Vault-13

KARYOPHARM THERAPEUTICS INC

COM · CUSIP 48576U106

115 institutional holders +0 vs Q1 2024
69,302,55269.3m shares reported held*
$60.1mreported value*
26 new 24 added 33 reduced 27 sold out net sold ≈ $6.9m (-8.0m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $0.87. Options: 8 managers hold calls ($1.2m notional), 6 hold puts ($89.5k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 147Q4 22: 156Q1 23: 132Q2 23: 139Q3 23: 121Q4 23: 121Q1 24: 115Q2 24: 115115Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 2022147
Q4 2022156
Q1 2023132
Q2 2023139
Q3 2023121
Q4 2023121
Q1 2024115
Q2 2024115

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 89 bought or addedQ4 22: 63 cut or sold outQ4 22Q1 23: 73 bought or addedQ1 23: 73 cut or sold outQ2 23: 73 bought or addedQ2 23: 66 cut or sold outQ2 23Q3 23: 56 bought or addedQ3 23: 64 cut or sold outQ4 23: 48 bought or addedQ4 23: 64 cut or sold outQ4 23Q1 24: 56 bought or addedQ1 24: 53 cut or sold outQ2 24: 50 bought or addedQ2 24: 60 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20228963
Q1 20237373
Q2 20237366
Q3 20235664
Q4 20234864
Q1 20245653
Q2 20245060

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5mQ3 23 calls: $785.4kQ3 23 puts: $181.6kQ3 23P/C 0.23Q4 23 calls: $456.0kQ4 23 puts: $26.4kQ4 23P/C 0.06Q1 24 calls: $330.3kQ1 24 puts: $320.5kQ1 24P/C 0.97Q2 24 calls: $1.2mQ2 24 puts: $89.5kQ2 24P/C 0.08
Numbers
QuarterCallsPutsP/C
Q3 2023$785.4k$181.6k0.23
Q4 2023$456.0k$26.4k0.06
Q1 2024$330.3k$320.5k0.97
Q2 2024$1.2m$89.5k0.08

Biggest buyers

Opaleye Management Inc. New +1,425,000+1.4m
JANE STREET GROUP, LLC Added +1,378,326+1.4m
KENNEDY CAPITAL MANAGEMENT LLC New +1,196,792+1.2m
MILLENNIUM MANAGEMENT LLC Added +906,547+906.5k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +819,842+819.8k
GOLDMAN SACHS GROUP INC Added +782,172+782.2k
AQR CAPITAL MANAGEMENT LLC Added +622,194+622.2k
Cubist Systematic Strategies, LLC New +568,975+569.0k
SUPERSTRING CAPITAL MANAGEMENT LP New +534,485+534.5k
BNP PARIBAS FINANCIAL MARKETS Added +500,437+500.4k

Biggest sellers

Avidity Partners Management LP Reduced -6,280,070-6.3m
BlackRock Inc. Reduced -5,277,890-5.3m
STATE STREET CORP Reduced -1,831,978-1.8m
GEODE CAPITAL MANAGEMENT, LLC Reduced -1,208,569-1.2m
MORGAN STANLEY Reduced -684,353-684.4k
VANGUARD GROUP INC Reduced -683,919-683.9k
Nuveen Asset Management, LLC Sold out -492,365-492.4k
Bank of New York Mellon Corp Reduced -320,745-320.7k
GSA CAPITAL PARTNERS LLP Reduced -315,734-315.7k
CHARLES SCHWAB INVESTMENT MANAGEMENT INC Reduced -258,909-258.9k

Biggest calls

GROUP ONE TRADING LLC Added $609.1k702.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $213.0k244.8k shares
SIMPLEX TRADING, LLC Added $147.0k170.3k shares
Alyeska Investment Group, L.P. New $125.4k144.5k shares
CITADEL ADVISORS LLC Added $69.1k79.6k shares
GTS SECURITIES LLC Added $16.0k18.4k shares
WOLVERINE TRADING, LLC Reduced $11.4k13.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $54.7k62.9k shares
CITADEL ADVISORS LLC Added $21.4k24.7k shares
WOLVERINE TRADING, LLC Added $9.9k11.4k shares
GROUP ONE TRADING LLC Reduced $2.4k2.8k shares
SIMPLEX TRADING, LLC Reduced $1.0k2.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Adage Capital Management, L.P. 13G · institution new · filed 2025-02-12 5.2% new 6.6m 2025-02-12

