84% of their portfolio | 85.2k $6.8m | Reduced -103.0k |
| Integral Health Asset Management, LLC 1.41% of their portfolio | 85.0k $6.8m | Reduced -30.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 79.6k $6.4m | Reduced -2.5k |
| Rafferty Asset Management, LLC 0.03% of their portfolio | 61.5k $4.9m | Reduced -101 |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 1.36% of their portfolio | 61.0k $4.9m | Added +16.0k |
| Driehaus Capital Management LLC 0.06% of their portfolio | 53.9k $4.3m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 52.9k $4.2m | Reduced -4.5k |
| Invesco Ltd. 0.00% of their portfolio | 51.6k $4.1m | Added +23.5k |
| CITIGROUP INC 0.01% of their portfolio | 50.6k $4.0m | Added +21.8k |
| NORGES BANK 0.00% of their portfolio | 48.1k $3.9m | Added +25.0k |
| Hennion & Walsh Asset Management, Inc. 0.22% of their portfolio | 45.2k $3.6m | Added +32 |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 41.1k $3.3m | Added +32.8k |
| Swiss National Bank 0.00% of their portfolio | 38.9k $3.1m | Reduced -4.5k |
| CWM, LLC 0.02% of their portfolio | 35.2k $2.8m | Reduced -2.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.22% of their portfolio | 34.0k $2.7m | Reduced -24.5k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 33.2k $2.7m | Reduced -29.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 32.5k $2.6m | Added +635 |
| DekaBank Deutsche Girozentrale 0.01% of their portfolio | 30.3k $2.4m | Unchanged |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 29.9k $2.4m | Unchanged |
| BARCLAYS PLC 0.00% of their portfolio | 29.9k $2.4m | Reduced -6.5k |
| UBS Group AG 0.00% of their portfolio | 28.1k $2.3m | Reduced -14.5k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 26.1k $2.1m | Added +17.9k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 26.1k $2.1m | Unchanged |
| KENNEDY CAPITAL MANAGEMENT LLC 0.06% of their portfolio | 25.8k $2.1m | Reduced -13 |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.02% of their portfolio | 25.6k $2.0m | Reduced -1.2k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 25.4k $2.0m | Added +12.6k |
| Informed Momentum Co LLC 0.39% of their portfolio | 24.7k $2.0m | Reduced -8.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 24.4k $2.0m | Reduced -4.7k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 24.1k $1.9m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 23.8k $1.9m | Reduced -366 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 22.6k $1.8m | New |
| EFG Asset Management (North America) Corp. 0.37% of their portfolio | 20.8k $1.7m | Reduced -1.2k |
| Bellevue Group AG 0.02% of their portfolio | 18.3k $1.5m | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 18.2k $1.5m | Added +13.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 17.3k $1.4m | Added +3.9k |
| HighMark Wealth Management LLC 1.07% of their portfolio | 17.2k $1.4m | Unchanged |
| ALPS ADVISORS INC 0.01% of their portfolio | 17.0k $1.4m | Reduced -467 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 16.8k $1.3m | Added +1.3k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 16.6k $1.3m | Reduced -968 |
| Parallel Advisors, LLC 0.04% of their portfolio | 16.1k $1.3m | Reduced -17 |
| Ergoteles LLC 0.05% of their portfolio | 15.8k $1.3m | Added +1.7k |
| MARTINGALE ASSET MANAGEMENT L P 0.02% of their portfolio | 13.6k $1.1m | Unchanged |
| SEI INVESTMENTS CO 0.00% of their portfolio | 13.0k $1.0m | Reduced -3.6k |
| Vontobel Holding Ltd. 0.01% of their portfolio | 12.9k $1.0m | Reduced -1.8k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 12.5k $1.0m | Added +2.3k |
| PROFUND ADVISORS LLC 0.06% of their portfolio | 11.6k $927.2k | New |
| Calamos Advisors LLC 0.00% of their portfolio | 11.5k $922.4k | New |
| MetLife Investment Management, LLC 0.01% of their portfolio | 11.2k $895.1k | Unchanged |
| HighVista Strategies LLC 0.72% of their portfolio | 11.1k $885.3k | Unchanged |
| Legato Capital Management LLC 0.16% of their portfolio | 10.9k $875.9k | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 10.6k $850.0k | Added +688 |
| AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio | 10.3k $824.3k | Added +204 |
| Legal & General Group Plc 0.00% of their portfolio | 9.2k $740.5k | Added +2.1k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 8.8k $705.8k | Added +4.3k |
| Privium Fund Management B.V. 0.23% of their portfolio | 8.7k $694.9k | Unchanged |
| MARSHALL WACE, LLP 0.00% of their portfolio | 8.6k $686.2k | Reduced -3.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 8.5k $682.2k | Added +36 |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO 0.00% of their portfolio | 7.8k $626.0k | Unchanged |
| Allianz Asset Management GmbH 0.00% of their portfolio | 7.6k $608.5k | Reduced -4.8k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 7.3k $585.0k | Unchanged |
| JACOB ASSET MANAGEMENT OF NEW YORK LLC 0.68% of their portfolio | 7.3k $581.7k | Added +329 |
| Quantum Private Wealth, LLC 0.31% of their portfolio | 7.2k $576.8k | Unchanged |
| BLAIR WILLIAM & CO/IL 0.00% of their portfolio | 7.1k $565.0k | Added +100 |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 7.0k $559.6k | Reduced -9.6k |
| HARBOR CAPITAL ADVISORS, INC. 0.15% of their portfolio | 6.4k $511.0k | Reduced -2.1k |