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 7,654,4827.7m $6.6m $6.6m 0.00% Reduced -683.9k -683,919
2 Palo Alto Investors LP 0.51% of their portfolio PALO ALTO, CA 5,102,1935.1m $4.4m $4.4m 0.51% Unchanged
3 Eversept Partners, LP 0.33% of their portfolio NEW YORK, NY 4,987,1805.0m $4.3m $4.3m 0.33% Reduced -29.1k -29,140
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio Boston, MA 4,319,8424.3m $3.7m $3.7m 0.01% Added +819.8k +819,842
5 BlackRock Inc. 0.00% of their portfolio New York, NY 4,169,7884.2m $3.6m $3.6m 0.00% Reduced -5.3m -5,277,890
6 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 3,101,3993.1m $2.7m $2.7m 0.00% Reduced -3.7k -3,670
7 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 2,580,8632.6m $2.2m $2.2m 0.00% Reduced -14.7k -14,736
8 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 2,551,7182.6m $2.2m $2.2m 0.00% Reduced -203.4k -203,450
9 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 2,290,4342.3m $2.0m $2.0m 0.00% Added +782.2k +782,172
10 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 2,274,1952.3m $2.0m $2.0m 0.00% Added +500.4k +500,437
11 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 2,092,4262.1m $1.8m $1.8m 0.00% Added +906.5k +906,547
12 Avidity Partners Management LP 0.07% of their portfolio DALLAS, TX 2,018,5002.0m $1.8m $1.8m 0.07% Reduced -6.3m -6,280,070
13 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 1,549,9761.5m $1.3m $1.3m 0.00% Added +1.4m +1,378,326
14 C WorldWide Group Holding A/S 0.01% of their portfolio COPENHAGEN, G7 1,500,0001.5m $1.3m $1.3m 0.01% Unchanged
15 Opaleye Management Inc. 0.28% of their portfolio BOSTON, MA 1,425,0001.4m $1.2m $1.2m 0.28% New
16 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,311,5361.3m $1.1m $1.1m 0.00% Reduced -1.2m -1,208,569
17 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 1,268,7771.3m $1.1m $1.1m 0.00% Reduced -56.2k -56,200
18 KENNEDY CAPITAL MANAGEMENT LLC 0.02% of their portfolio ST LOUIS, MO 1,196,7921.2m $1.0m $1.0m 0.02% New
19 AlphaCentric Advisors LLC 0.72% of their portfolio SAN JUAN, PR 1,125,0001.1m $976.0k $976.0k 0.72% Unchanged
20 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.03% of their portfolio CHICAGO, IL 1,102,3911.1m $956.9k $956.9k 0.03% Added +380.1k +380,064
21 GSA CAPITAL PARTNERS LLP 0.06% of their portfolio LONDON, X0 983,417983.4k $853.0k $853.0k 0.06% Reduced -315.7k -315,734
22 Birchview Capital, LP 0.38% of their portfolio BURLINGTON, VT 939,664939.7k $815.3k $815.3k 0.38% Unchanged
23 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 873,274873.3k $757.7k $757.7k 0.00% Reduced -19.5k -19,541
24 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 870,167870.2k $755.0k $755.0k 0.00% Reduced -88.6k -88,638
25 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 844,112844.1k $732.4k $732.4k 0.00% Reduced -118.7k -118,713
26 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 756,227756.2k $656.1k $656.1k 0.00% Reduced -150.6k -150,573
27 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 748,020748.0k $649.0k $649.0k 0.00% Added +622.2k +622,194
28 Altium Capital Management LLC 0.27% of their portfolio NEW YORK, NY 740,000740.0k $642.0k $642.0k 0.27% Unchanged
29 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 568,975569.0k $493.6k $493.6k 0.01% New
30 SILVERARC CAPITAL MANAGEMENT, LLC 0.12% of their portfolio BOSTON, MA 558,466558.5k $484.5k $484.5k 0.12% Unchanged
31 SUPERSTRING CAPITAL MANAGEMENT LP 0.58% of their portfolio NEW YORK, NY 534,485534.5k $463.7k $463.7k 0.58% New
32 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 505,684505.7k $438.9k $438.9k 0.00% Added +5.7k +5,684
33 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 453,810453.8k $393.7k $393.7k 0.00% Reduced -1.8m -1,831,978
34 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 443,474443.5k $384.8k $384.8k 0.00% Added +366.9k +366,875
35 Y-Intercept (Hong Kong) Ltd 0.02% of their portfolio HONG KONG, K3 410,954411.0k $356.5k $356.5k 0.02% New
36 Ikarian Capital, LLC 0.11% of their portfolio DALLAS, TX 409,355409.4k $355.2k $355.2k 0.11% Unchanged
37 LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio LOS ANGELES, CA 354,020354.0k $307.1k $307.1k 0.00% Reduced -33.5k -33,500
38 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 298,685298.7k $259.0k $259.0k 0.00% Added +140.8k +140,770
39 FMR LLC 0.00% of their portfolio BOSTON, MA 293,213293.2k $254.4k $254.4k 0.00% Added +19.4k +19,405
40 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 264,500264.5k $229.5k $229.5k 0.01% Added +75.0k +75,000
41 Atom Investors LP 0.02% of their portfolio AUSTIN, TX 261,847261.8k $227.2k $227.2k 0.02% Added +17.4k +17,450
42 Centiva Capital, LP 0.01% of their portfolio New York, NY 203,600203.6k $176.6k $176.6k 0.01% New
43 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 200,008200.0k $173.5k $173.5k 0.00% Reduced -684.4k -684,353
44 ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio Boston, MA 194,168194.2k $167.0k $167.0k 0.00% New
45 DAFNA Capital Management LLC 0.04% of their portfolio LOS ANGELES, CA 192,678192.7k $167.2k $167.2k 0.04% Unchanged
46 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 166,315166.3k $144.3k $144.3k 0.00% Reduced -320.7k -320,745
47 Point72 Asia (Singapore) Pte. Ltd. 0.03% of their portfolio SINGAPORE, U0 165,318165.3k $143.4k $143.4k 0.03% New
48 EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio Oklahoma City, OK 162,178162.2k $140.7k $140.7k 0.00% Reduced -50.5k -50,460
49 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 162,027162.0k $140.6k $140.6k 0.00% Added +143.1k +143,103
50 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 147,536147.5k $128.0k $128.0k 0.00% New
51 UBS Group AG 0.00% of their portfolio ZURICH, V8 140,678140.7k $122.1k $122.1k 0.00% Reduced -114.3k -114,255
52 XTX Topco Ltd 0.01% of their portfolio LONDON, X0 140,576140.6k $122.0k $122.0k 0.01% Reduced -102.3k -102,265
53 Woodline Partners LP 0.00% of their portfolio San Francisco, CA 134,112134.1k $116.4k $116.4k 0.00% Unchanged
54 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 106,470106.5k $92.4k $92.4k 0.00% New
55 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 97,10097.1k $84.0k $84.0k 0.00% Added +2.0k +2,009
56 BOOTHBAY FUND MANAGEMENT, LLC 0.00% of their portfolio NEW YORK, NY 91,09191.1k $79.0k $79.0k 0.00% Unchanged
57 State of Wyoming 0.01% of their portfolio CHEYENNE, WY 82,68582.7k $71.7k $71.7k 0.01% Added +35.4k +35,378
58 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 68,93268.9k $59.8k $59.8k 0.00% New
59 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 57,60057.6k $50.0k $50.0k 0.00% New
60 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 56,94556.9k $49.4k $49.4k 0.00% First filing
61 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 56,35756.4k $48.0k $48.0k 0.00% Reduced -80.7k -80,655
62 HSBC HOLDINGS PLC 0.00% of their portfolio LONDON, X0 53,09153.1k $48.1k $48.1k 0.00% Reduced -472 -472
63 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 51,00051.0k $44.2k $44.2k 0.00% Reduced -258.9k -258,909
64 Simplicity Wealth,LLC 0.00% of their portfolio SUMMIT, NJ 49,16049.2k $42.7k $42.7k 0.00% Added +5.1k +5,149
65 Bleakley Financial Group, LLC 0.00% of their portfolio PARSIPPANY, NJ 49,16049.2k $42.7k $42.7k 0.00% Added +5.1k +5,149
66 Focus Partners Wealth 0.00% of their portfolio ST LOUIS, MO 45,93045.9k $44.0k $44.0k 0.00% Unchanged
67 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 40,51140.5k $35.1k $35.1k 0.00% Added +12.5k +12,542
68 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 40,00040.0k $34.7k $34.7k 0.00% Unchanged
69 Freedom Investment Management, Inc. 0.00% of their portfolio SOUTH WINDSOR, CT 38,32638.3k $33.3k $33.3k 0.00% Added +9.1k +9,129
70 Baird Financial Group, Inc. 0.00% of their portfolio MILWAUKEE, WI 36,80036.8k $31.9k $31.9k 0.00% Added +16.0k +16,000
71 Point72 (DIFC) Ltd 0.00% of their portfolio DUBAI, C0 35,93935.9k $31.2k $31.2k 0.00% New
72 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 35,18435.2k $30.5k $30.5k 0.00% Added +33.5k +33,547
73 KENNEDY INVESTMENT GROUP, INC. 0.02% of their portfolio WEST DEPTFORD, NJ 35,00035.0k $30.4k $30.4k 0.02% Unchanged
74 Redwood Wealth Management Group, LLC 0.02% of their portfolio MEDFORD, NJ 34,03034.0k $29.5k $29.5k 0.02% New
75 Engineers Gate Manager LP 0.00% of their portfolio NEW YORK, NY 28,70028.7k $24.9k $24.9k 0.00% Unchanged
76 Catalyst Funds Management Pty Ltd 0.01% of their portfolio SYDNEY NSW, C3 28,60028.6k $24.8k $24.8k 0.01% New
77 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 26,79826.8k $23.2k $23.2k 0.00% New
78 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 25,20625.2k $22.0k $22.0k 0.00% Reduced -200 -200
79 Banque Cantonale Vaudoise 0.00% of their portfolio LAUSANNE, V8 25,00025.0k $22.0k $22.0k 0.00% Unchanged
80 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 22,95123.0k $19.9k $19.9k 0.00% New
81 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 22,56222.6k $19.6k $19.6k 0.00% New
82 O'SHAUGHNESSY ASSET MANAGEMENT, LLC 0.00% of their portfolio Stamford, CT 21,94121.9k $19.0k $19.0k 0.00% New
83 ELCO Management Co., LLC 0.01% of their portfolio New York, NY 19,66219.7k $17.1k $17.1k 0.01% Reduced -12.2k -12,239
84 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 16,43116.4k $14.3k $14.3k 0.00% Reduced -127.6k -127,597
85 Paloma Partners Management Co 0.00% of their portfolio GREENWICH, CT 15,43515.4k $13.4k $13.4k 0.00% New
86 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 15,17015.2k $13.2k $13.2k 0.00% Reduced -5.2k -5,178
87 Winthrop Advisory Group LLC 0.00% of their portfolio BOSTON, MA 15,00015.0k $13.0k $13.0k 0.00% Unchanged
88 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 13,99314.0k $12.1k $12.1k 0.00% New
89 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 13,86613.9k $12.0k $12.0k 0.00% Added +175 +175
90 Corient Private Wealth LP 0.00% of their portfolio MIAMI, FL 13,60013.6k $11.8k $11.8k 0.00% Reduced -300 -300
91 BLB&B Advisors, LLC 0.00% of their portfolio MONTGOMERYVILLE, PA 11,15011.2k $9.7k $9.7k 0.00% New
92 Snowden Capital Advisors LLC 0.00% of their portfolio New York, NY 11,00011.0k $9.5k $9.5k 0.00% Unchanged
93 Scientech Research LLC 0.00% of their portfolio JERSEY CITY, NJ 10,95010.9k $9.5k $9.5k 0.00% New
94 Janney Montgomery Scott LLC 0.00% of their portfolio PHILADELPHIA, PA 10,00010.0k $9.0k $9.0k 0.00% Unchanged
95 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 7,2137.2k $6.3k $6.3k 0.00% Reduced -1.4k -1,382
96 CWM, LLC 0.00% of their portfolio OMAHA, NE 6,2486.2k $5.0k $5.0k 0.00% Added +6.2k +6,236
97 Quent Capital, LLC 0.00% of their portfolio NEW YORK, NY 3,4893.5k $3.0k $3.0k 0.00% New
98 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 3,0003.0k $2.6k $2.6k 0.00% Unchanged
99 Founders Capital Management 0.00% of their portfolio HOUSTON, TX 2,0002.0k $1.7k $1.7k 0.00% Unchanged
100 MB, LEVIS & ASSOCIATES, LLC 0.00% of their portfolio CENTER VALLEY, PA 1,5001.5k $1.3k $1.3k 0.00% Unchanged